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[Comparison of the protective action of 2 respiratory protective devices in farmers with farmer's lung].

With the aid of provocative challenges with hay in patients suffering from farmer's lung, a comparison of the protective effectiveness of the Airstream Helmet (main filter P2) and of the Sundström Mask (main filter P3) was undertaken. A total of 42 farmers were admitted to the study. In 14, as indicated by an expertise, a workplace-related provocative challenge by the farmers' own hay was carried out and was shown to be positive with respect to the presence of farmer's lung disease. In 28 farmers in whom an inhalative provocative challenge with hay had been demonstrated to be positive, inhalative provocative challenges were again performed using the farmers' own hay while the farmers were wearing protective respirators--14 with the Airstream Helmet, (main filter P2) and 14 with the Sundström Mask (main filter P3). When the respirator was not worn, a statistically significant increase in the number of leukocytes and temperature vis-a-vis the baseline values was observed. Partial oxygen pressure, vital capacity, total lung capacity and DCO, all showed a statistically significant decrease as compared with the baseline figures. The provocative challenges performed while the subjects were wearing the respirators also revealed a statistically significant increase in the number of leukocytes and in temperature, which, however, was statistically significantly smaller than that induced by provocation without the respirator. A similar pattern of behaviour was also found in the decrease in vital capacity, oxygen partial pressure, total lung capacity and DCO. No statistically significant differences were observed between the provocation figures obtained with the Airstream Helmet as compared with those obtained with the Sundström Mask.(ABSTRACT TRUNCATED AT 250 WORDS)

Bronchial Provocation Tests↗

Minimum protection factors for respiratory protective devices for firefighters.

Carbon monoxide and oxygen concentrations were measured in seventy-two structural fires using a personal air sampler carried by working firefighters. In a total sampling time of 1329 minutes the carbon monoxide concentration exceeded 500 ppm approximately 29 percent of the time. The maximum carbon monoxide concentration was 27,000 ppm and in 10 percent of the fires, the maximum concentration exceeded 5500 ppm. Only six runs indicated oxygen concentrations less than 18 percent. On the basis of these exposure data, a minimum protection factor of 100 is proposed for breathing apparatus for structural firefighting.

Air↗

Earplugs--a computer program for simulation of personal hearing protection devices.

Earplugs is a program to allow predictive evaluation of earplugs and earmuffs. Written in Basic for the Apple II+, it is translatable into all other versions of Basic. The program allows the user to compare the attenuation capabilities of any earplug versus the environmental octave band analysis for the workplace in question. This version of the program provides a plot of the results.

Ear Protective Devices↗

[Optimal physiological parameters of respiratory tract protective devices].

The studies have been aimed at the evaluation of the effects of the use of purifying and insulating equipment of the respiratory system upon some physiological reactions. Also optimum physiological parameters for the respiratory tract safety equipment have been set up. The value of air flow resistance measured at constant air flow rate of 30 l/min should not exceed 10 mm H2O in the inhaling phase and 4 mm H2O in the exhaling phase. The dead space of the safety equipment should not exceed 150 ml, whereas CO2 concentration in the inhaled air -- 0.4%. The air flow rate should amount to 9 -- 12 m3/h during light physical effort of 48 Watt and 12 m3/h during moderately hard physical effort of 96 W. Air temperature in the facial part should be 19 -- 25 degrees C.

Adult↗

Effect of thermal conditions on the acceptability of respiratory protective devices on humans at rest.

The physiological and subjective responses of six sedentary subjects wearing half-facepiece respirators were observed over a wide range of room and respirator air conditions. Room air and dew-point (Ta:Tdp) temperatures were 25:11 degrees, 30:13 degrees, and 35:16 degrees C in still air. Respirator air temperatures were maintained independently of room conditions at 27 degrees, 30 degrees, 33 degrees, and 36 degrees C with relative humidity levels of 47% and 73%. Physiological measurements included local skin and dew-point temperatures. Subjective judgments of acceptability, thermal sensation, degree of discomfort, sense of skin moisture, and difficulty of breathing were recorded separately for the thermal environment in the room and inside the respirator. Respirator temperatures cooler than 33 degrees C were always comfortable and 100% acceptable; respirator air temperatures above 33 degrees C or higher humidity levels decreased respirator acceptability. Acceptability of the respirator environment decreased as lip temperature increased above 34.5 degrees C or when respirator dew-point temperature increased above 20 degrees C. Increased respirator air temperature and humidity often made breathing seem "slightly hard." The respirator conditions influenced the subjects' judgment of the acceptability of the surrounding thermal environment.

Adult↗

[Safety and efficacy of ANGIOGUARD protection device for the prevention of distal embolization during PCI in patients with unstable angina].

UNLABELLED: The use of IIbIIIa receptor blockers decreases the number of major ischemic adverse cardiac events during PCI. However, microinfarcts (post procedural CK-MB elevations) still occur despite optimal antithrombotic treatment. In patients (pts) with increased risk of atheroembolization during PCI the use of additional mechanical protection of embolization can be considered. The purpose of the study was to determine safety and efficacy of additional use of first generation coronary filter (Angioguard) to prevent microembolization during PCI in pts with unstable angina (UA). METHODS: 31 pts with UA (Braunwald IIB, IIIB) undergoing urgent PCI were randomized in the catheterization laboratory for additional use of Angioguard coronary filter or not (placebo). All pts were treated with aspirin, ticlopidine (500 mg/d), heparin (60 U/kg, ACT 200-300 sec.) and eptifibatide (bolus 2 x 180 micrograms/kg i.v. and 2 micrograms/kg/min. infusion for 18-24 h). We analyzed the extent of microembolization (serial CK-MB), presence of embolic material in the device after procedure, technical problems. Major cardiac events (death, myocardial infarction (MI), urgent target vessel revascularization (TVR)) were also considered. RESULTS: PCI was successful in all pts. There was no death, Q wave MI or urgent TVR. Angioguard was successfully installed in 100% pts; however balloon predilatation was necessary in 9 (60%) pts. In 9 pts (60%) there was no possibility to prevent embolization oflarge side branches that originated close to the culprit lesion. Presence of embolic material in the filter was confirmed in microscopic analysis of each device. However CK-MB level was elevated in 4 pts (29%) in Angioguard group comparing to 0% in control group without protection device. CONCLUSION: First generation Angioguard protection device do not successfully prevent distal embolisation during PCI in pts with UA and its use is associated with many technical problems.

Angina, Unstable↗