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At least 199 records · Page 11Linked to original sources
PubMed2002

Using oral tetracycline and topical betamethasone valerate to treat acrodermatitis continua of hallopeau.

Acrodermatitis continua of Hallopeau (ACH) is a rare type of localized pustular psoriasis. We report the case of a 65-year-old alcoholic woman who had severe inflammatory ACH for 10 years. Initial therapy with sulfasalazine was unsuccessful. The patient was then treated with oral tetracycline and topical betamethasone valerate with occlusive dressing. Her condition improved dramatically after one week.

Acrodermatitis↗
PubMed1992

Corneal involvement in acrodermatitis enteropathica: a case report.

A case of acrodermatitis enteropathica occurred with corneal changes consisting of superficial punctate lesions, nebulous subepithelial opacities and linear epithelial erosions. These manifestations exacerbated intermittently whenever the patient ran out of her oral zinc sulphate therapy, but regressed and disappeared when she resumed her medication.

Acrodermatitis↗
PubMed2004

Acrodermatitis continua.

A 54-year-old woman presented with a 5-year history of erythema and pustules on the distal portion of her left index finger. Acrodermatitis continua of Hallopeau is a rare, chronic, sterile pustular eruption affecting the distal aspects of the digits. It is often considered to be a variant of pustular psoriasis that tends to be resistant to both topical and systemic treatments for psoriasis.

Acrodermatitis↗
PubMed1992

Lyme borreliosis presenting as acrodermatitis chronica atrophicans.

A patient is described who developed acrodermatitis chronica atrophicans, arthralgias and polyneuropathy as manifestations of Lyme borreliosis. The clinical diagnosis was confirmed by histological and serological examinations. Despite a long delay before the diagnosis was established, the patient responded very well to treatment with doxycycline.

Acrodermatitis↗
PubMedDate not supplied

The successful use of etanercept in combination therapy for treatment of acrodermatitis continua of hallopeau.

Acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis which poses a challenge to treat and causes considerable pain and suffering for those afflicted. Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine involved in the pathogenesis of ACH and other forms of psoriasis. Inhibition of TNF-alpha has been shown to provide benefit in such inflammatory conditions as rheumatoid arthritis, psoriatic arthritis, and, most recently, plaque psoriasis. In this report, we present the case of a 65-year-old man with a 9-year history of recalcitrant ACH who demonstrated significant and sustained clinical improvement when etanercept, a competitive inhibitor of TNF-alpha, was added to his treatment regimen of acitretin and topical corticosteroids over a 12-week period.

Acitretin↗
PubMed2006

Etanercept responsive acrodermatitis continua of Hallopeau: is a pattern developing?

Acrodermatitis continua of Hallopeau (ACH) is a rare disease. Little is known about its etiology or relative effectiveness of the various therapeutic approaches. However, in the literature a pattern seems to be developing on successfully treated patients using biologic therapies. Here, we further emphasize the potential breakthrough presented by the novel immune based therapies. This report consists of a case of etanercept responsive ACH along with a brief review of the literature.

Acrodermatitis↗
PubMed1991

[Chronic atrophic acrodermatitis; a deceptive form of Lyme borreliosis].

Acrodermatitis chronica atrophicans (ACA) was diagnosed in 15 patients from the southern and eastern part of Friesland (the Netherlands). Twelve patients had one leg affected; three had more than one extremity involved. Frequent complaints were fatigue, paraesthesia, swelling and blue discoloration. The symptoms persisted for many years in most cases. The inflammatory stage was observed most frequently (13/15): violet-blue erythema, oedema, firm swelling and nodules. Atrophy (4/15) was observed once in the form of a scleroderma-like lesion. Neuropathy was found in five patients. Histological investigation showed infiltration with lymphocytes and plasma cells (13/15) and atrophy (2/15). Spirochaetes were demonstrated in biopsies of 13 patients. Specific antibodies against Borrelia burgdorferi were found in all patients. ACA appears to be not infrequent and must be distinguished from other inflammatory and vascular diseases, such as chronic venous insufficiency.

Acrodermatitis↗
PubMed1977

Acrodermatitis enteropathica, zinc, and the Paneth cell. A case report with family studies.

An infant with acrodermatitis enteropathica was studied before and after starting zinc therapy. Clinical recovery was rapid, and the plasma zinc, serum and mucosal alkaline phosphatase activities returned to normal. Light microscopy of small intestinal biopsies showed normal mucosa. Electron microscopy of the Paneth cells initially revealed abnormal inclusion bodies which disappeared during therapy, suggesting that the abnormality is secondary to zinc deficiency, and not a primary defect. These abnormal inclusions may represent altered secretory granules and a proliferation of lysosomes. We were unable to define the heterozygous state biochemically or histologically.

Acrodermatitis↗
PubMed1991

[Acrodermatitis enteropathica; a literature review].

A young girl with recurrent upper respiratory tract infection showed minor skin lesions and was found to suffer from acrodermatitis enteropathica. She responded dramatically to treatment with zinc sulphate. We review the signs and symptoms and their reported frequencies in 196 reported patients. The classical triad, dermatitis, alopecia and intractable diarrhoea is present in only 20% of the cases. Their intermittent occurrence and the vast range of other, also misleading symptoms, may cause a diagnostic problem. Treatment is effective, safe and simple: 3 to 30 mumol zinc per kg per day. Attention should be paid to sorbitol, added to the standard Dutch zinc sulphate prescription. It may induce diarrhoea.

Acrodermatitis↗
PubMedDate not supplied

[Enteropathic acrodermatitis in light of personal observations].

Observations are reported carried out on the course and treatment of enteropathic acrodermatitis in 14 children. In the children the characteristic clinical picture before treatment was associated with low serum zinc level. Determination of serum zinc level during the treatment with zinc sulphate is without decisive importance for the selection of maintenance doses and the drug must be taken often during many years. In the choice of the therapeutic dose the clinical effects should be taken into account, and the dose may not be so high that it would normalized serum zinc level.

Acrodermatitis↗
PubMed1985

Serologic studies of erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans with indirect immunofluorescence and enzyme-linked immunosorbent assays.

To determine whether antibodies to Borrelia spirochetes were present, sera from 88 patients with uncomplicated erythema chronicum migrans Afzelius (ECMA), from 9 patients with ECMA-related extracutaneous complications and from 26 patients with acrodermatitis chronica atrophicans (ACA) were submitted to an enzyme-linked immunosorbent assay (ELISA) and an indirect immunofluorescence (IF) assay. The assays were calculated to be 95% specific. There was good correlation between the IF test with a polyvalent conjugate and IgG ELISA. Of patients with uncomplicated ECMA, 18% were seropositive by IgG ELISA and 11% by IgM ELISA, and 15% showed elevated IF titers. Elevated serum antibody levels of IgG as measured by ELISA and elevated IF titers were found in all patients with extracutaneous complications and in the patients with ACA. Declining IgG titers were observed at follow-up 6-12 months after therapy, but the majority of the patients with ACA were still seropositive.

Acrodermatitis↗
PubMed1987

Acrodermatitis chronica atrophicans in association with lichen sclerosus et atrophicans: tubulo-interstitial nephritis and urinary excretion of spirochete-like organisms.

We report about a 38-year-old male patient with coexisting acrodermatitis chronica atrophicans, lichen sclerosus et atrophicans and recurrent diabetic metabolic disorders since 9 years. Serologically IgG antibodies against Borrelia burgdorferi could be detected. Moveless winded structures, morphologically resembling borreliae could be demonstrated in the urine sediment by dark field microscopy. Additionally a tubulo-interstitial nephritis was diagnosed by the presence of a dysmorphic hematuria, a pathological polyacrylamide gel electrophoresis and raised alpha 1- and beta 2-microglobulin in the urine. We suggest that the excreted spirochete-like structures are borreliae. They may be the putative infectious agent for the development of lichen sclerosus et atrophicans in the genital area.

Acrodermatitis↗
PubMed1989

[An association between hepatitis-B antigen-negative infantile papular acrodermatitis and Epstein-Barr virus infection].

The virological studies on 23 patients with infantile papular acrodermatitis (IPA) without hepatitis B virus (HBV)-associated antigens and antibodies were performed. The following results were obtained; 1) There was serological evidence of primary Epstein-Barr virus (EBV) infection in 17 out of 23 cases (74%). 2) The regression assays was done in 5 cases of IPA and 10 cases of infectious mononucleosis known to be associated with primary EBV infection in order to investigate the development of EBV-specific killer T cell activity in the primary EBV infection. The results confirm the evidence for EBV-specific cellular immunity in both patients with IPA and infectious mononucleosis. 3) The in vitro transformation assays was also done in 4 cases of IPA and 10 cases of infectious mononucleosis. Incidence of in vitro spontaneous transformation in the presence of cyclosporin A was significantly higher in patients of IPA and infectious mononucleosis than in the EBV seropositive controls. These results confirm that EBV plays an important role on the pathogenesis of HBV-negative IPA.

Acrodermatitis↗
PubMed1989

Acitretin monotherapy in acrodermatitis continua Hallopeau.

In a patient affected with acrodermatitis continua Hallopeau, acitretin (Ro 10-1670) monotherapy resulted in a complete clearance of pustulation at a dosage of 45 mg per day. At this dosage the leukotriene B4-induced intraepidermal accumulation of polymorphonuclear leukocytes was markedly inhibited.

Acitretin↗
PubMed1989

[Chronic atrophic acrodermatitis].

All the 18 patients with acrodermatitis chronica atrophicans (ACA) showed the specific borrelia antibody at the indirect immunofluorescence assay. The patients exhibited a large spectrum of arthritic and neurologic complaints besides the typical cutaneous symptoms. Changes of proteins, of liver-typical parameters and of the electrocardiogram are also assigned to the Lyme-borreliosis. The penicillin therapy - three times accompanied by a Jarisch-Herxheimer-reaction - led to regression of the clinical changes. The secessions of borrelia-antibody-titers happens only very delayed. That is why it can not be used for the direct therapy control. The increased documented polysymptomatic of Lyme-borreliosis requires a wider knowledge and the country-wide possibility of specific diagnostic.

Acrodermatitis↗
PubMedDate not supplied

Acrodermatitis enteropathica--a case report.

Acrodermatitis enteropathica is a rare disease affecting infant girls. The skin in these cases develop rashes which start as vesicles and then dries to form erythematous squamous psoriasiform type of lesions. Dystrophy of nails and alopecia with loss of eye lashes and eye brows is also seen. Low serum zinc level is found in these patients and is thought to be the cause of this disease.

Acrodermatitis↗
PubMedDate not supplied

[Gianotti-Crosti acrodermatitis. Description of a case of rare etiology].

Originally described in 1955, papular acrodermatitis is considered a rare disease whose manifestations are mainly cutaneous. The disease is characteristically associated to a non icteric hepatitis with B serologic tests positive. We recently observed a case whose etiology is unusual and, therefore, in our opinion worth of a brief description.

Acrodermatitis↗
PubMed1989

[Extensive acrodermatitis chronica atrophicans involving the face].

We report on an 81-year-old woman suffering from extensive acrodermatitis chronica atrophicans with facial involvement. This unusual manifestation may be related to an immunodeficiency state in the course of multiple malignancies. The cutaneous lesions cleared significantly during an aminopenicillin therapy administered orally over 4 weeks.

Acrodermatitis↗