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Results for “PSYCHOSES”

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PubMed1984

Dopamine and non-dopamine psychoses.

The time course of antipsychotic response following the initiation of an antipsychotic drug and functional dopamine receptor sensitivity were explored in a cohort of recently admitted psychotic (mood-incongruent) patients. The distribution of the latencies of antipsychotic response suggested at least two populations. Rapid responders (RRs) had 60% reduction of baseline psychotic symptoms by a mean of 5.5 days of drug treatment. Delayed/nonresponders required 2-7 weeks for a similar reduction of psychotic symptoms. The sensitivity of postsynaptic dopamine receptors was explored using a neuroendocrine probe: growth hormone response to the dopamine agonist, apomorphine (AP). RRs had an exaggerated growth hormone response to AP in comparison to delayed/nonresponders (P less than 0.05). Exaggerated sensitivity of postsynaptic dopamine receptors and rapid antipsychotic response following dopamine receptor blockade in RRs suggest a true functional dopamine hypersensitivity disorder in the RR group. In contrast, lower postsynaptic receptor sensitivity (as reflected by lower growth hormone response to AP) and failure of early response following dopamine receptor blockade focus attention away from dopamine hyperactivity as a relevant etiologic mechanism in delayed/nonresponders. Response rates to neuroleptic drugs and neuroendocrine probes of receptor sensitivity may separate two or more etiologically distinct diseases with schizophrenic-like symptoms.

Antipsychotic Agents↗
PubMed1982

Dose-response relationships of perphenazine in the treatment of acute psychoses.

A group of 26 acute psychotic patients received continuous oral treatment with perphenazine for a period of 5 weeks. Once-weekly blood samples were drawn for measurements of perphenazine levels and, simultaneously, the therapeutic outcome was registered. Another 26 acute psychotic patients received continuous oral treatment with perphenazine for a period of up to 4 weeks. A single blood sample was drawn and the perphenazine concentration was related to the appearance of extrapyramidal side effects. The following conclusions were made: (1) a high risk of provoking extrapyramidal side effects was associated with plasma levels of perphenazine above 3 nmol/l; (2) plasma levels below 2 nmol/l were associated with a poor therapeutic outcome; (3) a 'therapeutic window' between 2 and 3 nmol/l gives maximal therapeutic effect with a low risk of provoking extrapyramidal side effects.

Acute Disease↗
PubMed1995

Rates of first hospitalizations for affective psychoses in Costa Rica.

What demographic, geographic and temporal factors characterize the rate of first hospitalizations for affective psychosis in Costa Rica? This report presents graphically the first hospitalization rates for the whole country of Costa Rica, with analysis of specific rates for the subgroups by age, sex, marital status, level of education, occupation, place of residence, and place of birth, as well as separate rates by month and date of hospital admission, monopolar first admissions increased slowly from the age of 10 to the age of 45 years, then "exploded" to a peak between 55 and 65 years, then declined somewhat. The educational group among men with the highest rate was the group with at least some university education. Professionals, clerical workers, unskilled laborers, and those with no occupation had high rates. Higher rates were also associated with being single, divorced, widowed, having no occupation, and living in rural, coffee-growing areas that were not too distant from the hospital.

Adolescent↗

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