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Results for “11-Hydroxycorticosteroids”

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At least 199 records · Page 11Linked to original sources
PubMed1978

[Effect of prednisolone injections in early postnatal ontogeny on the circadian rhythm of corticosteroid function in adult rats].

The effect of prednisolone injections during the early postnatal ontogenesis on the diurnal rhythm of corticosteroid function and stress reactivity in adult animals has been studied in rats. The injections of prednisolone to 7--9 days old rats resulted in the subsequent disturbance of diurnal rhythmicity in the suprarenal cortex functioning: the diurnal fluctuations of the content of 11-oxycorticosteroids in the blood plasma are smoothed out; the diurnal changes in the hormonal reaction to the stress stimulation disappear. This disturbance appears to be due to changes in the central mechanisms of the control of hypophysis-suprarenal system. The reactivity of this system per se suffered no changes.

11-Hydroxycorticosteroids↗
PubMed1978

[Disruption of the homeostatic regulation of adrenal function in endogenous depression].

The authors studied the sensitivity to the inhibitory action of 0.5 mg of dexametasone (determined by a drop in 11-oxycorticosteroids in the blood content) in 22 patients with endogenous depressions. In 20 cases among the 22, the dexametasone test appeared to be disturbed. In 14 patients refractory to the action of dexametasone during the depressive period in intermissions the inhibitory effect was restituted. In 7 among 8 cases of reactive depressions the indices did not differ from the control group. The insufficiency in the regulation of glucocorticosteroids is considered as a significant link in the pathogenesis of endogenous depression which may be due to disorders of metabolism of the brain biogenic amines.

11-Hydroxycorticosteroids↗
PubMed1978

[Role of the adrenal glands in the cytostatic action mechanism of antitumor antibiotics].

The state of the steroidogenic function of the adrenal glands, lipid spectrum of the adrenal gland tissue and metabolism rate of 11-oxycorticosteroids (11-OCS) in the liver tissue and their levels in the blood plasma were studied on rats after a single administration of karminomycin in a dose of LD50 (1.55 mg/kg). The hormones of the adrenal cortex were shown to play a definite role in the mechanism of the karminomycin damaging effect. Dependence of the changes on the time of the drug effect was noted. The shifts were of a reversible character. No direct toxic damages in the tissue of the adrenal glands were observed. Only an increase in the 11-OCS blood levels and a decrease in the steroid metabolism in the liver tissue were shown. The latter must be due to the direct cytotoxic effect of karminomycin on the tissue of this organ.

11-Hydroxycorticosteroids↗
PubMed1977

[Indices of lipid metabolism, thyroid gland and adrenal cortical function in prolonged stress of the central nervous system in chronic stimulation of the adrenals].

The experiments were conducted in 14 male rabbits dynamically on the 5th, 10th, 20th, 30th, 40th, 60th and 80th day of the central nervous system tension or at rest, including the studies of lipid metabolism (total cholesterol and beta-lipoproteins content), the function of the thyroid gland (protein bound iodine content) and the function of the adrenal cortex (11-OCS content). Such lasting stimulation of the adrenal cortex was found to be accompanied by hypercholesterolemia, hyper-beta-lipoproteinemia, elevated 11-OCS level and lack of thyroid function changes. A lasting tension of the central nervous system against the background of chronic stimulation of the adrenals delays the development of hypercholesterolemia and hyper-beta-lipoproteinemia, reduces the function of the thyroid gland, and increases the function of the adrenal cortex. The observed shifts in the lipid metabolism may be of atherogenic importance. The obtained data may be useful for the study of the pathogenesis of hormonal shifts in atherosclerosis.

11-Hydroxycorticosteroids↗
PubMed1978

[Changes in the lymph nodes of adrenalectomized rats with staphylococcal poisoning].

Histological changes in lymph nodes and dynamics of 11-oxycorticosteroid levels in blood were studied in intact and adrenalectomized rats under staphylococcal intoxication. At early stages (up to 24 h) after staphylotoxin or staphylococcal injection, stress reaction of the organism, which produces a rise of corticosteroid level in blood, was demonstrated to play the major role in aplasy of the lymphoid tissue. At later stages, when the level of corticosteroids decreases, the lymphoid tissue begins to restore. In adrenalectomized rats, aplasy of the lymphoid tissue begins at later stages (in 3--4 days) because of a decreased amount of corticosteroids in blood. From the data obtained a suggestion is made that under intoxication, devastation of the lymphoid tissue occurs via mediated and direct action of the toxin.

11-Hydroxycorticosteroids↗
PubMed1978

[Effect of chronic pyrogenal stress on the mitotic regime and quantity of DNA-synthesizing cells in the epithelium of the cornea and tongue of white rats].

The effect of prolonged stress on mitotic regimen and the number of DNA-synthesizing cells in the corneal and tongue epithelium was studied on a model of pyrogenal stress. A five-day pyrogenal administration led to a 1.7-fold reduction of te number of mitoses in the corneal and tongue epithelium. Reduction in number of dividing cells was not associated with the change in the rate of mitosis. The percentage of pathological mitoses in the corneal epithelium of intact rats was 6.1, and it failed to change in stress. In control rats the labeled nuclei index in the corneal and tongue epithelium constituted 12.6 and 10.8. It was similar with the corresponding indices in experimental animals (12.2 and 12.2).

11-Hydroxycorticosteroids↗
PubMed1978

[Mechanisms of the immunodepression caused by ortho-aminoazotoluene and its noncarcinogenic analog in mice].

Single injections of ortho-aminoazotoluene (OAT) or aminoazobenzene (AB) decrease the immune response of DD mice to the strain-nonspecific Krebs-2 tumor. The immunosuppressive action of AB is due to its toxicity for lymphoid cells, whereas the OAT effect is mediated by adrenal glands. After OAT injection,II-oxycorticosteroids level is elevated although their production by adrenal glands is not increased. The accumulation of glucocorticoids in blood after OAT injection is assumed to be the result of a decreased hormone utilization because of the blockade of receptor proteins or metabolizing enzymes in liver cells by a carcinogen.

11-Hydroxycorticosteroids↗
PubMed1978

[Migration of hematopoietic stem cells in thermal burns].

Experiments on mice (CBA X C57BL) F1 have shown that a high level of endogenous glucocorticoids in the blood 30 min to 6 hours after burn is accompanied by a 2--2 1/2-fold decrease of the circulating CFU. At this period CFU migration from the bone marrow area shielded during the irradiation (850 R) is inhibited. The stem cells migration is increased 3--4 days after the burn.

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