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[The relationship between blood alcohol level and head injury].

Alcoholic intoxication and a traumatic intracranial lesion have many features in common. It is important for a doctor not to make an incorrect diagnosis between these two conditions, but it is difficult in some cases. The effect of alcohol on the conscious level may complicate the assessment of patients and make it more difficult to recognize the development of complications such as intracranial hematoma. The most immediate and correct diagnosis can be obtained by estimating the amount of alcohol in a patient's blood although it is often difficult in the usual emergency departments in Japan. To try to throw some light on this question, we decided to attempt both clinical and laboratory diagnosis of alcohol ingestion. In 68 adult patients who had head injuries with conscious disturbance admitted to our ward at night, alcohol levels in their blood were estimated by gas chromatography, during the past 24 months. At the same time clinical examinations for the diagnosis of drunkenness were made: on admission, it was recorded whether all patients had white or red conjunctiva, whether speech was clear or slurred, whether there was a distinctive smell on their breath, and whether coordination was good or poor. Of 68 patients (63 male, 5 female), 7 had no alcohol in their blood and 61 had positive alcohol results. The mean blood alcohol level was 233 +/- 130 mg/dl. Clinical diagnosis of alcohol ingestion; The amount of alcohol in the blood correlated highly with the strength of the smell on their breath and of conjunctival injection (p less than 0.001), on the other hand, did not correlate with the speech disturbance, skillfullness of coordination and level of consciousness.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Severe lactic acidosis due to metformin therapy in a patient with contra-indications for metformin].

A 52-year-old woman with a medical history of diabetes mellitus type 2, chronic alcoholism and liver function disorders was hospitalized because of complaints of haematemesis, abdominal complaints and dyspnoea. This was due to a severe lactic acidosis caused by acute alcohol intoxication and the use of metformin. With bicarbonate infusion and haemofiltration, the lactic acidosis disappeared, but she developed a distributive shock with multiple organ failure and died 23 days after admission. Lactic acidosis is a rare but serious adverse effect of metformin. Almost all patients described had contraindications to the drug, like renal failure, liver disease, alcohol abuse, and intercurrent conditions causing hypoxia or ischaemia. It is important to be aware of the circumstances in which metformin should not be prescribed.

Acidosis, Lactic↗

Use of horizontal gaze nystagmus as a part of roadside sobriety testing.

Alcohol is a central nervous system depressant that can affect eye movement control. Even at low blood alcohol concentrations (BAC's) smooth pursuit eye tracking can be lost and horizontal nystagmoid movements become apparent at relatively small angles of lateral gaze. Law enforcement officers across the nation are being taught evaluation techniques to use these eye movement signs as an indicator of alcohol intoxication. Information obtained at the Ohio State Highway Patrol (OSHP) course on the Advanced Detection, Apprehension, and Prosecution of subjects suspected of driving a vehicle while intoxicated is presented here including the testing and scoring techniques of the horizontal gaze nystagmus sobriety test.

Accidents, Traffic↗

Women's yielding to social group pressure as a function of alcohol and type of pressure.

Thirty-six women participated in an experiment exploring whether alcohol intoxication facilitates yielding to social persuasive information. Subjects were randomly assigned to either an Alcohol, a Placebo, or a Control Group. The alcohol dose was 1.0 ml of 100% alcohol/kg body weight. Subjects first estimated the length of a line and were then given faked feedback from either a male or a female peer reference group. This procedure was repeated 60 times. Analyses indicated that the Placebo group yielded more often than the Alcohol group irrespective of type of feedback. A measure of locus of control indicated no significant mean differences as a function of alcohol group but correlations between externality and yielding were strong for placebo subjects, that is, externally oriented placebo subjects yielded more than internally oriented placebo subjects. This was discussed in terms of feelings uneasiness caused by the discrepancy between feelings of intoxication and information about drink content.

Adult↗

Human auditory evoked responses during hangover.

Auditory evoked responses (AER) to trains of 6 click stimuli (1 click/sec) were studied in 9 subjects under hangover, tired control, and normal control conditions in order to find out whether the symptoms of hyperexcitability during hangover have a correlate in the characteristics of the AER. In addition, the audiograms were measured. AERs to the first click in a stimulus train were markedly smaller during hangover than in the other 2 states. The amplitude levels of the AERs during the repetition of the click stimulus were, however, similar under all three conditions. The audiograms obtained in the three states were similar except for a very slight decrease of auditory threshold sensitivity during hangover as compared with the tired control condition. The results show that the effects of hangover on AERs resemble those of alcohol intoxication. The symptoms of hyperexcitability during hangover cannot be explained in terms of increased peripheral sensitivity.

Acoustic Stimulation↗

[The importance of the parameter sex & gender in anesthesia and intensive care medicine dealing with patients under alcohol influence].

Alcoholised females and males belong to a specific group of risk patients in anesthesia and intensive care medicine. Knowledge about effects touching the interaction of chronic alcohol consumption and acute alcohol abuse with other drugs is on a very low level. The assessment of risk depends on several factors. In addition to the judgement of grades of seriousness of an alcohol intoxication the parameter of sex and gender can be seen as much a prominent parameter as age, morbidity, and co-morbidity. This thesis is confirmed by some significant sex-based biological differences related to biological effects of alcohol consumption and differences in pharmacodynamics and pharmacokinetics of anesthetics. The high rate of injuries and accidents under the influence of alcohol, strongly recommends the detection of a sex- and gender-sensitive approach by anesthesia and intensive care medicine to patients with chronic or acute alcohol abuse.

Alcoholic Intoxication↗

Alcohol level at head injury and subsequent psychotropic treatment during trauma critical care.

Alcohol intoxication at the time of traumatic brain injury (TBI) presents many complications for critical care treatment. This is the first reported data on psychotropic dosages administered to TBI patients in the critical care setting. In this study, the blood alcohol level (BAL)-positive patients (n = 14) tended to be older (P = 0.095), have lower admission Glascow Coma Scores (P = 0.031), and spent more days on respirators (P = 0.125) than the BAL-zero patients (n = 21). The BAL-positive group received more days of narcotics and benzodiazepines with markedly higher average daily doses, not statistically significant. These results are a basis for studying relationships between medication, treatment variables, and outcomes for TBI patients and then developing specific medication guidelines.

Adolescent↗

Effect of rapid decompression and associated hypoxic phenomena in euthanasia of animals: a review.

Documentation in the literature indicates that death is as painless following the induction of hypoxia by rapid decompression as by other methods that lead to hypoxia, such as exposure to high altitude, carbon monoxide, and inert gases (nitrogen, xenon, and krypton). Many of the signs and symptoms of hypoxia are the same as those for alcoholic intoxication and inert gas narcosis. Moreover, there is good evidence that analogous relationships or mechanisms may exist for hypoxia, inert gas narcosis, and anesthesia.

Alcoholic Intoxication↗

Motorcycle accident injury severity, blood alcohol levels, insurance status, and hospital costs: a 4-year study in St. Petersburg, Florida.

Clinical, demographic, and financial information for 337 patients injured in motorcycle accidents who were admitted to a community hospital over a 4-year period was reviewed for injury severity, prevalence and degree of alcohol intoxication, and effects of insurance status on hospital, patient, and community costs. Ninety percent of the patients were males (average age 31 years), and 52% had some form of insurance. Of those tested at the time of admission, 36% had blood alcohol levels of > or = 100 mg%. Uninsured patients had higher blood alcohol levels (p = 0.0001), as did older patients (p = 0.01). Forty percent of patients had injury severity scores of > or = 16. Uncompensated costs to the hospital of caring for the uninsured totalled > $850,000 over the 4 years. The need to enforce existing statutes and to increase awareness through education is discussed, and statutory changes are recommended.

Accidents, Traffic↗

Eating a meal increases the clearance of ethanol given by intravenous infusion.

We studied the effect of eating a meal on the rate of ethanol elimination (clearance) from the blood after giving 0.4 g/kg by intravenous infusion to six female and six male volunteers. Half of the subjects had eaten breakfast whereas the other half had fasted overnight. After the first infusion of alcohol, those who had fasted ate lunch, and all the volunteers received a second infusion with the same dose of ethanol. The blood ethanol concentration was measured repeatedly for up to 180-240 min after the start of each experiment. Intake of food (lunch or breakfast) increased the clearance of ethanol by about 60% (P < 0.001). Alcohol intoxication was less pronounced at the end of the ethanol infusions preceded by eating a meal (P < 0.01). Gender had no significant effect on the rate of ethanol elimination. We conclude that eating a meal increases the rate of ethanol elimination even when alcohol is given by intravenous infusion.

Adult↗

Nifedipine overdose accompanied by ethanol intoxication in a patient with congenital heart disease.

A 34-year-old female was brought to the emergency department after taking 200 to 250 mg of nifedipine and drinking an unknown amount of ethanol in a suicide attempt. She was hypotensive, acidotic, mildly hyperglycemic, and exhibited a conduction abnormality on the ECG. The patient was treated with IV fluids, thiamine, and calcium infusion. The patient was later found to have an endocardial cushion defect with a patched ventricular septal defect and an atrial septal defect of the ostium primum type. We did not observe any untoward effects due to the combination of drugs and congenital abnormalities that could be explained on an individual basis. Nifedipine overdose associated with alcohol intoxication, to our knowledge, has not been previously reported.

Adult↗

[The clinical picture and treatment of a positional compression syndrome of the neck and lower portions of the face].

Six patients with positional compression (PC) of the neck and lower third of the face are described. This condition, virtually never described in maxillofacial surgery, was caused by forced posture of a patient sleeping after alcoholic intoxication. Characteristic clinical signs of PC syndrome are described in patients with different duration and severity of the process. Differential diagnosis and pathogenetic therapy are discussed.

Adult↗

Chemical-induced changes in hepatic vascular innervation.

The aim of this work was to reveal the chemical-induced consequences of reversible and irreversible liver injury on the neural elements of liver vessels and to study the means of adaptation of the neuro-vascular unit to the compensatory changes during functional demands in the process from damage to regeneration. The effects of selective and non-specific hepatotoxic agents were studied in rats in acute and long-term poisoning. Acute intoxication with chemicals causing no obvious tissue destruction resulted in a decrease in the number of detectable monoaminergic nerve terminals and dense core vesicles of axons, and an increase in number of mast cells, in acute poisoning upon the effect of chemicals axondegeneration was not found. Long-term alcohol intoxication brought about hyperinnervation in the liver, decrease in blood pressure and hepatic arterial blood flow. The decrease in hepatic arterial blood flow due to noradrenaline was significantly less than in the control. During different stages of long-term carbon tetrachloride poisoning the alterations of hepatic innervation in the central and peripheral area of macroscopic liver lobe were not uniform. It is concluded that the experimentally altered environment transforms the target organ, which, in turn, can be regulated only by an adequately altered control unit. However, the functional-morphological unit operating compensatorily by means of a new innervation may respond to extraneuronal transmitters with a reaction different from that of the normal tissue.

Adrenergic Fibers↗

The influence of victim characteristics on potential jurors' perceptions of brain damage in mild traumatic brain injury.

PRIMARY OBJECTIVE: To determine the influence of victim/plaintiff sex, occupation and intoxication status at the time of injury on potential jurors' judgement about the presence of brain damage in mild traumatic brain injury (MTBI). RESEARCH DESIGN: Survey. METHODS AND PROCEDURES: One of eight scenarios describing a MTBI from a motor vehicle accident was presented to 460 participants at a Department of Motor Vehicles. Victim sex, occupation (accountant or cafeteria worker) and alcohol intoxication status at the time of injury (sober or intoxicated) were manipulated across eight scenarios. Participants rated whether the victim's complaints at 6 months post-injury were the result of brain damage. MAIN OUTCOMES AND RESULTS: Ratings were influenced by victim occupation and intoxication status (chi2>5.3, p<0.03), but not the sex of the victim. CONCLUSIONS: The occupational and intoxication status of MTBI victims may influence potential jurors' decision about the presence of brain damage.

Accidents, Traffic↗

[Special features of correction of hyperosmolar alcoholic syndrome in injured patients].

Hyperosmolar alcoholic syndrome in traumatologic patients, admitted to a hospital in a state of alcoholic intoxication, is not unusual. Recommended treatment of this state is based on correction of metabolic acidosis, forced diuresis and normovolemic hemodilution with the help of hyperoncotic solutions. In the process of examination of 94 patients have been revealed increase of osmolarity due to high content of blood alcohol, decrease of sodium concentration and increase of colloid-osmotic pressure level, connected with inadequate autohemodilution. In these patients pathogenetically justified is the use of hypotonic solutions of glucose-novocaine mixture, ensuring immediate replacement of extra- and intracellular water space deficiencies of organism, that made possible to abandon application of forced diuresis, metabolic acidosis correction and costly hyperoncotic solutions.

Alcoholic Intoxication↗

[A new method to estimate blood alcohol concentration from the breath of unconscious subjects (author's transl)].

The method of rebreathing and its particular importance to the estimation of blood alcohol concentration (BAC) are described. A face mask with an accompanying valve chamber to which a collection bag was attached proved to meet the requirements arising from the physiological exchange processes in rebreathed air. Practical tests in the laboratory revealed excellent agreement between the values obtained by direct measurements of breath alcohol by means of an IR-Spectrophotometer and those from stored samples. The application of the method described is of particular importance in cases of unconscious and benumbed patients, of sleeping and uncooperative patients and those with collapsed veins suspected of heavy alcohol intoxication. It has been proven to be an essential aid in differential diagnosis since it allows instantaneous determination and continuous monitoring of the BAC-level which aids in the observation of the reduction of this level. This was demonstrated in practice with 9 patients at the alcohol emergency clinic in Mainz on the carnival "Rosenmontag".

Alcoholic Intoxication↗

Metabolic factors and preference for ethanol.

Alcohol intoxication diminishes the metabolic differences between ethanol- and water-preferring rats in the levels of free amino acids (liver, brain, blood plasma), lipid fractions (liver), the activities of glucokinase (liver), and aldehyde dehydrogenase (brain), and the content of glucose-6-phosphate and prostaglandins (liver). The action of alcohol is discussed as that directed to the partial elimination of biochemical individuality, thus simplifying the regulation of metabolism in the living system. In this connection preferential ethanol consumption may be regarded as a biological mode of self-correction.

Acetaldehyde↗

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