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PubMed1979

The prevalence of antibodies to Mycobacterium johnei in colostrum deprived lambs.

The prevalence of antibodies to Mycobacterium johnei in pre-colostral lambs in a flock of sheep infected with Johne's disease was investigated. Blood from 134 ewes and their 143 lambs were collected immediately after lambing. Double immunodiffusion and counterimmunoelectrophoresis tests were used to detect antibodies to M johnei. Four (3 per cent) of 135 lambs born to 127 ewes with serological evidence of exposure to M johnei had detectable antibodies in their sera. All lambs fed colostrum from serologically positive ewes had serum antibodies.

Animals↗
PubMed1981

Laboratory diagnosis of Johne's disease: a potential source of error.

Gastrointestinal tract tissues from cattle with suspected clinical Johne's disease (JD), in which acid-fast bacilli were not identified in mucosal smears, were examined histopathologically. Twenty-two per cent were positive and 4 per cent were suggestive of JD. Failure to identify mycobacteria in mucosal smears appeared to result from the presence of mild, often focal mucosal lesions which contained relatively few bacilli. Ten of the 22 histopathologically positive cases had complement fixation titres for JD but several false-positive titres also occurred.

Animals↗
PubMed1994

A practice-based survey of the frequency of Johne's disease in south west England.

The frequency of Johne's disease in cattle in south west England was estimated from data collected by telephone interviews with veterinarians and farmers. The response rate was 81.6 per cent. The disease frequency was expressed as the proportion of farms with clinical disease and the cumulative incidence in the infected herds. The proportion of farms affected was 1.0 per cent and the cumulative incidence on those farms was 1.9 per cent per year. Similar values were obtained when diagnosis by faecal examination, post mortem examination and histology was taken into consideration; 0.9 per cent of farms were affected and the cumulative incidence in the infected herds was 2.0 per cent per year. The survey was validated against three external reference points. There was good agreement between the use of vaccine and MAFF records, and the total number of holdings and census data. When the responses of the veterinarians were compared with those of farmers there was also good agreement on the use of vaccine (kappa = 77.8 per cent), the number of cases reported in the last year of diagnosis (r = 0.78) and the total number of cattle in the herds (r = 0.75). However, the results suggested that the total number of cattle holdings was overestimated and consequently the proportion of farms affected may have been underestimated.

Animals↗
PubMed1998

Prevalence, incidence and geographical distribution of Johne's disease in cattle in England and the Welsh borders.

The prevalence, incidence and geographical distribution of clinical Johne's disease in dairy cattle in England and the border regions of Wales were determined by a postal survey of 3772 dairy farmers. The study area was divided into three regions; south, central and north. The response rate was 78.3 per cent. The proportion of farms that reported 'ever' having the disease was 17.4 per cent. For the 10 years between 1985 and 1994 it was 4.9 per cent, and only 1.5 and 1.3 per cent in 1993 and 1994 respectively. The highest prevalence figures were always in the south. The incidence rate of clinical disease was 3.0/10,000 cow-years in both years in all herds and 16.7 and 22.8/1000 cow-years in infected herds in 1993 and 1994 respectively. An estimate of the criterion validity of diagnosis by farmers was obtained by comparing the reporting of the clinical signs with positive veterinary or veterinary investigation centre diagnoses. The proportion of farmers reporting one or other of the correct clinical signs was 95.3 per cent, and 70.6 per cent reported both correct signs (diarrhoea and weight loss).

Animals↗
PubMed2002

Risk factors for Johne's disease in Scotland--the results of a survey of farmers.

The reported incidence of Johne's disease has been increasing in the east of Scotland since 1993. A postal questionnaire survey was sent to 127 farms to identify potential risk factors for Johne's disease in relation to wildlife and farm management practices, and 86 returns were obtained. Of 22 farms which had been assumed to be free of the disease, on the basis of information held by local veterinary centres, seven (32 per cent) reported cases of Johne's disease in the 1990s, indicating that the disease is under-reported. Logistic regression analyses showed that eight of 63 potentially explanatory variables were significant at the 5 per cent level in affecting the likelihood of farms reporting Johne's disease. Of these, large numbers of livestock and rabbits, and access of wildlife to feed stores were the clearest and most consistent risk factors associated with the disease. The application of manure to grazing pasture, the type of water supply for the cattle and the numbers of crows were also related to the presence of Johne's disease but the nature of these relationships was less clear. Only 38 per cent of the farms reported taking any control measures to combat Johne's disease, but three of the control measures were relevant to risk factors identified as significant by the survey, namely maintaining a clean water supply, controlling rabbits and not spreading manure on to grazing pasture.

Animals↗

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