Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “GLUTETHIMIDE”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 199 records · Page 11Linked to original sources
PubMed2004

Enantiomeric separation of glutethimide derivatives using a Ceramospher RU-2 column.

The enantiomeric resolution of p-acetylaminoglutethimide and p-nitroglutethimide was achieved on a Ceramospher RU-2 column using methanol as the mobile phase. The flow rates of the mobile phase were 1.0 and 0.5 mL/min for p-acetylaminoglutethimide and p-nitroglutethimide, respectively, with UV detection at 254 nm. The values of alpha of the resolved enantiomers of p-acetylaminoglutethimide and p-nitroglutethimide were 1.63 and 1.24 while the values of Rs were 1.44 and 0.86 respectively. The possible chiral mechanism was the formation of transient diastereomeric intermediates between the enantiomers and the chiral selector (1,10-phenanthroline) ruthenium II complex which was stabilized by pi-pi interactions.

Anticonvulsants↗