SEARCH · Search PubMed

Results for “Polyglactin 910”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources

PubMed2001

The Ipswich childbirth study: one year follow up of alternative methods used in perineal repair.

OBJECTIVE: To assess the long term implications of four alternative approaches to postpartum perineal repair. DESIGN: A stratified randomised controlled trial using a 2x2 factorial design. SETTING: Original recruitment at the Maternity Unit at Ipswich Hospital NHS Trust, a district general hospital, between 1992 and 1994. SAMPLE: Seven hundred and ninety three women who had participated in the Ipswich Childbirth Study--a trial among women who had required repair of episiotomy or first or second degree tears--at least one year previously. METHODS: Self-completed postal follow up at least one year after recruitment to trial comparing 1. two-stage repair leaving the skin unsutured with standard three-stage repair, and 2. polyglactin 910 with chromic catgut as suture material for the repair. MAIN OUTCOME MEASURES: Failure to resume pain-free intercourse; persistent perineal pain; perineum feeling different; resuturing; time to resume pain-free intercourse; and dyspareunia. RESULTS: Fewer women allocated two-stage repair reported that the perineum felt different (30% versus 40%; RR 0.75; 95% CI 0.61 to 0.91; 2P < 0.01); otherwise there were no clear differences between the two methods. Women allocated polyglactin 910 were less likely to have dyspareunia (8% versus 13%; RR 0.59, 95% CI 0.39 to 0.91; 2P = 0.02) and less likely to fail to resume pain-free intercourse (8% versus 14%; RR 0.57, 95% CI 0.38 to 0.87; 2P < 0.01). CONCLUSION: Two-stage repair of perineal trauma leaving the skin unsutured appears to reduce the likelihood of the perineum feeling different from before delivery, in addition to less pain and dyspareunia initially; there were no apparent disadvantages. Polyglactin 910 reduces dyspareunia long term, indicating that the short term benefits of this material over chromic catgut persist.

Adult↗

PubMed2006

A mechanical study of ligature security of commercially available pre-tied ligatures versus hand tied ligatures for use in equine laparoscopy.

OBJECTIVE: To determine a hand-tied ligature knot configuration, suture size, and suture type that would be an acceptable substitute to commercially available ligature knots for use in equine laparoscopic surgery. STUDY DESIGN: Three-factor ANOVA with the fixed effects being suture type, suture size, and knot type. The dependent variable was ligature security (load to failure). METHODS: Commercially available Endoloop and 4 hand-tied slipknot ligatures were compared with a 4-layer square knot. The hand tied ligature knots tested were the 4S modified Roeder knot, the Brooks knot, the modified Roeder knot, and the Weston knot. Two suture sizes (0, 2) of each of 2 suture types (polydioxanone, polyglactin 910) were tested with each hand tied knot. Two types (polydioxanone, polyglactin 910) of size 0 Endoloop were tested. Twenty repetitions of each knot suture type were tested for force to yield on a materials testing machine. Statistical analysis consisted of a 3-way ANOVA with individual comparisons made using the Bonferroni method. Significance was P< or = .05. RESULTS: Only the 4S modified Roeder knot in 2 polydioxanone (103 N) was comparable with the breaking strength of the square knots (157 N). All other knot suture combinations tested were significantly weaker than the square knot (range, 2-18 N). CONCLUSION: For equine laparoscopy, a 2 polydioxanone 4S modified Roeder knot would be an acceptable alternative to the commercially available Endoloop. CLINICAL RELEVANCE: Laparoscopic slip knots are commonly used in equine laparoscopic surgery. Various knot configuration and suture size and type combinations will affect the security of the slip knot.

Analysis of Variance↗

PubMed2006

Evaluation of the gross and histologic reactions to five commonly used suture materials in the skin of the African clawed frog (Xenopus laevis).

Surgical harvest of Xenopus laevis oocytes for developmental research is a common procedure that requires closure of a 0.5- to 2.0-cm incision with suture material. Although such harvests are a frequent practice, little published information exists to provide guidance regarding the most appropriate suture material for wound closure in laboratory amphibians. To determine which suture material elicits the least response in amphibian skin, we used Xenopus laevis as a model to investigate the gross and histologic tissue reactions to 5 commonly used suture materials-3-0 silk, monofilament nylon, polydioxanone, polyglactin 910, and chromic gut. The skin reacted in 3 ways to suture material, showing edema, epidermal changes, and inflammation. Although the gross reactions to monofilament nylon, polydioxanone, and polyglactin 910 were clinically indistinguishable and were associated with lowest gross reaction scores, monofilament nylon elicited the least histologic reaction and therefore seems to be the most appropriate choice for use in amphibian skin.

Animals↗

PubMedDate not supplied

Technical considerations in knot construction, part III. Knot asymmetry.

Lactomer and the Polyglactin 910 are coated synthetic braided absorbable sutures commonly used for dermal wound closure. Biomechanical performance tests demonstrated superior performance characteristics of the Lactomer sutures. Using narrow diameter sutures, the Lactomer sutures exhibited superior knot holding forces over the Polyglactin 910 sutures. Moreover, knot security could be reliably achieved with asymmetric and symmetric knots using the Lactomer sutures.

Biomechanical Phenomena↗

PubMed2001

Angiogenic effects of suture biomaterials. An experimental study in rats.

Angiogenesis is a limiting step of inflammation and wound healing. Although laboratory tests for the evaluation of the angiogenetic effects of biomaterials are available, no investigations have been performed. In this study we examine the angiogenetic effect of suture biomaterials in the rat mesenteric window model. Absolute controls had laparotomy only, controls had mesenteric window wounding, test groups had the insertion of either a thread of collagen, polyglactin 910, polyglycolic acid salt, silk or of a titanium clip. We considered the percentage area of the mesenteric window covered by neovessels. After 7 days, negligible angiogenesis was found in absolute controls, significant angiogenesis in controls, collagen, polyglactin 910 and polyglycolic acid salt treated rats, without differences between treatments. A significant increase of angiogenesis in comparison to the control group was found in rats treated with silk and titanium. Ultramicroscopy of the neovessels showed specific changes of their architecture in titanium-treated rats. In conclusion, angiogenesis during wound healing is differently influenced by the suture material used. Silk and titanium stimulated angiogenesis in a different way.

Animals↗

PubMed1996

Biomechanical performance of a braided absorbable suture.

Lactomer and Polyglactin 910 sutures are both made of copolymers of lactide and glycolide. Biomechanical performance tests demonstrated superior handling characteristics of the Lactomer sutures. Using sutures comparable in size and knot construction, the Lactomer sutures exhibited knot holding force superior to the Polyglactin 910. Moreover, the low knot rundown forces encountered by the Lactomer sutures facilitated construction of secure knots that failed by breakage rather than by slippage.

Animals↗

PubMed1985

Adhesion formation and histologic reaction with polydioxanone and polyglactin suture.

A suture material associated with a minimal inflammatory response might be expected to induce less frequent and less severe peritoneal adhesions. A comparison between polydioxanone and polyglactin 910 suture was performed in a rabbit model. Ten sexually mature virgin female New Zealand white rabbits underwent laparotomy and bilateral incisions into the distal uterine cavities. The serosa of the left uterine horn was always reapproximated with polyglactin 910 suture whereas the right uterine horn was repaired with polydioxanone suture. All animals were put to death 28 days later. An adhesion score was given for each uterine horn. Representative sections were obtained for histologic review. Similar histologic responses were found in both groups. No significant difference was noted in adhesion scores between the two sutures. The present study cannot justify the use of one of these sutures over the other with regard to adhesion formation or tissue reaction.

Animals↗

PubMed2001

Absorbable versus non-absorbable suture in carpal tunnel decompression.

This randomised prospective clinical study compared the use of an absorbable suture (subcuticular 4:0 polyglactin 910) and a non-absorbable suture (5:0 monofilament polypropylene) for elective carpal tunnel decompression wound closure. An increased perception of pain was reported by the patients in the polypropylene (Prolene) group. At the 6-week assessment, there was a higher level of residual wound inflammation in the polyglactin 910 (Vicryl) group.

Absorbable Implants↗

PubMed1989

Biliary tract complications in orthotopic adult liver transplantation.

In a series of orthotopic liver transplantations performed between April and August 1987 at the University of Pittsburgh, the monofilament absorbable suture polyglyconate was compared with a braided absorbable suture, polyglactin 910, for its biliary complication rate over a 6-month postoperative period. Complications that were suture-related (obstruction or leak from the anastomotic site) occurred in 1 of 21 transplantations in the polyglyconate group compared with 8 of 26 in the polyglactin 910 group (p = 0.02). Even though the patient sample was relatively small, it appears that the type of suture used for the biliary anastomosis directly correlates with the outcome. A larger patient trial could confirm these initial results.

Anastomosis, Surgical↗

PubMed1996

A prospective clinical evaluation of the longevity of resorbable sutures in oral mucosa.

A prospective, randomised and controlled clinical investigation was undertaken to evaluate the longevity of resorbable sutures in the oral environment. The sutures investigated were gut, polyglycolic acid and polyglactin 910, were of standard gauge and needle type, and were placed using a standard technique by trained clinicians. The sutures were monitored following apical surgery in 55 patients (110 sutures) and the median survival values were: gut - 4 days, polyglycolic acid - 15 days, polyglactin 910 - 28 days. These differences were highly statistically significant. A postal survey of 30 randomly selected oral and maxillofacial surgeons reveal most prefer to use resorbable sutures, with softgut the most popular choice. Most would like an ideal resorbable suture to last 5 to 14 days and in this respect none of the materials tested appears satisfactory.

Absorption↗

PubMed2002

Fabricating autologous tissue to engineer artificial nerve.

This study reports on the successful fabrication of artificial nerves with tissue engineering methods. Schwann cells were cultured for 2 weeks, seeded on polyglactin 910 scaffolds, and biomembrane-coated with rat-tail glue and laminin. Observation of the scaffolds' adsorptivity to Schwann cells, and of the growth and migration of Schwann cells, was made using a light microscope, and by scanning and transmission electron microscopy. The Schwann cells were able to migrate and proliferate on the polyglactin 910 fiber. Schwann cells were well-distributed, and formed a Büngner band on which the Schwann cells produced more matrices. Schwann cells on the biomembrane also grew well. We investigated the role of the tissue engineering conduit guide in vivo, using an established rabbit peripheral nerve regeneration model. At 8 weeks, axonal regeneration was observed in the distal nerve stump. Adult Schwann cells can be produced on the coated fiber and the biomembrane. Three-dimensional scaffolds with Schwann cells had the basic characteristics of the artificial nerve. These findings will provide a practical method for fabricating tissue-engineered artificial nerve to repair long nerve defects.

Animals↗

PubMed1986

Mechanical properties of coated absorbable multifilament suture materials.

The mechanical properties of coated polyglactin 910 (Vicryl) and coated plyglycolic acid (Dexon) were defined. Scanning electron microscopy of 0 gauges of both materials showed some differences. Coated polyglycolic acid had minimal surface aberrations. Unknotted tensile strength measurements of gauges 1, 0, 00, and 000 demonstrated no statistically significant difference between the two materials. Both materials reached knot security at the 2=1=1=1 configuration. The in vivo tensile strength measurement of 0 gauges showed polyglactin 910 to be significantly stronger at 21 days. Histologic evaluation revealed no statistically significant difference between the materials.

Animals↗

PubMed2003

Comparison of the performance of the Gea extracorporeal knot with the Roeder extracorporeal knot and the classical knot.

BACKGROUND: Laparoscopy is useful to treat surgical diseases, yet tying sutures in the cavity is a challenge. A knot to secure tissue approximation, which would be hand-made, secure, simple, easy, quick, reliable, and extracorporeal without extra mechanical devices, was developed and named the Gea knot. METHODS: A comparative study of the Gea knot, the Roeder knot, and the classical surgical knot, as the gold standard, using polypropylene, silk, catgut, polyglycolic acid, and Polyglactin 910, all of them of 1-0 caliber, was performed in pigs. Measurements were time to perform, slippage, and breaking point which was measured with a manual digital tensiometer. RESULTS: The Gea knot was significantly faster statistically to perform than the Roeder knot and more resistant against rupture and slippage. The slippage rate was significantly lower statistically in the Gea knot than in the Roeder knot when Polyglactin 910 and polypropylene were used. CONCLUSION: The Gea knot is a good alternative for laparoscopic procedures.

Absorbable Implants↗

PubMed2004

Effect of human pancreatic juice and bile on the tensile strength of suture materials.

BACKGROUND: Several suture materials are used for pancreatojejunal anastomosis. In this study, we tested the durability of these suture materials in human pancreatic juice and bile. METHODS: Plain and chromic catgut, polyglactin 910, polyglycolic acid, polydioxanone, polypropylene, and silk sutures were incubated in pancreatic juice and bile that was collected from patients. Fifteen samples of each type of suture material were placed in human juices for 1, 3, and 7 days. Tensile strengths were measured with a tensionmeter. RESULTS: Plain and chromic catgut disintegrated in pancreatic juice and pancreatic juice plus bile mixture. Polyglycolic acid and polyglactin 910 suture materials were vulnerable to pancreatic juice within 7 days. Polydioxanone retained most of its initial strength in pancreatic juice and bile. Polypropylene and silk retained 84% and 92% of their initial strength, respectively. CONCLUSIONS: We found that polidioxanone was the strongest suture material in pancreatic juice.

Anastomosis, Surgical↗

PubMed1997

Risk factors for wound infection following celiotomy in horses.

OBJECTIVE: To determine the prevalence of wound infection following celiotomy in horses and to determine risk factors associated with the development of such infections. DESIGN: Prospective study. ANIMALS: 210 horses that had 235 celiotomies. PROCEDURE: All horses that had celiotomies between March 1990 and March 1992 were considered for this study. Only horses that survived > or = 10 days after surgery were included in analysis of risk factors for postoperative wound infection. RESULTS: Of the 210 horses, 161 (76.7%) were discharged; of the horses discharged, 147 horses had a single celiotomy and 14 had multiple celiotomies. Twenty-six (12.4%) horses were euthanatized during surgery and were, therefore, excluded from further analysis. Twenty-three horses died during the postoperative period. Of these 23 horses, 15 that died within 10 days of surgery also were excluded from further analysis. Thus, 169 horses were included in the analysis of risk factors for developing incisional infection. Evidence of incisional infection was observed in 43 of 169 (25.4%) horses. Increased concentration of fibrinogen in peritoneal fluid obtained prior to surgery, performing an enterotomy, and use of polyglactin 910 to close the linea alba were all significantly (P < or = 0.05) associated with increased risk of postoperative wound infection. Whether incisional herniation developed was recorded for 76 horses. The proportion of horses with hernias among those with postoperative wound infection was 19.1%, compared with 3.6% of horses without evidence of postoperative wound infection, indicating a significant association between postoperative wound infection and development of incisional hernias. CLINICAL IMPLICATIONS: Increased concentration of fibrinogen in peritoneal fluid prior to surgery, performing an enterotomy, and use of polyglactin 910 to close the linea alba is significantly associated with increased risk for wound infection following celiotomy in horses.

Abdomen↗

PubMed2000

Osseointegration of subperiosteal implants using bovine bone substitute and various membranes.

An earlier study revealed incomplete osseointegration of individually made titanium subperiosteal implants covered by ePTFE membranes and fixated to the rabbit tibial bone surface. In addition, the newly-formed bone was dominated by large marrow spaces. In this subsequent study, subperiosteal implants were also fixated on the bone surface of both tibia of 9 Copenhagen White rabbits. Bio-Oss particles were packed densely covering the entire implant surface. One of 3 different membranes covered the implant and the particles. The membranes used were the degradable Polyglactin 910 mesh, a degradable bilayer collagen membrane and the non-degradable ePTFE membrane. Undecalcified sections were prepared for histologic evaluation after a 12 weeks' observation period. All 18 subperiosteal implants were completely osseointegrated. In addition, the marrow spaces were reduced compared to our previous study. The Bio-Oss particles proved to be biocompatible and osteoconductive. The ePTFE membranes revealed neither signs of collapse nor adjacent infiltration of inflammatory cells. The Polyglactin 910 mesh and the bilayer collagen membranes collapsed slightly. There were signs of resorption of the surface of the newly-formed bone under the degradable membranes. The cause of resorption can not be documented.

Animals↗

PubMed1989

Common bile duct healing. Do different absorbable sutures affect stricture formation and tensile strength?

Few basic investigations have addressed the problem of common bile duct strictures. We systematically investigated the healing canine end-to-end choledochal anastomosis and tested the hypothesis that common bile duct anastomoses sutured with monofilament polyglyconate absorbable suture would heal with less stricture formation and greater tensile strength than those sutured with braided polyglactin 910 and chromic catgut sutures. Seventy-six canines, randomized to control vs sutured groups, underwent either mobilization (controls) or transection of the mid-common bile duct and were allowed to heal 5, 10, 15, or 50 days postoperatively before sacrifice. The type of absorbable suture used to construct a common bile duct anastomosis was found to have no major effect on anastomotic strictures nor on anastomotic breaking strength. Polyglyconate suture caused significantly less perianastomotic inflammation than did chromic suture, with polyglactin 910 sutures evoking an intermediate inflammatory response. Surgeons may safely choose sutures for biliary procedures based on the clinical circumstances and personal preference.

Anastomosis, Surgical↗

PubMed2006

Abdominopelvic mesh compartmentalization reduces the complications of radiotherapy in children: a preliminary report.

AIM: The aim of this report was to assess the effects of radiotherapy (RT) in children with abdominopelvic tumours in whom a biodegradable (Polyglactin 910) mesh had been inserted prior to commencement of radiotherapy. METHODS: Retrospective analysis was carried out of four patients with abdominopelvic tumours who underwent radiotherapy between 2000 and 2002 as part of their management. RESULTS: All children tolerated radiotherapy well with no evidence of acute or chronic radiation enteritis. One child developed prolonged postoperative ileus and a second child developed infective diarrhoea and fever, not related to radiation. CONCLUSION: We have highlighted a good tolerance of radiotherapy in children following the insertion of a Polyglactin 910 mesh prior to starting radiation and would recommend further larger studies with longer follow-up to support this.

Abdominal Neoplasms↗