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The effect of context on discrimination and bias in recognition memory for pictures and words.

When the context accompanying a to-be-remembered word is changed between study and test, recognition memory is impaired. The deleterious effect of context change on recognition memory can be viewed as support for encoding specificity theory, semantic theory, or the existence of two bases for recognition. A fourth possible interpretation, examined here, is that the effect of context change on recognition memory is due to an accompanying change in response bias, rather than a "true" decrease in sensitivity to old and new items. In two experiments, the effect of context change on discrimination and bias in recognition of simple line drawings and their names was examined. Bias was measured using two measures shown by Snodgrass and Corwin (1988) to be theoretically independent of their associated discrimination measures. Context change produced marked conservatism in response bias in both experiments but demonstrated an effect on discrimination in the second experiment only. The shift from a neutral to a conservative response strategy as a result of context change may also be seen in other experiments, in which the same experimental paradigm was used with a variety of stimulus materials. We suggest that the major effect of context manipulation is to produce a change in bias. A stimulus in a familiar environment appears to be more familiar than a stimulus in a strange environment, regardless of its old/new status. In addition, there appears to be a true decrease in discrimination with context change, but this is more difficult to detect. The finding that pictures, which are less polysemous than words, are as affected by context change as words are supports encoding specificity theory over semantic theory.

Adult↗

Neural correlates of recognition memory with and without recollection in patients with Alzheimer's disease and healthy controls.

To dissociate recognition memory with and without recollection, event-related potentials (ERPs) of patients with Alzheimer's disease (AD) and matched controls were recorded in a test of verbal recognition memory accompanied by a source judgement. AD patients who had smaller hippocampi showed a disability to recollect the study context (source). Their ERPs elicited by correctly recognized old words compared to new items were more positive only between 300 and 500 ms with a maximum over the frontal scalp. Controls exhibited a sustained old/new effect over left temporoparietal and frontal sites. The present findings suggest that preserved recognition memory in patients with mild AD is independent of hippocampally mediated processes recollecting episodic memories.

Aged↗

D-cycloserine, a partial agonist at the glycine site coupled to N-methyl-D-aspartate receptors, improves visual recognition memory in rhesus monkeys.

Strychnine-insensitive glycine binding sites have recently been shown to positively modulate N-methyl-D-aspartate (NMDA) receptors. In the present study, the effects on recognition memory of D-cycloserine, a partial agonist at the glycine modulatory site on the NMDA receptor, were evaluated in rhesus monkeys performing a computer-automated version of delayed nonmatching-to-sample (DNMS) with a list length of 20 trail-unique graphic symbols. Single administration of D-cycloserine (100-1000 micrograms/kg i.m.) facilitated DNMS performance significantly with an inverted U-shaped dose-response curve when given 30 min before testing. To assess further the possible neural mechanisms, D-cycloserine was evaluated for its effects on the memory impairments after blockade of the glycine sites by HA-966, N-methyl-D-aspartate receptors by MK-801, or cholinergic receptors by scopolamine. D-Cycloserine completely reversed the visual recognition memory deficits produced by HA-966 (3.2 mg/kg i.m.). D-Cycloserine also dose-dependently and significantly restored the memory deficits produced by MK-801 (32 micrograms/kg i.m.). In addition, D-cycloserine produced a partial, though significant, improvement on the recognition memory deficits after cholinergic blockade with scopolamine (10 micrograms/kg i.m.). From these results, we propose that D-cycloserine has a cognition-enhancing property in non-human primates and that it may have a potential value in treating dementias. Furthermore, the present results provide new evidence for the important role for the glycine sites in the regulation of recognition memory.

Animals↗

The effects of stimulus novelty and familiarity on neuronal activity in the amygdala of monkeys performing recognition memory tasks.

The function of the amygdala in behavioural responses to novel stimuli and its possible function in recognition memory were investigated by recording the responses of 659 amygdaloid neurons in monkeys performing recognition memory and visual discrimination tasks. The aim was to determine the contribution of the amygdala in the encoding of familiarity and therefore its role in supporting memory-related neuronal mechanisms in the basal forebrain. The responses of three groups of neurons reflected different forms of memory. One group (n = 10) responded maximally to novel stimuli and significantly less so to the same stimuli when they were familiar. The calculated memory spans of these neurons were in the range of 2-10 intervening trials, and this short-term retention of information may reflect the operation of a neural mechanism encoding memory for the recency of stimulus presentation. Two other groups responded to the sight of particular categories of familiar stimuli: to foods (n = 6) or to faces (n = 10). The responses of some of these stimulus-selective neurons declined with repeated presentations of foods (3/4 tests) and faces (2/6 tests). The activity of these latter two groups of neurons may be involved in behavioural responses to familiar visual stimuli, particularly when such stimuli have affective or motivational significance. We conclude that the neurophysiological data provide evidence of amygdaloid mechanisms for the recognition of recently seen visual stimuli. However, these amygdaloid mechanisms do not appear to be sufficient to support the performance of long-term recognition memory tasks without additional and complementary functions carried out by other ventromedial temporal, prefrontal and diencephalic structures which also project to the basal forebrain.

Amygdala↗

A meta-analysis of infant habituation and recognition memory performance as predictors of later IQ.

A meta-analytic review of the literature on infant habituation and recognition memory performance as predictors of later IQ suggests several conclusions: (1) Habituation and recognition memory assessments made on a variety of risk and nonrisk samples in the first year of life predict later IQ assessed between 1 and 8 years of age with a weighted (for N) average of normalized correlations of .36 or a raw median correlation of .45. (2) The size of the predictive correlation is essentially the same for habituation and for recognition memory paradigms. (3) This prediction phenomenon is not obviously associated solely with one laboratory, one particular infant response measure, or a few extremely disordered infants. (4) The level of prediction to childhood IQ is substantial given the reliability of the infant measures. (5) Predictions are somewhat higher for risk than for nonrisk samples. (6) Predictions are consistently higher than for standardized infant tests of general development for nonrisk but not for risk samples, and they are not consistently higher than predicting from parental education and socioeconomic status or a few other infant behaviours for nonrisk samples. (8) Coefficients may be higher when the predicting assessments are made between 2 and 8 months of age than earlier or later, but prediction coefficients are remarkably consistent across the observed outcome age period of 2-8 years.

Child↗

Development of flexible visual recognition memory in human infants.

Research using the visual paired comparison task has shown that visual recognition memory across changing contexts is dependent on the integrity of the hippocampal formation in human adults and in monkeys. The acquisition of contextual flexibility may contribute to the change in memory performance that occurs late in the first year of life. To assess this skill, the images are presented on a background of one colour during familiarization and on a different coloured background during the recognition test. Our research showed that recognition memory is impaired by a change in context at 6 and 12 months of age but is unaffected at 18 and 24 months of age. The findings are discussed in relation to hippocampal development and the proposed developmental step in memory at 9-10 months of age.

Child Development↗

Partial learning and recognition memory in the aged.

A recognition-memory paradigm was used to test two hypotheses, storage and retrieval, which account for the adult age decrement seen in recall. Partial storage was minimized by using items in the recognition list which were similar to the to-be-remembered items. Recognition performance was unaffected by adult age differences, thereby supporting the retrieval hypothesis. However, older persons made a greater number of semantic errors in the recognition test list supporting the storage hypothesis. While the error difference did not affect overall recognition performance, the result does indicate some caution is necessary in interpreting age-recognition interactions.

Adult↗

Event-related potential evidence for a specific recognition memory deficit in adult survivors of cerebral hypoxia.

Transient global ischaemia due to cardiac arrest may lead to profound neuropsychological disorders. Recent research indicates that memory processes are particularly impaired after hypoxic brain injury. Visual recognition memory functions were examined in these patients by means of event-related potential (ERP) and performance data. Eight chronic hypoxic patients, matched with controls for sex and age, performed a visual recognition memory task requiring recognition judgements for either object forms or spatial locations and a visual classification (i.e. oddball) task that imposed negligible memory demands. Reliable P300 oddball effects were obtained both for patients and for controls, whereas the two groups differed in P300 latency and P300 scalp topography. In the memory task, old/new effects (i.e. larger ERP waveforms for previously studied than for unstudied items) were found for the controls. In contrast, in patients these old/new effects were absent or even inverted in polarity while recognition performance was well above chance level, except for one patient. These results suggest that recognition, based on the retrieval of an item's study episode, is degraded in patients who have suffered a period of transient global ischaemia. In the light of the patients' above-chance level of recognition performance and the outcome of post hoc analysis of practice-related changes in recognition performance, it is argued that the patients' memory disorders are best characterized as a degradation of explicit memory functions such as episodic retrieval of a study episode. Implicit functions such as cognitive skill learning were intact.

Adult↗

Preserved visual recognition memory in an amnesic patient with hippocampal lesions.

There is ongoing debate about whether performance on tests of recognition memory can remain preserved after hippocampal damage. In the present study, we report F.R.G., a patient who became severely amnesic following herpes simplex encephalitis. Although F.R.G. failed all tests involving recall and verbal recognition, she obtained normal performance on a wide number of tests evaluating visual recognition memory (14 of 18 different tests). Her performance was independent of various factors, such as test difficulty, duration of exposure to the stimuli, or delay separating encoding and recognition. F.R.G. also achieved normal performance on two tasks requiring that she associate pairs of visual stimuli. In addition, she demonstrated spared feeling of knowing, suggesting that her performance on recognition tests was explicit and likely to rely on familiarity. Brain imaging (MRI) revealed bilateral lesions of the hippocampus and lesions of the left parahippocampal gyrus, while the right parahippocampal gyrus remained relatively spared. The results of this study support the view that recognition memory can be preserved despite severe hippocampal damage and that familiarity is a distinct memory process that can be dissociated from recollection.

Adult↗

The influence of semantic encoding on recognition memory in Alzheimer's disease.

Within the framework of the distinction between episodic and semantic memory, it has been argued that these two memory systems are organised in a hierarchical way. The hierarchical hypothesis assumes that episodic memory is a specific subsystem of semantic memory and therefore implies that episodic memory cannot exist without semantic memory. If this hypothesis is correct, it should be expected that patients with impaired semantic memory also have impaired episodic memory. In the present study, two experiments investigated the influence of semantic encoding on recognition memory performance in a population of 20 patients with Alzheimer's disease and 18 normal controls. Both experiments assessed recognition memory for semantically-related items. In Experiment 2, but not in Experiment 1, subjects were explicitly instructed to make a semantic association between the items. Alzheimer's disease patients were impaired, compared to the normal controls, on the recognition memory performance of both experiments. The ability to make a semantic association between two items was significantly and positively correlated with the subjects' performance on the recognition tasks. A further analysis showed that patients who were impaired on the semantic association task did significantly worse on the recognition task of Experiment 2 than normal controls and patients who were unimpaired on the semantic association task. These findings are discussed in the context of memory deficits in Alzheimer's disease, and are interpreted as supporting the view that episodic memory for an item is affected by the level of semantic awareness of that same item.

Aged↗

Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790.

RATIONALE: Accumulating evidence suggests a potential role for the 5-HT(6 )receptor in cognitive function and the potential use of 5-HT(6) receptor antagonists in the treatment of learning and memory disorders. OBJECTIVES: The aim of the current study was to investigate the effect of the selective 5-HT(6) receptor antagonist, Ro 04-6790, on both the performance of normal adult rats and restoration of a pharmacological disruption of memory function produced by the non-selective muscarinic receptor antagonist, scopolamine, or the dopamine D(2) receptor antagonist, raclopride, in a rodent model of recognition memory. METHODS: Passive, perceptually based, recognition memory was assessed using a novel object discrimination task. Following habituation to an arena, rats were presented with two identical objects during trial 1 (T(1)) and a novel and familiar object during trial 2 (T(2)). The time spent exploring the two objects in each trial was measured and novel object discrimination assessed in T(2). RESULTS: In the absence of drug all rats spent an equal time exploring the two identical objects in T(1) but more time exploring the novel object in T(2). Scopolamine (but not N-methylscopolamine) and raclopride both produced a dose-dependent reduction in novel object discrimination whilst the 5-HT(6) receptor antagonist, Ro 04-6790, had no effect on discrimination when given alone but completely reversed the scopolamine- but not the raclopride-induced deficit. CONCLUSION: This study demonstrates that acute administration of Ro 04-6790 reverses a cholinergic but not a dopaminergic deficit in a rodent model of recognition memory and provides further support for a role of the 5-HT(6) receptor in the regulation of cognitive function.

Animals↗

Relationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys.

Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Neurosci 2000;20:451-463) found no significant correlation between extent of hippocampal damage and recognition memory performance, whereas Baxter and Murray (Hippocampus 2001;11:61-71) concluded that the extent of hippocampal damage in monkeys was inversely correlated with impaired performance. Here, we first consider the requirements for carrying out a valid meta-analysis, and point out that the analysis carried out by Baxter and Murray (Hippocampus 2001;11:61-71) is invalid on simple statistical grounds. We then adopt the appropriate statistical procedures (multiple regression analyses rather than simple correlational analysis) to assess the relationship between extent of hippocampal damage and recognition performance across different studies. None of these analyses, including a reanalysis of the data of Baxter and Murray (Hippocampus 2001;11:61-71), revealed a significant inverse relationship between lesion size and behavioral impairment. Most of the variance was explained by differences between the studies that contributed to the meta-analysis, not by lesion size itself. Indeed, analysis of covariance indicated that there were differences among the studies beyond lesion size that significantly affected performance. Finally, we consider what relationship might hold between lesion size and memory performance in the monkey.

Animals↗

Associative components of recognition memory.

Recent results indicate that visual recognition memory (as assessed by habituation and dishabituation of the orienting response) is influenced by associative knowledge, and that this influence is mediated by the hippocampus. A standard, associative model of learning has been recently reported to provide a parsimonious explanation for these results.

Animals↗

Cholinergic neurotransmission is essential for perirhinal cortical plasticity and recognition memory.

We establish the importance of cholinergic neurotransmission to both recognition memory and plasticity within the perirhinal cortex of the temporal lobe. The muscarinic receptor antagonist scopolamine impaired the preferential exploration of novel over familiar objects, disrupted the normal reduced activation of perirhinal neurones to familiar compared to novel pictures, and blocked production of long-term depression (LTD) but not long-term potentiation (LTP) of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for the involvement of cholinergic mechanisms in synaptic plastic processes within perirhinal cortex that are necessary for recognition memory.

Animals↗

An event-related potential study of recognition memory with and without retrieval of source.

Event-related potentials (ERPs) were recorded during the test phase of a recognition memory task in two experiments. In both experiments subjects made initial old/new judgements to visually presented words, and for words judged old, indicated in which of two voices (male/female) the words had been heard at study. In the second experiment only subjects had the option to signal that they were uncertain about the status of a test word. Two positive-going ERP effects differentiated the ERPs evoked by correctly recognized old words from those evoked by words correctly judged new. The two effects differed in their scalp topography and time course, and were both of greater magnitude in the ERPs evoked by recognized words for which a correct voice judgement was made. The findings are consistent with the view that multiple neural systems underlie the ability to recognize an item and to recall its study context. However, the findings offer little support for the view, articulated in certain 'dual-process' models of recognition memory, that recognition judgements with and without retrieval of study context depend upon qualitatively different memory processes or systems.

Analysis of Variance↗

Age-related differences in recognition memory for pictures.

This study provided a normative data base for the Continuous Recognition Memory Test and also investigated age-related differences in recognition memory for pictures in a sample of 299 normal subjects (age range 10-89). Data analysis revealed that older subjects consistently set a lower response criterion (Cx), resulting in a significantly higher number of within-class false alarms. Older subjects also displayed significantly lower sensitivity (d'). Changes in sensitivity were attributed to both an increase in false alarms and a concurrent decrease in hits in subjects over 65. Analysis of the likelihood ratio (beta) revealed no significant change across age groups.

Adolescent↗

Impaired recognition memory after head injury.

A continuous recognition memory task employing 120 line drawings of familiar stimuli was administered to patients recovering from closed head injury of varying severity and control patients. Mildly injured patients obtained significantly more correct responses, and higher memory sensitivity (d') values than moderately and severely injured patients who performed similarly. The measure of response criterion, c, was significantly lower in patients with injury of moderate severity when compared to mildly injured cases and control patients. Controls and mildly injured patients did not differ in their performance. In general, the total correct responses most impressively differentiated head injured patients with measurable coma duration as more than two-thirds had scores below the control group. Group differences in hits, false alarms and misses were examined also. Age and education, skull fracture, and hematoma were generally unrelated to any of the measures, whereas coma duration was significantly related to most measures of mnemonic efficiency.

Adolescent↗