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A case of abdominal abscess and bacteremia due to Cardiobacterium hominis and Clostridium bifermentans was successfully treated with surgical drainage and ampicillin-penicillin. This case represents the rare occurrence of C. hominis infection without apparent endocarditis.
A septic course suggestive of intra-abdominal abscess followed surgery in a small child with a perforated appendix. Usual diagnostic studies, fluoroscopy, and rectal and wound exploration failed to localized an abscess. The use of gallium 67 scanning accurately localized multiple abscesses which were successfully drained.
Ninety-three abdominal abscesses and fluid collections (pseudocysts, hematomas and bilomas) in 79 patients were treated under radiological guidance, for a total of 111 procedures (23 needle aspirations (NA) of 17 foci and 88 catheter drainages (CD) of 84 foci). In eight foci both methods were used. Catheter drainage was curative in 65% of abscesses and in 56% of pseudocysts and improved the patients' condition before surgery in another 11% or 10%, respectively. The aim of CD could not be achieved in 24% of the abscesses and in 34% of the pseudocysts. Needle aspiration showed little effect being curative in only 6% and partially beneficial in 24% as all the foci were considered. Complications occurred in 8% of CD:s and in 0% of NA:s. We suggest that radiologically guided CD of abscesses and fluid collections should be the primary therapeutic approach in all cases where this can be performed safely. The therapeutic effect of NA was poor.
An intra-abdominal abscess was diagnosed in a 7-year-old mare by palpation per rectum and from abnormal clinicopathologic findings. Initial treatment with procaine penicillin for 21 days was unsuccessful in halting the deterioration of the physical condition of the mare. Surgical exploration of the abdomen revealed a mass in the wall of the left ventral colon. Drainage was achieved by marsupialization. Serratia marcescens was isolated from the abscess. Recovery appeared complete, and the mare has resumed broodmare capability.
BACKGROUND: Colon wounds are recognized to be highly associated with intra-abdominal abscess (IAA) after penetrating trauma, whereas gastric wounds are thought to contribute minimally to abscess because of the bactericidal effect of low pH. This study evaluated the impact of stomach or colon wounds, the contribution of other risk factors, and associated abdominal injuries on IAA. METHODS: Patients with penetrating colon or stomach wounds during a 10-year period were reviewed and stratified by age, Injury Severity Score, transfusions, and associated abdominal injuries. Early deaths (<48 hours) from hemorrhage were excluded. Outcomes analyzed were IAA and death. RESULTS: A total of 812 patients were identified. There were 32 late deaths (4%), of which 28% were attributable to IAA and multiple organ failure. IAA rates for isolated stomach or colon wounds were 0 and 4.2%, respectively. The presence of associated injuries increased IAA rates to 7.5 and 8.8%, respectively. Independent predictors of IAA determined by multivariate analysis included age, transfusions, gunshot wounds, and associated injuries to the liver, pancreas, and kidney. CONCLUSION: Gastric injuries are equivalent to colon wounds in their contribution to IAA. Contamination from either organ without associated injury is minimally associated with IAA, but injury to both appears synergistic. The immunosuppressive effects of age and hemorrhage, in addition to significant associated injury, enhance the development of IAA.
A prospective study to evaluate the radiologic and sonographic features of intraabdominal abscesses in a mixed Nigerian population was undertaken. 30 patients with suspected abscesses were studied and a total of 70 abdominal abscess sites were confirmed at surgery or during autopsy in 22 patients. The more common abscess sites were the paracolic and pelvic areas. Typhoid enteritis, perforated duodenal ulcer and septicaemia were the aetiological factors in 54%, 13.6% and 13.6% respectively. The more common radiological feature was that of extraluminal gas vesicles and relatively echo free collections were identified during ultrasound. Poor prognosis was associated with typhoid enteritis, multiple abscess sites and acute renal failure.
Computed tomographic (CT) findings are reviewed in nine patients with clinically unsuspected abdominal abscesses. None of the patients in this series had significant fever or leukocytosis. Localized pain or a palpable mass was the primary clinical feature in seven patients. Computed tomography demonstrated encapsulated fluid collections without gas in five patients representing chronic abscess. Computed tomography was diagnostic of an abscess in three patients and guided aspiration was helpful in demonstrating an abscess in two other patients. The inability to make a correct preoperative diagnosis of an abscess in four of the nine cases was due to a low level of clinical suspicion, a nonspecific CT appearance, and failure to perform diagnostic aspiration.
An 11-year-old German shepherd dog cross was presented with a six-week history of weight loss and abdominal distension. A diagnosis of abdominal abscess and discospondylitis was made. The dog responded to surgical excision of the abscess and conservative medical treatment for discospondylitis.
Percutaneous drainage of abdominal abscesses is an alternative to surgical treatment. Two cases of abscesses with fistulous communication to the GI tract, percutaneously drained successfully, are presented. Reevaluation of these and other relative contraindications of this technique are reviewed.
OBJECTIVE: The objective of our study was to differentiate the CT findings of gelatin bioabsorbable sponges used as hemostatic agents from postoperative abdominal abscess. CONCLUSION: Gelatin absorbable sponge may mimic a postoperative abscess on CT. Findings that may help differentiate the hemostatic agent from abscess include linear arrangement of tightly packed gas bubbles, fixed position of gas bubbles on subsequent examinations, shape, lack of air-fluid level, and lack of enhancing wall.
Where a potentially hazardous approach for drainage of an intra-abdominal abscess or fluid collection is unavoidable, the double-needle puncture technique described here can prevent inadvertent penetration of bowel.
The microbiology of intra-abdominal abscess in children is similar to that of adults--a mixture of aerobes and anaerobes. In abscess specimens taken from 36 children, predominant pathogens were Bacteroides fragilis group species, Peptostreptococcus species, and Escherichia coli.
Using a recently developed, low mortality model of an intra-abdominal abscess in the Wistar rat, we have studied the penetration of fleroxacin into the abscess. Maximum serum concentration was 1.83 +/- 0.39 mg l and occurred 1 h after iv injection (20 mg/kg), but even at 4 h after administration the mean serum level was 1.21 +/- 0.27 mg/l. By contrast, levels in pus were 6.27 +/- 0.83 mg/l at 1 h rising steadily to a value of 12.7 +/- 3.69 mg/l at 4 h. The study has confirmed exceptional antibiotic penetration into the abscess, with levels at all time intervals between 0.5 and 8 h after administration in excess of the MIC50 for Escherichia coli, Proteus vulgaris and Clostridium perfringens.
This study describes the role of ultrasound in the evaluation of abdominal abscesses in children. A total of 41 abscesses were encountered in 36 patients (21 boys and 15 girls). The youngest patient was 1-month-old. Abscesses were localised at various sites (hepatic, renal, perirenal, paracolic, appendicular, pelvic, psoas, subphrenic, parietal), and of varied sonographic patterns (complex, anechoic, hypoechoic and containing uniform low level echoes). Most of them had irregular walls.
BACKGROUND: The present study evaluated the safety of treatment of colorectal liver metastases with radio frequency ablation (RFA) in combination with high doses of the selective cyclooxygenase-2 inhibitor celecoxib. MATERIALS AND METHODS: The study was performed in the CC531 rat model for colorectal cancer. The rats were inoculated with CC531 tumor cells subcapsularly in the liver. They were then randomized for treatment with celecoxib, RFA, or their combination. Celecoxib treatment was started at tumor induction. Three weeks later the liver tumors were treated with RFA and the effects on the health of the rats were monitored. RESULTS: Treatment that included RFA resulted in significantly (p=0.003) more deaths than sham-operated rats. Including celecoxib in the treatment resulted in significantly increased cutaneous wound abscess formation after surgery (p<0.0001). In addition, the combination of celecoxib treatment with RFA resulted in intra-abdominal abscess formation (p<0.0001). CONCLUSION: The results indicated that the combination of high-dose celecoxib and RFA for treating liver metastases should be used with caution when applied as an anticancer treatment modality since additional side-effects are induced.
A unique Helicobacter species, MZ640285, was isolated from a patient with X-linked hypogammaglobulinemia suffering from recurrent abdominal abscesses and was identified by 16S rRNA gene sequence analysis. In the phylogenetic tree, the isolate fell into a cluster which included Flexispira rappini, Helicobacter bilis, and Helicobacter sp. strain Mainz. Helicobacters are being increasingly recognized as pathogens in immunocompromised hosts. These fastidious bacteria are not easily cultured in the routine diagnostic laboratory, and this is the first report of their identification by 16S rRNA gene sequencing performed directly from a clinical specimen.
During the past five years, 65 patients were treated for intra-abdominal abscesses unassociated with prior operation. Radiologic tests proved quite accurate in confirming the diagnosis. Abdominal x-ray films were abnormal in 25 (57%) of 44 patients, as were ultrasonograms in 33 (89%) of 37 patients, computed tomography scans in 13 (100%) of 13 patients, and gallium scans in five (100%) of five patients. Celiotomy was performed in each patient with both abscess drainage and the appropriate management of the diseased organ. Seven patients (10.8%) died, and in five death was due to uncontrolled sepsis. Duration of hospitalization averaged 23 days (seven days preoperatively and 16 days postoperatively). Twenty-two (34%) of 65 patients had an incorrect preoperative diagnosis leading to prolonged antibiotic treatment and delay in operation. The mortality was significant in seven (10.8%) of 65 patients, unrelated to the type of operative drainage (Penrose v sump) but clearly related to uncontrolled intra-abdominal sepsis. A heightened suspicion of this problem should allow for an earlier diagnosis and an improved outcome. Prompt abdominal reexploration is indicated in those patients manifesting continued evidence of sepsis or organ failure.
A model was developed to permit direct assessment of antibiotic efficacy against Enterococcus species in experimental intra-abdominal abscess. Abscesses yielded Enterococcus faecalis in pure culture. Antimicrobials were delivered by precisely controlled continuous intravenous infusion. After five days of therapy, ampicillin alone or in combination with gentamicin reduced residual bacterial titers from 7.93 +/- 1.05 (untreated) to 3.51 +/- 1.07 and 3.52 +/- 0.81 log10 colony forming units per gram, respectively. Both the clindamycin and gentamicin combination (6.49 +/- 1.33) and metronidazole and gentamicin combination (6.79 +/- 0.90) significantly suppressed the growth of enterococci (p less than 0.01). Combined clindamycin and aztreonam was ineffective, as were any of the agents used alone (except ampicillin). These results may explain, in part, the clinical efficacy of certain drug combinations against the enterococcal component of polymicrobial abscesses despite the apparent lack of in vitro activity of individual agents.