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At least 199 records · Page 11Linked to original sources
PubMed1978

Tissue localization of zinc glycinate marker and carcinoembryonic antigen by immunofluorescence. I. Preparation of antisera against the zinc glycinate marker.

Antisera against the zinc glycinate marker (ZGM) were produced in New Zealand White rabbits with induced tolerance to normal tissue components and CEA, and in mature, previously uninoculated rabbits for use in immunofluorescent histologic localization of ZGM in colon cancers and other tissues. Analysis of the antisera by immunodiffusion and counterimmunoelectrophoretic techniques showed them to be specific for ZGM when tested with ZGM, carcinoembryonic antigen, normal tissue extracts, or cell elements of normal blood.

Animals↗
PubMed1998

Ultradian movements of shoots of two species of soybeans Glycine soja (Sieb. and Zucc.) and Glycine max (L.) Merr.

Circumnutation movements of shoot tips of two species of soybean were studied. Shoot tips of Glycine soja (Sieb. and Zucc.) moved in a counterclockwise direction with a mean period (+/- SD) of 108 +/- 9 minutes when the shoots were not handled prior to monitoring (n = 17). Effects of mechanical stress or stimulation (thigmomorphogenesis) resulted in the lengthening of the mean period by 15% when shoot lengths were measured (handled) prior to monitoring movements (124 +/- 18 minutes, n = 49) or handled and restaked prior to monitoring movements (124 +/- 14 minutes, n = 11). Shoot tips of G. max cultivars moved counterclockwise, and, depending on the cultivar, periods ranged from 112 minutes to 133 minutes, with an overall average period of 124 +/- 21 minutes (n = 21). This period was identical to the mean period of comparably handled G. soja shoot tips. Amplitudes for the four G. max cultivars were much smaller (0.12 cm to 1.43 cm) than for G. soja (2.9-8.7 cm). Factors that may have contributed to differences in rhythm characteristics between species and among cultivars included the presence of a distinguishable bending zone in G. soja, but not in G. max, and morphological features associated with shoot development.

Activity Cycles↗
PubMed1989

[Nucleotide sequences encoding glycinin B4 polypeptide of the cultivated soybean Glycine max and its presumed wild-type ancestor Glycine soja in connection with the origin of cultivated soybean].

Nucleotide sequences of cDNAs encoding soybean glycinin B4 polypeptide were compared in three soybean cultivars and two plant introductions of wild soybean Glycine soja. Only two nucleotide substitutions were found in three cultivars G. max, as compared with G. max and G. soja having nucleotide sequences which contain four nucleotide substitutions. These data serve as additional evidence, at molecular level, indicating the origin of G. max from G. soja. On the other hand, the time period required for four nucleotide substitutions' accumulation, as calculated from parameters of molecular evolution of 11S globulins, is much longer than the term having passed after soybean domestication.

Base Sequence↗
PubMed1995

[Simple glycine derivatives from lipid transporter systems of glycine. Carrier test of a small-size neutral acid amine to the central nervous system].

Glycine, an important amino acid, does not cross the blood-brain barrier. Some simple derivatives have been designed to improve the unfavourable physico-chemical parameters: N-benzyloxycarbonylglycine and its methyl ester exhibit anticonvulsant activities superior to the parent amino acid. The incorporation of N-benzyloxycarbonylglycine in a pseudo-triglyceride pattern led to more active substances.

Anticonvulsants↗
PubMed1997

Molybdenum(VI) Peroxo alpha-Amino Acid Complexes: Synthesis, Spectra, and Properties of MoO(O(2))(2)(alpha-aa)(H(2)O) for alpha-aa = Glycine, Alanine, Proline, Valine, Leucine, Serine, Asparagine, Glutamine, and Glutamic Acid. X-ray Crystal Structures of the Glycine, Alanine, and Proline Compounds.

The compounds MoO(O(2))(2)(alpha-aa)(H(2)O), alpha-aa = glycine (1), alanine (2), proline (3), valine (4), leucine (5), serine (6), asparagine (7), glutamine (8), and glutamic acid (9), were prepared from the acidic aqueous solutions and characterized by examination of their IR, (1)H and (13)C NMR, and UV-visible spectra. They represent the first complexes containing a peroxo-alpha-amino acid combination in a metal ion ligand sphere. The synthesis and crystallization of these complexes was pH and concentration dependent, and their stability varied for different alpha-amino acids. X-ray structural studies of 1-3 have shown that the alpha-amino acids are coordinated as a zwitterion via one oxygen. This oxygen of the monodentate carboxylato group occupies an equatorial position in a distorted pentagonal bipyramid and encloses the pentagonal ring with the two bidentate peroxo groups. The apical positions are occupied by an oxo group and a water molecule, respectively. The Mo-O(O(2)) bonds are nonsymmetrical, differing in length by 0.009-0.045 Å. The longer bonds are located next to the coordinated carboxylato oxygen. A correlation between O-O and Mo-O bond lengths with the IR and UV-visible spectra of complexes 1-3 is discussed. Crystal structure of MoO(O(2))(2)(alanine)(H(2)O): monoclinic, space group P2(1)/c; Z = 4; a = 10.727(3) Å; b = 8.026(2) Å; c = 10.794(4) Å; beta = 110.81(2) degrees; V = 869 (Å)(3); R = 0.041. (1)H and (13)C NMR spectra in D(2)O solutions showed the presence of one complex species, which decomposed by standing in solution. Analogies and differences between Mo(VI) and V(V) peroxo complexes are outlined.

Journal Article↗
PubMed2006

Levels of glycine betaine in growing cells and spores of Bacillus species and lack of effect of glycine betaine on dormant spore resistance.

Bacteria of various Bacillus species are able to grow in media with very high osmotic strength in part due to the accumulation of low-molecular-weight osmolytes such as glycine betaine (GB). Cells of Bacillus species grown in rich and minimal media contained low levels of GB, but GB levels were 4- to 60-fold higher in cells grown in media with high salt. GB levels in Bacillus subtilis cells grown in minimal medium were increased approximately 7-fold by GB in the medium and 60-fold by GB plus high salt. GB was present in spores of Bacillus species prepared in media with or without high salt but at lower levels than in comparable growing cells. With spores prepared in media with high salt, GB levels were highest in B. subtilis spores and > or =20-fold lower in B. cereus and B. megaterium spores. Although GB levels in B. subtilis spores were elevated 15- to 30-fold by GB plus high salt in sporulation media, GB levels did not affect spore resistance. GB levels were similar in wild-type B. subtilis spores and spores that lacked major small, acid-soluble spore proteins but were much lower in spores that lacked dipicolinic acid.

Adaptation, Physiological↗
PubMed1995

Identification and synthesis of chemotactic tripeptides from alkali-degraded whole cornea. A study of N-acetyl-proline-glycine-proline and N-methyl-proline-glycine-proline.

PURPOSE: To identify and synthesize the polymorphonuclear leukocyte chemoattractant(s) released from alkali-degraded corneas. METHODS: Corneas were degraded in 1.0 N NaOH, neutralized, ultrafiltered, and dialyzed. The final active ultrafiltrate was subjected to high-performance liquid chromatography on a Protein PAK I-60 column. The most active fractions were further separated on a mu-Bondapak-C18 and I-60 column in sequence. RESULTS: Fraction 38 from the final I-60 column associated with a 210-nm absorption peak and elicited a polarization and chemotactic response from polymorphonuclear leukocytes. The loss of polarization activity in fraction 38 after exposure to prolidase suggests that this peptide contains a Pro-X (X = amino acid) peptide bond. The amino acid composition of fraction 38 was 35% glycine and 53% proline. Peptide sequence analysis was unable to establish a primary sequence even though Picotag analysis showed the presence of large amounts of the two amino acids. Mass spectrometry revealed only two molecular species of 312 MWt and 284 MWt. Tripeptides were synthesized using all possible amino acid permutations of 2 Pro and 1 Gly and tested in the polarization and chemotactic assays. These techniques demonstrated that n-acetyl-Pro-Gly-Pro, and to a lesser degree n-methyl-Pro-Gly-Pro, were the only synthetic tripeptides with activity similar to the purified chemoattractant. CONCLUSIONS: The data show that the chemotactic peptides, purified from alkali-degraded whole cornea and confirmed with identical synthetic tripeptides, are N-acetyl-Pro-Gly-Pro and N-methyl-Pro-Gly-Pro. Although a number of proteins contain the Pro-Gly-Pro sequence, large amounts of collagen in the cornea suggest this as a major source. The small size and hydrophilic nature of these chemoattractants are predictive of a high degree of diffusibility. These chemoattractants are likely to play a major role in the early neutrophil response after an alkali injury.

Amino Acid Sequence↗