Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Rotator Cuff”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources
PubMed2005

Tendon-bone interface motion in transosseous suture and suture anchor rotator cuff repair techniques.

BACKGROUND: Although many studies involving rotator cuff repair fixation have focused on ultimate fixation strength and ability to restore the tendon's native footprint, no studies have characterized the stability of the repair with regard to motion between the tendon and repair site footprint. HYPOTHESIS: Suture anchor fixation for rotator cuff repair has greater interface motion between tendon and bone than does transosseous suture fixation. STUDY DESIGN: Controlled laboratory study. METHODS: Twelve fresh-frozen human cadaveric shoulders were tested in a custom device to position the shoulder in internal and external rotations with simulated supraspinatus muscle loading. Tendon motion relative to the insertional footprint on the greater tuberosity was determined optically using a digital camera rigidly connected to the humerus, with the humerus positioned at 60 degrees of internal rotation and 60 degrees of external rotation. Testing was performed for the intact tendon, a complete supraspinatus tear, a suture anchor repair, and a transosseous tunnel repair. RESULTS: Difference in tendon-bone interface motion when compared with the intact tendon was 7.14 +/- 3.72 mm for the torn rotator cuff condition, 2.35 +/- 1.26 mm for the suture anchor repair, and 0.02 +/- 1.18 mm for the transosseous suture repair. The transosseous suture repair demonstrated significantly less motion when compared with the torn rotator cuff and suture anchor repair conditions (P < .05). CONCLUSION: Transosseous suture repair compared with suture anchor repair demonstrated superior tendon fixation with reduced motion at the tendon-to-tuberosity interface. CLINICAL RELEVANCE: Development of new fixation techniques for arthroscopic and open rotator cuff repairs should attempt to minimize interface motion of the tendon relative to the tuberosity.

Arthroscopy↗
PubMed2005

Functional outcome and health-related quality of life after surgical repair of full-thickness rotator cuff tear using a mini-open technique.

BACKGROUND: Rotator cuff tear, a common shoulder injury, can lead to shoulder pain and functional loss. HYPOTHESIS: Surgical repair of full-thickness rotator cuff tears using the mini-open surgical technique will improve shoulder function and health-related quality of life. STUDY DESIGN: Cohort study. Level of evidence, 2. METHODS: Patients with a full-thickness rotator cuff tear who underwent a mini-open repair were evaluated for (1) active shoulder range of motion preoperatively, and 6 months and 12 months postoperatively and (2) health-related quality of life preoperatively, 6 months postoperatively, and annually up to 5 years postoperatively. Satisfaction with the repair and return to work status were ascertained 1 year postoperatively. A subgroup analysis of tear size and patient age was also undertaken. RESULTS: Of the subjects, 61 (73%) were men, and the average age was 53.2 ( +/- 9.9) years. According to repeated-measures analysis of variance, shoulder range of motion (flexion and external rotation) improved significantly from before surgery to 1 year after surgery (P <.001). The mean American Shoulder and Elbow Surgeons scores improved from 53.3 ( +/- 20.6) preoperatively to 90.6 ( +/- 11.7) 1 year postoperatively (P <.001). The mean Western Ontario Rotator Cuff scores also improved from 43.2 ( +/- 20.2) preoperatively to 87.2 ( +/- 14.3) 1 year postoperatively (P <.001). No differences were seen in either the American Shoulder and Elbow Surgeons scores or Western Ontario Rotator Cuff scores between the 1-year examination and the last follow-up assessment undertaken at a median of 5 years postoperatively (P >.05). Ninety-six percent of patients were satisfied or very satisfied with the results of their repair; 78% of patients who were working before surgery returned to work without modification by 1 year postoperatively. For the most part, patient age and size of tear did not influence postoperative range of motion or health-related quality of life. CONCLUSION: Mini-open rotator cuff repair led to improved shoulder function and health-related quality of life up to 5 years postoperatively.

Adult↗
PubMed1990

Roentgenographic assessment of the rotator cuff.

In assessment of the rotator cuff, roentgenograms are mandatory. They permit judgment of the degree and site of bony involvement, assessment of the relationship between humeral head and glenoid, and differential diagnosis. Single-contrast arthrography is used to confirm the presence or the absence of a tear in the rotator cuff, particularly when a small tear is suspected. If the tear is large or if active lateral rotation is absent, tomoarthrography using air should be performed in the frontal and sagittal planes. If an anteromedial dislocation of the long head of the biceps or a tear of the subcapularis is suspected, computed tomoarthrography (CTA) is indicated. CTA shows the major part of the anterior cuff tendons. Computed tomography (CT) densitometry of the rotator cuff muscles, performed routinely before and after surgery, permits an objective evaluation of their functional status.

Humans↗
PubMed2002

Trabecular microstructure and surface changes in the greater tuberosity in rotator cuff tears.

OBJECTIVE: When planning surgery in patients with rotator cuff tear, strength of bone at the tendon insertion and trabecular bone structure in the greater tuberosity are usually taken into consideration. We investigated radiographic changes in bone structure of the greater tuberosity in rotator cuff tears. DESIGN: Twenty-two human cadaveric shoulders from subjects ranging from 55 to 75 years of age were obtained. The integrity of the rotator cuff was examined by sonography to determine if it is intact without any tear, or torn partially or completely. The humeral head was sectioned in 3 mm thick coronal slab sections and microradiographed. After digitization of the microradiographs and imaging processing with in-house semi-automated image processing software tools developed using software interfaces on a Sun workstation, the trabecular histomorphometrical structural parameters and connectivity in the greater tuberosity were quantified. The degenerative changes on the surface of the greater tuberosity were interpreted blindly by 2 independent readers. RESULTS: Among the 22 shoulder specimens, the rotator cuff was found intact in 10 shoulders, partially in 7 and fully torn in 5. Statistically significant loss in apparent trabecular bone volume fraction, number of trabecular nodes, and number of trabecular branches, and a statistically significant increase in apparent trabecular separation and number of trabecular free ends were found in the greater tuberosity of the shoulders with tears. The loss was greater in association with full tear than in partial tear. Thickening of the cortical margin of the enthesis, irregularity of its surface, and calcification beyond the tidemark were observed in 2 (20%) shoulders with intact rotator cuff, in 6 (86%) shoulders with partial tear, and in 5 (100%) shoulders with full tear. CONCLUSIONS: Rotator cuff tears are associated with degenerative changes on the bone surface and with disuse osteopenia of the greater tuberosity. Aging, degenerative enthesopathy of the supraspinatus tendon, and rotator cuff tears appear closely related.

Aged↗
PubMed2002

Mechanical strength of arthroscopic rotator cuff repair techniques: an in vitro study.

BACKGROUND: Retears after rotator cuff repairs occur relatively frequently and may compromise the functional result. The goal of this study was to analyze the mechanical properties following arthroscopic techniques for rotator cuff repair and to evaluate possible alternative techniques. METHODS: In the first part, five different bone anchors (the Revo screw; Mitek Rotator Cuff anchor, 5.0-mm Statak, PANALOK RC absorbable anchor, and 5.0-mm Bio-Statak) were tested in vitro under cyclic loading on five pairs of cadaveric shoulders. Then five types of arthroscopic tendon suturing instruments were tested on rotator cuff tendons. Finally, the arthroscopically performed mattress and modified Mason-Allen stitches, fixed with either the Revo screw or the Bio-Statak, were evaluated on ten pairs of human cadaveric shoulders. RESULTS: The holding strengths of the various anchors were similar, ranging from 130 to 180 N, and approximated the holding strength of knotted number-2 suture materials. The fixation of the tested anchors yielded comparable values of stiffness except for one anchor, which showed significantly greater subsidence under cyclic load (p = 0.003). All tested, commercially available arthroscopic suturing devices were unsuitable for performing a modified Mason-Allen stitch on normal supraspinatus tendons. Modification of a commercially available suture punch with a longer needle allowed us to consistently perform a modified Mason-Allen stitch. The modified Mason-Allen stitch, which has shown favorable mechanical properties in open repairs of the rotator cuff, was not found to be stronger than the mattress stitch when performed arthroscopically and used with bone anchors. When the modified Mason-Allen stitch was fixed to one anchor, it was even weaker than a mattress stitch repaired with another anchor (168 versus 228 N). Unequal loading of the two suture branches due to the more rigid modified Mason-Allen stitch may be the reason for this difference. CONCLUSIONS: Arthroscopic techniques for rotator cuff repair with use of the mattress stitch and bone anchors allow for a relatively solid fixation. The holding strength is not improved with use of the modified Mason-Allen stitch. Although a direct comparison with previous in vitro studies is not possible, the holding strength of open fixation techniques seems to be stronger. If rotator cuffs are subjected to high postoperative loading, open repair might be preferred to reduce the risk of a retear, until stronger arthroscopic fixation techniques are developed.

Arthroscopy↗
PubMed1992

Ultrasonography of rotator cuff tears.

This is a prospective study of ultrasonography of the rotator cuff mechanism as an alternative to arthrography for screening rotator cuff tears. Seventy-two patients (40 men and 32 women) with possible rotator cuff tears were referred for shoulder arthrography. Before arthrography, bilateral shoulder sonography was performed by a technician under the direction of a radiologist. Arthrograms and sonograms were read separately, and a decision as to the absence or presence of a rotator cuff tear was made without knowledge of the results of the other examination. The results showed 90% sensitivity and 91% specificity, with a positive accuracy of 87%, and a negative accuracy of 93%. Ultrasonography of the rotator cuff is a noninvasive, painless, and cost-effective screening method for patients with a suspected rotator cuff tear.

Adolescent↗
PubMed2004

Arthroscopic revision of failed rotator cuff repairs: technique and results.

PURPOSE: The purpose of this study was to review the results of arthroscopic revision rotator cuff repair in patients for whom a previous rotator cuff repair had failed. TYPE OF STUDY: Case series. METHODS: From October 1998 to October 2000, 14 patients with a mean age of 57.9 +/- 9.2 years underwent arthroscopic revision rotator cuff repair and were available for follow-up evaluation. The mean time from primary to revision procedure was 41.4 months (range, 8 to 240 months). Eleven patients had undergone a previous rotator cuff repair, 2 patients had undergone 2 rotator cuff repairs, and 1 patient had undergone 3 rotator cuff repairs. We found 2 medium, 1 large, and 11 massive recurrent rotator cuff tears, with a mean tear size of 4.4 x 5.5 cm. All large and massive tears required extensive arthroscopic dissection and mobilization of the rotator cuff to delineate the tear margins and repair the rotator cuff. All patients were evaluated preoperatively and postoperatively using a modified University of California Los Angeles (UCLA) scoring system. RESULTS: At a mean of 23.4 +/- 9.8 months after arthroscopic revision rotator cuff repair, 13 of 14 patients were satisfied with the procedure. The mean UCLA score increased from 13.1 +/- 2.3 preoperatively to 28.6 +/- 7.1 postoperatively (P <.00001). We noted 4 excellent, 5 good, 4 fair, and 1 poor result. The mean active forward elevation increased from 120.7 degrees +/- 48.9 degrees preoperatively to 153.6 degrees +/- 33.1 degrees postoperatively (P =.006). The mean active external rotation increased from 26.1 degrees +/- 19.3 degrees preoperatively to 44.3 degrees +/- 15.9 degrees postoperatively (P =.006). Of the 4 patients without active overhead function preoperatively, 3 gained overhead function postoperatively. One patient who did not regain overhead function had a poor result secondary to anterior deltoid detachment after the primary procedure. CONCLUSIONS: Revision arthroscopic rotator cuff repair is a technically demanding procedure. However, appropriate patient selection and careful attention to rotator cuff dissection, mobilization, and repair by arthroscopic means can lead to significant improvements in overall shoulder pain and function. LEVEL OF EVIDENCE: Level 4, case series (no or historical control group).

Aged↗
PubMed1998

The association between irregular greater tuberosities and rotator cuff tears: a sonographic study.

OBJECTIVE: Although an association between irregular greater tuberosities and rotator cuff tears has been suggested, no formal studies have been done. This study was designed to investigate the relationship between greater tuberosity irregularities, rotator cuff tears, and age. SUBJECTS AND METHODS: Sonographic examinations of both shoulders of 77 asymptomatic individuals (154 shoulders) between 30 and 80 years old were performed. The rotator cuffs and greater tuberosities were evaluated. Full- and partial-thickness rotator cuff tears were given equal significance. A two-tailed Fisher's exact test, a Student's t test, and logistic regression analysis were used to analyze the data. RESULTS: Sonography showed the greater tuberosity to be irregular in 36 (90%) of 40 shoulders with a rotator cuff tear. The greater tuberosity was irregular in only 12 (11%) of 114 shoulders without a rotator cuff tear. When the greater tuberosity was irregular, sonography showed 36 (75%) of 48 shoulders to have rotator cuff tears. When the greater tuberosity was normal, 102 (96%) of 106 of the rotator cuffs were normal on sonography. Statistical significance was detected (p < .001) for the association of greater tuberosity irregularity and rotator cuff tear. After accounting for age, a statistically significant association was found (p < .001) between rotator cuff status and greater tuberosity status. CONCLUSION: On sonography, greater tuberosity irregularities are reliable indicators in the assessment of shoulders for rotator cuff tears. In addition, we have shown that greater tuberosity irregularities are not simply related to aging.

Adult↗
PubMed2005

Biomechanical comparison of bioabsorbable sutureless screw anchor versus suture anchor fixation for rotator cuff repair.

PURPOSE: Anchors that directly fix the rotator cuff to bone without using sutures may simplify the challenges associated with arthroscopic rotator cuff repair. This study compared a bioabsorbable screw fixation device to a standard suture anchor fixation method. TYPE OF STUDY: Randomized trial. METHODS: A poly-L-lactide acid (PLLA), bioabsorbable screw anchor was compared with a metallic suture anchor loaded with No. 2 braided polyester suture in 12-week-old fresh-frozen bovine shoulders. Twelve specimens were randomly assigned to the 2 repair groups (6 per group). A 1 x 2-cm defect was created at the insertion site of the infraspinatus tendon. Two anchors were implanted 1 cm apart in the anatomic insertional area of the infraspinatus tendon. After preconditioning to 10 N, each construct was cycled between 10 and 180 N for up to a maximum of 2,500 cycles at a rate of 33 mm/second using a materials testing machine. The number of cycles to 5- and 10-mm gap formation at the repair site and mode of failure were recorded. Clinically, 10-mm gap formation defines complete fixation failure. Data were evaluated using an analysis of variance with significance set at P < .05. RESULTS: Mattress suture fixation had significantly higher number of cycles to 10-mm failure compared with the PLLA device (P = .015). Failure occurred by tissue pullout in half the specimens and by device failure in the other half, without differences in failure modalities between groups. CONCLUSIONS: This anchor provides low-profile fixation of the rotator cuff and eliminates suture placement and knot tying during arthroscopic and mini-open cuff repair. However, these data suggest that this anchor may not perform adequately under cyclic loading conditions in patients during postoperative rehabilitation. CLINICAL RELEVANCE: This bioabsorbable anchor may not provide sufficient fixation for rotator cuff repair in humans.

Absorbable Implants↗
PubMed2001

Surgical repair of chronic rotator cuff tears. A prospective long-term study.

BACKGROUND: Rotator cuff disease or injury is one of the most frequently seen orthopaedic conditions, and surgical repair of rotator cuff tears is a common procedure. A prospective analysis of the operation, with consistent assessment of patient characteristics, variables associated with the rotator cuff tear and repair techniques, and outcome factors, was performed. METHODS: One hundred and five shoulders with a chronic rotator cuff tear underwent open surgical repair and acromioplasty between 1975 and 1983. The patients were followed for an average of 13.4 years (range, two to twenty-two years). There were sixteen small tears, forty medium tears, thirty-eight large tears, and eleven massive tears. The tears were repaired directly (seventy-two tears), by V-Y plasty (twelve), by tendon transposition (twenty), or by reinforcement with a fascia lata graft (one). The long head of the biceps had been previously torn in eleven shoulders and was tenodesed in three other shoulders. In fifty-six shoulders, the distal part of the clavicle was excised for treatment of degenerative arthritic changes, often associated with osteophyte formation. RESULTS: Satisfactory pain relief was obtained in ninety-six shoulders (p < 0.0001). There was significant improvement in active abduction (p < 0.001) and external rotation (p < 0.007) as well as in strength in these directions of movement (p < 0.03 and p < 0.002, respectively). At the latest follow-up evaluation, the result was rated as excellent for sixty-eight shoulders, satisfactory for sixteen, and unsatisfactory for twenty-one. Tear size was the most important determinant of outcome with regard to active motion, strength, rating of the result, patient satisfaction, and need for a reoperation. Older age, less preoperative active motion, preoperative weakness, distal clavicular excision, and a transposition repair technique were all associated with larger tear size. There were eight reoperations; five were for rerepair of a persistent or recurrent rotator cuff tear. CONCLUSIONS: Standard tendon repair techniques combined with anterior acromioplasty, postoperative limb protection, and monitored physiotherapy can produce consistent and lasting pain relief and improvement in range of motion. Improving the results of this procedure will depend upon the development of new techniques to address the active motion and strength deficiencies following repair of massive rotator cuff tears.

Acromion↗
PubMedDate not supplied

[Subacromial impingement syndrome and rotator cuff tear. Ultrasonography of 140 cases].

We investigated the role of rotator cuff impingement in causing tears of supraspinatus and biceps tendons and the comparative reliability of plain radiography and sonography (US). One hundred forty patients with symptoms referrable to the rotator cuff were examined with plain radiography and US of the shoulder. US findings were correlated with MR or double contrast arthrography results in 10 patients and 39 patients were submitted to surgery (acromionplasty). Radiographic studies were performed first and diagnosed rotator cuff impingement (63 patients) caused by abnormal acromial margins or size (23 patients), by acromioclavicular joint protrusion (17 patients), by anterior acromial osteophytosis (10 patients), or by massive periarthritic calcifications (13 patients). In the same 140 patients. US showed normal cuffs in 46 cases, tendonitis in 34, calcific tendonitis in 13, partial-thickness cuff tears in 13, full-thickness cuff tears in 20 and biceps tendon tears in 14 cases. Six of 13 partial tears were studied with MRI, with 4 true positives and 2 false positives. US diagnosis was confirmed by arthrography in 4 complete tears. Twenty-nine of 39 patients undergoing acromionplasty were examined only with plain radiography and US. US accurately diagnosed all 20 massive full-thickness tears, with no false positives nor false negatives (US versus surgery and arthrography). Eleven true positives, 2 false positives and no false negative were observed in 13 partial-thickness cuff tears (US versus surgery and MRI). These findings suggest that rotator cuff US and plain radiography are easily performed, reproducible routine examinations to study the whole rotator cuff and the acromioclavicular joint in the many patients who need an accurate, safe, painless, rapid and cost-effective differential diagnosis, leaving it up to the surgeon to consider MRI or arthrography. Rotator cuff impingement tendonitis, overuse or calcific tendonitis, partial-thickness cuff tears and full-thickness tears ranging from light to severe cause similar shoulder pain and weakness on arm raising. The differential diagnosis must distinguish all these common causes of shoulder dysfunction and cuff problems from other conditions. We conclude that US and plain radiography are accurate routine tests of rotator cuff integrity and rotator cuff impingement.

Adult↗
PubMed2004

An arthroscopic stitch for massive rotator cuff tears: the Mac stitch.

Arthroscopic repair of rotator cuff tears has become popular with the advancement in technology and arthroscopic technique. As we attempt to arthroscopically repair larger rotator cuff tears, we are relying more on tissue fixation. The tendon-suture interface has been recognized as the weak link in rotator cuff repair. In this article, we propose the use of the Mac stitch--a simple modification of suture placement, a combination of a horizontal and vertical loop at the site of repair--to increase the strength of tissue fixation. The Mac stitch is a simple arthroscopic stitch that can be used for small and massive rotator cuff repairs.

Arthroscopy↗
PubMed2002

The effect of rotator cuff tears on reaction forces at the glenohumeral joint.

The rotator cuff muscles maintain glenohumeral stability by compressing the humeral head into the glenoid. Disruption of the rotator cuff compromises concavity compression and can directly affect the loads on the glenohumeral joint. The purpose of this study was to quantify the effect of rotator cuff tears on the magnitude and direction of glenohumeral joint reaction forces during active shoulder abduction in the scapular plane using nine cadaveric upper extremities. Motion of the full upper extremity was simulated using a dynamic shoulder testing apparatus. Glenohumeral joint reaction forces were measured by a universal force-moment sensor. Five conditions of rotator cuff tears were tested: Intact, Incomplete Supraspinatus Tear, Complete Supraspinatus Tear, Supraspinatus/Infraspinatus Tear, and Global Tear. Reaction forces at the glenohumeral joint were found to steadily increase throughout abduction and peaked at maximum abduction for all conditions tested. There were no significant differences in reaction force magnitude for the intact condition (337 +/- 88 N) or those involving an isolated incomplete tear (296 +/- 83 N) or complete tear (300 +/- 85 N) of the supraspinatus tendon. Extension of tears beyond the supraspinatus tendon into the anterior and posterior aspect of the rotator cuff led to a significant decrease in the magnitude of joint reaction force (126 +/- 31 N). Similarly, such tears resulted in a significant change in the direction of the reaction force at the glenohumeral joint. These results suggest that joint reaction forces are significantly affected by the integrity of the rotator cuff, specifically, by the transverse force couple formed by the anterior and posterior aspects of the cuff. The quantitative data obtained in this study on the effect of rotator cuff tears on magnitude and direction of the reaction force at the glenohumeral joint helps clarify the relationship between joint motion, joint compression and stability.

Aged↗
PubMed2001

Arthroscopic rotator cuff interval capsular closure.

Closure of the rotator cuff interval is an important component of open stabilization techniques in shoulder surgery. This study describes a technique in which the deep layer of the capsule within the rotator cuff interval is closed arthroscopically. The effect of closure of this capsule within the rotator cuff interval on glenohumeral motion also is quantified. Sutures were placed from the superior glenohumeral ligament to the middle glenohumeral ligament and tied intra-articularly in fresh-frozen cadaveric shoulders. Closure of the interval capsule resulted in statistically significant limitation of humeral elevation, external rotation, and extension. Arthroscopic closure of the deep layer of the rotator cuff interval capsule produced a visible superior shifting of the middle and inferior glenohumeral ligaments and imbricated the anterosuperior capsule of the shoulder. In addition, this procedure can be performed in conjunction with arthroscopic capsulolabral reconstruction.

Aged↗
PubMed1991

The vascularity of the rotator cuff.

The major arterial supply to the rotator cuff is derived from the ascending branch of the anterior humeral circumflex artery, the acromial branch of the thoracoacromial artery, as well as the suprascapular and posterior humeral circumflex arteries. The pathogenesis of rotator cuff tears has been considered to be influenced by the microvascular supply of the rotator cuff tendons. Most cadaver studies have demonstrated a hypovascular area within the critical zone of the supraspinatus tendon. It has been suggested that this area of hypovascularity has a significant role in the attritional degeneration of the aging tendon. More recent studies of the microvascular supply to the supraspinatus tendon in symptomatic patients with impingement syndrome suggest that in the area of greatest impingement, i.e., the critical zone, there is actually hypervascularity. In contrast to the cadaver investigations, these studies seem to imply that hypervascularity or neovascularization is associated with symptomatic rotator cuff disease secondary to mechanical impingement.

Humans↗
PubMed1988

Ultrasonography of rotator cuff tears: a review of 500 diagnostic studies.

Ultrasonography of the rotator cuff has been shown to be of value in diagnosing rotator cuff tears. This report summarizes our experience with our first 500 diagnostic examinations. All patients were examined in the hyperextended internal rotation view with commercially available high-resolution real-time ultrasound equipment. Patients were diagnosed as having a rotator cuff tear if a focal echogenic lesion or a defect within the rotator cuff was identified. This study confirmed the value of ultrasonography for the diagnosis of rotator cuff tears. Accuracy, sensitivity, and specificity all exceeded 90%, and correlated with surgical findings. This was better than arthrography in the same patient population. Ultrasound is an accurate noninvasive method of examining the rotator cuff for the presence of tears. We suggest that rotator cuff ultrasonography is the procedure of choice for the diagnosis of tears if adequate instrumentation is available.

Arthrography↗
PubMed2026

Impact of smoking on structural failure after arthroscopic rotator cuff repair: a systematic review and meta-analysis.

BACKGROUND: Rotator cuff tears cause significant shoulder pain and functional limitation. Arthroscopic rotator cuff repair improves symptoms, yet structural failure rates remain substantial. Smoking may impair tendon-to-bone healing, but clinical studies report mixed findings due to heterogeneous methodology. Therefore, a systematic synthesis of imaging-confirmed outcomes is needed to clarify the association between smoking and structural failure after arthroscopic rotator cuff repair. METHODS: This review followed PRISMA 2020 and was registered in PROSPERO (CRD420251246197). PubMed, Embase, Scopus, Web of Science, and the Cochrane Library were searched from inception to 12 December 2025. Comparative clinical studies of adults undergoing arthroscopic rotator cuff repair that reported imaging-confirmed structural integrity (magnetic resonance imaging or ultrasonography) at &#x2265;6 months were included. Two reviewers independently screened studies, extracted data, and assessed quality using the Newcastle-Ottawa Scale. The primary outcome (structural failure) was pooled as risk ratios using a random-effects model with the restricted maximum likelihood estimator and Hartung-Knapp adjustment. Secondary continuous outcomes were synthesized using Bayesian random-effects models; subgroup, sensitivity, and meta-regression analyses explored heterogeneity. RESULTS: Ten cohort studies (1,683 shoulders) were included. Smoking was associated with a higher risk of imaging-confirmed structural failure (risk ratio 1.53; 95% confidence interval 1.13-2.08; P = .011) with low heterogeneity (I2 = 24.7%). Subgroup and sensitivity analyses supported robustness, with no evidence of effect modification by region, follow-up duration, tear size, or smoking definition. Meta-regression showed no significant influence of age, smoking prevalence, or diabetes prevalence on the pooled effect. Secondary outcomes (3 studies) suggested slightly lower postoperative American Shoulder and Elbow Surgeons scores among smokers, while visual analog scale pain scores and forward flexion showed no clear between-group differences. No publication-bias signals were detected for the primary outcome. CONCLUSION: Smoking is associated with a higher risk of imaging-confirmed structural failure after arthroscopic rotator cuff repair. Functional outcomes were broadly similar between groups, with only a small, likely clinically negligible reduction in American Shoulder and Elbow Surgeons scores among smokers. These findings support careful smoking history assessment and perioperative risk modification, including smoking cessation strategies.

Humans↗
PubMed2002

Apoptosis in rotator cuff tendonopathy.

The aim of this study was to investigate the involvement of apoptosis (programmed cell death) in the pathogenesis of rotator cuff disorders. The edges of torn supraspinatus rotator cuff tendons were collected from patients with rotator cuff tear (n = 25). Samples of the intra-articular portion of subscapularis tendons were collected from patients without rotator cuff tear as control (n = 6). To minimize individual variance, we also collected six pairs of supraspinatus tendon and subscapularis tendon from six patients with rotator cuff tears. Apoptosis was detected by in situ DNA end labelling assay and DNA laddering assay. Immunohistochemical staining was performed to identify cells undergoing apoptosis. Control subscapularis tendon had normal morphology. Tendon from torn supraspinatus rotator cuff showed significant mucoid degeneration. Within the areas of degeneration, there were large numbers of apoptotic cells. The percentage of apoptotic cells in the degenerative rotator cuff (34%) was significantly higher than that in controls (13%) (p < 0.001). The excessive apoptosis detected in degenerative rotator cuff tissue was confirmed by DNA laddering assays. This is the first report of excessive apoptosis in degenerating rotator cuff tendon. Cells undergoing apoptosis in rotator cuff were mainly fibroblast-like cells. These finding indicate that apoptosis may play an important role in the pathogenesis of rotator cuff degeneration.

Adult↗