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Results for “Conjunctival Neoplasms”

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At least 199 records · Page 11Linked to original sources
PubMed1982

Ocular adnexal lymphoid tumors. Correlative ultrastructural and immunologic marker studies.

Twenty-two ocular adnexal lymphoid infiltrates were analyzed by electron microscopy as well as immunologically and cytochemically. Five reactive polyclonal lesions were found to be preponderantly composed of small mature lymphocytes (presumably T cells) with clumped nuclear chromatin, sparse cytoplasmic organelles, and numerous monoribosomes. In 11 monoclonal B-cell lesions, both the 1-micrometer plastic sections examined by light microscopy and the electron micrographs disclosed immature cells, with more dispersed nuclear chromatin, prominent nucleoli, abundant cytoplasmic polyribosomes, and increased numbers of mitochondria and strands of endoplasmic reticulum particularly in plasmacytoid lesions). The remaining six monoclonal B-cell lesions were composed of comparatively well-differentiated cells requiring electron microscopy to show somewhat more prominent nucleoli, slightly less dense clumping of the nuclear chromatin, increased numbers of mitochondria and short segments of rough-surfaced endoplasmic reticulum, and monoribosomes rather than polyribosomes. The importance of distinguishing this group of well-differentiated monoclonal lesions from the less well-differentiated ones was underscored by the results of the follow-up examinations, in that no evidence of extraorbital disease has been discovered in the former group, while a 50% incidence occurred in the latter.

Adolescent↗
PubMed1983

Nitrous oxide cryotherapy for intraepithelial epithelioma of the conjunctiva.

Nine patients were treated with the nitrous oxide eyelid cryoprobe for large or recurrent intraepithelial epithelioma of the conjunctiva or cornea. Nitrous oxide cryotherapy is more convenient for ocular cryosurgery than liquid nitrogen therapy and seems to be as effective for intraepithelial epithelioma. Surgical debulking of the lesion is recommended before cryosurgery. An obvious advantage of cryosurgery over surgical modalities for intraepithelial epithelioma is that large areas of tumor as well as surrounding tissues can be treated. This procedure results in a higher cure rate and avoids grafting and symblepharon formation. The complications of light cryosurgery seem to be minor even when the cornea is treated. Heavy cryosurgery may result in severe iritis, posterior synechiae, and corneal scarring. A biopsy-proved diagnosis of intraepithelial epithelioma can be misleading and does not rule out the presence of underlying malignant disease.

Aged↗
PubMed1983

Conjunctival myxoma. A clinicopathologic study of four cases and a review of the literature.

Myxomas are benign tumors that resemble a primitive mesenchyma and rarely occur in the conjunctiva. A clinicopathologic study of four new cases is reported, with a review of the clinical, structural, and behavioral characteristics of the previously reported eight cases. In this study, histochemical analysis of the mucous substance indicated that hyaluronic acid and chondroitin sulfates were present. On ultrastructural examination, the myxoma cell had secretory vacuoles and numerous intermediate-sized cytoplasmic filaments. Adults of an average age of 50.8 years were most often affected. The most common initial complaint was of a painless, slow-growing conjunctival mass, present for an average of 31 months. These tumors typically had a smooth, fleshy, gelatinous appearance. The high recurrence rate that has been noted in orbital and cardiac myxomas was not a feature of these conjunctival myxomas. With an average follow-up of 29 months, a single excision appeared to have been adequate treatment.

Adolescent↗
PubMed1984

Mucoepidermoid carcinoma of the conjunctiva.

A 73-year-old man had a limbal nodule that, on histopathologic examination, proved to be mucoepidermoid carcinoma of the conjunctiva. Despite radiation therapy and extensive corneoscleral lamellar resection, widespread invasion of the lids and orbit ultimately led to exenteration. Although mucoepidermoid carcinoma of the conjunctiva resembles squamous cell carcinoma clinically and histopathologically, it pursues a more rapid and destructive clinical course. Intraepithelial invasion often leads to tumor involvement of conjunctiva and skin that seem normal on clinical examination. Special stains and a high level of suspicion are required for diagnosis of mucoepidermoid carcinoma of the conjunctiva, and proper initial management demands more aggressive surgical resection than is usually indicated for squamous cell carcinoma.

Aged↗
PubMed1985

Pilomatrixoma. An unusual case with secondary corneal ulcer.

A 51-year-old man presented with a three-month history of a red and painful right eye. A corneal ulcer was diagnosed, and laboratory workup failed to disclose an etiologic factor. A white tumor, with an irregular and calcified surface, found in the superior tarsal conjunctiva, was considered to be the cause of the corneal ulcer. The tumor proved to be a pilomatrixoma that presumably developed from a congenitally ectopic hair follicle.

Conjunctival Neoplasms↗
PubMed1986

Bilateral total corneal and conjunctival choristomas associated with epidermal nevus.

A 4-year-old boy had been noted from birth to have bilateral masses obscuring the entire outer portion of the eyes. Systemic findings included mild growth retardation, multiple cortical lesions of the distal metaphyseal ends of the lower extremities, and diffuse skin pigmentation of the right side of the body. The epibulbar lesions were excised; on the right side, there was a thin cornea that necessitated corneal transplantation. The diagnosis of composite epibulbar choristomas associated with linear epidermal nevus was established by pathologic examination. This case report as well as a literature review establish the association of epibulbar choristomas with cutaneous linear nevi of the epidermal and sebaceous types.

Biopsy↗
PubMed1986

Embryonal rhabdomyosarcoma of the conjunctiva. A clinicopathologic and immunohistochemical study.

Rhabdomyosarcoma of the conjunctiva is a rare lesion, with few previously reported cases. We have observed such a tumor occurring in a 16-year-old girl. The clinical and pathologic entities to be considered in differential diagnosis in such cases are several; in this circumstance, immunohistologic reactivity for desmin and myoglobin (two muscle-related proteins) allows a definitive interpretation of rhabdomyosarcoma to be made. This article documents the clinicopathologic features of the epibulbar rhabdomyosarcoma seen in our patient and discusses the immunocytochemical characteristics of myogenic tumors in general, in the context of ocular neoplasia.

Adolescent↗
PubMed1986

Genital tract papillomavirus type 6 in recurrent conjunctival papilloma.

An infant boy born of a mother who had condylomata (genital warts) during pregnancy and at delivery developed recurrent conjunctival papillomas and papillomas on the soft palate and the false vocal cords. A conjunctival lesion was first noticed by the mother when the infant was 4 months old and was excised and histologically diagnosed as a papilloma when he was 11 months old. The DNA sequences of genital tract human papillomavirus type 6 (HPV-6) were identified in conjunctival papilloma tissue by Southern transfer hybridization of tissue DNA extracted from a lesion excised at 29 months of age as well as by in situ hybridization of paraffin sections of the diagnostic biopsy specimen obtained at 11 months of age. It is probable that the infant acquired conjunctival infection from the mother, very likely during passage through the infected birth canal.

Condylomata Acuminata↗