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Filmless radiology at the Baltimore VA Medical Center: a 9 year retrospective.

The transition from conventional film based to filmless operation at the Baltimore VA Medical Center in 1993 was successful and has resulted in a number of clinical and economic benefits. The subsequent integration of the Department of VA hospitals in Maryland into a single network, the VA Maryland Health Care System, resulted in the opportunity to establish a 'virtual' radiology and nuclear medicine department. This integrated department is based upon a wide area network in which outlying medical centers utilize a central HIS/RIS and a central commercial Picture archival and communication system (PACS) as well as a VA 'home grown' image management and communication system, the VISTA imaging system. The creation of this virtual radiology/nuclear medicine department has resulted in additional savings and improvements in clinical care. The benefits of the PACS were made possible, to a large extent, by the high level of integration of the PACS and medical modalities with the hospital information and transcription systems. Our experience suggests that it is absolutely essential to integrate the PACS into the patient's electronic medical record in order to maximize efficiency and clinical effectiveness of the system.

Baltimore↗

Shock trauma Baltimore, USA.

Following attendance at a lecture by an anaesthetist who had spent time at the R. Adams Cowley shock trauma centre, and after seeing a documentary about Cowley's work on BBC TV, we began to investigate the possibility of spending time at the trauma centre as observers. In July 1993, we spent 2 weeks in Baltimore observing a system that has been tailored to meet the needs of multiply injured patients by utilising resources and the skills of all members of the multidisciplinary team.

Baltimore↗

Epidemiology of unexplained fatigue and major depression in the community: the Baltimore ECA follow-up, 1981-1994.

BACKGROUND: Fatigue is a common, non-specific, subjective symptom associated with several medical and psychiatric illnesses. The purpose of this investigation was to explore further the epidemiology of unexplained fatigue in the general population and the relationship between fatigue and depression. METHODS: The design was a prospective population-based study. Subjects included community-dwelling adults who were participants of the Baltimore sample of the Epidemiologic Catchment Area Program in 1981 and who were reinterviewed 13 years later. Lay interviewers using the Diagnostic Interview Schedule interviewed subjects. RESULTS: Number of somatization symptoms and history of a dysphoric episode at baseline were the two strongest predictors of both new onset of fatigue as well as recurrent/chronic fatigue over the 13-year follow-up interval. In addition, individuals who reported a history of unexplained fatigue at baseline as well as during the follow-up, were at markedly increased risk for new onset major depression as compared to those who never reported such fatigue, (RR = 28.4, 95% CI) (11.7, 68.0). Similarly, respondents who developed new fatigue or had remitted fatigue after 1981 were also at increased risk for developing major depression. CONCLUSIONS: Somatization was the strongest predictor of both new and chronic fatigue with unknown cause. In addition, fatigue was both predictive and a consequence of the depression syndrome.

Adolescent↗

Incidence of suicide ideation and attempts in adults: the 13-year follow-up of a community sample in Baltimore, Maryland.

BACKGROUND: Utilizing a prospectively designed community sample, we set out to estimate the rate of newly-incident suicidal ideation and attempts (non-fatal suicide behaviour) in a community sample, to evaluate antecedent sociodemographic characteristics and psychiatric disorders, and to assess use of mental health services in relation to non-fatal suicide behaviour. METHOD: Prospectively-gathered data was utilized from 3481 continuing participants in the 13-year follow-up of the Baltimore sample of the NIMH Epidemiologic Catchment Area survey interviewed in 1981, 1982 and 1993/6. RESULTS: The incidence of suicide attempts was estimated at 148.8 per 100,000 person-years and ideation at 419.9 per 100,000 person-years. Persons in the youngest age group, in the lowest socioeconomic status, and previously married persons were at increased risk for non-fatal suicide behaviour during the follow-up interval. Persons who reported suicidal ideation at baseline were more likely to report having attempted suicide at follow-up (RR = 6.09, 95% CI 2.58-14.36). Psychiatric disorders, especially depression and substance abuse, were associated with new-onset of non-fatal suicidal behaviour. While persons who reported newly-incident suicidal behaviour were more likely to report use of mental health services, few said that suicidal ideation or attempts were the reason for the visits. CONCLUSIONS: Suicidal ideation is a common and important antecedent to suicide attempts and deserves more attention in community and general medical settings.

Adolescent↗

A survey of zoonotic pathogens carried by Norway rats in Baltimore, Maryland, USA.

Norway rats (Rattus norvegicus) carry several zoonotic pathogens and because rats and humans live in close proximity in urban environments, there exists potential for transmission. To identify zoonotic agents carried by rats in Baltimore, Maryland, USA, we live-trapped 201 rats during 2005-2006 and screened them for a panel of viruses, bacteria, and parasites. Antibodies against Seoul virus (57.7%), hepatitis E virus (HEV, 73.5%), Leptospira interrogans (65.3%), Bartonella elizabethae (34.1%), and Rickettsia typhi (7.0%) were detected in Norway rats. Endoparasites, including Calodium hepatica (87.9%) and Hymenolepis sp. (34.4%), and ectoparasites (13.9%, primarily Laelaps echidninus) also were present. The risk of human exposure to these pathogens is a significant public health concern. Because these pathogens cause non-specific and often self-limiting symptoms in humans, infection in human populations is probably underdiagnosed.

Animals↗

The epidemiology of delirium in the community: the Eastern Baltimore Mental Health Survey.

The 1981 East Baltimore Mental Health Survey, part of the Epidemiological Catchment Area (ECA) program, provided data for the examination of the prevalence of delirium in the general adult population. From an original 3,841 households surveyed, 810 individuals were selected for psychiatric evaluation and, of these, 6 individuals were diagnosed as suffering from delirium. The estimated prevalence of delirium in the population was .4% and 1.1% among those 55 years of age and over. A comparison of these cases with cases of diagnosed dementia and individuals of the same age range who did not receive a psychiatric diagnosis found that those with a diagnosis of delirium suffer from a greater number of medical conditions, take more prescribed medications, and have a higher level of physical disability.

Aged↗

Review of accidents/injuries among emergency medical services workers in Baltimore, Maryland.

OBJECTIVES: To characterize the types of occupational exposures and injuries reported by emergency medical service (EMS) workers. METHODS: A blinded review of accidents/exposures among EMS workers employed by a Baltimore County fire department was conducted. Medical records for 1992 were reviewed. RESULTS: Two hundred and twenty-six reports were filed by EMS workers (n = 197) employed by a large, urban fire department in 1992. The most commonly reported injuries were sprains (23%), strains (20%), and exposure to blood and body fluids (15%). The body site most commonly injured was the back (20%) followed by the respiratory system (10%). Most incidents were treated at the employee health clinic, and 13% of the incidents resulted in a hospital visit. Fifteen percent of the injuries resulted in more than seven lost work days. Most incidents were caused by stretcher mishaps, especially during transport of heavy patients. Walkway impediments (e.g., icy steps, wet leaves, broken and uneven pathways) also played an important role in creating slipping and tripping hazards. CONCLUSION: These results suggest a variety of prevention strategies aimed at reducing accidents and exposures among EMS workers.

Absenteeism↗

Mass spectrometry of individual particles between 50 and 750 nm in diameter at the Baltimore Supersite.

The performance of the real-time single-particle mass spectrometer RSMS III is evaluated for ambient fine and ultrafine particle number concentration measurements. The RSMS III couples aerodynamic size selection with laser ablation time-of-flight mass spectrometry for single-particle analysis. It was deployed at the Baltimore particulate matter Supersite for semi-continuous operation over an 8-month period. The sampling protocol adopted for this study permitted the analysis of on average 2000 particles per day. The number of particles analyzed is a tradeoff between generating a statistically significant data set and maintaining instrument operation over a long period of time. The optimum particle size range of analysis was found to be ca. 50-770 nm in diameter, although particles as small as 45 nm and as large as 1250 nm were also analyzed. While nitrate, sulfate, and carbon (elemental and organic) were found to dominate the ambient aerosol, over 10% of the detected particles contained transition and/or heavy metals. The (size-dependent) detection efficiency, defined as the fraction of particles entering the inlet that are analyzed, was determined by comparison with scanning mobility particle sizing data. Using the experimentally determined detection efficiencies, particle number concentrations of specific chemical components were estimated. While the sampling protocol allowed the particle concentrations of major chemical components to be followed as a function of both time and particle size, minor components required averaging over time and/or size to achieve adequate precision.

Aerosols↗

Impact of the 2002 Canadian forest fires on particulate matter air quality in Baltimore city.

With increasing evidence of adverse health effects associated with particulate matter (PM), the exposure impact of natural sources, such as forest fires, has substantial public health relevance. In addition to the threat to nearby communities, pollutants released from forest fires can travel thousands of kilometers to heavily populated urban areas. There was a dramatic increase in forest fire activity in the province of Quebec, Canada, during July 2002. The transport of PM released from these forest fires was examined using a combination of a moderate-resolution imaging spectroradiometer satellite image, back-trajectories using a hybrid single-particle Lagrangian integrated trajectory, and local light detection and ranging measurements. Time- and size-resolved PM was evaluated at three ambient and four indoor measurement sites using a combination of direct reading instruments (laser, time-of-flight aerosol spectrometer, nephelometer, and an oscillating microbalance). The transport and monitoring results consistently identified a forest fire related PM episode in Baltimore that occurred the first weekend of July 2002 and resulted in as much as a 30-fold increase in ambientfine PM. On the basis of tapered element oscillating microbalance measurements, the 24 h PM25 concentration reached 86 microg/m3 on July 7, 2002, exceeding the 24 h national ambient air quality standard. The episode was primarily comprised of particles less than 2.5 microm in aerodynamic diameter, highlighting the preferential transport of the fraction of PM that is of greatest health concern. Penetration of the ambient episode indoors was efficient (median indoor-to-outdoor ratio 0.91) such that the high ambient levels were similarly experienced indoors. These results are significant in demonstrating the impact of a natural source thousands of kilometers away on ambient levels of and potential exposures to air pollution within an urban center. This research highlights the significance of transboundary air pollution and the need for studies that assess the public health impacts associated with such sources and transport processes.

Air Movements↗

Use of social services by pregnant Medicaid eligible women in Baltimore.

OBJECTIVES: To use linked health and social service databases to determine differences in the use of social services by pregnant women in different managed care systems. METHODS: Comparison of service use by women enrolled in a fee-for-service primary care case management program (Maryland Access to Care or MAC), in a capitated health maintenance organization (HMO), or not assigned to managed care using six state databases. Participants included 5181 women receiving Medical Assistance (MA) and delivering in Baltimore City in 1993. Outcome measures were receipt of WIC, AFDC, and Food Stamps. RESULTS: The overall proportions of women receiving WIC, AFDC, and Food Stamps at delivery were 52.7%, 89.2%, and 62.7%, respectively. Women enrolled in an HMO at delivery were less likely to be receiving WIC (adjusted odds ratios, 0.8, 95% CI, 0.69 to 0.93), AFDC (OR, 0.20; CI, 0.03 to 0.43 for women with prior children and OR 0.13; CI, 0.09 to 0.20 for women without prior children), and Food Stamps (OR 0.77; CI, 0.59 to 0.95 for women with prior children and OR, 0.49; CI, 0.35 to 0.67 for women without prior children) than their MAC counterparts. Women not assigned to managed care also generally were less likely than their MAC counterparts to receive WIC (OR 0.55; CI, 0.46, 0.66), AFDC (OR 1.07; CI 0.83, 1.30 for women with prior children and OR 0.24; CI 0.18, 0.34 for women without prior children), and Food Stamps (OR 0.31; CI 0.08, 0.55 for women with prior children and OR 0.31; CI 0.23, 0.41 for women without prior children). CONCLUSIONS: Although many low-income pregnant women qualify for select social services, receipt of WIC and Food Stamps was low. Increasing efforts are needed by managed care systems and public health agencies to ensure delivery of appropriate services for women.

Adolescent↗

Hierarchical linear modeling analyses of the NEO-PI-R scales in the Baltimore Longitudinal Study of Aging.

The authors examined age trends in the 5 factors and 30 facets assessed by the Revised NEO Personality Inventory in Baltimore Longitudinal Study of Aging data (N=1,944; 5,027 assessments) collected between 1989 and 2004. Consistent with cross-sectional results, hierarchical linear modeling analyses showed gradual personality changes in adulthood: a decline in Neuroticism up to age 80, stability and then decline in Extraversion, decline in Openness, increase in Agreeableness, and increase in Conscientiousness up to age 70. Some facets showed different curves from the factor they define. Birth cohort effects were modest, and there were no consistent Gender x Age interactions. Significant nonnormative changes were found for all 5 factors; they were not explained by attrition but might be due to genetic factors, disease, or life experience.

Adult↗

Prediction of hourly microenvironmental concentrations of fine particles based on measurements obtained from the Baltimore scripted activity study.

Researchers have developed a variety of computer-based models to estimate population exposure to air pollution. These models typically estimate exposures by simulating the movement of specific population groups through defined microenvironments. During the summer of 1998 and winter of 1999, researchers with the Harvard School of Public Health (HSPH) conducted a field study in Baltimore, MD, to acquire data for improving microenvironmental models. Using a special roll-around instrument system, a technician measured 1- and 12-h pollutant concentrations while engaging in scripted sequences of activities typical of retirees. Each scripted activity assigned the technician to a geographic location and to a microenvironment. The technician recorded special conditions associated with each activity (e.g., open windows, environmental tobacco smoke) in a real-time diary. Data on ambient pollutant levels, temperature, and other potential explanatory factors were also collected. Eleven pollutants were measured by the roll-around instrument system, including particulate matter with an aerodynamic diameter less than 2.5 microm (PM2.5), ozone, carbon monoxide, and benzene. This article presents the results of statistical analyses performed solely on the 1-h PM2.5 data measured by a DustTrak monitor, which ranged from 1.5 to 444.8 microg/m3 with a median value of 14.6 microg/m3. Results of stepwise linear regression (SLR) suggest that PM2.5 exposure is significantly increased by passive smoking, high ambient PM2.5 concentrations reported by fixed-site monitors, food preparation, charcoal grills, car travel, outdoor roadside locations, and high humidity. Analysts should explicitly represent the effects of these parameters within any model developed to estimate population exposure to PM2.5. In a related study, a panel of volunteer retirees each carried a personal PM2.5 monitor and a real-time diary for nominal 24-h sampling periods as they engaged in normal daily activities. A regression equation derived from SLR analysis of the scripted activity database was applied to eight subject-days of diary data provided by the volunteer seniors to produce estimates of PM2.5 exposure for each event documented in each diary. The event-specific exposure estimates were then averaged over all events in each sampling period to produce nominal 24-h average exposure estimates. The absolute difference between the estimate obtained from the regression equation and the corresponding personal monitor measurement averaged 13%. The fixed-site monitors generally provided poorer estimates of exposure; the absolute differences for the Old Town and Clifton Park monitors averaged 26.7% and 19.5%, respectively, of the personal monitor values.

Air Pollutants↗

The 1998 Baltimore Particulate Matter Epidemiology-Exposure Study: part 1. Comparison of ambient, residential outdoor, indoor and apartment particulate matter monitoring.

A combined epidemiological exposure panel study was conducted during the summer of 1998 in Baltimore, Maryland. The objectives of the exposure analysis component of the 28-day study were to investigate the statistical relationships between particulate matter (PM) and related co-pollutants from numerous spatial boundaries associated with an elderly population, provide daily mass concentrations needed for the epidemiological assessment, and perform an extensive personal exposure assessment. Repeated 24-h integrated PM2.5 (n=394) and PM10 (n=170) data collections corresponding to stationary residential central indoor, individual apartment, residential outdoor and ambient monitoring were obtained using the same sampling methodology. An additional 325 PM2.5 personal air samples were collected from a pool of 21 elderly (65+ years of age) subjects. These subjects were residents of the 18-story retirement facility where residential monitoring was conducted. Mean daily central indoor and residential apartment concentrations were approximately 10 microg/m3. Outdoor and ambient PM2.5 concentrations averaged 22 microg/m3 with a daily range of 6.7-59.3 microg/m3. The slope of the central indoor/outdoor PM2.5 mass relationship was 0.38. The average daily ratio of PM2.5/PM10 mass concentrations across the measurement sites ranged from 0.73 to 0.92. Both the central indoor and mean apartment PM2.5 mass concentrations were highly correlated with the outdoor variables (r>0.94). The lack of traditionally recognized indoor sources of PM present within the facility might have accounted for the high degree of correlation observed between the variables. Results associated with the personal monitoring effort are discussed in depth in Part 2 of this article.

Aged↗

The 1998 Baltimore Particulate Matter Epidemiology-Exposure Study: part 2. Personal exposure assessment associated with an elderly study population.

An integrated epidemiological-exposure panel study was conducted during the summer of 1998 which focused upon establishing relationships between potential human exposures to particulate matter (PM) and related co-pollutants with detectable health effects. The study design incorporated repeated individual 24-h integrated PM2.5 personal exposure monitoring. A total of 325 PM2.5 personal exposure samples were obtained during a 28-day study period using a subject pool of 21 elderly (65+ years of age) residents of an 18-story retirement facility near Baltimore, Maryland. Each sample represented a unique 24-h breathing zone measurement of PM2.5 mass concentration. PM2.5 and PM10 mass concentrations collected from the apartments of the subjects as well as residential and ambient sites were compared to individual and mean PM2.5 personal exposures. Daily PM2.5 personal exposure concentrations ranged from 2.4 to 47.8 microg/m3 with an overall individual study mean of 12.9 microg/m3. Mean PM2.5 personal exposures were determined to be highly correlated to those representing the central indoor (r=0.90) and ambient sites (r=0.89). Subjects reported spending an average of 92% of each day within the confines of the retirement center. Based upon measured and modeled exposures, a mean PM2.5 personal cloud of 3.1 microg/m3 was estimated. Data collected from these participants may be unique with respect to the general elderly population due to the communal lifestyle within the facility and reported low frequency of exposure to sources of PM.

Activities of Daily Living↗

No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants.

Recent studies by Ebstein et al and Benjamin et al found associations between long repeat polymorphisms in the D4 dopamine receptor gene (D4DR) and individual variation in a human personality trait, identified as 'Novelty Seeking' (NS). Ebstein et al used the Tridimensional Personality Questionnaire (TPQ) to measure NS scores; Benjamin et al used the Revised NEO Personality Inventory (NEO-PI-R) to estimate NS scores. However, Malhotra et al failed to replicate the association between the direct measure of NS using the TPQ and the long alleles of the D4DR genotypes in two Finnish samples. In an attempt to confirm the association found by Benjamin et al using NEO-PI-R estimated NS, the present study used an alternative design extreme groups strategy to select high and low novelty seeking research volunteers from the Baltimore Longitudinal Study of Aging (BLSA). There were no significant associations between long alleles (7-repeat allele) and high novelty seeking groups. The findings of Ebstein and colleagues and those of Benjamin and colleagues do not generalize to this American middle-aged, mixed-gender sample, a conclusion also consistent with the findings of a recent Swedish study. Demographic factors such as the age and gender composition of the samples are important sources of variation in allelic association studies and future research must carefully address whether the D4DR genetic polymorphisms vary substantially across demographic groups.

Adult↗

The prevalence of blindness and visual impairment among nursing home residents in Baltimore.

BACKGROUND: Although the prevalence of blindness and visual impairment increases with age, most surveys of ocular disease do not include nursing home residents. METHODS: We conducted a population-based prevalence survey of persons 40 years of age or older residing in nursing homes in the Baltimore area. Of 738 eligible subjects in 30 nursing homes, 499 (67.6 percent) participated in the study. They had their eyes examined and their visual acuity tested and were interviewed in detail. The nonparticipants were more likely to be older, to be white, and to have lower scores on the Mini-Mental State Examination. RESULTS: The prevalence of bilateral blindness (visual acuity < or = 20/200) was 17.0 percent. The prevalence of visual impairment (< 20/40 but > 20/200) was 18.8 percent. The frequency of blindness increased from 15.2 percent among those under 60 years of age to 28.6 percent among those 90 or older. The age-adjusted prevalence of blindness was 50 percent higher among blacks than among whites (P < 0.01). As compared with the noninstitutionalized population from the same communities, the rate of blindness among nursing home residents was 13.1 times higher for blacks and 15.6 times higher for whites. Cataract was the leading cause of blindness, followed by corneal opacity, macular degeneration, and glaucoma. We judged that 20 percent of the functional blindness and 37 percent of the visual impairment could be remedied by adequate refractive correction. CONCLUSIONS: Blindness and visual impairment are highly prevalent among nursing home residents. Much of this loss of vision could be treated or prevented with appropriate ophthalmologic care.

Adult↗

A heroin epidemic at the intersection of histories: the 1960s epidemic among African Americans in Baltimore.

In the drug field the fundamental epidemiological question-why illicit drug use, here, now, among these people-has still not been adequately answered. Drawing on the work of colleagues in medical anthropology, we attempt to move closer to an answer by developing a "trend theory." In this article we analyze a single case: the increase in heroin use and addiction among African Americans in the City of Baltimore in the 1960s. We found that the two most important historical processes behind the epidemic were (1) a changing distribution/supply system and (2) the mix of hope and despair that was part of the early civil rights movement.

Black or African American↗

Correlates of initiation of injection drug use among young drug users in Baltimore, Maryland: the need for early intervention.

This article examines individual and social factors associated with initiation of illicit drug injection, with a focus on racial differences. Data were derived from across-sectional survey of young injection and noninjection drug users in Baltimore, Maryland. Participants were aged 15 to 30 and had initiated use of heroin, cocaine, and/or crack within the prior five years. Bivariate and multivariate logistic regression models were used to identify correlates of injection initiation. Of 579 drug users, 73% were injectors, 56% were male, and 41% were African American. In a multivariate model controlling for age, correlates of injection initiation were: being an African American male [Adjusted Odds Ratio (AOR): 0.08; 95% Confidence Interval (CI): 0.04, 0.17] or female (AOR = 0.12; 95%CI: 0.06, 0.27) compared to being a White male; younger age of first use of alcohol, marijuana, or inhalants (AOR=0.73; 95%CI: 0.65, 0.82); shorter time between first use of alcohol, marijuana, or inhalants and first use of heroin, crack, or cocaine (per year decrease, AOR=0.63, 95%CI: 0.40, 0.87); parental drug use (AOR=0.54, 95%CI: 0.32, 0.92); seeing someone inject prior to injection, AOR=1.96, 95%CI: 1.01, 3.50); and crack smoking (AOR=1.77, 95%CI: 1.07, 2.99). Early drug use patterns and drug exposure factors are associated with initiation injection. Interventions are needed that target noninjection drug users to prevent transition to injection drug use.

Adolescent↗