Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Thyroid Function Tests”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources
PubMed1991

Thyroid function test in patient with acute-severe-nonthyroidal illnesses.

Patients with acute-severe-nonthyroidal illnesses had FT4 and T3 values below the normal range with the magnitude of change greater for T3 than FT4. Some patients had depressed and some had elevated TSH values. In the recovery phase, FT4 levels appeared to rise before T3 levels and TSH exhibited an exaggerated increase. These results are consistent with other studies which suggest that dysfunction of the hypothalamic-pituitary-thyroid axis may be associated with anomalous results for thyroid function test parameters in patients with acute-severe-nonthyroidal illnesses. This anomaly should be given due consideration when interpreting results of thyroid function test parameters in such patients.

Acute Disease↗
PubMed2000

Thyroid function tests: often justified in the acutely ill.

It is claimed that inappropriate requesting of thyroid function tests (TFTs) is common in acutely ill patients. Consecutive inpatient TFTs (n = 129) were assessed in relation to clinical history and common symptoms and signs of thyroid disease. Requests were justified in 69% of cases, most commonly on the basis of atrial fibrillation and/or tachycardia. There were no clear reasons for requesting TFTs in the remaining cases, although the yield of abnormal results in these patients was similar to that in those with justified requests. Thyroid stimulating hormone (TSH) concentration was increased (median 7.5 mU/L, range 4.8-38.6 mU/L) in 22 patients, six of whom had biochemical and/or clinical evidence of hypothyroidism (previously undiagnosed) and five of whom had pre-existing hypothyroidism. Of the remaining 11 patients with increased TSH levels, three were confirmed to have compensated hypothyroidism; non-thyroidal illness (NTI) (including the effect of drugs) accounted for four cases. In four patients (one of whom died during the admission) follow-up was not possible. Of six patients with reduced TSH concentration (range <0.05-0.35 mU/L), one was thyrotoxic on carbimazole, one was receiving thyroxine for hypothyroidism, one had NTI and three were lost to follow-up (two of whom died during their admission). Manifestations of thyroid disease are protean and often subtle, and TFTs are thus clinically justified in many unwell inpatients. Although NTI contributes to some cases of abnormal TSH levels, a significant number of TFT abnormalities are consistent with underlying thyroid abnormality requiring investigation/treatment.

Acute Disease↗
PubMed1993

[Thyroid function tests and their use by the general practitioner].

OBJECTIVE: We aimed to discover how thyroid function tests (TFTs) were used in general practice (GP) consultations. We would evaluate how many TFTs were requested, their efficiency, cost and their impact on referrals to endocrinology. DESIGN: This was a longitudinal, retrospective and observational study. SITE. At the Primary Care level, in the La Chana Health Centre, Granada. PATIENTS: 69 patients with possible Thyroid Disease, and who had a TFT performed by their GP, were surveyed. The test comprised parallel TSH, free T4 and free T3. MAIN MEASUREMENTS AND RESULTS: 2.46 TFTs per GP per year were requested. 14 showed positive (20.28%) and a definite diagnosis of Thyroid Function Disease (TFD) was made in 11 cases (15.94%). The cost per test was 1,718 pesetas; and per diagnosis, 8,467 pesetas. 78.26% of the cases were resolved by the GP without need of referral. CONCLUSIONS: The GPs carried out few FTFs; but those they did were very efficient. Cost was low and patients benefited from the fact that their GPs were able to use this technique. Endocrinology referrals were reasonable. All general practitioners should have use of TFTs.

Adolescent↗
PubMed2004

Effect of adjuvant androgen deprivation on thyroid function tests in prostate cancer patients.

Androgen deprivation (AD) used in the treatment of prostate cancer is known to alter concentrations of sex hormones and their binding globulins. Less is known as to its effect on thyroid hormones. In this prospective study the effects of AD on thyroid function were clarified. Levels of serum thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid binding globulin concentrations were measured in prostate cancer patients treated with either radical radiotherapy and androgen deprivation for 12 months (AD) or radical radiotherapy alone (RT). Measurements were made at baseline, and at 3, 6 and 12 months. At baseline and at 3 months the results of thyroid function tests did not differ significantly between groups. A significant decline in serum testosterone in the AD group was accompanied by a significant decline in FT4 at 6 and 12 months, while no significant changes in thyroid function were observed in the RT group. The decline in FT4 among AD patients did not evoke a normal TSH response. Prolonged use of AD hampers the interpretation of thyroid test results. This finding has substantial implications for the follow-up of patients in hormonally treated prostate cancer.

Aged↗
PubMed1985

Performance of five thyroid-function tests by radioimmunoassays with antibodies attached to paramagnetic micro-particles.

We have assessed the analytical and clinical performance of five thyroid-function tests by commercially available radioimmunoassays in which antibodies attached to paramagnetic micro-particles are used (Corning MAGIC assays). We evaluated the methods for measuring thyroxin, triiodothyronine, triiodothyronine uptake, thyrotropin (thyroid-stimulating hormone), and free thyroxin. Precision, patients' results, and clinical correlation of the MAGIC assays were similar to those of the well-established RIAs used as the comparative methods in this study; the MAGIC assays, however, are much faster and easier to perform.

Evaluation Studies as Topic↗
PubMed1975

The one-step approach to thyroid function tests. The diagnostic thyroxine ratio (DTR)/serum thyroxine (T4) level combination.

A one-step approach to thyroid function tests is reported, using Tetralute kits (Ames). Two parameters are obtained simultaneously--namely, the serum thyroxine (T4) level and the diagnostic thyroxine ratio (DTR), which correlates well with the free thyroxine index (FTI) as determined by two separate tests-the T4 level and the triiodothyronine resin uptake ((T3U)) estimations. Data presented from patients with a variety of thyroid states prove that the DTR, particularly in combination with the T4 level, is adequate for the assessment of thyroid dysfunction in almost all circumstances.

Adolescent↗
PubMed1995

Hashimoto thyroiditis: correlation of MR imaging signal intensity with histopathologic findings and thyroid function test results.

PURPOSE: To assess the clinical usefulness of magnetic resonance (MR) imaging of the thyroid gland in Hashimoto thyroiditis. MATERIALS AND METHODS: Signal intensity ratios on spin-echo T1-, proton-density-, and T2-weighted images were measured prospectively in 37 patients with Hashimoto thyroiditis (33 women, four men; mean age, 51 years) and in 10 patients with thyroid lymphoma (six women, four men; mean age, 68 years). Signal intensity ratios were correlated with histopathologic findings and thyroid function test results with stepwise regression analysis. Diagnosis of lymphoma with signal intensity ratios was compared with morphologic diagnosis by using receiver operating characteristic curves. RESULTS: A proton-density-weighted signal intensity ratio of 1.54 or higher indicated hypothyroidism (R = .445, P = .008; 29% sensitivity [two of seven patients]). A T2-weighted signal intensity ratio of 5.08 or higher suggested advanced glandular destruction (R = .677, P < .001). Diagnosis by each observer was better than diagnosis with signal intensity ratios. CONCLUSION: MR imaging results can reflect thyroid function and histopathologic findings in the thyroid gland and help discriminate malignant lymphoma from Hashimoto thyroiditis.

Adult↗
PubMed1981

Screening investigations in the elderly.

The study evaluates the usefulness of some commonly used screening investigations in the management of elderly acutely ill medical patients. It was performed on 50 consecutive admissions to one ward and all patients received a full blood count, ESR, urea and electrolyte estimation, liver function tests, thyroid function tests, examination of a mid-stream urine specimen and P-A chest X-ray examination. When performed in the absence of clinical indication these tests were considered to be screening tests. On assessing the tests performed prospectively, it was shown that only a full blood count, urea and electrolyte estimation, ward testing of urine, and, possibly, a P-A chest X-ray examination are worthwhile screening investigations in this patient population. The ESR and liver function tests and mid-stream urine specimens seem to be of little value in the absence of clinical indication.

Aged↗