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Results for “Foreign-Body Migration”

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PubMed1976

[Migration of the wire after osteosynthesis].

In a 20 year old woman, sudden death due to hemopericardium ensued on osteosynthesis with Kirschner wire of a dislocated sternoclavicular joint. The wire moved to the aorta ascendens and to the right auricle thus causing lethal bleeding into the pericardium. The pathogenesis of the wandering wire is discussed and compared with observations in the literature describing causes, history and clinical phenomena. Wandering after osteosynthesis due to dislocation of the sternoclavicular joint is particularly dangerous, whereas in the case of broken clavicle, dislocation of the acromioclavicular joint, fracture of the humereus or in the region of the hips, no serious complications occur as a rule. Present-day text-books on surgery do not make sufficiently detailed reference to the wandering wire syndrome.

Adult↗
PubMed1979

Missing threads.

Explore the source record for details and available documents.

Ambulatory Care↗
PubMed1977

Experimental studies of sensitization to beryllium, zirconium, and aluminum compounds in the rabbit.

In a study designed to assess the potential sensitizing and granulomagenic capacities of selected metallic salts, rabbits were inoculated intradermally with zirconium aluminum glycinate (ZAG), sodium zirconium lactate (NZL), aluminum chlorhydrate (ACH), BeSO 4, and ovalbumin (OVA) by single and multiple injections. Animals immunized with BeSO4 and with OVA developed delayed skin reactivity as well as antigen-specific alveolar macrophage migration inhibition. Neither single nor multiple injections of ZAG or ACH resulted in clear-cut positive skin reactivity, macrophage migration inhibitory factor (MIF) production, or lymphocyte stimulation. Rabbits inoculated with multiple injections of NZL (500 microng) showed some marginally positive macrophage migration inhibition and skin reactivity. Histologically, ZAG and ACH were found to induce well-organized foreign-body granulomas after intradermal injection in both normal and inoculated rabbits. NZL and BeSO4 also induced skin granulomas, but these were less organized and distinct. Cell viability and ultrastructural studies indicated that BeSO4 was highly toxic for isolated alveolar macrophages in vitro at concentrations above 10 microng/ml, but NZL and ZAG did not exert such an effect at these dose levels. BeSO4 also depressed lymphocyte stimulation in sensitized animals which demonstrated delayed skin reactivity and macrophage migration inhibition.

Aluminum↗
PubMed1976

Ultrastructural features of proliferating fibroblasts in inflammatory granulomas.

Proliferating fibroblasts in subcutaneous connective tissue of rats after injection of peanut oil or implantation of an almost insoluble synthetic material (silicap) were characterized electron microscopically. In tissue samples of both the foreign body granulomas typical fibroblasts with abundant rough endoplasmic reticulum and a peculiar cellular modulation resembling histiocytes concerning their organelle composition were found. The morphological picture of the latter cells does not allow the conclusion that their function must be a merely phagocytic one. True myofibroblasts as detected in other stages of connective tissue proliferation are not present. The capillary vessels show a clear proliferation of their vascular cells and migration of these cells with assumption of fibroblastic features is suggested basing on morphological observations.

Animals↗
PubMed1977

Experimental study of tissue response to ruptured gel-filled mammary prostheses.

Miniature "soft gel" filled breast prostheses were implanted into rats, and half of these were purposefully ruptured upon insertion. At sacrifice of the animals later, the position of the exuded gel, the variability of the capsule thickness, and the extent of the capsule formation were evaluated. The capsule thickness was significantly increased around the ruptured prostheses, in response to the exuded gel. Also, the gel migrated through the fibrous capsule and into the surrounding tissue, eliciting an inflammatory response there to produce capsule thickening.

Animals↗
PubMed1979

Experimental granulomatous inflammation: the ultrastructure of the granuloma induced by injection of tubercle bacilli into Freund adjuvant-sensitised guinea-pigs.

Injection of killed tubercle bacilli into a sensitised guinea pig produces a characteristic biphasic response with the development of an organised epithelioid cell granuloma in the second phase. Previous sensitisation to tubercle bacilli is a requirement for development of the organised granulomatous response. The main components of the granuloma are epithelioid cells, although multinucleate cells of both Langhans and foreign-body type are present. Epithelioid cells appear to evolve from monocytes, probably in the sequence: (a) monocyte, (b) monocytic transition form, (c) immature epithelioid cell, (d) mature epithelioid cell, although some may possibly develop through a macrophage stage. Differentiation of monocytes into epithelioid cells is a continual process in the experimental tuberculous granuloma with monocytes migrating into the lesion at all stages examined. Epithelioid cells are not obviously phagocytic. Their differ4ntiation has a phase suggestive of biosynthesis during which RER is the predominant cytoplasmic component. This is followed by a storage/secretory phase in which the cytoplasm contains membrane-lined vesicles and prominent Golgi apparatus. The vesicles and, where distended, the RER laminae contain a lightly staining, finely granular material the biological activity of which is unknown.

Animals↗
PubMed1992

Evaluation of a collagen/hydroxylapatite implant for orbital reconstructive surgery.

A variety of autogenous and alloplastic materials have been used to correct enophthalmos. Hydroxylapatite (HA), is a calcium-phosphate-based compound that has been extensively studied as a bone replacement material. We studied the properties of a new dense particulate form of HA in a collagen matrix (PFC/HA) implanted in the subperiosteal space of ten rabbit orbits for a period of 6 months. All animals were studied with pre- and postoperative computed tomography (CT) scans, and measurements of induced proptosis and implant volume were made. The proptosis induced by the implant averaged 2.2 mm and was stable over a 6-month period. Implant volume was constant throughout the study. Three-dimensional computer-generated images of the soft tissue, skeletal, and implant surfaces confirmed the implant stability. All animals were studied histologically with fluorochrome bone markers, which revealed minimal foreign body reaction to the implant, no evidence of infection, and marked fibrovascular ingrowth. We found the PFC/HA to possess properties that make it an ideal implant material: ease of availability, ease of handling, no resorption, minimal immunogenicity, infection resistance, no observed migration, biointegration, and no risk of disease transmission. PFC/HA may make an excellent implant material to manage orbital volume.

Animals↗
PubMed1975

Production of lymphoid tissue in the rat brain by implants containing phytohemagglutinin.

Large numbers of plasmacytes and lymphocytic cells develop at the tip of miniature pipettes containing phytohemagglutinin (PHA) implanted into the brain of adult Lewis rats. The accumulation of lymphoid elements is present in tissue exposed to PHA for 1 week, and it persists in animals which were allowed to survive up to 10 weeks. It did not occur around control or non-active implants. Lymphoid cells usually serve as a morphologic index of immune mediated phenomena, but no evidence was seen in the present study to indicate that they produce damage to axons, dendrites or glial cells of the central nervous system despite direct contact with them. Plasma cells in the brain appear to develop from "dark" cells resembling lymphocytes that migrate into the central nervous system from reactive lymphoid tissue near the tip o.f the implant. Nerve, glial and subependymal cells do not respond with mitogenic activity to PHA.

Animals↗
PubMed1975

Studies on the feeding of larval Argas persicus Oken.

The development of the lesions caused by Argas persicus larvae while feeding on chickens, their natural hosts, was followed using histological techniques. Penetration of the skin by the mouthparts was accompanied by rapid lysis of the cells of the epidermis and dermis within 100 mum of the mouthparts. A foreign-body reaction developed within 2 mm of the attachment and was characterized by rapid dilation of blood vessels, emigration of leucocytes, particularly heterophil leucocytes (heterophils) into the tissues and oedema. Haemorrhage developed near to the mouthparts and within 2 h of the start of feeding, erythrocytes were seen in the gut caeca of the larvae. Whole blood provides the diet of the larva throughout the entire period of feeding and unlike the situation described with nymphal and adult. A. persicus the blood is lysed immediately after ingestion. By 30 h the extra-vascular heterophils had migrated to the mouthparts around which they formed a loose, superficial, collar. Further emigration of heterophils into the tissues then ceased, although some were present in the blood being ingested. It appears that the heterophils mask the mouthparts so that they are no longer recognised as foreign by the host and thus provide an example of the concept of adaptation tolerance. But the development of lymphocyte and monocyte infiltrations in the dermis close to the mouthparts indicates that the immunological response of the host to salivary secretions is not suppressed. Oedema which develops around the site of attachment further protects the larvae from the host's predations.

Animals↗
PubMed1977

Uses of RTV silicone in orbital reconstruction.

In a five-year follow-up of 42 patients with unsatisfactory cosmetic results after enulceation, room-temperature vulcanizing (RTV) silicone was used in the surgical correction of enophthalmos and superior sulcus depression. RTV silicone with a catalyst was placed in a dissected pocket subperiosteally along the floor and lateral wall of the orbit to correct the volume deficit. When vulcanizing in situ into soft silicone rubber, the implant conformed to the orbital wall and did not migrate. We determined tissue tolerance to in situ vulcanizing silicone histologically in 30 rats by inserting prevulcanized and in situ vulcanized material in paired subcutaneous pockets. No statistical difference was noted between the two methods. In 11 cases, the same material was used as a convenient stent to maintain the pressure over a graft and to maintain socket size after the reconstruction of a contrated socket, by filling the socket with RTV silicone which surrounded a Kirschner wire drilled through the lateral orbital rim.

Animals↗
PubMed1992

Silicone gel infiltration of a peripheral nerve and constrictive neuropathy following rupture of a breast prosthesis.

Following rupture of a subpectoral breast prosthesis, massive amounts of silicone gel migrated into the arm of a patient. The patient developed painful paresthesias and decreased sensation in the cutaneous distribution of the superficial radial nerve. Nerve conduction studies showed both an increase in distal latency and decreased amplitude in this nerve compared with the normal opposite side. Subsequent neurolysis confirmed dense fibrosis surrounding the nerve. Silicone droplets also were observed within the thickened epineurium of the median nerve, but no electrophysiologic evidence of neuropathy occurred. Multiple debridements of the subcutaneous tissue of the arm were necessary. In one of these specimens, histologic sections demonstrated silicone gel infiltration of a subcutaneous nerve. This is the first reported case of silicone gel infiltration of a nerve and constrictive neuropathy associated with a prosthesis rupture.

Female↗
PubMed1979

Foreign material in the capsules around breast prostheses and the cellular reaction to it.

Thirteen capsules which had formed around breast prostheses were examined, using the technique of splitting the capsule wall. A foreign material in droplet form was present in all the capsules. The foreign material was taken up by phagocytes, and the cytological evidence is that it has cytotoxic activity. It was shown that the material migrates to the vessels in the outer layer of the capsule and may reach the lumen of those vessels. On the basis of the microscopic appearance and the results of infrared spectrum analysis, the foreign material in the capsules was assumed to be silicone.

Breast↗
PubMedDate not supplied

Experimental aural cholesteatoma causing bone resorption.

A series of experiments were carried out on 55 guinea pigs in four groups to study the conditions fostering bone resorbin epidermal cysts. The first group had free grafts of canal wall skin applied to the cochlea with and without talc application. The second group had canal skin flaps applied to the cochlea with and without subsequent talc application. The third group had talc applied either to the tympanic membrane or on the cochlea. The fourth group had a canal skin flap inserted into a mucosal pocket in the bulla. The animals were killed three to four months after surgery and the temporal bones were prepared for histology. Epidermal cysts were found at the cochlea in 8 of 55 animals. Cochlear fistulas were found in 6 of 55 animals. The fistulas were associated with epidermal cysts in three cases, otitis media in two cases, and talc granuloma in one case. These experiments show that migrating skin attached to a source of epithelium is capable of inducing bone resorption. Chronic foreign body granulomas and chronic sepsis are also capable of resorbing bone. These three conditions all produce a layer of undifferentiated connective tissue containing chronic inflammatory cells lying against the resorbing bone.

Animals↗