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PubMed1989

Longitudinal changes in cranial base angulation in mandibulofacial dysostosis.

Longitudinal measures of cranial base angulation (nasion-sella-basion angle; N-S-Ba) were obtained in 24 patients with mandibulofacial dysostosis (MFD), with records available over time spans ranging from 2 years to 29 years. Initial measurements, obtained at ages ranging from 1 month to 13 years, 6 months, indicated basilar kyphosis (N-S-Ba less than 120 degrees) in five patients. Twenty-one patients showed increasing flexure of the cranial base angle (CBA) over time, eight to such a degree that their initially normal CBAs eventually fell into the kyphotic range. At the time of the final available records (age range 4 years, 0 months to 29 years, 2 months), a total of 54 percent of patients thus fell into the kyphotic range. These results point to the time-dependent nature of the appearance of abnormal CB angulation in some patients. In addition, there was a predominance of males in those patients showing significant change in cranial base angulation over time.

Adolescent↗

PubMed2000

Adolescent-parent interactions in middle-class African American families: longitudinal change and contextual variations.

Family interactions were examined longitudinally over 2 years in 79 middle-class African American families with early adolescents. Mothers and adolescents (as well as fathers and adolescents and triads in 2-parent families) were videotaped discussing a conflict for 10 min. A macro-coding system (J. G. Smetana, J. Yau, A. Restrepo, & J. L. Braeges, 1991) was modified to be culturally sensitive to African American families. Interaction ratings were reduced, through principal-components analyses, into composite variables. After control for family income, mothers' communication in triadic interactions became less positive over time. Both mothers' and fathers' communication was more positive in dyadic than triadic interactions. In triadic interactions, mothers validated sons more than daughters, and in dyadic interactions with either parent, boys were more receptive to parents than were girls. Findings extend previous research on adolescent-parent relationships to African American families.

Adolescent↗

PubMed2003

Longitudinal changes in craniofacial factors among snoring and nonsnoring Bolton-Brush study participants.

The extent to which craniofacial risk factors are manifested from childhood in habitual snorers and those with obstructive sleep apnea hypopnea syndrome (OSAHS) is unknown. The purpose of this study was to examine the differences in craniofacial factors between snorers and nonsnorers from childhood to adulthood. The sample consisted of 80 Bolton-Brush subjects (men, 52%; white, 100%) recalled at adult ages (53-78 years) who had existing prepubertal (age, 4-5 years) and pubertal (age, 12-13 years) records. Snoring was assessed at the adult age through subjective and spousal reports. Cephalometric radiographs were used to characterize 13 craniofacial hard and soft tissue measurements. The t tests revealed that there was a trend (P <.10) for longer hyoid-to-mandibular plane distance at prepubertal and pubertal ages and significant (P <.05) differences at adult recall for snorers. Posterior airway space was significantly smaller for snorers at adult recall. The longitudinal analysis did show a significant change in 9 craniofacial variables over time, but this change was not different between snorers and nonsnorers. We concluded that snorers exhibit a lowered hyoid position from childhood and that longitudinal changes must be explored further with a larger sample.

Adolescent↗

PubMed1996

Subjective memory complaints, psychological distress, and longitudinal change in objective memory performance.

Between 1992 and 1993, the Memory Function Questionnaire General Frequency of Forgetting Scale (MFQ-GEN), the Symptom Checklist-90-Revised General Severity Index (GSI), and Mayo Cognitive Factor Scales Learning and Retention (MCFS-LRN and MCFS-RET) current and change scores were obtained for 294 of 397 (74%) participants, ages 55-97 years, originally assessed in a 1988-1990 normative study. In multiple regression modeling, the GSI and MCFS-LRN current score contributed 20% and 3%, respectively, to MFQ-GEN variance. Thus, emotional status was a better predictor of subjective memory ratings than either absolute objective memory performance or objective longitudinal memory change. Persons who developed cognitive impairment over the longitudinal interval reported greater memory problems, but memory complaints had little sensitivity in identifying these persons. In an approximate census sample of these older people, minor memory problems were reported to be frequent but not serious.

Aged↗

PubMed1999

Longitudinal changes in visual acuity and visual ability in a cohort followed from the age of 70 to 88 years.

PURPOSE: To assess the change in visual acuity (VA) for distance and near and to correlate VA to changes in visual ability in a longitudinal study group followed from 70 to 88 years. METHODS: In the population-based study H70 in Gothenburg, Sweden, 958 subjects from the original cohort were eye examined at age 70 and the surviving subjects were reexamined at age 82 (n=203) and at 88 years (n=129). Evaluation of change in visual function between age 82 and 88 was made in 66 subjects who took part in all three eye examinations. RESULTS: The VA in the subsample (n=66) showed minimal difference compared to the cross-sectional groups. At age 70 nearly 100% of both sexes had VA> or =0.8. At age 82 about 50% and at age 88 about 25% had this VA level. Males retained a slightly better visual acuity compared to women. VA< or =0.3 was found in about 10% at age 82 and in >20% at age 88. Reading ability remained high, but at 82 years 1.6% and at 88 years 10.5% could benefit from adjustment of their near glasses. Visual ability corresponded well to VA at age 82, but not at 88 years. Women lost the ability for most tasks, whereas men showed small changes. CONCLUSIONS: The majority of old people had good distance and near vision. A deterioration in visual acuity did not necessarily mean a negative change in visual ability. This emphasizes the importance of relating objective and subjective findings regarding VA and visual impairment to functional ability of the oldest of the elderly.

Activities of Daily Living↗

PubMed1992

Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women.

The effect of dietary factors on manganese-dependent superoxide dismutase (MnSOD) activity in humans has not been studied. We longitudinally evaluated changes in MnSOD activity and other indices of manganese and iron status in 47 women during a 124-d supplementation study. Subjects received one of four treatments: placebo, 60 mg iron, 15 mg manganese, or both mineral supplements daily. Manganese supplementation resulted in significant increases in lymphocyte MnSOD activity and serum manganese concentrations from baseline values but no changes in urinary manganese excretion or in any indices of iron status. Oral contraceptive use and the stage of the menstrual cycle did not confound the use of lymphocyte MnSOD activity or serum manganese to monitor manganese status, but fat intake affected both indices. This work demonstrated that lymphocyte MnSOD activity can be used with serum manganese concentrations to monitor manganese exposure in humans.

Adult↗

PubMed1996

Longitudinal changes in antibody avidity to Actinobacillus actinomycetemcomitans in periodontitis.

Longitudinal investigations concerning immunological responses and periodontal disease activity support a relationship between serum antibody levels and the micro-organisms associated with dental plaque. To define this host response further, we studied the relationship of antibody avidity to Actinobacillus actinomycetemcomitans (Aa) in 11 adult periodontitis and 6 localized juvenile periodontitis (LJP) patients with Aa infections. Patients were monitored every 3-4 months for immunological and clinical variables including probing pocket depths (PD), bleeding on probing (BOP), plaque index (PLI), and the number of disease active sites (DA). Avidity indices were determined using an ELISA and significant changes from each patients' baseline level were determined. The results showed different response patterns between and within the patient groups. A subset of the subjects experienced significant changes in antibody avidity over time. Between group comparisons yielded no significant differences in the number of positive or negative avidity index changes, although there were more frequent changes in the disease active adult periodontitis group. There were also no significant correlations between clinical parameters and antibody avidity, although there were changes in the clinical parameters between baseline and significant avidity change points, and also between baseline and the determination of active disease. Further studies will be necessary to define fully the role of antibody avidity and its relationship to the pathogenesis of periodontal diseases.

Adult↗

PubMed2026

Autistic-like traits and longitudinal changes in health-related quality of life among individuals with bipolar disorder: A 12-month study.

OBJECTIVE: Autistic-like traits are common in bipolar disorder (BD) and have been linked to poor functional outcomes, yet their longitudinal impact on quality of life (QOL) remains unclear. This study examined whether autistic-like traits are associated with 12-month changes in health-related QOL in BD. METHODS: Seventy-eight outpatients with BD who completed 12-month follow-up assessments were included (mean age = 34.9 years). Autistic-like traits were assessed using the Social Responsiveness Scale for Adults (SRS-A), with participants classified into elevated- and non-elevated-traits groups. Depressive and manic symptoms were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Young Mania Rating Scale (YMRS). QOL was measured using the 36-Item Short-Form Health Survey (SF-36). Linear mixed models were used to examine longitudinal changes. RESULTS: HAMD-17 scores demonstrated significant main effects of time and group, reflecting overall improvement but persistently higher depressive symptoms in the elevated-traits group. YMRS scores indicated a significant group effect only. Physical QOL remained stable, while mental QOL improved over time without group differences. Role/social QOL showed significant main effects of time and group, with consistently lower scores in the elevated-traits group. No group × time interactions emerged, suggesting similar rates of change between groups. CONCLUSIONS: This prospective study suggests that autistic-like traits in BD are associated with persistently poorer role/social functioning over time rather than differences in recovery trajectories. Assessing autistic-like traits may help identify patients at risk of poorer functioning and guide tailored psychosocial interventions.

Autistic-like traits↗

PubMed1989

Longitudinal changes in regional cerebral blood flow in a normal elderly group.

Only one published study to date has examined longitudinal age-changes in regional cerebral blood flow (rCBF) in an elderly group. It found rCBF declined significantly in their elderly sample over a 24 to 42 month period. The current study attempts to cross-validate the earlier study's findings with an older normal elderly group and a longer time interval between rCBF studies. This study is consistent with that investigation. The normal elderly did exhibit significant declines in blood flow across a variety of indices including: gray and white matter and the Initial Slope Index. These declines were generally on the order of.50 to.75 of a standard deviation loss. No significant differences in blood flow decline between males and females were discerned. While the young-old did exhibit greater blood flow than the old-old there were no significant differences in the rate of decline between the two age-groups.

Journal Article↗

PubMedDate not supplied

Longitudinal changes in body composition in women approaching the midlife.

This population-based longitudinal study describes the 4.5-year changes in body composition and body mass distribution in women aged 20-45 years, and characterizes predictors of these changes. Body weight, waist-to-hip ratio, Quetelet index, fat and lean body mass were measured in 404 white menstruating women aged 20-40 at baseline and 4.5 years later (follow-up). Variables considered for predicting body composition differences were hormonal status, menstrual status, parity, diet and physical activity. Average body weight increased 4.3 kg in 4.5 years (6.4 kg increase in fat and 2.1 kg decrease in lean)--a net increase of 7.1% total body fat. Measured predictors were not significantly associated with weight or Quetelet index; however, they were associated with measured amounts of lean and fat. Longitudinally, women who preserved the most lean body mass tended to be nulliparous, to be still menstruating, to have higher testosterone levels, and to smoke. Physical activity was associated with preserving lean body mass. Increasing age and higher follicle-stimulating hormone levels were associated with increasing waist-to-hip ratio. Average body weight showed a steady increase--characterized by an expanding fat compartment and a shrinking lean compartment--with the older women increasing more in waist girth relative to hip girth than younger women. Predictor variables of these changes included hormonal environment, physical activity, smoking behaviour, parity, and oophorectomy.

Adipose Tissue↗

PubMed2002

Concomitant longitudinal changes in frequency of and bother from lower urinary tract symptoms in community dwelling men.

PURPOSE: Care for men with benign prostatic hyperplasia consumes a sizable amount of health care resources, which is largely driven by bother from lower urinary tract symptoms. While cross-sectional studies have demonstrated a strong correlation between frequency of symptoms and associated bother, there are few longitudinal data demonstrating how these track together. MATERIALS AND METHODS: In 1989, 2,115 white men between 40 and 79 years old were recruited from a random sample of the Olmsted County population. These men completed a self-administered questionnaire that assessed lower urinary tract symptom severity and associated bother with questions similar to those in the American Urological Association Symptom Index. Questionnaires were completed biennially thereafter through 1996. RESULTS: Annualized changes in symptom score increased from a median of 0.02 per year (25th, 75th percentile -0.35, 0.60) for men in their forties to 0.43 (-0.12, 1.16) for men in their sixties. The median change in bother scores was 0 (-0.30, 0.29) across all ages. The correlation between longitudinal symptom score slopes and bother score slopes was 0.55 (p <0.001) overall and did not differ substantively across age. CONCLUSIONS: These results demonstrate that there is a great deal of variability between individuals in the amount of longitudinal change in lower urinary tract symptom severity and bother. While for bother, there is little change across individuals on average, within individual frequency and bother track together fairly closely. However, there remain some men with increases in frequency who do not report similar increases in bother, possibly representing some component of adaptation or acceptance of worsening symptom severity with age.

Adult↗

PubMed1999

Longitudinal change in height of men and women: implications for interpretation of the body mass index: the Baltimore Longitudinal Study of Aging.

Age differences in height derived from cross-sectional studies can be the result of differential secular influences among the age cohorts. To determine the magnitude of height loss that accompanies aging, longitudinal studies are required. The authors studied 2,084 men and women aged 17-94 years enrolled from 1958 to 1993 in the Baltimore Longitudinal Study of Aging, Baltimore, Maryland. On average, men's height was measured nine times during 15 years and women's height five times during 9 years. The rate of decrease in height was greater for women than for men. For both sexes, height loss began at about age 30 years and accelerated with increasing age. Cumulative height loss from age 30 to 70 years averaged about 3 cm for men and 5 cm for women; by age 80 years, it increased to 5 cm for men and 8 cm for women. This degree of height loss would account for an "artifactual" increase in body mass index of approximately 0.7 kg/m2 for men and 1.6 kg/m2 for women by age 70 years that increases to 1.4 and 2.6 kg/m2, respectively, by age 80 years. True height loss with aging must be taken into account when height (or indexes based on height) is used in physiologic or clinical studies.

Adolescent↗

PubMed2002

Longitudinal changes in body composition in older men and women: role of body weight change and physical activity.

BACKGROUND: Estimates of body-composition change in older adults are mostly derived from cross-sectional data. OBJECTIVE: We examined the natural longitudinal patterns of change in fat-free mass (FFM) and fat mass (FM) in older adults and explored the effect of physical activity, weight change, and age on these changes. DESIGN: The body composition measured by hydrodensitometry and the level of sports and recreational activity (SRA) of 53 men and 78 women with a mean (+/-SD) initial age of 60.7 +/- 7.8 y were examined on 2 occasions separated by a mean (+/-SD) time of 9.4 +/- 1.4 y. RESULTS: FFM decreased in men (2.0% per decade) but not in women, whereas FM increased similarly in both sexes (7.5% per decade). Levels of SRA decreased more in men than in women over the follow-up period. Baseline age and level of SRA were inversely and independently associated with changes in FM in women only. Neither age nor level of SRA was associated with changes in FFM in men or women. Weight-stable subjects lost FFM. FFM accounted for 19% of body weight in those who gained weight, even in the presence of decreased levels of SRA. Loss of FFM (33% of body weight) was pronounced in those who lost weight, despite median SRA levels >4184 kJ/wk. CONCLUSIONS: On average, FM increased; however, the increase in women was attenuated with advancing age. The decrease in FFM over the follow-up period was small and masked the wide interindividual variation that was dependent on the magnitude of weight change. The contribution of weight stability, modest weight gains, or lifestyle changes that include regular resistance exercise in attenuating lean-tissue loss with age should be explored.

Adipose Tissue↗

PubMed1994

Acute effects on forced expiratory volume in one second and longitudinal change in pulmonary function among wood trimmers.

Wood trimmers are exposed to molds that periodically grow on timber, and may develop acute as well as chronic pulmonary function impairment. This study examined whether these acute changes in pulmonary function are predictors for a longitudinal deterioration in pulmonary function, beyond normal aging and exposure. Across-shift changes in pulmonary function, measured during a working week, were evaluated in 15 wood trimmers with a follow-up time of 27 months. Twenty-six sawmill workers, employed at the same plants as the wood trimmers, served as control subjects. The highest concentration of viable mold spores for the wood trimmers was 10(6) colony-forming units (cfu)/m3, i.e., several times higher than the corresponding value for the sawmill workers. At the follow-up, wood trimmers had a lower forced vital capacity (FVC) on average, after adjustment for age and height, compared to the sawmill workers. In addition, a correlation was found between the across-week change in forced expiratory volume in 1 second (FEV1) and the decline in FEV1 between the first and the second occasion, after adjusting for normal aging in nonsmoking wood trimmers (r2 = 84%, p < 0.001). The results from the present study suggest that across-shift decrease in FEV1 (measured during a working week) might serve as a guide to identify subjects being at risk for a further decrement in pulmonary function over and above the effects of normal aging and exposure to mold spores in the wood trimming department.

Air Pollutants, Occupational↗

PubMed1988

Longitudinal changes in adolescent cigarette smoking behavior: onset and cessation.

Employing a 1-year longitudinal design, this study examined factors related to change in adolescent smoking. Predictors of smoking onset differed from predictors of continued smoking, underscoring the importance of studying factors related to adolescent smoking onset separately from mechanisms associated with changes in smoking among current smokers. Peer smoking predicted continuation of smoking after smoking initiation. Smokers received over 26 times more offers to smoke than did nonsmokers, suggesting that smokers attempting to quit need effective refusal skills to be successful. Habitual smoking was found to develop slowly, providing a substantial time window for refusal skill training and other prevention efforts. Predictors of smoking onset differed by developmental level. Peer smoking, and marijuana use were stronger predictors of smoking onset for high-school students, and number of cigarette offers predicted better among middle-school students. Parent variables were not significant predictors of later smoking. Intention to smoke was unrelated to onset and was redundant with pretest smoking behavior in predicting cessation.

Adolescent↗

PubMed2003

Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Bogalusa Heart Study.

The occurrence of metabolic abnormalities related to insulin resistance syndrome in nondiabetic offspring of type 2 diabetic parents is known. However, information is lacking on the timing and the course of development of the components of this syndrome from childhood to adulthood in the offspring of parents with diabetes. This aspect was examined in a community-based cohort with (n = 303) and without (n = 1,136) a parental history of type 2 diabetes followed longitudinally since childhood (ages 4 to 17 years; mean follow-up period, 15 years) by repeated surveys. Offspring with parental diabetes versus those without such history had significantly excess generalized and truncal adiposity as measured by body mass index (BMI) and subscapular skinfold beginning in childhood, higher levels of fasting insulin and glucose and homeostasis model assessment index of insulin resistance (HOMA-IR) from adolescence, and higher levels of low-density lipoprotein (LDL) cholesterol and triglycerides and lower levels of high-density lipoprotein (HDL) cholesterol in adulthood. Many of these risk variables changed adversely at an increased rate in offspring of diabetic parents. In a multivariate analysis, parental diabetes was an independent predictor of longitudinal changes in adiposity, glucose, insulin, HOM-IR, systolic and diastolic blood pressure, and LDL cholesterol in the offspring, regardless of race and gender. As young adults, the offspring of diabetic parents had a higher prevalence of generalized (BMI > 30, 36% v 16%, P =.0001) and visceral (waist > 100 cm, 15% v 6%, P =.0001) obesity, hyperinsulinemia indicative of insulin resistance (insulin > 18 microU/mL, 15% v 8%, P =.0001), hyperglycemia (>or=110 mg/dL, 2% v 0.5%, P =.02), high LDL cholesterol (>or=160 mg/dL, 11% v 7%, P =.02), low HDL cholesterol (<40 mg/dL for males and <50 mg/dL for females, 40% v 31%, P =.004), high triglycerides (>or=150 mg/dL, 23% v 15%, P =.0001), and hypertension (>140/90 mm Hg, 11% v 6%, P =.004). Thus, the offspring of diabetic parents displayed excess body fatness beginning in childhood and accelerated progression of adverse risk profile characteristics of insulin resistance syndrome from childhood to young adulthood. These observations have important implications for early prevention and intervention.

Adolescent↗

PubMed2005

Longitudinal changes in energy expenditure in girls from late childhood through midadolescence.

BACKGROUND: Longitudinal data on energy expenditure in children and adolescents are scarce. OBJECTIVE: The purpose of this study was to examine changes in energy expenditure and physical activity in girls from late childhood through midadolescence. DESIGN: We measured total energy expenditure (TEE) by doubly labeled water, resting metabolic rate (RMR) by indirect calorimetry, body composition by 18O dilution, and time spent in activity by an activity diary in 28 initially nonobese girls at approximately 10, approximately 12, and approximately 15 y of age. Changes with age in TEE, RMR, and activity energy expenditure (AEE), both in absolute terms and in adjusted analyses, and in physical activity level (PAL) and time spent sleeping, being sedentary, and in moderate and vigorous activity were evaluated by mixed-model repeated-measures analyses. RESULTS: Absolute TEE and AEE increased significantly from age 10 to age 15 y (P < 0.0001 for both). Absolute RMR at ages 12 and 15 y did not differ significantly, despite significant increases in fat-free mass and fat mass between the visits. PAL was significantly higher (P < 0.0001) at age 15 y than at age 10 or 12 y, whereas time spent being sedentary increased significantly from age 10 to age 15 y (P < 0.001), and AEE adjusted for fat-free mass appeared to decrease over the same interval. CONCLUSION: Conclusions drawn regarding changes with age in physical activity depend on the measure of physical activity assessed.

Adolescent↗

PubMed1997

Heritability of longitudinal changes in coronary-heart-disease risk factors in women twins.

Numerous studies have demonstrated genetic influences on levels of coronary heart disease (CHD) risk factors, but there also may be genetic effects on the intraindividual variation in these risk factors over time. Changes in risk factors are likely to reflect genetic-environmental interactions and may have important implications for understanding CHD risk. The present study examines the heritability of changes in CHD risk factors, using data from the two examinations by the Kaiser Permanente Women Twins Study, performed a decade apart. The sample consisted of 348 pairs of women twins who participated in both examinations, including 203 MZ pairs and 145 DZ pairs. Average ages at the two examinations were 41 and 51 years, respectively. By means of three different statistical analytic approaches, moderate heritability estimates were demonstrated for changes in LDL cholesterol (h2 = .25-.36) and in HDL cholesterol (h2 = .23-.58), some of which were statistically significant. Although small to moderate heritability estimates were found for systolic blood pressure (.18-.37; P < .05 for some estimates), no genetic influence on changes in diastolic blood pressure was detected. Based on longitudinal twin data in women, this study demonstrates a genetic influence on changes in both lipoprotein risk factors and systolic blood pressure over a decade. In addition to environmental factors, which clearly are operating, the effect of various "variability genes" may be acting independently of the genetic influences on the absolute levels of these risk factors. Both mapping the gene(s) underlying intraindividual variations in these CHD risk factors and understanding their function(s) could lead to targeted intervention strategies to reduce CHD risk among genetically susceptible individuals.

Adult↗