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PubMed1981

Platinosomes produced in cultured cells by platinum coordination complexes.

Cells in culture were exposed to cis-dichlorodiammineplatinum (II) and platinum-uracil blue. No platinum could be demonstrated in an intracellular location morphologically or by electron-probe x-ray analysis in the case of the former compound. However, platinum was readily demonstrated in phagosomes or phagolysosomes after exposure of cells to platinum-uracil blue.

Cell Line↗
PubMed1993

Composition and biological activity of chromium-pyridine carboxylate complexes.

Coordination complexes of chromium (Cr) and two pyridine carboxylate isomers, nicotinate (nic) and picolinate (pic) were synthesized and analyzed. Cr mono and dinicotinate complexes were formed with 1:1 and 1:2 ratios of Cr3+ and nic at pH 7.5. Cr dinicotinate was the only complex formed from a 1:3 ratio of Cr3+ and nic. Mono, di, and tri picolinate complexes were formed with 1:1, 1:2, and 1:3 ratios of Cr3+ and pic at pH 7.5. Cr is coordinated with nic through the carboxyl carbon while Cr is coordinated with pic through both the pyridine nitrogen and the carboxyl carbon. Cr dinicotinate enhanced insulin activity in isolated adipose tissue. None of the other complexes were active in this assay system. In contrast, Cr tripicolinate, which is lipophilic, increased glucose uptake by skeletal muscle cultures but none of the other complexes were effective. In addition, dietary supplements of Cr tripicolinate increased rate of lean body mass development in humans and decreased hemoglobin glycation in aging rats. None of the other complexes was effective in these in vivo assays. The results of this investigation prove that the chemical properties of Cr nic and Cr pic complexes differ markedly. The chemical differences result in a vast difference in the biological action of the complexes.

Adipose Tissue↗
PubMedDate not supplied

[Thin layer chromatography of coordinated Ag+-complexes of plant diacylglycerols].

Coordination complexes of unsaturated rac-1,2-diacylglycerols (DAGs) with silver ions were separated by adsorption and reversed-phase TLC (Ag-TLC and Ag-rpTLC, respectively). During the Ag-TLC, the silver ion complexes were shown to be formed by the DAG coordination centers of various structures and only on the adsorbent surface. Separation of the complexes proceeds according to the adsorption mechanism, and there is an inverse exponential functional relationship between the DAG mobility and their double bond number. Meanwhile, during the Ag-rpTLC, the Ag(+)-complexes are formed only with double bonds, only in solution, and at a 1:1 ratio. The complexes are fractionated by partitioning between two liquid phases, and the relationship between the mobility and unsaturation of these complexes is directly proportional. Nevertheless, despite all the differences between the two TLC methods, the polarity of DAGs with a bent configuration of their acyl chains greatly exceeds that of DAGs with the same unsaturation but with the acyl-chain conformation close to extended: it is two to three times greater in Ag-TLC and 30-40% greater in Ag-rpTLC. In addition, the relationship between the mobility and unsaturation of DAG complexes exhibits quantitative rather than qualitative differences in both versions of argentation TLC. Thus, under all conditions of argentation liquid chromatography, the mobility of complexes and, therefore, their polarity are determined not only by their composition (unsaturation), but also by the spatial structure (conformation) of their molecules.

Chromatography, High Pressure Liquid↗