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PubMed1995

Study of the elastic fibres' framework of the rat lung.

A combination of intravascular resin injection and formic acid incubation was used to study the three-dimensional organization of the elastic fibres of the adult rat lung by scanning electron microscopy (SEM). After SEM observations, the same samples were further processed for transmission electron microscopy (TEM) in order to confirm the presence of the elastic fibres and to complement some aspects of its surface morphology observed under the SEM. Complementary studies by light microscopy (LM) and TEM using specific histochemical methods for the elastic fibres were also performed. The SEM study clearly demonstrated that the cast of the microvasculature acted as a scaffold to preserve the in vivo arrangement of the easily collapsible elastic tissue. The methodology used allowed the observation of a fine framework of elastic fibres representing remnants of the alveolar walls in close association with the capillaries interwoven with the network of elastin. Each thick elastic fibre was composed of a bundle of thin fibres. Some of these thin fibres separated from the main fibre, join other fibres, giving the appearance of an anastomosing net. The interwoven network of elastin and its proximity with the capillaries suggests that the distensibility of the alveolar wall should contribute to the subtle rhythmical change of the alveolar microcirculation at each respiratory movement. On the sub-pleural region of the lung, the elastic fibres were observed forming a continuous and fine mesh network. The elastic fibres linking the walls of the intrapulmonary conducting airways, the vessels wall and the alveolar and sub-pleural elastic network establish an interrelated and interlaced continuous framework, certainly with great physiological implications to the overall process of the mechanics of the lung respiratory function. The methodology applied was a useful tool in order to study the spatial organization of the pulmonary elastic fibres, its branching and close relation with the other lung structures.

Animals↗

PubMed1998

Mechanical properties of buccal compact bone of the mandibular ramus in human adults and children: relationship of the elastic modulus to the direction of the osteon and the porosity ratio.

With recent advances in computers, the finite element method has been used for stress analysis of bone. In particular, the dynamic behavior of the jaw bone has been a subject of interest and analyzed by this method. However as the elastic modulus needed for this method, a uniform value is used without considering differences according to site or direction. Therefore, we measured the elastic modulus at various sites and in various directions of the mandible in adults and children. In addition, the association between the elastic modulus and histological structures was evaluated. Ten specimens of dried mandible from human adults and children were used. The elastic modulus was measured in two regions prepared by equally dividing the ramus of the mandible into lower and upper regions. Samples of 6 mm x 960 microns x 425 microns were collected from the buccal compact bone. The elastic modulus was measured using a three-point bending test. After measurement, the direction of the osteon was examined using SEM. The porosity ratio was also measured after CMR were taken. In both adults and children, anisotropy in the elastic modulus of each direction in the upper region was similar to the anisotropy in unidirectional fiber reinforced composite materials, but not in the lower region. The elastic modulus decreased slightly with an increase in the angle of the direction of osteons to the longitudinal axis of specimens. The direction of osteon may significantly influence anisotropy in the elastic modulus. The elastic modulus in adults was higher than in children in all directions. The porosity ratio in adults was smaller than that in children in all directions. The difference in the porosity ratio between adults and children may significantly influence the value of the elastic modulus.

Adult↗

PubMed2000

Elastic measurements of layered nanocomposite materials by Brillouin spectroscopy

Surface Brillouin spectroscopy makes it possible to measure surface elastic wave propagation parameters at frequencies up to 20 GHz or more. This enables us to measure the elastic properties of surface layers only a small fraction of a micrometre thick. The wavelength and incident angle of the light determine the wavenumber of surface elastic waves (SAW) that scatter the light inelastically, and their frequency can be found by measuring the change in wavelength of the scattered light. By analysing the elastic wave modes present in the surface, the elastic properties can be deduced. We have used this technique to measure the elastic properties of layered nanocomposite materials, which are widely used in the packaging industry. 12 microns polymer films (PET) were coated with glass oxide layers of thickness as little as 25 nm, to give transparent nanocomposite structures with excellent gas barrier properties. In order to understand and model the behaviour of these films under deformation, it is necessary to determine the elastic properties of the different layers. Evaluation of the elastic properties presents several challenges. First, the oxide layers are much thinner than the wavelengths of the surface phonons in surface Brillouin spectroscopy (and hence the depth probed), which usually lie in the range 250-500 nm. The anisotropic elastic properties of the PET substrate must therefore be measured accurately, and this can be done using bulk Brillouin spectroscopy. Second, a thin layer of metal (usually 10-20 nm) must be deposited on the glass surface so that the surface phonons scatter the light effectively. The elastic properties of the glass layer can then be deduced from surface Brillouin spectroscopy measurements, by simulating the surface wave modes of the metal/glass/polymer composite, and adjusting the parameters to give the best fit. In this way it is possible to observe how the properties of the glass vary as a function of thickness, and in turn to understand how to improve systematically the properties under deformation.

Journal Article↗

PubMed2005

Effect of the elastic constant anisotropy on disclination interaction in the nematic polymers.

In this work, disclination interaction behavior in relation to Frank elastic constant anisotropy in nematics has been studied. A large number of (+(1/2), -(1/2)) disclination pairs are revealed by spontaneous band texture in a semiflexible copolyester. The pairs show no preferential relative orientation, with the intervening fields showing intermediate patterns. A two-dimensional tensor lattice model considering unequal elastic constants is applied to simulate the interaction behavior and patterns of disclination pairs in the presence of elastic anisotropy. Scaling laws for disclination density rho(t) as a function of time step t with different elastic anisotropy are obtained as t(-nu). The value of the exponent nu decreases as elastic anisotropy is increased. Obviously, elastic anisotropy slows the texture coarsening. The simulations also show that angular forces arise in the presence of elastic anisotropy and change the patterns of pairs during the texture coarsening. When disclination density is considerably decreased, some +(1/2) disclinations start to rotate to the energetically favored patterns depending on the sign of the elastic anisotropy. As a result of the disclination rotation, the distribution of patterns of pairs continues to change during the annihilation. However, disclination pairs are influenced not only by elastic anisotropy but also by disclination interaction during the whole annihilation. Therefore, in a real system, the dependence of pairs on elastic anisotropy is not as strong as the theoretical prediction for an isolated pair, and the full pattern range of disclination pairs can be observed.

Journal Article↗

PubMedDate not supplied

Quantification of skin elasticity changes associated with pulsed carbon dioxide laser skin resurfacing.

BACKGROUND: While skin resurfacing using pulsed carbon dioxide lasers appears to have a skin-tightening effect clinically, the debate continues over its actual effects on dermal collagen. OBJECTIVES: To provide quantitative measures of skin elasticity changes associated with pulsed carbon dioxide laser skin resurfacing and to introduce to the facial plastic surgery community the Cutometer SEM 575 skin elasticity meter, an instrument that is useful in the measurement of skin elasticity. SETTING: University-based facial plastic surgery clinic and wound healing laboratory. DESIGN: Intervention. MAIN OUTCOME MEASURES: Measurements taken prior to and 6 months after procedure. SUBJECTS AND INTERVENTION: Thirty-two patients undergoing pulsed carbon dioxide full-face laser skin resurfacing participated. There were 12 test sites measured in 6 aesthetic units per participant. The Cutometer SEM 575 skin elasticity meter was used to measure skin elasticity changes accompanying this procedure. This device measures skin deformation with an accuracy of 10 microns. RESULTS: The change in elastic recovery (Ur/Ue) was determined. At all 6 of the facial sites, there was a statistically significant increase in skin elasticity (P < .001). Overall, there was an 18.2% improvement in skin elasticity. Site-specific changes ranged from 9% (forehead) to 22% (prejowl and periorbital). CONCLUSIONS: Skin resurfacing with the pulsed carbon dioxide laser produces a true skin-tightening effect. The Cutometer is a valuable instrument that permits accurate quantification of skin elasticity and may be useful in the evaluation of other facial plastic procedure results.

Adult↗

PubMed1986

SEM observations of the elastic networks in canine femoral artery.

Scanning electron microscopy was used to study the normal architectural arrangement of elastic tissue in a medium-sized muscular artery. Selective NaOH sonication digestion or formic acid digestion was used to expose and isolate the elastic networks in the femoral arteries of four healthy dogs. The digested segments were neutralized and freeze-dried before mounting for scanning electron microscopy (SEM) observation. The fenestrated internal elastic lamina (IEL) had a smooth surface with scattered regions of the fine elastic fibers that made up lacy networks protruding from the luminal surface. Prominent ellipsoid fenestrae, randomly scattered across the surface, were grouped into small and large sizes based on their mean diameter. The openings of most fenestrae were bridged by elastic fibers to give the fenestrae a sieve-like appearance. Large, transversely oriented, fusiform gaps were randomly scattered along the length of the IEL. These gaps, filled in by an elastic fiber network, sometimes spanned as much as a quarter of the vessel circumference. It is suggested that these gaps represent splits in the IEL that have been repaired. The tunica media contained a complex network of anastomosing elastic fibers and lamellae that were primarily circumferential in orientation. A well-defined external elastic lamina formed a solid sheet at the junction of the tunica media and the tunica adventitia. The tunica adventitia contained 8-10 incomplete lamellae of large, interconnecting, longitudinally oriented fibers. The architecture of the elastic network in canine femoral artery was compared with that previously described in medium-sized canine veins and in the rat femoral artery.

Animals↗

PubMed2005

Modeling elastic properties in finite-element analysis: how much precision is needed to produce an accurate model?

The influence of elastic properties on finite-element analysis was investigated using a finite-element model of a Macaca fascicularis skull. Four finite-element analyses were performed in which the model was assigned different sets of elastic properties. In analysis 1, elastic properties were modeled isotropically using published data obtained from human limb bones. Analyses 2-4 used data obtained from skulls of a closely allied species, M. mulatta, but varied as to how those data were incorporated into the model. In analysis 2, the model was assigned a single set of isotropic elastic properties. In analysis 3, each region within the model was assigned its own set of isotropic elastic properties. Finally, in analysis 4, each region received its own set of orthotropic elastic properties. Although a qualitative assessment indicates that the locations of strain concentrations across the model are broadly similar in all analyses, a quantitative assessment of strain indicates some differences between the analyses. When strain data from the finite-element analyses were compared to strain data derived from in vivo experiments, it was found that the model deformed most realistically using the orthotropic elastic properties employed in analysis 4. Results suggest that finite-element analyses can be adversely affected when elastic properties are modeled imprecisely, and that modelers should attempt to obtain elastic properties data about the species and skeletal elements that are the subjects of their analyses.

Anatomy↗

PubMed1995

Elastic responses to longitudinal torsion of single-strand, rectangular, orthodontic archwire segments.

OBJECTIVES: This study was undertaken to characterize elastic responses of orthodontic archwire segments in longitudinal torsion, to compare experimental results with predictions from structural engineering theory, and to examine the potential interaction between flexural and torsional responses of archwires. METHODS: Passively straight and deflected rectangular wire segments were activated in torsion to states beyond their elastic limits. The wire parameters that were controlled included: the alloy, the cross-sectional size, and the gauge length. The research design included 48 cells and 240 separate tests. From torque-twist plots, values of elastic stiffness, elastic range, and unit elastic range were obtained. Raw experimental data were subjected to analyses of variance and means to a Tukey's post-hoc test. Mean stiffness and elastic range outcomes were compared with theoretical values. RESULTS: Most plots were generally characteristic of Hookean materials. All three wire parameters significantly influenced the three dependent variables; few statistical interactions emerged. Theoretical stiffness values were reasonably comparable to those obtained experimentally; however, the elastic range predictions were conservative. Torsion theory predicts unit elastic ranges independent of gauge length; the experimental data displayed a nonlinear relationship. The minor influences of flexural deformations on the responses of wire segments activated in torsion are suggested as clinically inconsequential. SIGNIFICANCE: Few clinically relevant, controlled studies of archwire torsion have been published. A modified or new formula is needed to predict elastic range magnitudes of archwires in torsion. When flexure and torsion exist in an archwire, it may be possible to separate them to determine overall structural response.

Alloys↗

PubMed2004

Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age: comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement.

BACKGROUND: Endothelial dysfunction is the earliest marker for age-related abnormalities in vascular function, and examination of endothelial function has important clinical relevance. The present study was performed to evaluate effects of aging on arterial elasticity by using pulse waveform analysis and to investigate whether the changes in arterial elasticity might be used as a noninvasive measure for endothelial dysfunction. METHODS: A total of 24 healthy male volunteers were divided into young (n = 12) and elderly (n = 12) groups. Endothelial function was evaluated by delivering acetylcholine (Ach) and sodium nitroprusside (SNP) to the forearm vessels using iontophoresis, respectively, and measured blood flow using laser Doppler fluximetry. Large and small artery elasticity indices were noninvasively assessed using pulse wave analysis. RESULTS: Basal blood flow was similar between the young and elderly groups (14.58 +/- 3.4 v 13.52 +/- 3.41 PU, P = NS). Peak blood flow induced by Ach was significantly reduced in the elderly group compared with the young group (83.4 +/- 11.9 v 93.75 +/- 10.87 PU, P < .05). However, peak blood flow induced by SNP was similar in the two groups (119.17 +/- 16.76 v 128.33 +/- 21.29 PU, P = NS). In parallel, C1 large artery elasticity and C2 small artery elasticity indices were significantly reduced in the elderly group compared with the young group (11.42 +/- 1.67 v 16.75 +/- 2.09 mL/mm Hg x 10, P < .001; and 7.67 +/- 1.56 v 10.75 +/- 1.86 mL/mm Hg x 100, P < .001, respectively). The Ach-induced peak blood flow correlated with C1 large and C2 small artery elasticity indices. CONCLUSIONS: Advancing age is associated with endothelial dysfunction and reduced arterial elasticity. Reduced arterial elasticity parallels changes in impaired endothelium dependent vasodilation. It appears that reduced arterial elasticity may be used as a noninvasive measure for the determination of endothelial function.

Acetylcholine↗

PubMed2003

The in vitro transport of pergolide from surfactant-based elastic vesicles through human skin: a suggested mechanism of action.

This paper reports the in vitro transport of pergolide from L-595-PEG-8-L elastic vesicle formulations. Several aspects of vesicular delivery were studied in order to elucidate the possible mechanisms of action and to establish the optimal conditions and drug candidates for usage with L-595-PEG-8-L elastic vesicles. All studies were performed using human skin and flow-through Franz diffusion cells. Pergolide was chosen as model drug. The findings show that there was a strong correlation between the drug incorporation to saturated levels and the drug transport, both of which were influenced by the pH of the drug-vesicular system. The optimal pH was found to be 5.0, giving the highest drug incorporation as well as the highest drug transport. Non-occlusive co-treatment with elastic vesicles improved the skin delivery of pergolide compared to the non-occlusive buffer control by more than 2-fold. However, non-occlusive pre-treatment of skin with empty vesicles did not enhance drug transport. Occlusion improved drug transport from both elastic vesicle as well as buffer solutions due to the fact that water is an excellent penetration enhancer for pergolide. However, in contrast to non-occlusive application, the action of the elastic vesicles themselves was diminished, as occlusive treatments with elastic vesicles showed a lower flux compared to occlusive treatment with the buffer control. Hence, the highest pergolide skin permeation in this study was obtained from an occluded saturated buffer solution, giving a steady-state flux of 137.9 ng/h cm(-2). The volume of application did not have any effect on the drug transport. In conclusion, these results showed no evidence that a penetration enhancing effect is the main mechanism of action. The pH of the drug-vesicular system is an important factor to consider when optimising elastic vesicle delivery systems. Occlusion reduces the actions of elastic vesicles, but could increase the pergolide transport since water is a good penetration enhancer for this particular drug. Based on the results obtained, a mechanism of action for the elastic vesicles was proposed.

Biological Transport↗

PubMed2002

Elastic modulus measurements of human liver and correlation with pathology.

Viral hepatitis causes fibrosis in the liver and may change mechanical properties of the liver. To evaluate the impact of fibrosis on elastic properties of human liver and to investigate potential benefits of ultrasonic elasticity imaging, 19 fresh human liver samples and 1 hepatic tumor (focal nodular hyperplasia) sample obtained during operations were studied. Simple 1-D estimates based on the cyclic compression-relaxation method were performed. Elastic modulus values were derived from the predetermined strain (controlled by a step motor system) and the stress values (measured by an electronic balance). Each specimen subsequently received histologic examination and a grade of liver fibrosis was scored from 0 to 5. Results show that the elastic modulus values were on the order of several hundreds to thousands of Pascals. The elastic modulus generally increased with the fibrosis grade, although some discrepancies existed at the middle grades of fibrosis (scores 1 to 3). The correlation between the fibrosis score and the elastic modulus was significant (p < 0.01) based on the statistical analysis using the Pearson correlation method. In addition, the relation between the elastic modulus and the fibrosis grade generally exhibited a quadratic trend. It was concluded that severity of fibrosis had a good correlation with stiffness of the liver. Results also indicated that the elasticity imaging of the liver may provide significant clinical values if the elastic modulus can be accurately measured.

Elasticity↗

PubMed1995

The elastic system of a pressure-bearing tendon of the bullfrog Rana catesbeiana.

Elastic system components have been described in the pressure-bearing tendon of the bullfrog, Rana catesbeiana, as a result of histochemical tests and transmission and scanning electron microscopy. The tension region was shown to possess microfibril bundles, some of which exhibited central deposits of amorphous material. The use of ANS-butanol plus fluorescence microscopy enormously facilitated the identification of elastic system components in both tension and compression regions of the frog tendon. The compression region exhibited pre-elastic and mature elastic fibers, which were shown to be associated with the surface of the convoluted collagen bundles. Thin fibrils were observed in the compression region after ANS treatment. The visceral paratenon had an increased number of elastic fibers located between the collagen bundles and close to the cells. Congo red plus polarization microscopy failed to impart birefringence to the elastic fibers, but they could be identified by their intense staining and isotropic appearance against the bright background of birefringent collagen fibers. SEM demonstrated the three-dimensional aspects of the elastic fibers. They are composed of fibrils of a sinuous nature. The use of ruthenium red in the fixative allowed for the observation of an intimate association of proteoglycan granules with the microfibril bundles. The elastic components identified in the pressure-bearing tendon are assumed to be important for the tissue supramolecular organization, especially in the maintenance of the convoluted state of the collagen fibers in the compression region and their crimp morphology in the tension region. The elastic system must also play an important role in the restoration of the resting shape of the tendon after the deformation achieved during mechanical stimulation.

Animals↗

PubMed2001

Molecular basis for elastic energy storage in mineralized tendon.

Animals store elastic energy in leg and foot tendons during locomotion. In the turkey, much of the locomotive force generated by the gastrocnemius muscle is stored as elastic energy during tendon deformation. Little energy storage occurs within the muscle. During growth of some avians, including the turkey, leg tendons mineralize in the portions distal to the attached muscle and show increased tensile strength and modulus as a result. The purpose of this study is to test the hypothesis that the degree of elastic energy storage in mineralizing turkey tendon is directly related to the tendon mineral content. To test this hypothesis, the stress-strain behavior of tendons was separated into elastic and viscous components. Both the elastic spring constant and the elastic energy stored, calculated up to a strain of 20%, were found to be proportional to tendon mineral content. It is concluded that mineralization is an efficient means for increasing the amount of elastic energy storage that is required for increased load-bearing ability needed for locomotion of adult birds. Examination of molecular models of the hole region, where mineralization is initiated within the collagen fibril, leads to the hypothesis that elastic energy is stored in the tendon by direct stretching of the flexible regions. Flexible regions within the collagen molecule fall within the positively stained bands of the collagen D period. It is proposed that mineralization increases the stored elastic energy by preventing flexible regions within the positively stained bands from stretching. These observations suggest that mineralization begins in the hole region due to the large number of charged amino acid residues found in the d and e bands.

Animals↗

PubMed2002

Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles: characterization and in vitro transport studies.

PURPOSE: The aim of this study was to investigate the effect of elastic and rigid vesicles on the penetration of pergolide across human skin. METHODS: Vesicles used consisted of the bilayer-forming surfactant L-595 (sucrose laurate ester) and the micelle-forming surfactant PEG-8-L (octaoxyethylene laurate ester), together with the stabilizer sulfosuccinate. A series of L-595/PEG-8-L/sulfosuccinate vesicles were investigated, ranging from very rigid to very elastic. Pergolide-loaded elastic and rigid vesicles were visualized using Cryo-TEM and characterized for size and stability. Transdermal penetration of pergolide from different vesicle compositions was studied in vitro using flow-through Franz diffusion cells. A saturated buffer solution served as the control. RESULTS: Vesicle composition had a major effect on the physicochemical characteristics, morphology and drug solubility of the vesicular system. L-595/PEG-8-L/sulfosuccinate (70/30/5) elastic vesicles gave the best balance between vesicle stability and elasticity, as well as the highest drug solubility. Transport studies clearly showed that elastic vesicles were superior to rigid vesicles. Elastic vesicles enhanced the drug transport compared to the buffer control, although rigid vesicles decreased the drug transport. The best drug transport was achieved from L-595/PEG-8-L/sulfosuccinate (70/30/5) elastic vesicles, resulting in a steady-state flux of 13.6 +/- 2.3 ng/ (h*cm2). This was a 6.2-fold increase compared to the most rigid vesicles. CONCLUSIONS: This study supports the hypothesis that elastic vesicles are superior to rigid vesicles as vehicles for transdermal drug delivery.

Administration, Cutaneous↗

PubMed2004

Visco-elasticity of seminal fluid in relation to the epididymal and accessory sex gland function and its impact on sperm motility.

Seminal viscopathy was shown to be associated with male infertility. However, our knowledge about the regulatory mechanism of this process is still limited. In semen samples from 411 men attending for fertility assessment, traditional semen parameters including visco-elasticity were assessed according to the World Health Organization guidelines. Sperm motility was evaluated by use of computer aided sperm analysis (CASA). Seminal activity of neutral alpha-glucosidase (NAG) and concentrations of prostate-specific antigen (PSA), zinc, and fructose were measured. The activity of NAG, and the concentrations of PSA and zinc were significantly lower in hyper-visco-elastic semen samples (medians: 5 vs. 8 mU/mL; 741 vs. 924 mg/L; 1 vs. 2 mM/L), than in those with normal visco-elasticity (p = 0.004, 0.005 and 0.011, respectively). When comparing the total amounts, only for seminal fructose there was a difference between samples with high visco-elasticity as compared with those of normal visco-elasticity (median: 74 vs. 53 microM/ejaculate, p = 0.007) This seminal marker was the only significant independent parameter in predicting seminal visco-elasticity in a multiple logistic regression analysis (odds ratio for the highest quartile = 4.67). Hyper-visco-elasticity was associated with a lower percentage of motile spermatozoa (43 vs. 50%, p = 0.045). Similar trend was found for the CASA motility characteristics curvilinear velocity (VCL), average path length (VAP), amplitude of lateral head displacement (ALH) (p = 0.008, 0.038 and 0.020, respectively). Our study demonstrated the interplay between the regulatory effect of post-testicular organs on semen visco-elasticity. Hyper-visco-elasticity was associated with asthenozoospermia and lower levels of VCL, VAP and ALH.

Adult↗

PubMed1999

Degenerative processes of elastic fibers in sun-protected and sun-exposed skin: immunoelectron microscopic observation of elastin, fibrillin-1, amyloid P component, lysozyme and alpha1-antitrypsin.

Degenerative processes of elastic fibers in sun-protected and sun-exposed skin were analyzed by light and electron microscopic (post-embedding) immunocytochemistry using antisera to elastin, fibrillin-1, amyloid P component, lysozyme and alpha1-antitrypsin. To assess the effect of aging and sun exposure, biopsy specimens of sun-protected skin (back) and severely and moderately sun-exposed skin (face and forearms) were obtained from a young age group (1-27 years), an adult group (31-56 years) and an old aged group (61-100 years). Elastin and fibrillin-1 were the essential components of elastic fibers; elastin being localized in the electron-lucent matrix and fibrillin-1 in the dense microfibrillar strands. Aging and sun exposure provoked degenerative condensed spots, which represented widened dense microfibrillar strands, in the matrix of altered elastic fibers in the reticular dermis. Amyloid P component was first deposited on the peripheral microfibrils, and then in the intermediate density zone of the spots. Lysozyme was observed in both the electron-dense core and in the intermediate density zone of the spots. Deposition of lysozyme correlated with basophilic degeneration of the elastic fibers. In the severely photodamaged facial skin of the aged, which showed solar elastosis in the upper reticular dermis, fibrillin-1 immunoreactivity was lost from the thickened and vacuolated elastic fibers that lacked condensed spots, and amyloid P component, lysozyme and alpha1-antitrypsin were diffusely deposited in the elastin-positive matrix. It seemed that amyloid P component deposition on the elastic fibers was closely associated with aging, while immunoreactive lysozyme was related to sun exposure. Vertically oriented, thin, elastic (oxytalan) fibers in the papillary dermis tended to decrease with age, with frequent deposition of amyloid P component but no lysozyme. In the facial skin of the aged, dermal papillae disappeared, with the formation of degenerative elastic globules beneath the dermal-epidermal junction. The present study demonstrated an intimate relationship between ultrastructural alterations and deposition of exogenous substances on the degenerative elastic fibers in sun-exposed and/or aged skin.

Adolescent↗

PubMed2002

Integrated magnetic and elastic force systems.

Magnetic force increases as the distance (d) of the force- generating elements (F approximately 1/d(2)) decreases, whereas elastic force decreases as the distance decreases (F approximately kd). These opposing characteristics suggest that combining both force systems will establish an integrated system with a long-range working ability. The objective of this study was to determine the vertical closure force (F(X)) and the transverse axis moment (M(Y)) of an integrated force system, ie, attracting magnets with elastics (vertical or Classes II and III). F(X) and M(Y) were examined on the orthodontic measurement and simulation system. It was found that the integrated force system had a positive closure force (+F(X)) that never declined to 0 and a long working range. Three regions characterized the force-deflection curve of F(X): the magnetic region (0-3 mm, for magnets with 3/16-in medium elastics), in which the decline in magnetic force was larger than the increase in elastic force (6.3-2.5 N); the constant region (3-7 mm), in which the decline in magnetic force equaled the increase in elastic force (2.5-2.9 N); and the elastic region (7-10 mm), in which there was only an increase in elastic force (2.9-3.5 N). The transverse axis moment (+M(Y)), which tends to close the bite, developed especially in magnets with a single vertical elastic. Clinically, inactivation of vertical elastics by closing the mouth can be overruled by the integrated force system because it exerts adequate force level at both short and long distances.

Computer Simulation↗

PubMed2003

An in vitro comparison of 4 brands of nonlatex orthodontic elastics.

The purpose of this study was to compare 4 brands of nonlatex orthodontic elastics with respect to initial force produced and force decay over a 24-hour period. Sample sizes of 12 elastics from American Orthodontics (Sheboygan, Wis), Ortho Organizers (San Marcos, Calif), GAC International (Islandia, NY), and Masel (Bristol, Pa) were used. Equivalent or near-equivalent products were tested: the quarter-in (6.35 mm), 4 or 4.5 oz (113 or 128 g) elastics from each company. An apparatus that repeatedly cycled the elastics to simulate interarch usage with chewing was used to measure force decay over a 24-hour period. Results showed a wide range of initial forces between the brands at an extension of 3 times the marketed internal diameter. The elastics from American Orthodontics, Ortho Organizers, and Masel generated forces statistically below their marketed force levels at 3 times their marketed internal diameter extensions. GAC elastics generated significantly higher forces than marketed at 3 times internal diameter extension. All elastics generated forces below those marketed at 2 times internal diameter. Initial force production was significantly correlated with the measured cross-sectional area of the elastics (P <.01). The force decay patterns of all brands were very similar, but there were significant differences in their abilities to withstand testing. Grouped average percentages of initial force at 4, 8, and 24 hours were 68%, 61%, and 49%, respectively, for the elastics that did not break during testing.

Analysis of Variance↗