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[Comparative study of reproduction and Scheimpflug's photography of the crystalline lens].

Two types of lens photography are compared in the same patients: photography according to Schaimpflüger and reproduction biomicrophotography with subsequent densitometry of the negatives. The authors find Schaimpflüger's photography preferable, its advantages consisting in convenience of the procedure and possibility to make standard pictures. An experienced worker can make high-quality images of the lens optic section with a slit photographic lamp, this permitting an objective assessment of changes in the optic densities of different lenticular laminae.

Densitometry↗

Age in angle-closure glaucoma and the normal - a study in profile photography.

The horizontal corneal diameters of normal subjects of differing age and of those with angle-closure glaucoma were measured by surface and profile photography in the absence of the influence of axial length. The correlationship found between age and corneal diameter of surface photography for normal subjects was not found in the case of measurement by the technique which was independent of opacification of the peripheral zones of the cornea i.e., profile photography. No relationship was found between age and corneal diameter by either technique for the angle-closure glaucoma subjects.

Adult↗

[Further fields of application of the infrared false colour film in ophthalmological photography (author's transl)].

Aside from the distinction between old hemorrhages and pigmented changes of the ocular fundus, the use of metaspectrophotography of the eye with the Kodak Ektrachrome Infrared Film IE 135-20 can be extended successfully to other fields of ophthalmological photography. By shifting the spectral range used for photography towards near infrared and cutting off the short wavelenght part by a yellow filter, spoiling scattering is avoided up to 98 percent. Thus clear goniophotography is rendered possible even with higher magnification. Better pictures are achieved in photography of the periphery of the ocular fundus, of the fundus of eyes with moderate opacity of the cristalline lens, of juvenile macular degeneration, and of pigmented areas of the iris suspected to be tumorous.

Eye Diseases↗

Screening for diabetic retinopathy in a clinical setting: a comparison of direct ophthalmoscopy by primary care physicians with fundus photography.

BACKGROUND: Type II diabetes mellitus is a major health problem among Native Americans, and diabetic retinopathy is a frequent complication of this disease. Screening for retinopathy can identify early disease and prevent major vision loss, but the most cost-effective screening method has not yet been determined. METHODS: In a rural clinic that served more than 400 Native Americans with diabetes, we compared the accuracy of referrals made based on two screening methods: ophthalmoscopy by trained primary care physicians and seven-view nonstereoscopic, mydriatic fundal photography read by two general ophthalmologists and a retinal specialist. Patients in whom abnormal findings were detected by either screening method were then referred to a general ophthalmologist for further evaluation. RESULTS: Two hundred forty-three examinations were performed and 83 referrals made. Both screening methods had high sensitivity for referring patients with retinopathy that required treatment or follow-up sooner than 1 year (100% for direct ophthalmoscopy by primary care physicians, 94% for the general ophthalmologist photography readers, and 100% for the retinal specialist reader). The calculated costs of screening by direct ophthalmoscopy and by retinal photography were 64% less and 44% to 35% less, respectively, than the cost of yearly ophthalmological examinations by ophthalmologists. CONCLUSIONS: Careful screening for treatable diabetic eye disease by trained primary care physicians proved to be a clinically acceptable, cost-effective strategy. Screening methods for diabetic retinopathy should be evaluated based on the absolute sensitivity, specificity, and predictive values of their ability to correctly refer patients rather than their diagnostic accuracy.

Cost-Benefit Analysis↗

The nude in medical photography: a historical perspective, with modern legal ramifications.

Taking medical photographs of nude patients was common in the nineteenth century and was related to the diagnostic promises of photography. Nude photography today, while just as diagnostically important, is a carefully thought out practice fraught with serious legal ramifications especially when dealing with children and adolescents. As members of the human race, we are diverse in our practices and not only on a country wide but a regional level. What is acceptable in New York is not necessarily acceptable in central Kansas. Unfortunately, in many circumstances, it is difficult to measure intent. Vintage medical photographs have become valued as art, as well as historic and cultural documents. Nude vintage medical photographs fully expose the human condition and have become among the most valued of historic medical photographs. The implications for the future treatment of nude medical photography is well established. The passage of time, nostalgia, and, most importantly, the attempt to learn the secrets of life and means of death in past epochs will result in preserving and valuing these most important clinical photographs.

Attitude↗

Digital photography for the light microscope: results with a gated, video-rate CCD camera and NIH-image software.

In this report, we describe a relatively inexpensive method for acquiring, storing and processing light microscope images that combines the advantages of video technology with the powerful medium now termed digital photography. Digital photography refers to the recording of images as digital files that are stored, manipulated and displayed using a computer. This report details the use of a gated video-rate charge-coupled device (CCD) camera and a frame grabber board for capturing 256 gray-level digital images from the light microscope. This camera gives high-resolution bright-field, phase contrast and differential interference contrast (DIC) images but, also, with gated on-chip integration, has the capability to record low-light level fluorescent images. The basic components of the digital photography system are described, and examples are presented of fluorescence and bright-field micrographs. Digital processing of images to remove noise, to enhance contrast and to prepare figures for printing is discussed.

Microscopy, Video↗

The history of photography in dermatology. Milestones from the roots to the 20th century.

From the Middle Ages to the 20th century, talented artists have created illustrations of signs of human diseases. Since the birth of photography in 1840, artists and physicians have used photographic techniques to illustrate the diseases of the skin; dermatology especially relies on these visual signs. In dermatology today, photography is still very important because of the need for adequate illustrations in medical textbooks and journals. From the early days of daguerreotypes to modern times, medical photography was developed in different stages and many physicians have taken part in the development of photographic techniques and chemistry. This historical survey describes the milestones in the development of medical photographic illustration from its beginning to the 20th century.

Dermatology↗

Forensic photography: an expanding technology.

Forensic dental photography involves different goals and, therefore, different techniques than traditional dental photography. One of these techniques involves using different parts of the light spectrum to uncover and document evidence that is difficult or impossible to see under normal lighting conditions. This article describes some of the techniques and equipment used in forensic photography.

Bites, Human↗

Ocular fundus photography.

This chapter is a review of fundus photography techniques, with particular emphasis on the important parameters of producing high quality fundus photographs. The role of fundus photography has extended beyond that of a documentary service to one with specific diagnostic value. Thus, ocular fundus photography relates directly to patient care and is an essential part of the sophisticated armamentarium of any clinical ophthalmological unit.

Fundus Oculi↗

Screening and follow-up of diabetic retinopathy using a new mosaic 9-field fundus photography system.

AIM: To evaluate the clinical usefulness of a newly developed fundus photographing system and assess its applicability to telemedicine. METHODS: Nine overlapping 45 degrees fundus photographs were taken by a new camera equipped with nine internal fixation targets to provide standardized 9-field photographs. The digitally stored images were either edited in 3x3 form or reconstructed as collage (9F) and compared to the ophthalmological examination (OP) and single-field non-mydriatic photography (SC). In telemedicine, 9-field images derived from 61 adolescent diabetics were sent to ophthalmologists over an analog phone line. RESULTS: The sensitivities of the examinations by 9F without and with mydriasis (78 and 82%) were equivalent to OP (84%) and superior to SC (64%). The diagnosis of severity by 9F was also comparable to those by OP, whereas SC tended to underestimate the severity. An average of 1 min 19 s was required to send one edited 9-field photography (average size 259+/-30 KB) over the Internet. Twelve of these eyes were diagnosed as diabetic retinopathy on a desktop monitor whereas SC gave only seven. CONCLUSION: This new 9-field fundus photography system can be appropriate for the screening and follow-up of diabetic retinopathy in adult and adolescent diabetic subjects, especially when applied to telemedicine over the Internet.

Adolescent↗

Is retinal photography useful in the measurement of stroke risk?

BACKGROUND: The retinal microcirculation can be viewed non-invasively to give a unique perspective of the cerebral microcirculation in vivo. Studying pathological changes of retinal blood vessels (microaneurysms, retinal haemorrhages, and retinal arteriolar narrowing) may help to understand the causes of various cerebrovascular disorders. Retinal photography provides such an opportunity. RECENT DEVELOPMENTS: Several recent studies have shown that retinal microvascular changes are reliably documented by retinal photographs. These retinopathy changes seem to be fairly common in the general population, even in people without hypertension or diabetes. Retinopathy is related to incident clinical stroke and stroke mortality and to MRI-defined subclinical cerebral white-matter lesions and cerebral atrophy, independent of blood pressure, diabetes, and other cerebrovascular risk factors. WHERE NEXT?: Retinal microvascular abnormalities seem to be markers of concomitant cerebral microangiopathy, and retinal photography may be useful for the investigation of microvascular disorders of the brain in clinical and epidemiological settings. Future research should be aimed at the development of standardised photographic methods for the assessment of retinal microvascular changes, the replication of these findings in other populations and in people with other cerebrovascular disorders, and the examination of the increased accuracy of stoke-risk stratification given by retinal photography

Brain↗

[Determination of the axis after totalendoprosthesis of the knee: functional X-ray photography as golden standard].

AIM: To examine the question of which X-ray photography technique should be given preference after implantation of total endoprosthesis of the knee. METHOD: 20 patients (age 74.1; 12 men, 8 women) with total endoprosthesis of the knee (Type Sigma, PFC, Johnson and Johnson) because of primary athrosis. Postoperatively X-ray photographs of the whole leg in standing and 40 x 20 a. p. in a flat position were taken. The angles of the axis were determined and the information analysed. RESULTS: By means of X-ray photography of the whole leg we obtained the following angles: caput-collum-diaphyse 125 +/- 4.3 degrees, femur/basis of the knee 83.2 +/- 2.6 degrees, mechanical femur axis/basis of the knee 89.3 +/- 1.8 degrees, tibia/basis of the talus 89.2 +/- 2.2 degrees. With the 40 x 20 a. p. X-ray photographs we determined the following angles: femur/basis of the knee 82.3 +/- 3.1 degrees, basis of knee/tibia 92.2 +/- 3,6 degrees. Correlating the angles of femur/basis of the knee and basis of the knee/tibia were relations of 0.42 (p < 0.05) and 0.27 (p < 0.05). CONCLUSION: For gaining information about the axis of the leg under functional conditions, one should give preference to X-ray photography of the whole leg.

Aged↗

Digital ultraviolet reflectance photography can be used to quantify improvements in photodamage.

OBJECTIVE: Increasing attention has focused on the treatment and reversal of ultraviolet- induced photodamage. This study was designed to determine whether ultraviolet reflectance photography could quantify the clinical effects of erbium:YAG laser resurfacing on photoaged skin. METHODS: Twenty patients (ages 46-67) with moderate to severe photodamage underwent dual-mode variable pulsed erbium:YAG laser facial resurfacing. Pretreatment and post-treatment evaluations at 3 and 6 months were performed clinically and photographically with white and ultraviolet reflectance photography. RESULTS: Image conversion of the ultraviolet reflectance imaging data demonstrated an average of 36% and 42% reduction in photodamage at 3 and 6 months, respectively. This correlated well with the wrinkle reduction and correction of dyspigmentation observed in all patients following laser resurfacing. Histologic examination confirmed a thicker, more orderly epidermis and dermal collagen remodeling after treatment. CONCLUSION: Reduction in photodamage using the dual-mode variable pulsed erbium:YAG laser can be quantitatively measured with ultraviolet reflectance photography using digital imaging. This model should prove useful in developing treatment regimens for photodamage.

Journal Article↗

Assessment of the dark-adaptation time required for recovery of electroretinographic responses in dogs after fundus photography and indirect ophthalmoscopy.

OBJECTIVE: To investigate the duration of dark-adaptation time required for recovery of electroretinographic responses after fundus photography or indirect ophthalmoscopy in dogs. ANIMALS: 6 dogs. PROCEDURE: Initially, scotopic-intensity series of electroretinograms (ERGs) were recorded after 20 minutes of dark adaptation. The fundus of the left eye of each dog was photographed (n = 10) or examined via indirect ophthalmoscopy for 5 minutes with moderate- (117 candela [cd]/m2) or bright-intensity (1,693 cd/m2) light; ERGs were repeated after a further 20 or 60 minutes of dark adaptation (6 procedures/dog). RESULTS: Following 20 minutes of dark adaptation after fundus photography, the b- and a-wave amplitudes were reduced in response to brighter stimuli, compared with pretest ERGs; after 60 minutes of dark adaptation, ERG amplitudes had recovered. Following 20 minutes of dark adaptation after indirect ophthalmoscopy (moderate-intensity light), significantly lower b-wave amplitudes were recorded in response to 2 of the brighter flash stimuli, compared with pretest ERGs; after 60 minutes of dark adaptation, ERG amplitudes had recovered. Following 20 minutes of dark adaptation after indirect ophthalmoscopy (bright-intensity light), all ERG amplitudes were significantly decreased and implicit times were significantly decreased at several flash intensities, compared with pretest ERGs; after 60 minutes of dark adaptation, ERG amplitudes and implicit times had returned to initial values, except for b-wave amplitudes recorded in response to dimmer stimuli. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that at least 60 minutes of dark adaptation should be allowed before ERGs are performed in dogs after fundus photography or indirect ophthalmoscopy.

Adaptation, Ocular↗

[Diagnostic references in optic nerve diseases using retinal nerve fiber photography].

Two patients with optic nerve disease are reported. The first patient was 20 years old and had suffered a closed head injury 1 year earlier. She presented with an incongruous right hemianopsia; retinal nerve fiber layer photography disclosed an infragenicular lesion and descending atrophy of the medial postchiasmal parts of the optic tract. The second patients was 24 years old. He had had depressed visual acuity in his right eye for 7 h before presentation. Perimetry showed a quadrant anopsia of the lower nasal field. The diagnosis made on the basis of fluorescein-angiography was recurrent retinochorioiditis with acute occlusion of an arterial branch. Retinal nerve fiber layer photography in this early stage showed a more pronounced nerve fiber pattern in the area normally supplied by the occluded artery, most probably caused by axoplasmic edema; along the course nerve fibers showed ascending atrophy in this circumscribed area. In both cases papillometry had given no evidence of any alteration in the area of the neuroretinal rim. In contrast to glaucomatous optic atrophy, localized disturbances of perfusion apparently cannot be detected by examination of the area of the neuroretinal rim of the optic nerve. In nonglaucomatous optic nerve diseases retinal nerve fiber layer photography is more informative.

Adult↗

Ultrasonographic biomicroscopy, Scheimpflug photography, and novel provocative tests in contralateral eyes of Chinese patients initially seen with acute angle closure.

OBJECTIVES: To compare ocular biometry of the contralateral eyes of individuals seen with acute angle closure (AAC) with eyes of population-based control subjects, and to assess novel provocative tests to study the mechanism of AAC. DESIGN: Prospective case-control study. PARTICIPANTS: Chinese persons seen as incident cases of AAC and Chinese population-based controls. METHODS: Slitlamp assessment, ultrasonographic biomicroscopy, Scheimpflug photography, and provocative testing were performed. MAIN OUTCOME MEASURES: Ocular biometric parameters including anterior chamber depth, limbal anterior chamber depth, axial length, lens thickness, and radius of corneal curvature were obtained. Ultrasonographic biomicroscopy parameters that include the angle-opening distance at 500 micro m and the angle-recess area were noted. Scheimpflug photography produced a single measure of angle width. RESULTS: Contralateral eyes of cases of AAC had shorter axial lengths, shallower anterior chamber depths, thicker lenses, and steeper radii of corneal curvature (P<.01). After adjusting for age and sex, cases had a mean adjusted axial length that was 1.2 mm shorter, an optical anterior chamber depth that was 0.63 mm shallower (24% shallower than controls), and lenses that were, on average, 0.35 mm thicker (P<.01). Furthermore, using multiple logistic regression to adjust for age and sex, patients with primary angle-closure glaucoma were 19 times as likely to have a shallower limbal anterior chamber depth (25%; 95% confidence interval, 8.3-45.2). Adjusting for age and sex, the mean angle-opening distance at 500 microm was 0.14 U less for cases, with a mean of 0.26 U in controls, making the angle-opening distance at 500 microm, on average, 54% less among cases. Scheimpflug photographs revealed an adjusted angle width of 21.6 degrees for controls and 15.1 degrees for cases (P<.05). Dynamic testing showed that the angle of control eyes tended to shallow less when going from light to dark and tended to open more when given 1 drop of pilocarpine hydrochloride. CONCLUSIONS: Contralateral eyes of individuals having an AAC attack tend to be shorter and have more crowded anterior segments than those of healthy controls. These static measures of ocular biometry indicate why some individuals are predisposed to AAC. Dynamic measures of the response to luminance changes and pilocarpine therapy indicate that differential reactions to these stimuli are also associated with an AAC attack.

Acute Disease↗

Monochromatic fundus photography of human albinos.

The clinical diagnosis of albinism can often be uncertain, particularly when one is confronted with blond patients with congenital nystagmus. Monochromatic fundus photography was carried out on 31 patients with congenital nystagmus to examine three retinal features: the macular pigment, foveal vasculature, and the retinal pigment epithelium. All subjects who were later classified as albinos did not exhibit any signs of macular pigmentation. Our results imply that monochromatic fundus photography can be a useful aid in the diagnosis of albinism.

Albinism↗

Color photography vs fluorescein angiography in the detection of diabetic retinopathy in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group.

During eligibility screening for the Diabetes Control and Complications Trial, we compared stereoscopic color fundus photography and stereoscopic fluorescein angiography in the detection of diabetic retinopathy in 320 patients (mean age, 24 years [SD, eight years]) with insulin-dependent diabetes (mean duration, 7.0 years [SD, 4.0 years]) and no or mild diabetic retinopathy. Of 153 patients classified as having no retinopathy according to color photographs of seven standard 30 degrees fields of both eyes, 21% of the patients had evidence of retinopathy (mostly one or two microaneurysms in one eye) on review of fluorescein angiograms, including two standard 30 degrees fields in each eye. Of those patients with no retinopathy detected on angiograms, 19% had retinopathy on review of color photographs. When used in conjunction with color photography, angiography allows a modest increase in sensitivity to the earliest signs of retinopathy, a gain potentially useful in some research applications, although not of demonstrated value in patient management.

Adolescent↗