Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Pirinitramide”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources
PubMed1982

Etomidate-analgesic combinations for the induction of anaesthesia in cardiac patients. Part I: Studies in patients with coronary artery disease.

UNLABELLED: In a total of 150 patients undergoing coronary revascularization procedures etomidate was given for the induction of anaesthesia using 12 different dosages and combinations with piritramide, morphine, fentanyl and nitrous oxide. The aim of this study was to establish a method which would result in the smallest possible changes in arterial blood pressure and heart rate during the whole of the induction period, including the stressful phase of endotracheal intubation. In 68 patients cardiac output and pulmonary artery pressure were also measured. RESULTS: 1. In general, more favourable results were obtained when anaesthetic drugs were administered extremely slowly (e.g. by infusion) and according to a standardized dosetime regime. Conversely, the commonly used method - slow incremental injections according to the estimated requirements of the individual patient - led to much greater variations of arterial pressure, especially when fentanyl was combined with etomidate. 2. Combinations of etomidate and morphine led to unsatisfactory results. Dependent on the dose given, hypertension or hypotension were commonly seen. When piritramide was substituted for morphine much more stable haemodynamic conditions were obtained. 3. Surveying our investigations to find the most suitable dose relationship between the hypnotic, etomidate, and the opioid analgesic, piritramide, only small and negligible differences were found: comparing two procedures for the induction of anaesthesia using either high dose piritramide (3 mg . kg-1 given over 10 min), supplemented by low dose etomidate (0.1 mg . kg-1 given over the first 2 min) or an etomidate infusion (50 gamma . kg-1 . min-1) supplemented by a low dose piritramide (0.3 mg . kg-1 given over 1 min) excellent results were found in both groups. 4. In contrast, studies aimed at achieving equally favourable results using the combination of etomidate-fentanyl suggested that the safe dose-range of fentanyl is very narrow: etomidate-infusion (50 gamma . kg-1 . min-1) together with fentanyl 3 gamma . kg-1 led to unacceptable rises in blood pressure and heart rate after intubation, and the larger dose of 6 gamma . kg-1 fentanyl frequently led to hypotension.

Analgesics↗
PubMed1982

[Postoperative analgesia by peridural piritramide application].

Postoperative analgesia was achieved by peridural injection of small doses of piritramide (Dipidolor Gedeon Richter Budapest) to 24 gynaecological and surgical patients. Periods of action were longer than those obtainable from equivalent intramuscular or intravenous injections. Undesirable side effects of the opiates, such as disorders of respiration, vomiting, clouded consciousness, and suppression of cough reflex, were not observed. The method did not affect locomotor and sympathetic nerve fibres and, consequently, proved to be superior to postoperative analgesia by means of local anaesthesia. Repetitive injections can be made by nurses. Peridural opiate analgesia can be recommended for postoperative situations and for other patients with pain.

Adolescent↗
PubMed1981

[Comparative clinical investigations on the cardiovascular effects of piritramide (dipidolor) and fentanyl (author's transl)].

In 36 patients with acquired heart disease effects of 0.15 mg/kg piritramide on hemodynamics, inotropic state and myocardial oxygen consumption were investigated during and after cardiac surgery (basic neuroleptanalgesia). It could be demonstrated, that piritramide is not inducing any negative inotropic effects compared to a control group (n = 36) and a fentanyl group (0.003 mg/kg, n = 31). There were only small changes in HR, SV, PRA and PLA. A slight decrease in Part, PLV, and arterial perfusion pressure during extracorporeal circulation is interpreted as a peripheral vasodilatation. The resulting decrease in heart work caused a significant decrease in myocardial oxygen consumption (-18%), which is of special advantage in patients with coronary heart disease.

Anesthesia, General↗
PubMed1981

[Plasma-antidiuretic hormone level as indicator of postoperative stress (part II) (author's transl)].

For a period of five days serum levels of antidiuretic hormone (ADH) have been investigated postoperatively in a group of 20 patients with upper abdominal surgery. In addition serum electrolytes (Na+, K+) and plasma osmolality have been controlled regularly. Patients in group A (n = 10) received Fentanyl epidurally (0.1-0.2 mg diluted with 0.9% saline solution) for treatment of postoperative pain, whereas in group B (n = 10) systemic opiate therapy was performed by intramuscular application of piritramide (Dipidolor, 15-25 mg). There was a significant increase in ADH in all patients, whereas serum electrolytes (Na+, K+) and plasma osmolality stayed within normal range. ADH-levels in group A (epidural opiate), however, were significantly lower than mean values in group B (systemic opiate application). The postoperative increase in ADH is interpreted as a reaction to stress and trauma, being less pronounced, when epidural opiate therapy is performed for postoperative pain treatment.

Adult↗
PubMed1981

[Analgesics].

Explore the source record for details and available documents.

Analgesics↗
PubMed1993

[Comparative evaluation of effectiveness of narcotic analgesics for intravenous autoanalgesia].

The three groups of patients who had morphine hydrochloride, phentanyl and dipidolor been used for intravenous autoanalgesia were examined. In each group, the state of the central hemodynamics, pulmonary ventilation and gas composition of the blood were studied. The effectiveness of analgesia was assessed, side effects were considered. The effectiveness of the use for postoperative intravenous autoanalgesia of morphine and phentanyl has been proved.

Adolescent↗
PubMed1993

Analgesic efficiency of propacetamol hydrochlorid after lumbar disc surgery.

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients scheduled for lumbar disc surgery were randomly allocated to two groups. They were given either propacetamol 2 g or saline every 6 hours, starting at the end of procedure for a 24 hours period. The pain intensity (VAS) was not significantly different between the two groups except 3 and 4 hours after surgery, where it was higher in the paracetamol group. The cumulative narcotic consumption (piritramide on request) was higher in the placebo group from 6 hours till 9 hours after surgery but not significantly different after 24 hours. Piritramide administration decreased VAS score significantly in both groups while propacetamol reduced it in a significant way only when given from 12 hours after surgery.

Acetaminophen↗
PubMed1994

[Clinical tests on reno-ureteral lithiasis with a new Lithostar 2 model C shock wave generator system].

Lithotripsy has confirmed its place in the treatment of urinary stones and there are now few indications for open surgery in this disease. Lithotripsy used to be rarely used, as it required a great deal of patience on the part of the patient, lying in the water bath, and the medical team. Increasing efficient systems are now available with a marked advantage for patients. Simple analgesia-sedation is often sufficient when requested by the patients and the duration of treatment has been considerably decreased. The authors present a review of their results with the new Lithostar 2 Model C shock wave generator system. The modifications made to this system take into account physical possibilities and medical requirements. As a result of the new configuration of this system, the treatment time per patient has been further decreased, a higher energy is applied to the stones and the disintegration rate is excellent.

Colic↗
PubMed1993

[Postoperative analgesia--a comparative study in laparoscopic cholecystectomy and lower abdominal laparotomy].

From September 1992 through February 1993 27 randomly chosen female patients were evaluated for differences in postoperative pain intensity (as determined by visual-analogue-scale (VAS)) and analgesic requirements via patient-controlled-analgesia (PCA), either after open lower-abdominal-laparotomy (n = 16, group 1) or after minimal-invasive-cholecystectomy (n = 11, group 2). The type of anaesthesia has been standardized, either as balanced or total intravenous anaesthesia. There were no statistically significant differences between the groups regarding to age, height, weight, intraoperative anaesthetic drug consumption, or duration of anaesthesia and surgery (205.6 vs 185.5 minutes; 139.1 vs 105.0 minutes). All patients could be extubated while still in the operation theatre. The 10-hour study period started after transfer to the recovery room. Heart- and respiratory-rate, systolic/diastolic blood pressure, endtidal pCO2, oxygen-saturation via pulsoxymetry (SaO2), and demands from PCA-pump were recorded, furthermore pain scores were determined every hour. The VAS-scores showed no significant differences between the two groups. The pain level as a whole was low, with the scores ranging from a maximum of 23.4 mm (group 1 after the first hour) to a minimum of 1.8 min (group 2 after 5, 8 an 10 hours). The overall analgesic requirements differed significantly (37.7 vs 17.3 mg piritramid, p < .01). There was a difference throughout the whole study period, although statistically significant only at the 1., 2. (p < .05), 5. and 6.-8. hour (p < .01). This study showed that pain scores were similar after laparoscopic upper or open lower abdominal surgery, both requiring adequate analgesic therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

[Patient-controlled analgesia (PCA) for postoperative pain relief. A prospective observational study for evaluating the technology in a ward routine].

Patient-controlled analgesia (PCA) is rarely used on surgical wards despite described advantages of this method as compared to conventional techniques. Uncertainties in patient selection and insufficient evaluation of this technique may explain these circumstances. The aim of our study was to evaluate PCA on general surgery and traumatology wards by means of standardized criteria for technology assessment (i.e. safety, practicability, benefit for patients and medical staff) and the efficacy of pain relief. In a prospective study we investigated 120 patients. In phase I, we performed analgesic therapy with tramadol/metamizol (50 ASA status I-IV patients). In phase II, piritramid had been applied to 70 ASA status I-II patients after an intermediate analysis of phase I. In 7% of the patients technical problems led to an early interruption even at the end of the study period. There were, however, no incidents which caused vital problems for the patients. A mean postoperative pain level of 55 visual analogue scale points (0-100 point scale) was achieved with tramadol/metamizol. PCA was stopped in 16% of the patients due to the occurrence of nausea or vomiting and in two patients due to insufficient pain relief. The use of piritramid in phase II led to lower pain levels and no interruptions of PCA because of ineffectivity or nausea/vomiting.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗