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At least 199 records · Page 11Linked to original sources
PubMed1992

[Local anesthetics. CVII. Local anesthetic effects of phenylcarbamates--the effect of connecting chain modification].

The preceding study of the effect of the branching of the connecting chain by the metoxymethyl-, ethoxymethyl- and propoxymethyl group on the alpha carbon on local anaesthetic activity was a stimulus for the preparation of 16 drugs of the group of 1-ethoxyethoxymethyl-2-(1-pyrrolidinyl-), 2-piperidino- and 2-(1-perhydroazepinyl) ethyl esters of o-, m- and p-alkoxyphenylcarbamic acids. The discontinuation of the substituent on the alpha carbon of the connecting chain by another oxygen atom (introduction of an ethoxyethoxymethyl group) has a positive effect on surface and infiltration anaesthesia. Of the prepared agents, 2-piperidino- and 2-(1-perhydroazepinyl-) derivatives with a hexyl or heptyloxy group in the o-position of the benzene ring were most effective; they exceeded the standards cocaine and procaine more than one hundred times. p-Derivatives were least effective; in some cases their indices of effectiveness did not achieve the effectiveness of the standards in both surface and infiltration anaesthesia under study. Acute toxicity of all drugs lies within the range of the toxicities of the standards.

Anesthetics, Local↗
PubMed1991

[Anesthetic gases, the ozone layer and the greenhouse effect. How harmful are the anesthetic emissions for the global environment?].

During the last decade, world society has acknowledged the harmful effects on the environment of the greenhouse effect and of depletion of the ozone layer, caused by industrial emissions of man-made compounds. Ozone depletion is caused mainly by chlorine compounds or nitrogen oxides released by degradation in the stratosphere. The greenhouse effect is caused by increased trapping of terrestrial heat radiation. Degradation of the anaesthetic vapours halothane, enflurane and isoflurane releases chlorine, and nitrous oxide degradation produces reactive nitrogen oxides. Nitrous oxide in particular, but also the vapours, absorb terrestrial radiation. The total discharge of anaesthetic vapours contributes to less than 0.01% of the total atmospheric chlorine load, and the annual Norwegian release of approximately two tons accounts for 0.2% of the world total. It is estimated that the total amount of nitrous oxide released from anaesthetics accounts for 0.05% of the greenhouse effect, while annual Norwegian emissions of nitrous oxide (less than 160 tons) comprise 0.2-0.4% of world total. Because of their favourable clinical properties and their modest contribution to ozone depletion and the greenhouse effect, medical use of inhalational anaesthetic agents should not be banned. However, low flow anaesthetic techniques should be employed, in order to reduce their negative impacts on the atmosphere.

Air Pollutants↗