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At least 199 records · Page 11Linked to original sources
PubMed1987

Effect of indomethacin on the injection-abortion interval of 15(S) 15 methyl PGF2 alpha-induced mid-trimester abortions--a randomized study.

There have been conflicting reports on the effect of non-steroidal anti-inflammatory drugs on the abortifacient effect of prostaglandins. The efficacy of intra-amniotic 1.5 mg 15(S) 15 methyl PGF2 alpha (15 me PGF2 alpha) in terminating mid-trimester pregnancy in 10 subjects has been compared with the effect of the same medication given to 10 others who had had indomethacin 25 mg and 50 mg orally three and one hour before the PG administration. In the subjects who had the PG analogue only the injection-abortion interval was 17.0 hours. This was significantly shorter (P less than 0.01) than in those who had also received indomethacin (25.4 hours).

Abortifacient Agents↗
PubMed2004

New fetoproteins, as presumptive antigenic inducers of abortions and congenital anomalies. Temporal forking of immunological abortions. A working hypothesis.

In a previous experimental study soluble alloantigens and soluble foreign (not recognized by the dam's immune system) transitory antigens in chick embryo have been detected. When a chick embryo extract was injected in hens and their eggs were incubated, the death or a delay in chick embryo development or congenital anomalies were observed. Based on the foregoing, the following working hypothesis is established: any fetoprotein not coming into contact with the fetal immune system during the central clonal selection period becomes a foreign antigen. If it is a female fetus that becomes pregnant at adult age, then passage to the maternal circulation or to the decidua of the same foreign fetoprotein from her fetus is a candidate to induce a humoral or cell-mediated response. If specific IgG or toxic factors of the different cells activated by cell-mediated immunity in the mother access the inductive antigen (e.g., an enzyme) in the conceptus, there functions may be cancelled or the antigen-carrier cell may undergo lysis. This will result in damage to tissues leading to abortion or to a viable but morphologically or functionally abnormal offspring. This can occurs with some of soluble foreign transitory antigens existents. The soluble alloantigens are foreign for the mother because are coded by paternal genes and act of similar way.

Abortion, Spontaneous↗
PubMed2002

Experimental transmission of epizootic bovine abortion (foothill abortion).

Advances in defining the biology of epizootic bovine abortion (EBA), including identification of the etiologic agent, have been hampered by the inability to reproduce the disease with confidence. Experimental reproduction of EBA, by feeding the tick vector Ornithodoros coriaceus on susceptible pregnant heifers, is not reliable. The primary objectives of this study were to identify specific tissue(s) obtained from EBA-infected fetuses that could transmit the disease, and then utilize such an infectious challenge system to better define the pathogen, host immunity and geographic distribution of the agent. Described here is the ability to routinely reproduce EBA following inoculation of cryopreserved suspensions of homogenized thymus into susceptible pregnant heifers. This challenge system permitted experiments demonstrating the agent was non-filterable, inactivated upon sonication and susceptible to antibiotics. These findings suggest a prokaryotic microbe and represent a major advance in EBA research. Additional experiments demonstrated that inoculation of the cryopreserved EBA-infectious tissue into heifers, prior to breeding, conferred immunity. Furthermore, such immunized heifers were resistant to challenge with heterologous sources of infectious tissue, suggesting monovalent vaccine development might be feasible. Lastly, challenge studies employing animals from Central Nevada, an area considered free of EBA, demonstrated partial immunity, suggesting the pathogen, and possibly the disease, enjoy a broader distribution than previously thought.

Abortion, Veterinary↗
PubMed1988

[Population genetic study of differential human fertility (exemplified by habitual abortion). VI. Nonspecific risk factors for habitual abortion].

The associations between variation of morphophysiological traits, biochemical and immunological loci and incidence of repeated spontaneous abortions were examined in Moscow population. Early age of menarche, great difference in wife/husband body length and the presence of rare genotypic paired combinations for 8 biochemical and 5 immunological loci have been shown to be the main nonspecific risk factors for this type of pathology. Direct estimations of relative risk are presented.

Abortion, Habitual↗