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PubMed1976

Cryosurgical treatment of cancerous and noncancerous diseases of dogs, horses, and cats.

Cryosurgery was used to treat a variety of cancerous and noncancerous diseases in dogs, horses, and cats. Follow-up evaluation on 52 animals revealed an overall "no recurrence" rate of 61%. Among the animals with no recurrence were 12 of 17 with cutaneous lesions and 5 of 8 (horses) with sarcoids. Seven of 10 dogs with anal fistulas healed after cryosurgery, but 2 had recurrence of the disease. Treatment of invasive neoplasms of the oral and nasal cavities was not successful. Side effects and complications were minimal.

Animals↗
PubMed1999

Prevalence of disease in dogs purchased from an animal rescue shelter.

The prevalence of diseases suffered by dogs within two weeks of their acquisition from a rescue shelter in Northern Ireland was investigated. A postal questionnaire was completed by 556 people who had purchased a dog from the Ulster Society for the Prevention of Cruelty to Animals (USPCA) to provide information on the diseases suffered by their dog. The majority of the dogs (53.7 per cent) had an ailment the most common being coughing and diarrhoea. Of the respondents who returned their dog to the USPCA, 92 per cent did so because the animal was unhealthy. Stray dogs were more likely to have an ailment than unwanted dogs, specifically coughing, and/or skin problems. More puppies suffered from parvovirus, vomiting, and/or diarrhoea than did juveniles or adults. Adult dogs were more likely to have a cough than juveniles or puppies. There was no association between the sex of the dogs and their ailments.

Animal Welfare↗
PubMed2004

Histopathology and immunohistochemistry of canine distemper virus-induced footpad hyperkeratosis (hard Pad disease) in dogs with natural canine distemper.

Hard pad disease represents an uncommon manifestation of canine distemper virus (CDV) infection with a still uncertain pathogenesis. To study the pathogenesis of this uncommon, virally induced cutaneous lesion, the footpads of 19 dogs with naturally occurring distemper were investigated for histologic changes and distribution pattern of CDV antigen. All dogs displayed clinical signs of distemper, which had lasted from 10 to 75 days. Overt digital hyperkeratosis was observed in 12 animals (group A), whereas the footpads of the remaining seven dogs appeared normal macroscopically (group B). Orthokeratotic hyperkeratosis (12/12; 100%), irregular acanthosis (11/12; 92%), thickened rete ridges (10/12; 83%), and mild mononuclear perivascular (10/ 12; 83%) and periadnexal (7/12; 58%) dermatitis were the most common findings in dogs with hard pad disease. Surprisingly, orthokeratotic hyperkeratosis (5/7; 71%), irregular acanthosis (5/7; 71%), and thickened rete ridges (4/7; 57%) were also seen in the dogs without clinical evidence of digital hyperkeratosis. CDV-specific inclusion bodies and ballooning degeneration were not observed in the footpad epidermis of the 19 dogs. Immunohis-tochemistry revealed that CDV antigen was most frequently found in the stratum spinosum and granulosum and in the epithelial cells of the eccrine sweat glands and only rarely in the basal layer. Fibroblasts, pericytes, endothelial cells, and hair follicles were also positive in some animals. Despite the obvious difference regarding the macroscopic picture, the microscopic changes were less prominent between the animal groups. The selective infection of keratinocytes in the stratum spinosum might be the key event for the development of hard pad disease in the dog.

Animals↗
PubMed1989

Regional distribution of ten common skin diseases in dogs.

We investigated the regional distributions of the most commonly diagnosed skin diseases in dogs from 17 North American veterinary teaching hospitals. Between January 1983 and December 1983, 11,456 diagnoses of skin disease were made. The 10 most common diagnoses were fleabite allergic dermatitis, skin cancer, pyoderma, seborrhea, allergy, demodectic acariasis (demodicosis), sarcoptic acariasis, immune-mediated skin disease, endocrine related skin disease, and acral lick dermatitis. Regional differences in the frequency of skin diseases were apparent. The northeast region had high frequencies of fleabite allergic dermatitis, allergy, and immune-mediated disease, and a low frequency of seborrhea. The midwest had a high frequency of seborrhea, and low frequencies of demodectic acariasis and allergy. In the plains region, low frequencies of fleabite allergic dermatitis, pyoderma, seborrhea, allergy, and demodectic acariasis were detected. In the west, the frequencies of fleabite allergic dermatitis, skin cancer, pyoderma, seborrhea, and acral lick dermatitis were high, whereas few dogs had allergic disease and sarcoptic acariasis. The southwest had high frequencies of fleabite allergic dermatitis and demodectic and sarcoptic acariasis. Fleabite allergic dermatitis, pyoderma, and demodectic and sarcoptic acariasis were frequently diagnosed in the southeast, but the number of dogs with seborrhea was low.

Animals↗
PubMed1991

[Anti-Borrelia burgdorferi antibody in dogs: Lyme disease as zoonosis].

To obtain epidemiological data on human Lyme disease (LD) in Japan, anti Borrelia burgdorferi (Borrelia) antibody was measured in dogs by enzyme-linked immunosorbent assay (ELISA). The anti-Borrelia antibody titer was high in 106 (27.3%) of 387 clinically healthy dogs that may have a chance of tick bite but not in any of 31 negative control dogs not exposed to ticks; the difference of the antibody titer between two groups was significant. However, no signs of arthritis were observed in any of the 106 dogs with a high anti-Borrelia antibody titer. The antibody titer was also significantly differed between the age groups less than 1 year old and 1 year old or more, the group maintained indoors and that maintained outdoors, the group with tick bites and that without tick bites, and hounds and the other dogs but not between males and females or the group vaccinated and that unvaccinated with leptospires. According to districts, high antibody titers were observed in 20% of the dogs or more in Hokkaido, Saitama, Kanagawa, Niigata, Kyoto, Kochi, and Fukuoka Prefectures. These districts were nearly consistent with the distribution of the ticks. Western blot analysis of serum samples with a high anti-Borrelia antibody titer showed 31-, 41-, 66-, and 83-Kd bands, which are also observed in sera of human patients with LD. Though no dog had clinical signs of LD, dogs serologically positive for Borrelia were detected throughout the country. The data suggested that there were the dogs infected by Borrelia burgdorferi in Japan. The data on anti-Borrelia antibody in dogs obtained by ELISA may be very useful for studying the epidemiology of LD in humans.

Animals↗
PubMed1993

Field trial of vaccination against American trypanosomiasis (Chagas' disease) in dogs.

In Santiago del Estero, an area endemic for Chagas' disease in northwestern Argentina, household dogs were vaccinated with live-attenuated Trypanosoma cruzi, and the prospective incidence of natural infection by this parasite was assessed during a two-year followup period. Vaccinated dogs received 10(7) attenuated, TCC strain T. cruzi epimastigotes and were given booster vaccinations two and 14 months later. The number of animals that could be evaluated in vaccinated versus control groups was 73 and 75 after one year and 49 and 40 after two years, respectively. Parasitologic evaluation by xenodiagnosis indicated that vaccination had reduced natural T. cruzi infection from 26.7% to 12.3% after one year (P = 0.015). The preventive effect of vaccination after the second year was less significant in spite of the booster vaccinations. Inclusion of indirect hemagglutination data for the diagnosis of infection slightly increased the number of infected dogs without affecting the evidence for protection in the first year. Serologic, parasitologic, and isoenzyme studies indicated that protection was mediated by an attenuated, self-cured infection. In 15 dogs in which the vaccination failed to completely prevent natural infection, immunization nevertheless impaired their ability to infect the natural insect vectors of the disease in humans.

Agglutination Tests↗
PubMed1975

A disease in dogs resembling human pemphigus vulgaris: case reports.

A pemphigus-like disease occurred in 5 dogs. The canine disease closely resembled pemphigus vulgaris in man and was characterized by ulcerative lesions in the oral cavity, on the skin, and at mucocutaneous junctions. Histologically, the first sign of the disease was disappearance of the intercellular bridges in the lower epidermis. The resulting acantholysis was diagnostic for pemphigus. Antibodies to the intercellular space substance were detected by immunofluorescent staining in serum of 4 of the dogs. High doses of corticosteroids were effective in controlling the disease.

Acantholysis↗
PubMed1996

The incidence of eye disease in dogs in a veterinary academic hospital: 1772 cases.

Information on the incidence of eye disease in dogs, presented to the Onderstepoort Veterinary Academic Hospital, was extracted from the records of the ophthalmology clinic for the 5 years 1990-1995. The German shepherd dog and maltese each accounted for more than twice as many patients as any other breed. The most important diseases according to breed incidence were cataracts, glaucoma, corneal ulcers, progressive retinal atrophy, iris prolapse, pannus/pigmentation and keratoconjunctivitis sicca. Problem areas in private practice were clearly identifiable and arose for different reasons.

Animals↗
PubMedDate not supplied

A study of skin diseases in dogs and cats. III. III. Microflora of the skin of dogs with chronic eczema.

The microflora of the skin was studied in 10 dogs with chronic eczema without clinical signs of secondary infection (Table I). The skin surface was swabbed at 7 different sites, making a total of 70 swabs, 25 of which were taken from visibly inflamed areas and 45 from apparently unaffected skin (Table II). Staph. aureus, Staph. epidermidis, micrococci, alpha-hemolytic streptococci, and Acinetobacter spp. were found consistently. Ten different Gram-negative bacteria, 3 different Gram-positive bacteria, and 2 yeasts were found to occur sporadically (Table III). Compared to a group of 10 healthy dogs a more prolific growth of aerobic microorganisms, a greater number of sites carrying Staph. aureus, and a higher recovery of Gram-negative transients were found in dogs with eczema (Table IV--VII). Within the group of dogs with eczema the growth of Staph. aureus was significantly heavier from eczematous skin areas than from clinically normal skin (Table VIII). In dogs with non-infective dermatitides the colonization of the skin by potentially pathogenic microorganisms may have to be considered in the clinical handling of these diseases.

Animals↗
PubMedDate not supplied

Postprandial venous ammonia concentrations in the diagnosis of hepatobiliary disease in dogs.

A postprandial ammonia tolerance test (PPATT) was performed on normal dogs and dogs with signs that suggested they may have liver disease. All dogs underwent transcolonic scintigraphy, liver biopsy, or both and were assigned to extrahepatic disease, primary hepatocellular, and congenital portosystemic vascular anomalies (PSVA) groups. Each dog was fed a chicken and rice diet providing 25% of its estimated daily metabolizable energy requirement (MER) as an ammonia challenge. This is practical in patients with liver disease because ammonium chloride administration often causes vomiting or ammonia toxicity. Venous ammonia concentrations were measured before feeding and every 2 hours after feeding for 8 hours. No difference in mean ammonia concentrations between dogs with extrahepatic disease and control dogs was found. Therefore, the specificity of the PPATT was 100%. Dogs with hepatocellular disease showed no change in mean ammonia concentration at any time point, before or after feeding, but sensitivity was greatest when venous ammonia was measured 6 hours after feeding (sensitivity before feeding, 28%, and after feeding, 36%). Among dogs with congenital PSVA, mean ammonia concentrations were higher than the reference range at all time points before and after feeding, and peak mean ammonia concentration occurred 6 hours after feeding. In this group, the sensitivity of the PPATT was 81% before feeding and 91% 6 hours after feeding. This study demonstrates that the measurement of venous ammonia concentration is a useful test to detect congenital PSVA, and the sensitivity of the test may be improved by sampling 6 hours after feeding. The PPATT has poor sensitivity in detecting primary hepatocellular disease.

Ammonia↗