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At least 181 records · Page 10Linked to original sources
PubMed1994

[Taste changes in patients with AL amyloidosis. Preliminary studies].

Taste acuity in 20 subjects affected by AL amyloidosis without oral complications was investigated by threshold determination. Sixteen cases did not recognize one or more fundamental tastes. Sour was the most frequently lost taste, as it was not recognized by 10 out of 20 cases. So, sensorial neuropathy, altering taste generation and/or transmission, seems frequently associated to AL amyloidosis. Further researches will show if taste losses realize typical symptomatic features in this disease.

Adult↗
PubMed1995

[Decrease and asymmetry in taste perception in patients with nerve trunk damage].

The purpose of this article was the gustatory perception state study (NaCl solution perception) in patients with one-sided damages of branchial plexus as well as of radial, facial and ulnar nervous trunks. The decrease of gustatory perception was observed in 78 (70.3%) cases, while the lack of such alterations in 33 (29.7%) patients. The gustatory perception disturbances (increase of the absolute threshold on the ipsilateral tongue's half) took place in 82.2% and 69.6% at right and left limbs damages respectively. The results presented testified the strengthening of normally existing asymmetry in gustatory perception especially in patients with left-sided denervation. The degree of gustatory perception restoration may serve as a prognostic test at surgery of such patients.

Chronic Disease↗
PubMed1996

[Side effects of drugs on the respiratory tract: experiences of the Swiss Drug Monitoring Center from 1991 to 1995].

Between 1991 and 1995 about 3% of the unwanted drug-induced side effects reported to the Swiss Drug Monitoring Center (SANZ) concerned pulmonary disturbances (144 out of a total of 4824 reports). The most frequent reports were those about cough and taste disorders caused by ACE-inhibitors, smell disorders caused by antimicotics, and asthma attacks caused by nonsteroidal antirheumatics or betablocking eye drops. 33% of these unwanted side effects have been classified as severe. By spontaneous reporting a correct calculation of incidence is not possible. The reports, however, have signal function. Precise case analysis, temporary correlations (reaction and exposure time and onset of reaction), exclusion of other causes for the disease, comparisons between similar cases and critical study of literature concerning drug-related side effects are still the most important foundations for diagnosis.

Drug Monitoring↗
PubMed1977

Distribution of taste thresholds for phenylthiocarbamide among different age groups in Turkey.

The relation between age and taste threshold in populations living both in Istanbul and Resadiye, a town located in eastern part of Turkey, was investigated. In Turkey the nontaster/taster ratio has been found lower than in the other countries of Europe and Asia (3 ,4 ,8 ,9). With aging the taste sensitivity of tasters does diminish. However, the differences in the taste threshold levels of nontasters, in different age groups, have been found as being statistically not significant.

Adolescent↗
PubMed1989

Medical management of taste and smell disorders.

Chemosensory dysfunction is most often secondary to one of only a few causes: nasal/sinus disease, viral infection, toxic chemical exposure, head trauma, as well as medication-related and idiopathic conditions. Medication-related disorders are corrected by discontinuance of the causative medicine. Our experiences have also shown that only dysfunctions of smell caused by disorders of the nose and/or sinuses are amendable to therapy.

Adrenal Cortex Hormones↗
PubMed1994

Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.

Drugs in every major pharmacological category can impair both taste and smell function and do so more commonly than presently appreciated. Impairment usually affects sensory function at a molecular level, causing 2 major behavioural changes--loss of acuity (i.e. hypogeusia and hyposmia) and/or distortion of function (i.e. dysgeusia and dysosmia). These changes can impair appetite, food intake, cause significant lifestyle changes and may require discontinuation of drug administration. Loss of acuity occurs primarily by drug inactivation of receptor function through inhibition of tastant/odorant receptor: (i) binding; (ii) Gs protein function; (iii) inositol trisphosphate function; (iv) channel (Ca++,Na++) activity; (v) other receptor inhibiting effects; or (vi) some combination of these effects. Distortions occur primarily by a drug inducing abnormal persistence of receptor activity (i.e. normal receptor inactivation does not occur) or through failure to activate: (i) various receptor kinases; (ii) Gi protein function; (iii) cytochrome P450 enzymes; or other effects which usually (iv) turn off receptor function; (v) inactivate tastant/odorant receptor binding; or (vi) some combination of these effects. Termination of drug therapy is commonly associated with termination of taste/smell dysfunction, but occasionally effects persist and require specific therapy to alleviate symptoms. Treatment primarily requires restoration of normal sensory receptor growth, development and/or function. Treatment which restores sensory acuity requires correction of steps initiating receptor and other pathology and includes zinc, theophylline, magnesium and fluoride. Treatment which inhibits sensory distortions requires reactivation of biochemical inhibition at the receptor or inactivation of inappropriate stimulus receptor binding and/or correction of other steps initiating pathology including dopaminergic antagonists, gamma-aminobutyric acid (GABA)-ergic agonists, calcium channel blockers and some orally active local anaesthetic, antiarrhythmic drugs.

Anti-Infective Agents↗
PubMed1989

Neurologic evaluation of taste and smell disorders.

Specific neurologic causes of chemosensory deficits are uncommon. A careful history and neurologic examination and the use of appropriate neurodiagnostic studies will identify the underlying cause in many cases and allow for appropriate management. The neurologic evaluation of the patient with abnormalities of smell, taste, or both is reviewed with specific reference to the disorders of the central and peripheral nervous system that may be causative.

Humans↗
PubMed1992

Office management of taste and smell disorders.

Chemosensory disorders have been receiving increasing clinical attention but remain a difficult diagnostic problem. With the development of several well-standardized testing methods, taste or smell loss can now be verified, and this has added to knowledge concerning the common causes of dysfunction. Diagnosis typically rests upon the history and physical examination, but, except in the case of obstructive nasal and sinus pathologic conditions, therapy usually remains elusive.

Ambulatory Care↗
PubMed1987

Disorders of smell and taste.

This article describes the anatomy and physiology of the gustatory and olfactory organs in man. Dysfunction of these senses is closely examined with respect to etiology, diagnosis, and treatment. Taste and smell are closely interrelated. An influence on the function of one sense often affects the function of the other sense.

Humans↗
PubMed1996

Disorders of smell, taste, and food intake in a patient with a dorsomedial thalamic infarct.

BACKGROUND: We report that a lasting deficit in the hedonic character of olfactory and gustatory perception can be observed in bilateral dorsomedial and intralaminar thalamic lesions. CASE DESCRIPTION: A 68-year-old patient abruptly presented with vigilance disorders associated with a reduction of olfactory and gustatory perceptions. A severe drop in appetite for foods and a weight loss of 10 kg were observed, which were partially reversed with time. Two years later, the main persisting disorder was a change in the quality of perceptions: odors and taste were perceived either in a neutral way, their pleasant character having disappeared, or as unpleasant. However, identification was preserved. MRI showed that lesions principally involved the dorsomedial thalamic nuclei and the adjacent part of the intralaminar nuclei. CONCLUSIONS: This case suggests that the dorsomedial thalamus may play a role in the hedonic perception of food, thus affecting short-term regulation of food intake, and may possibly have a role in the long-term control of body weight.

Aged↗