Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “PHOSPHORUS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources

Milk production, reproductive performance, and fecal excretion of phosphorus by dairy cows fed three amounts of phosphorus.

Milk production was measured and phosphorus (P) excretion in feces was estimated in dairy cows fed three amounts of P. A basal diet was formulated to contain 0.31% P (DM basis). Sodium monophosphate replaced corn in the basal diet to give two additional diets containing 0.40 and 0.49% P. The diets were fed to eight, nine, and nine multiparous Holsteins from the beginning to the end of lactation. Milk yields for the 308-d lactation were 10,790, 11,226, and 11,134 kg for the three treatments, respectively. The lowest milk yield resulted from decreased milk production during late lactation with the 0.31% P group. Reproductive performance of the cows was not related to dietary P content. Fecal P concentration, determined in wk 2, 4, 6, 8, 23, and 40 of lactation, increased as dietary P intake was increased. Cows fed the lowest P diet conserved P by minimizing P excretion in feces and urine, whereas cows in the other two treatments excreted more P through these routes. A reduction in dietary P from 0.49 to 0.40% reduced fecal P excretion by 23%. Apparent P digestibilities of less than 40% are indicative of surplus dietary P. Feeding 0.40% P appeared sufficient to maintain P balance and the level of milk production achieved in this experiment. An example is given which illustrates the relationship between dietary and fecal P.

Animals↗

Influence of phosphorus intake on excretion and blood plasma and saliva concentrations of phosphorus in dairy cows.

Phosphorus (P) balance, and blood plasma P and saliva P concentrations were measured in multiparous dairy cows through two lactations and two dry periods. The cows were fed three amounts of P at either 100, 80 or 67% of the Dutch P recommendation, actually resulting in dietary P concentrations of 3.2 to 3.9, 2.6 to 2.9 and 2.2 to 2.6 g P/kg dry matter during lactation for the three treatments, respectively. On the basis of plasma P values as low as 0.9 mmol/l and saliva P values as low as 5.1 mmol/l during the second lactation period within the experiment, the 67% group was considered to be deficient in P. By decreasing milk production, and thus lowering P losses with milk, P retention in the 67% group remained near zero. The P supply with the 80% ration was considered to be just sufficient. At high milk yield and marginal dietary P concentrations, plasma P and saliva P concentrations were decreased. The higher P intake in high-compared with low-producing cows resulted in a constant absolute fecal P excretion, due to the fact that the apparent P digestibility was raised with increasing milk yield. There was a direct relationship between milk P output and the percentage of apparent P digestibility for individual animals.

Animals↗

Utilization of phosphorus in lactating cows fed varying amounts of phosphorus and forage.

The objective of this study was to determine the effect of dietary forage proportion and P content on fecal P excretion. Four dietary treatments were formed in a 2 x 2 factorial arrangement. The P content was 0.33 or 0.42%, and the forage proportion was 48 or 58% on a dry matter (DM) basis. The neutral detergent fiber content was 27 and 30% for the low and high forage diets, respectively. The P amount was varied by using monosodium phosphate, and the forage amount by changing the proportions of alfalfa silage and corn. The diets were fed to 44 midlactation Holsteins for 14 wk. Fecal P excretion was estimated using Cr marker and grab sampling. Dietary P content did not affect DM intake, milk yield, or milk composition. The P intake averaged 74 and 96 g/d and fecal P averaged 0.69 and 0.92% (DM basis) or 49 and 65 g/d for the low and high P diets, respectively. Thus, reducing dietary P from 0.42 to 0.33% resulted in approximately 25% less estimated fecal P excretion. Increasing dietary forage reduced milk yield (34.0 vs. 36.5 kg/d), but increased milk fat content (3.66 vs. 3.25%). Estimated apparent digestibility of P tended to decrease (31.1 vs. 36.6%) when the forage proportion increased, but most of the change occurred when the diets contained the low amount of P. Overall, the effect of forage proportion on estimated fecal P excretion was small when diets contained 48 or 58% forage, varied by alfalfa silage. Phosphorus intake has a much larger impact on fecal P excretion than forage proportion, and it does not seem necessary to adjust the dietary P content according to the forage proportion to provide the same amount of absorbed P.

Animals↗

Efficiency of use of imported nitrogen, phosphorus, and potassium and potential for reducing phosphorus imports on Idaho dairy farms.

Eight commercial dairies from south central Idaho were surveyed to estimate the whole-farm surpluses of N, P, and K and to investigate the possibility of reducing P excretions through dietary manipulation. Nitrogen, P, and K imports and exports were monitored in a 12-mo period, and samples from the diets, feeds, feces, urine, and manure were collected at regular farm visits. Soils from manure-amended fields were sampled in the spring and fall. In all cases, the largest import of N, P, and K to the dairy was with purchased feeds. Major nutrient export items were milk and manure and forages, in the case of a dairy with a large land base (dairy F). Whole-farm N surplus varied from 90 to 599 t/yr (91 to 222 kg/yr per cow). The efficiency of use of imported N varied from 25 to 64%, with dairy F having the greatest efficiency of imported N use. Phosphorus and K surpluses were also significant (average of 29 and 182 t/yr and 12 and 76 kg per cow per year, respectively). During the study period, dairy F was a net exporter of K. The average efficiency of use of imported P and K was 66 and 58%, respectively. Soil P levels in the 30-cm layer were above state threshold standards, most likely from overapplication of manure. Soil nitrate-N concentrations were also high, but K concentrations were within the accepted range. Average P content of the lactating cow diets at the start of the study was 0.49% and was reduced to 0.38%. The estimated reduction in imported P due to the reduced dietary P levels was from 5.7 to 61.4 t/yr per farm, or on average 12 kg per cow per year. This study demonstrated that in addition to exports with milk and manure, export of nutrients with forages produced on the farm (dairy F) is a major factor in reducing whole-farm N, P, and K surpluses.

Animal Feed↗

Soil and litter phosphorus-31 nuclear magnetic resonance spectroscopy: extractants, metals, and phosphorus relaxation times.

Phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy is an excellent tool with which to study soil organic P, allowing quantitative, comparative analysis of P forms. However, for 31P NMR to be tative, all peaks must be completely visible, and in their correct relative proportions. There must be no line broadening, and adequate delay times must be used to avoid saturation of peaks. The objective of this study was to examine the effects of extractants on delay times and peak saturation. Two samples (a forest litter and a mineral soil sample) and three extractants (0.25 M NaOH, NaOH plus Chelex (Bio-Rad Laboratories, Hercules, CA), and NaOH plus EDTA) were used to determine the differences in the concentration of P and cations solubilized by each extractant, and to measure spin-lattice (T1) relaxation times of P peaks in each extract. For both soil and litter, NaOH-Chelex extracted the lowest concentrations of P. For the litter sample, T1 values were short for all extractants due to the high Fe concentration remaining after extraction. For the soil sample, there were noticeable differences among the extractants. The NaOH-Chelex sample had less Fe and Mn remaining in solution after extraction than the other extractants, and the longest delay times used in the study, 6.4 s, were not long enough for quantitative analysis. Delay times of 1.5 to 2 s for the NaOH and NaOH-EDTA were adequate. Line broadening was highest in the NaOH extracts, which had the highest concentration of Fe. On the basis of these results, recommendations for future analyses of soil and litter samples by solution 31P NMR spectroscopy include: careful selection of an extractant; measurement of paramagnetic ions extracted with P; use of appropriate delay times and the minimum number of scans; and measurement of T1 values whenever possible.

Caustics↗

Effects of moderate dietary phosphorus restriction on intestinal absorption and external balances of phosphorus and calcium in growing female rabbits.

The effects of moderate dietary P restriction on intestinal net fluxes and external balances of P and Ca were studied in growing female albino rabbits that were fed a P-deficient diet for 10 consecutive days while they were housed in metabolism cages. Intestinal P secretion occurred during the first 24 h of P restriction and thereafter changed to absorption. During recovery, when the rabbits were consuming a normal diet, P absorption was significantly greater than either prerestriction control values or than in a separate group of time control rabbits. Phosphorus balance was negative during the 1st day of P restriction but thereafter became positive. This pattern occurred because intestinal P secretion changed to absorption and because urinary losses of P were negligible. Intestinal Ca absorption increased within 24 h of P restriction, reached maximal values by 4 days, and remained elevated for each of the remaining 6 days that dietary P was low. It also was elevated compared to P-sufficient time controls for 8 days after replenishment of dietary P. Despite increased intestinal absorption, Ca balance was significantly reduced during P restriction because of substantial hypercalciuria. Thus, selective dietary P restriction reduced the positive balances of both P and Ca that are characteristic of growth. We conclude that in growing rabbits moderate dietary P restriction induces both intestinal and renal adaptations that conserve this mineral; concomitantly, positive Ca balance is reduced. With dietary P replenishment, adaptations persist to restore the positive mineral balances that were lost because of dietary P restriction during growth.

Animals↗

Lung function in workers refining phosphorus rock to obtain elementary phosphorus.

Elevated levels of phosphoric acid, phosphorus pentoxide, fluorides and coal tar pitch volatiles were present in workplace air of a two-oven industrial refinery. One hundred thirty-one workers prospectively underwent annual pulmonary function testing (forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow). Regression of these spirometric data, analyzed longitudinally over 3 to 7 years and also cross-sectionally reveals no residual significant effect of industrial exposure after adjusting for the effect of age and smoking. This industrial exposure contributes only weakly and inconsistently to the well-documented reduction of spirometric lung function that occurs from smoking alone. No significant reductions of spirometry occurred in exposed nonsmokers or former smokers.

Adult↗

Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats.

To determine the parathyroid hormone (PTH) action on kidney and bone by high phosphorus (P) diet, this study investigated PTH/PTH-related peptide (PTHrP) receptor mRNA expression in 6-week-old parathyroidectomized (PTX) rats received constant amount of PTH. To maintain serum PTH levels equally to sham operated rats, PTX rats were constantly exposed to rPTH (1-34) and fed a control diet (0.3% P) and a high P diet (1.2% P) for 7 days, respectively. There were no significant differences in serum PTH (1-34) concentration in rats fed the control diet. In sham groups, serum PTH concentrations, both (1-84) and (1-34) fragments, were increased in rats fed the high P diet than in rats fed the control diet. Urinary excretions of P and C-terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. PTH/PTHrP receptor mRNA expression in kidney and femur was not changed in both PTX and sham rats by the high P diet. In conclusion, high P diet did not change PTH action in PTX rats and increased urinary excretion of P and bone resorption regardless of PTH action.

Animals↗

Nutrient recycling by two phosphorus-rich grazing catfish: the potential for phosphorus-limitation of fish growth.

In ecosystems where excretion by fish is a major flux of nutrients, the nitrogen (N) to phosphorus (P) ratio released by fish can be important in shaping patterns of algal biomass, community composition, primary production, and nutrient limitation. Demand for N and P as well as energy influences N/P excretion ratios and has broad implications in ecosystems where nutrient recycling by fishes is substantial. Bioenergetics and stoichiometric models predict that natural fish populations are generally energy-limited and therefore N/P recycling by fishes is relatively invariant. Yet, the potential for P limitation of growth has not been examined in herbivorous fishes, which are common in many aquatic habitats. We examined N/P excretion ratios and P demand in two P-rich herbivorous catfishes of the family Loricariidae, Ancistrus triradiatus (hereafter Ancistrus) and Chaetostoma milesi (hereafter Chaetostoma). Both fishes are common grazers in the Andean piedmont region of Venezuela where we conducted this study. Mass balance (MB) models indicate that these fishes have a high P demand. In fact, our Ancistrus' P MB model predicted negative P excretion rates, indicating that Ancistrus did not consume enough P to meet its P demand for growth. Direct measurement of excretion rates showed positive, but very low P excretion rates and high N/P excretion ratios for both taxa. To obtain measured P excretion rates of Ancistrus from the MB model, gross growth efficiency must be reduced by 90%. Our results suggest that growth rates of both of these herbivorous and P-rich fish are likely P-limited. If P limitation of growth is common among herbivorous fish populations, herbivorous fishes recycle likely at high N/P ratios and act to diminish the quality of their food.

Animals↗

Rainfall intensity and phosphorus source effects on phosphorus transport in surface runoff from soil trays.

Phosphorus runoff from agricultural fields amended with mineral fertilizers and manures has been linked to freshwater eutrophication. A rainfall simulation study was conducted to evaluate the effects of different rainfall intensities and P sources differing in water soluble P (WSP) concentration on P transport in runoff from soil trays packed with a Berks loam and grassed with annual ryegrass (Lolium multiflorum Lam.). Triple superphosphate (TSP; 79% WSP), low-grade super single phosphate (LGSSP; 50% WSP), North Carolina rock phosphate (NCRP; 0.5% WSP) and swine manure (SM; 70% WSP), were broadcast (100 kg total P ha-1) and rainfall applied at 25, 50 and 75 mm h-1 1, 7, 21, and 56 days after P source application. The concentration of dissolved reactive (DRP), particulate (PP), and total P (TP) was significantly (P<0.01) greater in runoff with a rainfall intensity of 75 than 25 mm h-1 for all P sources. Further, runoff DRP increased as P source WSP increased, with runoff from a 50 mm h-1 rain 1 day after source application having a DRP concentration of 0.25 mg L-1 for NCRP and 28.21 mg L-1 for TSP. In contrast, the proportion of runoff TP as PP was greater with low (39% PP for NCRP) than high WSP sources (4% PP for TSP) averaged for all rainfall intensities. The increased PP transport is attributed to the detachment and transport of undissolved P source particles during runoff. These results show that P source water solubility and rainfall intensity can influence P transport in runoff, which is important in evaluating the long-term risks of P source application on P transport in surface runoff.

Fertilizers↗

Soil phosphorus quantity-intensity relationships to predict increased soil phosphorus loss to overland and subsurface flow.

Soil phosphorus (P) quantity-intensity (q-i) relationships, based on common extraction methods, may potentially be used to estimate the risk of P loss in overland flow and subsurface drainage water. Some workers have used nonlinear q-i relationships to derive thresholds in soil test P (STP; a quantity factor) above which the risk of P loss increases, while others find linear relationships and no threshold. We present here a simple modelling exercise (based on Langmuir adsorption theory) along with data from literature to explain the behaviour of q-i relationships, and to give an explanation for this apparent discrepancy. The data indicate that q-i relationships are dependent upon the soil to solution ratio of the P intensity parameter, adsorption capacity (Qmax) and strength (K) of the soil, and the total range in STP. In turn, this affects the calculation of a threshold in STP. The q-i relationship tends towards linearity under conditions of a narrow total range of STP and/or when using a wide soil to solution ratio for estimating the P intensity parameter. Under such conditions, a threshold is difficult to detect, and uncertain. We conclude that the sensitivity of thresholds to experimental conditions and soils needs to be considered if thresholds are to be successful in environmental management to decrease P loss to surface waters.

Phosphorus↗

Phospholipids chiral at phosphorus. Characterization of the sub-gel phase of thiophosphatidylcholines by use of X-ray diffraction, phosphorus-31 nuclear magnetic resonance, and Fourier transform infrared spectroscopy.

A recent study using differential scanning calorimetry (DSC) showed that the thermotropic phase behavior of 1,2-dipalmitoyl-sn-glycero-3-thiophosphocholine (DPPsC) is sensitive to the configuration at phosphorus and that the Rp isomer displayed only a broad transition at 45.6 degrees C [Wisner, D. A., Rosario-Jansen, T., & Tsai, M.-D. (1986) J. Am. Chem. Soc. 108, 8064-8068]. We have employed X-ray diffraction, 31P NMR, and Fourier transform infrared (FT-IR) spectroscopy to characterize various phases of the isomers of DPPsC, to compare the structural differences between 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and isomers of DPPsC, and to identify structural factors responsible for the unique behavior of the RP isomer. The results from all three techniques support the previous proposal based on DSC studies that (SP)- and (RP + SP)-DPPsC undergo a subtransition, a pretransition, and a main transition analogous to those of DPPC, while (RP)-DPPsC is quite stable at the subgel phase and undergoes a direct subgel----liquid-crystalline transition at 46 degrees C. Quantitative differences between DPPC and DPPsC (i.e., the effect of sulfur substitution rather than the configurational effect) in the subgel phase have also been observed in the chain spacing, the motional averaging, and the factor group splitting (revealed by X-ray diffraction, 31P NMR, and FT-IR, respectively). In particular, DPPsC isomers are motionally rigid and show enhanced factor group splitting in the subgel phase. These results suggest that DPPsC is packed in different subcells relative to DPPC in the subgel phase.(ABSTRACT TRUNCATED AT 250 WORDS)

Calorimetry, Differential Scanning↗

Applicability of the phosphorus-31 (oxygen-17) nuclear magnetic resonance method in the study of enzyme mechanism involving phosphorus.

The phosphorus-31 (oxygen-17) [31P (17O)] NMR method [Tsai, M.-D. (1979) Biochemistry 18, 1448-1472] is tested for its general applicability by correlation with the line widths of the 17O NMR signals for the following compounds: trimethyl [17O4]phosphate (1), [17O4]phosphate (2), [alpha-17O2]adenosine 5'-(thiophosphate) (3), [alpha-17O, alpha beta-17O]-adenosine 5'-(1-thiotriphosphate) (4) [gamma-17O3]adenosine 5'-triphosphate (5), [alpha beta, beta gamma-17O2, beta-17O2]adenosine 5'-triphosphate (6), magnesium [gamma-17O3]adenosine 5'-triphosphate (7), and magnesium [alpha beta, beta gamma-17O2, beta-17O2]adenosine 5'-triphosphate (8). It is found that the line broadening effect of 17O on the 31P signals of the directly bonded 31P nuclei is present for all the functional groups in the above compounds which include examples of small 17O line widths (1 and 2), of intermediate 17O line widths (3, 5, and the nonbridge 17O of 4 and 6), and of very large 17O line widths (7, 8, and the bridge 17O of 4 and 6). On the basis of the established approximate relationship delta chi delta Q approximately aJ2, where delta chi and delta Q are the 31P and 17O line widths, respectively, of the 31P-17O groups, alpha is a constant, and J is the 31P-17O coupling constant, the results suggest that for most of the phosphate derivatives of biochemical interest, the line broadening effect of 17O should be present and detectable; i.e., delta chi should be larger than the limiting value (approximately 20 Hz). It is also found that Mg2+ causes the 17O signal of 5 and 6 to broaden (delta Q increases), which in turn causes the 31P signal to sharpen (delta chi decreases). The finding suggests that the 31P (17O) NMR methods, in combination with 17O NMR, could become a tool to study diamagnetic metal ion-nucleotide interactions.

Adenosine Triphosphate↗

Calcium and phosphorus requirements of the ewe during pregnancy and lactation. 2. Phosphorus.

Mineral balance and radioisotope studies have been carried out to test the adequacy of the recent Agricultural Research Council (1980) recommendations for calcium and phosphorus for pregnant and lactating ewes. At the same time, P metabolism was compared throughout pregnancy and lactation in ewes fed according to these recommendations and in ewes fed a plentiful supply of dietary Ca and P. Bone mineral stores were mobilized in late pregnancy and early lactation, irrespective of the rate of P absorption. These stores were then replaced in mid- to late lactation in ewes given the plentiful Ca and P intake but not in the ewes given the restricted intake. Results suggest that these changes in bone stores occurred as a result of changes in Ca requirements rather than in P requirements, and that accretion of P into bone or resorption of P from bone occurred merely as a consequence of this change in Ca requirements. Immediate demands for P for maintenance and fetal or milk production do not reflect net P demands, which also take into account changes in bone P metabolism. The rate of P absorption was directly related to net demands and the rate of endogenous excretion was inversely related to net demands. Absorption and endogenous faecal loss of P were also both directly related to P intake. A lack of dietary Ca, particularly in mid- to late lactation, makes it impossible to draw conclusions on the adequacy of the Agricultural Research Council (1980) recommendations for P. Results do suggest, however, that P requirements ought to be calculated according to net demands for P rather than immediate demands.

Animals↗

[The phosphorus supply of swine between 11 and 38 kg. live weight. 2. The phosphorus, calcium and ash deposit in skeletal and soft tissue homogenates during P deprivation and during the use of two different phosphate feedings and different ration conditions].

The influence of phosphorus (P) supply on the content of ash, P and Ca of the skeleton and soft tissue as well on the P deposition in the empty body of pigs (approximately 35 kg live weight) was studied in 3 individual feeding experiments with different diets (P-content 2.97, 2.41 or 3.7 g/kg diet). In each experiment 2 of the 3 groups (7 or 8 animals per group, initial weight approximately 11 kg) were supplemented with the feed grade phosphates "Rükana" or "Cefkaphos". In the experiments the supplemented amount of P as "Rükana" or "Cefkaphos" was 2.50, 2.33 or 0.5 g/kg of the diet. After intake of approximately 65 kg of the diet the animals were slaughtered. Homogenates of bones and soft tissues of the left half of the empty body were analysed for ash, P and Ca. Both of the feed grade phosphates increased these parameters in the skeleton and soft tissues as well the P deposition in the body to the same level. In the middle of the experiments the P deposition per kg live weight gain amounted to 4.6 g ("Rükana") and 4.4 g ("Cefkaphos").

Animal Feed↗

Inevitable losses of phosphorus in pigs, estimated from balance data using diets deficient in phosphorus.

Faecal losses of phosphorus (P) were determined in 66 growing pigs weighing between 30 and 70 kg on a semi-purified diet containing less than 1.3 g P/kg DM. Regression analysis showed that the coefficient of absorption of P from this diet was 82.5% and that inevitable faecal P excretion of pigs fed this diet was, on average, 5.9 mg/kg BW.d-1 with no statistically significant effect of body weight on faecal P excretion within the range of body weight studied. Semi-purified diets almost identical in composition were also fed to 5 piglets weighing about 20 kg and to 4 heavy pigs of about 150 kg BW. Inevitable daily faecal losses of P were calculated to be 6.2 mg/kg BW in piglets and 6.8 mg/kg BW in the heavy pigs. It is concluded that inevitable faecal losses of P do depend on body weight and that the variation faecal P excretion was too great to allow detecting this effect within the limited range between 30 and 70 kg BW. Further diets were obtained by blending various ingredients into the semi-purified diet. From a total of 262 balances measured under the condition of suboptimal P supply it is concluded that daily inevitable urinary losses of P depend on body weight and, on average, amount to 0.35 mg/kg BW. It is concluded that under the conditions of suboptimal P supply the utilisation of digestible P is almost complete.

Animal Feed↗

Effect of dietary protein and phosphorus levels on calcium and phosphorus metabolism of the young, fast growing rat.

Utilizing a 2 X 2 factorial design, male weanling rats were fed diets containing either 25% or 45% casein with 0.35% or 0.8% phosphorus (P). Dietary calcium (Ca) was set at 0.9% for each diet. During the 7 weeks of this experiment, food intakes and body weights were measured weekly; urine and fecal samples were collected daily. Regardless of dietary P level, increasing dietary protein resulted in significantly decreased fecal Ca output accompanied by an increase in the Ca content of urine. Increasing dietary P resulted in significantly increased fecal Ca content, decreased absolute and percent Ca absorption, and decreased urinary Ca output. Increased fecal and urinary P excretion were obtained when dietary P levels were increased. Increasing dietary protein at the 0.35% P level slightly increased the values for absolute and percent Ca and P absorption. However, when 0.8% P was fed, increasing the protein level of the diet decreased these Ca (weeks 1-5) and P absorption values. Ca and P balances were positive at all times.

Absorption↗

Dietary protein and phosphorus: effect on calcium and phosphorus metabolism in bone, blood and muscle of the rat.

Four- or 12-week-old rats were fed diets containing either 25 or 45% casein and either 0.35 or 0.8% phosphorus (P) for 7 weeks. Calcium (Ca) level of each diet was 0.9%. In the young, fast-growing rat (expt 1), plasma P was increased (P less than 0.01) when 0.8%, rather than 0.35%, P was fed. In the more mature rats (expt 2), increased dietary P depressed Ca in plasma but elevated P; high protein intake elevated whole-blood Ca, but depressed plasma P. Dietary treatment had little effect on muscle of mature rats, but wet weight and total P content of muscle were higher in young rats fed 0.8%, rather than 0.35%, P. Femur dry weight and P concentration were greater when 0.8%, rather than 0.35%, P was fed to young rats; dietary P did not affect any other parameter of bone (expt 1, 2). Excessive protein intake elevated femur P concentration in young rats, but depressed length and strength of femurs in mature rats. Some parameters of bone, blood and muscle can be influenced by dietary levels of protein and P. The response, however, is dependent on the physical maturity of the rat when dietary treatment begins.

Animals↗