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Two-stage revision hip arthroplasty for infection: comparison between the interim use of antibiotic-loaded cement beads and a spacer prosthesis.

BACKGROUND: A two-stage revision is a well-accepted method for the treatment of a deep infection of a hip with a joint implant. In the present study, the results associated with the interim use of antibiotic-loaded cement beads were compared with those associated with the interim use of an antibiotic-loaded cement prosthesis. METHODS: One hundred and twenty-eight consecutive patients who were managed with a two-stage revision hip arthroplasty for the treatment of an infection were followed clinically and radiographically for an average of 4.9 years. Cement beads were implanted following resection arthroplasty in the first seventy hips, and a custom cement prosthesis was implanted in the subsequent fifty-eight hips. RESULTS: There was no evidence of recurrent infection in 122 patients (95.3%); the infection-free rates in both groups were similar. The use of a spacer prosthesis was associated with a higher hip score, a shorter hospital stay, and better walking capacity in the interim period; a decreased operative time, less blood loss, and a lower transfusion requirement at the time of reimplantation; and fewer postoperative dislocations. CONCLUSIONS: The present study supports the safety and efficacy of the routine use of an antibiotic-loaded cement prosthesis in the interim between the stages of a two-stage revision procedure for the treatment of an infection at the site of a hip arthroplasty.

Adult↗

Persistent infection associated with residual cement after resection arthroplasty of the hip.

BACKGROUND: The danger of residual bone cement after resection of infected prosthetic components is controversial. PATIENTS AND METHODS: We analyzed 10 patients with infected total hip prosthesis who had been treated previously with resection arthroplasty and antibiotics and who had persistent infection with residual cement. In 9 patients, surgical debridement with resection of all the PMMA was performed, and adequate intravenous antibiotics were administered. 1 patient refused surgical treatment, but accepted antibiotics. RESULTS: At an average of 4 (1-18) years of follow-up, 8 patients had no signs or symptoms of recurrent infection. 1 severely immunodeficient patient died 2 years after the removal of residual cement, for reasons other than his hip. The patient who refused surgical treatment continues to have an active sinus 4 years after first consultation. INTERPRETATION: Residual cement may be responsible for chronic infection. At resection arthroplasty, as part of the treatment of an infected hip arthroplasty, all devitalized or foreign material must be removed.

Adult↗

[Incorporation of bone allografts with the use of Octopus revision system in total hip arthroplasty].

PURPOSE OF THE STUDY: The study describes the revision arthroplasty of hip joints with grade III acetabular defects, as rated according to Paprosky, employing morsellized bone allografts and the Octopus revision acetabular system. MATERIAL: In the period from 1998 to 2002, a total of 8297 operations were performed in our Department; of these 1527 (18.4%) were total hip replacements. In this group, 267 (15.5%) revision arthroplasties were carried out, with the the Octopus revision system being used in 32 patients (age range, 30 to 79 years; average age, 60.3 years). The average period between the initial surgery and reimplantation was 6.5 (range, 2-14) years. METHODS: Acetabular defects were filled with morsellized cancellous bone allografts (one to three femoral heads per patient) obtained from the tissue bank. In nine patients, allografts were combined with hydroxypatite (Biovan). Osteointegration of the bone allografts and, if it occurred, loosening of the implant were checked by X-ray examination. RESULTS: The patients were examined at intervals of two months. The average Harris hip score was 76 points at 1 to 3 years. None of the patients had deep post-operative wound infection; in one patient, the distal hook of the Octopus system broke off. The complete incorporation of allografts was seen on X-ray images in 28 patients; at follow-up, a radiolucent zone between the acetabular bed and the allograft was still visible in four patients. No implant loosening was recorded. DISCUSSION: The Octopus system has an advantage of using morsellized allografts instead of solid ones that are associated with poorer incorporation and a higher risk of loosening. The remodeling of an allograft below the ring leads to the production of bone tissue, which is useful if revision arthroplasty were to be performed. CONCLUSION: Based on their experience, the authors regard the Octopus revision system with the use of morsellized bone allografts from the tissue bank as an effective surgical procedure for the treatment of Paprosky grade III acetabular defects. The allografts below the ring are fully incorporated and remodeled; as a result the initial defect is gradual filling with the patient's own tissue, which has very good clinical outcomes.

Adult↗

Patella resurfacing versus nonresurfacing in total knee arthroplasty: results of a randomized controlled clinical trial at a minimum of 10 years' followup.

Patellar resurfacing in total knee arthroplasty remains controversial. This study evaluates the results of resurfacing and nonresurfacing the patella in a randomized controlled, clinical trial at a minimum of 10 years followup. One hundred knees (90 patients) with osteoarthritis were enrolled in a prospective randomized clinical trial using a posterior-cruciate-retaining total knee arthroplasty. Patients were randomized to receive resurfacing or retention of the patella. Evaluations were done preoperatively and yearly, up to a minimum of 10 years (range, 10.1-11.5 years) postoperatively. Disease-specific (Knee Society clinical rating score) and functional (stair climbing, flexion/extension torques, patellar examination) outcomes were measured. Patient satisfaction, anterior knee pain, and patellofemoral questionnaires were completed. Intraoperative grading of the articular cartilage was done. No patients were lost to followup; 45 patients remained alive. Nine revisions (in nine of 90 knees; 10%) were done in seven patients in the nonresurfaced group (15% of knees) and in two patients in the resurfaced group (5% of knees). No significant difference was found between the groups regarding revision rates, Knee Society clinical rating scores, and functional, patient satisfaction, anterior knee pain, patellofemoral, and radiographic outcomes. Intraoperative cartilage quality was not a predictor of outcome. This study currently is the longest followup of a randomized controlled, clinical trial that examines patellar resurfacing in total knee arthroplasty. The results showed no significant difference between the groups for all outcome measures at a minimum of 10 years of followup.

Aged↗

Patellofemoral arthroplasty: pros, cons, and design considerations.

Patellofemoral arthroplasty is a worthy alternative to total knee arthroplasty or patellectomy in patients with arthritis localized to the anterior compartment of the knee, particularly when there is no considerable patellar malalignment or maltracking. The results can be optimized by accurately aligning the prosthesis and balancing the soft tissues to enhance patellar tracking. However, some designs are particularly vulnerable to patellofemoral complications. Postoperative patellofemoral dysfunction should be reduced by using a trochlear component that engages the patella within the trochlear groove and articulates with the patella completely in extension, but which is relatively unconstrained in extension and has a sagittal radius of curvature that fits well with the native distal femur. The incidence of patellofemoral complications was reduced in my series from 17% with a first generation implant to 4% with a second generation implant. Evolving designs likely will eliminate many of the complications of early generation implants, leaving tibiofemoral degeneration the major source of failure of patellofemoral arthroplasties.

Arthroplasty, Replacement, Knee↗

[Evaluation of selected factors modifying blood loss after total hip arthroplasty and techniques for the prevention of protracted postoperative bleeding].

The aim of this work was to evaluate blood loss in total hip arthroplasty patients, to determine the effect of some factors on bleeding including age, gender, blood group, body build, bone density, and hip replacement technique, and to develop a method for preventing excessive and protracted postoperative bleeding. Altogether, 59 patients with degenerative hip disease were enrolled. Postoperative bleeding was determined after 12 and 24 hours from surgery by measuring the volume of blood in flasks connected to Redon suction drains. The mean volume of blood lost after hip arthroplasty was 797.3 mL after 12 hours and 1029.4 mL after 24 hours. Total blood loss after surgery was 1257.9 mL. No statistically significant differences in blood loss were noted depending on body weight. In consequence, the percentage of blood lost in relation to total blood volume was determined. This indicator was found to be the only objective measure of blood loss in hip arthroplasty patients. Postoperative bleeding was smaller in patients with higher systolic blood pressure intraoperatively, reduced bone density in the femoral neck and spine, and in females. A tendency to reduced bleeding was observed in the elderly and for shorter surgery times. Blood group and hip replacement technique had no effect on blood loss.

Adult↗

The effect of tibial polyethylene insert design on range of motion: evaluation of in vivo knee kinematics by a computerized navigation system during total knee arthroplasty.

Computer-assisted navigation for total knee arthroplasty offers the unique opportunity to assess in vivo knee kinematics during surgery and implement changes whenever appropriate. Using a computerized navigation system, the effect of 2 tibial polyethylene insert designs on knee kinematics in general and knee range of motion (ROM) in particular was evaluated in 37 knee arthroplasties in 30 patients. The Scorpioflex tibial insert was found to provide a significant increase in mean extension, mean flexion, and overall ROM of the knee compared with the standard tibial insert (P<.005) without affecting knee ligamentous balance. Navigation is a very effective and useful tool for intraoperative assessment of knee kinematics and accurate recording of ROM. Based on the information obtained from the navigation software, the surgeon can implement changes in selection of the knee components with beneficial effects in knee kinematics in general and knee ROM in particular. This may, in turn, translate to better clinical outcome of the knee arthroplasty.

Aged↗

[Shoulder arthroplasty in traumatological indications, long-term results].

PURPOSE OF THE STUDY: To evaluate the long-term results of shoulder arthroplasty in trauma cases, using ProSpon and MMS-M.I.L. novel systems. MATERIAL AND METHODS: The shoulder endorosthesis designed by the authors, and manufactured as two products by ProSpon (Czech Republic) and MIL (France) companies, was used in surgical treatment of 43 cases of acute fractures and 33 cases of post-traumatic conditions. The Constant score was used to evaluate the clinical outcome. RESULT: In patients with acute trauma, the average Constant score was 59 points (range, 23-82). The average maximal elevation was 88 degrees (range, 40-140). No postoperative pain, mild pain at strain and arm activity-limiting pain were recorded in 25%, 72% and 3% of the patients, respectively. In patients with post-traumatic destruction of the shoulder, the average Constant score was 53.5 points (range, 20-88) and the average maximal elevation was 85 degrees (range, 30-130). No pain, mild pain and activity-limiting pain were present in 36%, 52% and 12% of the patients, respectively. The patients in whom the reconstruction of the proximal humerus and rotator cuff was performed with the use of a special toothed plate and screws, as designed by the authors, the overall average Constant score was higher by 12 and 11 points for acute trauma and post-traumatic destruction, respectively, when compared with the conventional technique of reconstruction by suture. Two serious complications were recorded, namely, a failure of the reconstruction due to splitting of the greater tubercle fragment at the site of plate fixation and an instability of the shoulder. In patients who were indicated for shoulder arthroplasty due to post-traumatic destruction, the average increase in the Constant score was 12 points in comparison with the pre-operative status. DISCUSSION: Our results of shoulder arthroplasty in acute injury to the proximal humerus are in agreement with the results published in the literature. In reconstruction of the tubercles, there was a considerable difference in results between our screws-and-plate technique and the conventional suture method. With the former, the average Constant score was higher by 12 and 11 points and the average active elevation was better by 15 and 10 degrees for acute trauma and post-traumatic destruction, respectively. Clinical observations also show that osteosynthesis of the tubercle, particularly of the greater one, has better stability with the use of screws and plate, rehabilitation is associated with less pain and shoulder motion improves more rapidly. CONCLUSIONS: The results presented here are comparable with those reported in the literature. In the group treated by the technique designed by the authors, the outcomes are markedly better. This technique of shoulder reconstruction provides better stability for attachment fixation of the rotator cuff, facilitates reconstruction of the proximal humerus in acute trauma and restoration of biomechanical properties of the shoulder joint.

Adult↗

In vitro biomechanics of cervical disc arthroplasty with the ProDisc-C total disc implant.

An in vitro biomechanical study was conducted to compare the effects of disc arthroplasty and anterior cervical fusion on cervical spine biomechanics in a multilevel human cadaveric model. Three spine conditions were studied: harvested, single-level cervical disc arthroplasty, and single-level fusion. A programmable testing apparatus was used that replicated physiological flexion/extension, lateral bending, and axial rotation. Measurements included vertebral motion, applied load, and bending moments. Relative rotations at the superior, treated, and inferior motion segment units (MSUs) were normalized with respect to the overall rotation of those three MSUs and compared using a one-way analysis of variance with Student-Newman-Keuls test (p < 0.05). Simulated fusion decreased motion across the treated site relative to the harvested and disc arthroplasty conditions. The reduced motion at the treated site was compensated at the adjacent segments by an increase in motion. For all modes of testing, use of an artificial disc prosthesis did not alter the motion patterns at either the instrumented level or adjacent segments compared with the harvested condition, except in extension.

Aged↗

Heterotopic ossifications subsequent to knee arthroplasty.

The occurrence of heterotopic ossifications constitutes a rare but possible complication in knee arthroplasty surgery. The authors retrospectively reviewed data for more than 250 patients submitted to knee arthroplasty with the purpose of ascertaining the incidence of the occurrence of heterotopic ossifications after surgery and of understanding any clinical repercussions and possible risk factors. A total of 14 cases of heterotopic ossifications were observed out of 276 knee arthroplasties (4.7%). Lesions were grade 1: 4, grade II: 3, grade III: 7. The authors stress the importance of local factors as compared to general ones and the need to adopt a respectful surgical method, avoiding notching or excessive trauma to the periosteum, as well as the need to define parameters in order to single out subjects at risk and in whom prophylaxis should be administered.

Adult↗

[Total dislodgement of the femoral component following cemented total knee arthroplasty: a case report].

Total dislodgement of the components, which is the most severe form of loosening, has hitherto been unreported following total knee arthroplasty. An eighty-four-year-old woman presented with complaints of pain and sensation of insecurity of her right knee after cemented total knee arthroplasty. On physical examination, a clunk was elicited during movements of the knee; however, radiographs appeared normal except for a separated fragment of the medial femoral condyle. Further examination with varus and valgus stress tests under fluoroscopic control showed dislodgement of the femoral component, which was only apparent on stress radiographs. She underwent revision cemented total knee arthroplasty and her complaints disappeared completely within a follow-up period of three years. This case illustrates the need for stress radiographs when standard radiographs are normal in the face of a high suspicion of loosening.

Aged↗

[Our experience with revision total knee arthroplasty].

PURPOSE OF THE STUDY: In the period from 1990 and June 2003, 885 total knee replacements were performed at the orthopedic ward of the Ceske Budejovice Hospital. Of these, 19 (2.14 %) patients underwent revision surgery; in addition, 25 patients who had had primary surgery in other hospitals were operated on. Of these 44 patients, 25 were followed up and evaluated. The aim of the study was to evaluate the pre-operative treatment including examination for bacterial infection by cultivation, the selection of an optimal procedure (one- or two-stage operation, surgical approach and implantation technique) and postoperative therapy. MATERIAL: The 25 evaluated patients were followed up for an average of 34.5 months (range, 6-109 months) after reimplantation. Loosening occurred in most of the commonly used types of primary implants. The group comprised five men and 19 women; the average age at the time of reoperation was 70 years (range, 51-78 years). Ten patients had repeat surgery on the left and 14 on the right knee at an average of 43.5 months (range, 4-120 months) after primary surgery. Fourteen patients were treated by one-stage and 10 patients by two-stage surgery. The Genesis system (Smith Nephew) was used in 13 patients, Sigma PFC revision implant (Johnson and Johnson) in eight, Walter-Motorlet implant (reuse of the primary implant at the time when a revision system was not available) in one and external fixator in five patients. METHODS: Revision arthroplasty was indicated on the basis of clinical symptoms and X-ray, scintigraphic and biochemical (CRP, WBC, FW) examinations. The use of recently adopted methods (procalcitonin, orosomucoid, alpha-1-antitrypsin, beta-2- macroglobulin, ceruloplasmin, PCR and PET) was not evaluated because of short-term applications. Patients in whom infection or colonization of the implant was suspected were treated by two-stage reimplantation, using a canalized spacer with a stem and a patellar pelota made of antibiotic-loaded cement. The average time between implant removal and reimplantation was 108 days (range, 60-244 days). Each removed implant was placed in a culture medium for 5 to 7 days. This resulted in a high occurrence of positive cultivation results even in the patients who, on the basis of previous examination, were first considered to have had aseptic loosening and had undergone one-stage surgery. All patients with positive tests received long-term antibiotic therapy, usually a combination of ciprofloxacin and rifampicin, according to the cultivation results. RESULTS: Out of 14 one-stage reimplantations (indicated for by the negative results of all laboratory examinations), implant colonization was recorded in five cases, with a coagulase-negative staphylococcus being the most frequent infectious agent. No recurrent infection was found after the long-term antibiotic course. One patient with the implant infected with Staphylococcus aureus underwent primary arthrodesis. Out of 10 two-stage reimplantations (in patients with positive laboratory tests), recurrent infection was found in two cases and was caused by a pathogen different from the original one. The patients were treated by arthrodesis. Good outcomes, defined as a functional total knee replacement free from infection at least 6 months after reimplantation, were achieved in 79 % of the patients. Better functional results were obtained by onestage surgery. Patients with concomitant rheumatoid arthritis had aseptic loosening more frequently, and patients with impaired immunological status, due to diabetes mellitus, cytostatic drug or corticosteroid administration, more often showed septic loosening. DISCUSSION: The 2.14 % loosening of total knee arthroplasty in our patients (19 out of 885) can be considered a good result. A functional joint was achieved in all patients (100 %) with aseptic loosening and in 69 % of those with infected or colonized implants. The results of routine biochemical tests and bacteriological cultivation did not allow us to distinguish aseptic from septic loosening with certainty. Therefore, we adopted new screening markers (PCR and PET) and a new method of microbiological examination of the removed implant and collected tissue. However, we could evaluate the role of these specialized tests only on the basis of literature data, since we had only short-term experience with them ourselves. Our results with the treatment of early loosening of total knee arthroplasty suggest that patients benefit more from the two-stage procedure. CONCLUSIONS: We strongly emphasize the employment of all possible means to prevent loosening, i. e., to use an appropriate surgical technique for primary implantation, to observe aseptic principles and to administer antibiotic therapy in conditions suspected of bacteremia. The shorter the interval between the onset of complaints and the reimplantation, the better results. Early loosening should be treated by two-stage surgery. Our method of bacteriological examination gives good results. Because of complexity of the problem, patients with a loose knee prosthesis should be referred to orthopedic departments with experienced and skilled surgical teams and high-quality examination facilities.With the observation of appropriate procedures, there is a great chance of achieving good results. Arthrodesis is still regarded as a justified "salvage" operation, particularly in cases with pre-operative findings of Staphylococcus aureus. Procedures for repeat surgery following the failure of a reimplanted joint have so far yielded doubtful results and still await further development.

Aged↗

Kinematics of mobile-bearing total knee arthroplasty.

In a comparison of in vivo knee kinematic patterns of mobile-bearing total knee arthroplasty with thosefrom studies of fixed-bearing total knee arthroplasty and the normal knee, no major differences in the "average" kinematic patterns of fixed- versus mobile-bearing implants was observed. However, there was less AP translation of both the medial and lateral femoral condyles during gait in patients with mobile-bearing implants. This is probably the result of the increased sagittal femorotibial conformity of most mobile-bearing implants, which reduces polyethylene shear stresses and should lessen polyethylene wear rates. In rotating-platform mobile-bearing implants, axial rotation occurs primarily on the inferior surface of the polyethylene bearing instead of on the superior surface, which reduces shear forces on the superior aspect of the polyethylene bearing, thereby lessening wear: Although the average axial rotational values after total knee arthroplasty were limited (< 10 degrees), a significant number of patients exhibited higher magnitudes of rotation (> 20 degrees), which exceeds the rotational limits of most fixed-bearing implants. Rotating-platform mobile-bearing implants may therefore be advantageous in that they can accommodate a wider range of axial rotation without creating excessive polyethylene stresses.

Arthroplasty, Replacement, Knee↗

Free gracilis interposition arthroplasty for severe hallux rigidus.

Surgery for the management of hallux rigidus aims to relieve pain and improve function. Arthrodesis, though reliable in terms of pain relief may encounter some resistance from patients reluctant to have a fusion. Results of other techniques, such as silastic implants, may give poor long-term results. Excisional arthroplasty and cheilectomy are also routinely used. Interposition arthroplasty has been used with some success in other joints. We describe a technique of autologous interposition arthroplasty using a free ipsilateral gracilis tendon graft for patients with severe hallux rigidus with moderate to high activity levels and who do not wish to undergo fusion.

Arthroplasty↗

Two-stage total knee arthroplasty for non-salvageable septic arthritis in diabetes mellitus patients.

Pyogenic knee arthritis in a patient with advanced osteoarthritis is a serious medical problem. We have performed arthroscopic debridement in 136 patients with pyogenic knee arthritis from January 1999 to December 2001. Five of these patients were diabetic, they did not respond to the standard treatment protocol and they continued to have infection. For these patients, we performed open arthrotomy, with implantation of antibiotic cement as a spacer, and staged total knee arthroplasty. The clinical results were evaluated using the Hospital for Special Surgery (HSS) scoring system. At an average follow-up of 38 months (range: 29 to 46), the average pain score was 83 and the functional score was 73 with no patient having recurrence of the infection. This study shows that just as a 2-stage revision is now done for infected total knee arthroplasty, primary uncontrolled infected knees may be treated by a 2-stage arthroplasty as well.

Age Factors↗

Early attempts at hip arthroplasty--1700s to 1950s.

Over the last three centuries, treatment of hip arthritides has evolved from rudimentary surgery to modern total hip arthroplasty (THA), which is considered one of the most successful surgical interventions ever developed. We here review the history of the early hip arthroplasty procedures for hip arthritis that preceded Charley total hip arthroplasty. An evaluation of such past enterprises is relevant, and reminds us of the ephemeral nature of human industriousness, and how medical research and procedures are not isolated developments, but correlate to the social, economical, and cultural framework of their time.

Arthritis↗

Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients.

BACKGROUND: A blood transfusion is a costly transplantation of tissue that may endanger the health for the recipient. Blood transfusions are common after total hip arthroplasty. The total saving potential is substantial if the blood loss could be reduced. Studies on the use of tranexamic acid have shown interesting results, but its benefits in total hip arthroplasty have not yet been resolved. PATIENTS AND METHODS: 100 patients receiving a total hip arthroplasty (THA) got a single injection of tranexamic acid (15 mg/kg) or placebo intravenously before the start of the operation. The study was double-blind and randomized. Total blood loss was calculated from the hemoglobin (Hb) balance. Volume and Hb concentration of the drainage was measured 24 h after the operation. Intraoperative blood loss was estimated volumetrically and visually. RESULTS: The patients who received tranexamic acid (TA) bled less. The total blood loss was on average 0.97 L in the TA group and 1.3 L in the placebo group (p < 0.001). 8/47 (0.2) in the TA group were given blood transfusion versus 23/53 (0.4) in the placebo group (p = 0.009). Drainage volume and drainage Hb concentration were less in the TA group (p < 0.001 and p = 0.001). No thromboembolic complications occurred. INTERPRETATION: Considering the cost of blood and tranexamic acid only, use of the drug would save EUR 47 Euro per patient. We recommend a preoperative single dose of tranexamic acid for standard use in THA.

Aged↗

Conversion of knee fusion to total arthroplasty: complications in 8 patients.

BACKGROUND: There are no clear indications for conversion of knee fusion to total arthroplasty. In this paper we report outcome and complications in 8 patients. PATIENTS AND METHODS: We reviewed 8 total knee arthroplasties after takedown of previous fusion 24-55 months after the conversion. The original diagnoses were complications following injury in 3 patients, rheumatoid arthritis in 3, complication after chondromalacia in 1 patient and tuberculous arthritis in 1 patient. The age at operation ranged from 31 to 67 years. The time since arthrodesis ranged from 1 to 49 years. RESULTS: 5 patients had to undergo reoperation for postoperative complications. 2 patients experienced recurrence of previous deep infection, which led to thigh amputation in one and chronic fistulation in the other. Only 1 patient had an uneventful course after the conversion procedure, but he died later on due to a heart attack. As another patient also died of cardiovascular disease, 5 of the 8 patients were available for evaluation of knee function. In these patients the knee flexion ranged from 90 to 120 degrees, extension lag ranged from 10 to 40 degrees, and all knees were aligned at 6 to 8 degrees of valgus. The Knee Society clinical scores ranged from 47 to 74, the Womac scores ranged from 9 to 47, and EuroQol ranged from 0.1 to 0.8. INTERPRETATION: Our findings indicate that conversion of knee arthrodesis to total arthroplasty should only be performed in selected cases, and after giving the patient extensive information about the high risk of rather serious complications.

Adult↗

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