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PubMed2001

Costly signaling and cooperation.

We propose an explanation of cooperation among unrelated members of a social group in which cooperation evolves because it constitutes an honest signal of the member's quality as a mate, coalition partner or competitor, and therefore results in advantageous alliances for those signaling in this manner. Our model is framed as a multi-player public goods game that involves no repeated or assortative interactions, so that non-cooperation would be a dominant strategy if there were no signaling benefits. We show that honest signaling of underlying quality by providing a public good to group members can be evolutionarily stable, and can proliferate in a population in which it is initially rare, provided that certain plausible conditions hold, including a link between group-beneficial signaling and underlying qualities of the signaler that would be of benefit to a potential mate or alliance partner. Our model applies to a range of cooperative interactions, including unconditionally sharing individually consumable resources, participating in group raiding or defense, and punishing free-riding or other violations of social norms.

Animals↗
PubMed2005

Determinants of spacing contraceptive use among couples in Mumbai: a male perspective.

This study aimed to determine the factors influencing the use of spacing contraceptive methods in India, particularly from men's perspective. Data were obtained through a semi-structured interview schedule from 2,687 married men aged between 18 and 40 years from central Mumbai City, India, during 1999. Chi-squared tests and binary logistic regression analysis was carried out to determine the relationship between various variables and the likelihood of a couple using spacing contraceptive methods. Of the 2,687 couples, 1,395 (51.9%) were using one or other method of spacing contraceptives and 1,292 (48.1%) were not using any method at the time of survey. Male participation in contraceptive use was 23% (condom and withdrawal). The results indicate that the use of spacing contraceptive methods was significantly higher among those couples where the men desired one or two children (OR=4.3), had knowledge of five or more contraceptive methods (OR=1.9) and discussed with their wives obtaining family planning information (OR=3.2), spacing (OR=2.7) and permanent (OR=2) contraceptive methods. Age, income, desired number of children, knowledge of a greater number of contraceptive methods, inter-spouse communication regarding obtaining family planning information, spacing and permanent methods were found to be strong predictors of the use of spacing contraceptive methods. The study underlines the importance of intervention programmes aimed at promoting a small family norm, increasing the number of contraceptive choices available and encouraging inter-spouse communication. Hence, policymakers and programme managers should encourage interventions in this direction, targeting couples to enhance the use of spacing contraceptive methods.

Adolescent↗
PubMed1996

Perceiving interpersonal conflict and reacting to it: the case for agreeableness.

Two converging, multimethod studies probed the hypothesis that individual differences in Agreeableness are related to patterns of interpersonal conflict. In Study 1, participants (N = 263) evaluated the efficacy of 11 modes of conflict resolution within the context of 5 different interpersonal relationships. Across all relationships, high- and low-agreeable participants rated negotiation and disengagement tactics as better choices that power assertion tactics. However, low-agreeable participants rated power assertion as a better choice than did high-agreeable participants. In Study 2, participants (N = 124) were assigned partners and were asked to resolve jointly 2 social conflict problems. Partners were videotaped, and observers coded behaviors. Participants also completed ratings of perceived conflict, partner perception, and liking of their partner. Agreeableness differences, sex of participant, and type of dyad partner were related to patterns of interpersonal conflict. Results were discussed in terms of personality and social influences during interpersonal conflict.

Adult↗
PubMed2002

Confirmation and lucidity during conversations with a woman with severe dementia.

RATIONALE: Patients with severe dementia sometimes surprise the care providers because they seem to be much more aware of their situation and function much more adequately than usual. Such episodes are labelled 'episodes of lucidity' (ELs). The aim of this study was to describe the characteristics of the particular conversations with a woman with severe dementia when ELs occurred as compared with conversations when she was not lucid. METHODOLOGICAL DESIGN: A woman with a probable diagnosis of Alzheimer's disease (AD) was selected. Her Mini Mental State Examination (MMSE) was estimated as 3. The first author met the woman for 4 hours five times over a period of 2 weeks. RESEARCH ETHODS: The conversations were tape-recorded and transcribed verbatim. The text was divided into 278 content units and analysed. FINDINGS: Lucidity is promoted by supporting the patient in various ways, that is sharing the patient's view, repeating and reformulating the patient's utterance, reinforcing the patient by using positive utterances, not emphasizing errors and supporting the patient's language in various ways, and avoiding making demands. The relation between the patient and her conversation partner during ELs is characterized by confirmation and communion. CONCLUSIONS: This case study indicates that a supportive attitude in conversation with the patient with severe dementia promotes lucidity. A supportive attitude includes the avoidance on the part of the conversational partner making demands on the patient, confirming the patient as an important, unique and valuable person and creating communion. The connection between supporting and avoiding demands and lucidity/nonlucidity during conversation needs further study.

Alzheimer Disease↗
PubMedDate not supplied

A theoretically based evaluation of HIV/AIDS prevention campaigns along the trans-Africa highway in Kenya.

Print HIV/AIDS prevention campaign materials (e.g., posters, pamphlets, stickers) from 10 public health organizations in Kenya were evaluated according to the Extended Parallel Process Model (EPPM), a health behavior change theory based on the fear appeal literature, at various sites along the Trans-Africa Highway in Kenya. Three groups each of commercial sex workers (CSWs), truck drivers (TDs) and their assistants (ASSTs), and young men (YM) who live and work at the truck stops participated in focus group discussions where reactions to the campaign materials were gathered according to this theoretical base. Reactions to campaign materials varied substantially, according to the poster or pamphlet viewed. Overall, most participants wanted more detailed information about (a) the proper way to use condoms, (b) ideas for how to negotiate condom use with reluctant partners, and (c) accurate information on symptoms of AIDS and what to do once one contracted HIV. Both quantitative and qualitative analyses of the campaign materials are reported.

Acquired Immunodeficiency Syndrome↗
PubMed1993

Endothelial cells promote anti-CD3-induced T-cell proliferation via cell-cell contact mediated by LFA-1 and CD2.

T-cell activation requires not only T-cell receptor (TCR) engagement and subsequent TCR/CD3 cross-linking, but also one or more secondary activation signals generated by accessory cells (AC). We investigated the accessory function of endothelial cells (EC) in an in vitro model for T-cell activation where the first cross-linking signal was delivered to peripheral human T lymphocytes by either immobilized anti-CD3 monoclonal antibody (MoAb) or by PHA. In a previous report, we showed that EC provided a potent costimulatory signal in this model system. We have now analysed the nature of the EC-derived costimulatory signal by testing whether EC could be substituted by cytokines, by studying the effect of EC fixation and by testing the involvement of a number of adhesion molecules. Our findings indicate that EC accessory function is mediated mainly by membrane-bound factors. The nature of these membrane-bound factors was analysed by studying the inhibitory properties of a series of MoAbs directed against several adhesion molecules. Antibodies directed against CD44, E-selectin, CD31, CD26, B7/BB1, VLA-4 or VCAM-1 were not inhibitory. However, an inhibition, was clearly observed with antibodies against LFA-1 and CD2. Remarkably, this inhibition was not found with MoAbs to their respective counterstructures ICAM-1 and LFA-3. In summary, we postulate that both LFA-1/ICAM-1, and CD2/LFA-3 interactions are involved in EC accessory function, although the role of the EC-associated adhesion partners is not fully understood.

Antibodies, Monoclonal↗
PubMed1995

Mixed signals on translation software's future.

Health care providers have been slow to acquire and implement translation software to streamline electronic data interchange with payers, suppliers and other trading partners. Proponents argue that after the movement to standard electronic transactions picks up speed, the market for the software will explode. But skeptics argue that the benefits of the software are limited and predict that demand will remain modest.

Commerce↗
PubMed2000

HIV prevention among male clients of female sex workers in Kaolack, Senegal: results of a peer education program.

This article reports the results of a peer-led HIV prevention education and condom promotion program among transport workers in Kaolack, Senegal. As part of a 2-year longitudinal follow-up study, changes in men's AIDS-related knowledge, sexual behavior, condom use, and perceived barriers to condom use were evaluated by self-reports obtained from a systematic sample of transport workers interviewed before and after intervention. In addition to men's self-reports, preintervention and postintervention data on men's sexual and condom use behavior were gathered from a sample of licensed, commercial sex workers, who cited transport workers as their primary source of clients. Significant increases in men's HIV-related knowledge, previous use of condoms (from 30.4% to 53.5%), and consistent condom use with regular sex partners were documented over the study period, as were significant declines in perceived barriers to condom use. Though men reported significantly fewer sexual encounters with casual and commercial partners at follow-up compared to baseline, these data were unreliable. Women's postintervention reports indicate that a greater proportion of clients (including, but not limited to transport workers) "always" agree to use condoms (p < .01) compared with baseline and that fewer men offer more money for unprotected sex (p < .01). However, women also report taking greater initiative in the mechanics of condom use (supplying the condom, putting it on, and taking it off) than they did prior to the intervention, and significantly (p < .05) fewer women think that most of their clients know how to use a condom. The findings indicate that the peer-mediated intervention had a positive impact on several important outcomes measured and suggest that HIV prevention efforts need to focus on male client groups despite the logistical and methodological challenges.

Adult↗
PubMed2003

GABARAP: lessons for synaptogenesis.

The clustering of neurotransmitter receptors at the postsynaptic terminals is a critical requirement for efficient neurotransmission and neuronal communication. This process is facilitated by adaptor proteins, which bridge the postsynaptic receptors and the underlying cytoskeleton. One such molecule, the GABAA receptor-associated protein, GABARAP, was identified as a potential linker between GABAA receptors and microtubules. GABARAP belongs to an expanding family of proteins that are implicated in a variety of intracellular transport processes. GABARAP has been shown to interact with myriad binding partners, including the gamma2 subunit of the GABAA receptor, tubulin and microtubules, the N-ethyl maleimide sensitive factor, gephyrin, and the transferin receptor. The recent determination of the GABARAP crystal structure has revealed individual GABARAP domains, motifs, and surface regions involved in specific protein-protein interactions. Currently, a more general role is emerging for GABARAP, including shipping GABAA receptors to and from the cell surface, organizing them into postsynaptic clusters, and regulating the steady-state receptor density.

Adaptor Proteins, Signal Transducing↗
PubMed2006

[The HIV situation in Northwest Russia and the Baltic].

BACKGROUND: An increased incidence of communicable diseases, especially HIV-infection, has since the mid 1990ies been observed in Northwest Russia and the Baltic countries. Injecting drug use has until now been the most important factor in the spread of HIV in the area. MATERIAL AND METHODS: This paper is based on surveillance data published by EuroHIV, Epi North and the Norwegian notification system for communicable diseases, and on personal experience. We present an overview of the epidemiological HIV situation in Northwest Russia and the countries of the Baltic Sea area, and the effect this has on the HIV-epidemic in Norway. RESULTS AND INTERPRETATION: In Northwest Russia and the Baltic countries, a sharp rise of newly diagnosed HIV-cases started in 1998 and a peak was observed in 2001. The reduction of reported cases observed during the last few years is mainly caused by fewer newly diagnosed HIV-cases in intravenous drug users. An increasing proportion of the newly diagnosed cases of HIV occur among women. It is uncertain if this reflects sexual spread to drug users' partners, or if it is the beginning of a heterosexual epidemic in the general population. Men who have sex with men do currently not account for a large proportion of total cases in Northwest Russia and the Baltic countries, but stigmatisation of this group may cause underreporting of this transmission route. The epidemiological situation in the neighbouring countries has had little effect on the HIV epidemic in Norway. This is probably because HIV in Northwest Russia until now has been limited to social groups that have little contact with Norway or Norwegians visiting Russia.

Baltic States↗
PubMedDate not supplied

[Evaluating radiotherapy patients' need for information: a study using a patient information booklet] .

The French Radiotherapy-Oncology Society (SFRO) and the National Trade of Radiotherapists-Oncologists (SNRO) elaborated and published a patient information booklet on radiotherapy, in 1999. This present study appraises the pertinence of the form and substance of this booklet one year after its release. Eight radiotherapy centers participated in this research which evaluated 162 patients at treatment initiation. The conclusions of this study demonstrated the importance of clearly informing patients of their disease, treatment, and the secondary effects of treatment. It is essential to emphasize that 97% of the patients declared that an information booklet is a real necessity, and that the one provided by the SFRO responds to the majority of their concerns. Obtaining technical and practical knowledge resulted in a reassurance about their treatment. The most revealing result is that 87% requested direct communication about their illness, and that cancer be named by this word and not other, evasive terms. Seventy-two percent of the patients requested more information about their cancer, different treatment options, and quality of life issues in an attempt to psychologically prepare themselves to face an illness for which they have little control. Patients refuse to be passive, and claim the right to become 'partners' of the medical teams, concerning their treatment and recovery.

Data Collection↗
PubMed1990

A legal perspective on AIDS.

AIDS presents difficult and unprecedented legal problems. Because modern law requires that persons with disabilities or illnesses be integrated into the mainstream of society, past responses to those with communicable diseases are no longer acceptable. Laws dealing with AIDS patients will have to evolve gradually and build upon commonsense solutions to problems.

Acquired Immunodeficiency Syndrome↗
PubMed1993

A TQM model for home care coordination & provider partnering.

Quality Improvement Teams can identify areas of customer dissatisfaction and raise coordinators' and caregivers' awareness of problems. Through home care coordination--whereby an expert home care nurse develops partnerships with key referral sources and facilities--they improved services and built both market share and service excellence into the wellness continuum.

California↗
PubMed2003

Interdisciplinary collaboration: the obvious need and basic structures.

In the last decade there has been an exponential increase in knowledge in the field of medicine in general and particularly in Neurosciences. In order for the continuation of progress, it is important for professionals in all fields to collaborate with each other. Interdisciplinary collaboration is an absolute must to be able to obtain new knowledge, quickly and efficiently. Another important aspect is for professionals to collaborate with industry--especially the pharmaceutical industry. The global pharmaceutical companies account for a large amount of resources including personnel, knowledge, and especially funds. Although interdisciplinary collaboration is essential, many times potential partners overlook the obvious need for their own personal ongoing politics. Such competition needs to be overcome and new fields with multiple perspectives from different specialties will lead the way through the new millennium.

Drug Design↗
PubMed2005

Connecting the providers in your healthcare community: one step at a time.

The practice of medicine is a business of communications. Communications can be facilitated by technology. Healthcare providers organized in medical practices, hospitals, and nursing homes have tremendous needs to effectively communicate within their organizations and between their organizations. The focus on electronic medical records comes not only from the need to communicate but also from a desire to reduce administrative costs and to improve services and quality of care to patients. Frustration with the inadequacies of a paper chart-filing system drives providers in all delivery venues toward technology at an increasing rate. Implementation barriers to technology adoption in medical practices can be overcome by incremental approaches and knowledge-transfer assistance from affiliated community healthcare partners such as hospitals.

Diffusion of Innovation↗
PubMedDate not supplied

Working together as culture brokers by building trusting alliances with bilingual and bicultural newcomer paraprofessionals.

The authors' reflect on the challenges and rewards of partnering as casework supervisors with bilingual and bicultural newcomer paraprofessionals in resettlement work with refugee youth. Such individuals are generally recruited for their linguistic abilities and cultural knowledge, but they can lack formal clinical training or licensing credentials. Drawing on their own experience as supervisors of bilingual and bicultural newcomer paraprofessionals from Cambodia, Laos, and Vietnam, the authors compare their early attempts to establish trust and communication with insights gained in more recent supervisory experiences. Recommendations are offered that promote mutual understanding between newcomer paraprofessionals and their Western-trained supervisors.

Acculturation↗
PubMed1996

Glia-neuron intercommunications and synaptic plasticity.

It is established that astrocytes are the intimate partner of neurons throughout their lifespan. However, astrocytes play different roles at different stages of the lifespan. During neurogenesis and early development, glial cells provide a scaffold for the correct migration of neurons and growth cones. They provide guidance cues and may also be involved in neuronal proliferation. In the adult, astrocytes maintain neuronal homeostasis and synaptic plasticity. This review discusses some of the cell-cell communication signals which are involved in the maintenance of synaptic plasticity. They are divided into: (a) glia-to-glia signaling, which involves non-synaptic communication by coupling of astrocytes. In this cell communication, cytoplasmic exchange of ions and small molecules among cells is accomplished through cell coupling of cells via cell-to-cell contacts, termed gap junctions; (b) neuron-to-glia signaling, which involves synaptic interactions. This cell-cell intercommunication has received considerable attention. Of special interest is the role of astrocytes in glutamic acid compartmentation and in preventing glutamic acid neurotoxicity. A glutamate-induced calcium signaling appears to be involved in this neuron-astrocyte interaction. The intriguing possibility is that neuronally induced astrocyte calcium signals may feed back to influence neuronal excitability or regulate synaptic transmission; (c) signals from astrocytes to neurons: a new concept of neuron-glia intercommunication. As mentioned, calcium appears to be the molecule in this glia-neuron signaling, although glial cell receptor-mediated signals are involved also. Receptor interactions on astrocytes through a cascade of events lead to modification in the extracellular concentration of glutamate. The role of astrocytes in synaptic plasticity is not as well understood during ageing and their role in neuronal cell death during ageing and neurodegeneration can only be speculated. However, astrocytes in the aged brain exhibit various receptors, including glutamate receptors. Thus, astrocytes can be expected to modify the expression of endogenous neurotoxins and thus contribute to synaptic plasticity in ageing. Synaptic plasticity continues to be a homeostatic relationship between neurons and glial cells. The possibility of signaling from astrocytes to neurons has opened new horizons for glial cell function and new challenges of research for gliobiologists.

Animals↗

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