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[Systematic and local reactions during phlebography of the leg with special reference to postphlebographic complications. Randomized, prospective, intraindividual double-blind study of iopamidol and ioxithalamate (250 mg I/ml) using the 125I-fibrinogen test: II].

The rate of positive 125I-fibrinogen accumulations after typical ascending phlebography was significantly less (9/40 = 23%) with iopamidol compared with ioxithalamate (16/40 = 40%). The iodine content of the contrast media used in this intraindividual study (40 patients) was 250 mg/ml. With the 125I-fibrinogen uptake accepted as a method of reference, the clinically observed postphlebographic symptoms of thrombophlebitis were false positive in 1/6 and false negative in 3/4 of the cases. These incidences were registered for both contrast media. With the lowered iodine content (250 mg/ml), too, pain reactions were seen in approx. 50% during the injection of the ionic agent, but in none of the cases using the non-ionic agent. Not one of the commercial contrast media can be regarded as "ideal" at this time. Nevertheless, it can be concluded, that non-ionic contrast media with iodine content of 250 mg/ml are highly effective in preventing acute and delayed reactions. Moreover, this concentration seems to be adequate for optimal imaging in phlebography.

Clinical Trials as Topic↗

A comparative trial of the diagnostic quality of and tolerance for two concentrations of ioxaglate when used for phlebography.

We report a prospective, randomised, double blind study comparing the diagnostic quality of and tolerance for ascending phlebography in 100 patients using two different concentrations of ioxaglate, 320 mg/ml and 200 mg/ml. The immediate and delayed side effects were minimal in both groups and the difference between the two concentrations was not statistically significant. All the phlebograms were of diagnostic quality. We conclude that, with its lower osmolality, lower viscosity and lower cost, ioxaglate 200 mg/ml is a suitable medium for routine use in ascending phlebography of lower limbs.

Adolescent↗

Side-effects at phlebography with ionized and non-ionized contrast medium.

In two studies 267 consecutive patients with suspected venous thrombosis were examined 125I-fibrinogen uptake test at phebography. In 161 patients meglumine metrizoate (Isopaque Cerebral) and in 106 patients metrizamide (Amipaque) was used as contrast medium. The quality of the examinations was equal in the two groups. During the examinations most of the patients examined with meglumine metrizoate had symptoms from the calf described as a cramp-like pain. Only few of the patients examined with metrizamide had such symptoms. In the two groups 47 patients examined with meglumine metrizoate and 41 examined with metrizamide had normal phlebography as well as initially normal 125I-fibrinogen uptake test. After phlebography, 29 of the patients in the first group had a significant rise in fibrinogen uptake while such a rise was not found in patients from the second group. Rephlebography showed fresh deep vein thrombosis in 7 out of 9 patients examined with meglumine metrizoate indicating that thrombosis could be provoked in as many as about half the patients with this high osmolar contrast medium. We have now used metrizamide in about 400 patients without any side-effects.

Humans↗

Thrombosis after phlebography?

In contrast to the report by Albrechtsson, we have never seen clinically manifest thrombosis in more than 20,000 phlebographies; only small, clinically insignificant thrombi in a very few cases. The reason is because we have used only 40 cm3 of a 45% contrast medium in connection with heparin precaution. However, there is the possibility that the deep venous valves are damaged. Therefore Amipaque is important for the phlebography. Our test, 20 cm3 45% conventional contrast medium injected directly into varicose veins, always gives a venous thrombosis of about 20 cm. The same amount of Amipaque has never shown a reaction.

Diatrizoate↗

[Quality criteria of phlebography examination methods. Technically conditioned possibilities of error prediction (author's transl)].

The article describes the technical and anatomical limitations of information supplied by phlebography. Injection of contrast medium into the v. mediana hallucis enables optimal contrast medium distribution. The more proximal the site of injection, the greater the uncertainty of achieving continuous filling of the deep veins with contrast medium. Obstructions during compression (ulcer, oedema) may prove an obstacle to the assessment of insufficient v. perforantes due to overfilling of superficial veins with contrast medium. Even without any abnormal finding it is not possible to stain muscle veins and the v. femoris profunda in about 50% of the examinations. Muscular traction can result in deformation of mainly the v. poplitea and hence results in discontinuous filling with contrast medium if the musculature is not properly relaxed. The veins of the thigh and pelvis must be stained with high contrast in a continuous manner, since otherwise occlusions and collaterals are overlooked in an otherwise normal distal phlebogram. Valve motility can be assessed without additional examination measures directly after ascending phlebography during recumbency of the patient.

Contrast Media↗

[Roentgen diagnosis of the veins in the upper half of the body using the digital subtraction technic - digital subtraction phlebography].

Digital subtraction phlebography (DSP) is suitable for x-ray examinations of the shoulder veins and the veins of the upper mediastinum. Acute thromboses, post-thrombotic syndromes, malformations and collateral systems can be demonstrated. The main advantages of DSP over conventional phlebography are the possibility of using contrast medium solutions of low osmolarity enabling pain-free examinations not involving the risk of thromboses, the saving in the amount of contrast medium, and the reduction of examination time.

Adolescent↗

Phlebography. Survey and present state.

Milestones in the history of phlebography are shortly reviewed. The present state of phlebography with emphasis upon the role of the new non-ionic contrast media is presented.

Clinical Trials as Topic↗

Iohexol in phlebography of the leg. A comparative investigation with meglumine metrizoate.

Comparing iohexol 240 mg I/ml, iohexol 300 mg I/ml and meglumine-Ca metrizoate 200 mg I/ml in phlebography of the leg in patients on or without anticoagulants, no sign of post-phlebographic thrombosis was found using the 125I-fibrinogen uptake test and repeat phlebography. More adverse reactions occurred with metrizoate than with iohexol. Metrizoate provided significantly poorer demonstration than the two iohexol concentrations with higher iodine content.

Adult↗

[Comparative hemodynamic evaluations of varicocele by bidirectional ultrasonic Doppler sonography and phlebography of the internal spermatic vein].

Clinical studies (degree of severity) and bidirectional ultrasonic Doppler sonography (Pressure-type, Shunt-type) of varicocele were compared with the phlebography of the internal spermatic vein (degree of spermatic incompetence, diameter of the int. spermatic v.). Doppler probe and phlebography are equivalent methods to demonstrate the venous reflux in palpable varicocele and for follow-up examination after sclerotherapy. The subclinical varicocele is discussed. The slight degree of spermatic incompetence (reflux by Valsalva's manoeuvre) is responsible for the small varicocele (grade I) and the Pressure-type. The severe degree of spermatic incompetence (spontaneous reflux) causes the Shunt-type and the large varicocele (grade III) as well as a dilatation of the internal spermatic vein.

Hemodynamics↗

Preoperative 'dynamic' antegrade phlebography of the spermatic vein: physiological detection of spontaneous reflux in clinical and subclinical varicocele. A study of 142 patients.

From March 1977 to December 1982, 142 patients with varicocele of various sizes underwent preoperative antegrade or retrograde phlebography of the left spermatic vein. In 8 of them both procedures were carried out. A retrospective analysis of 68 preoperative antegrade venographies in supine (0 degree) and upright (30 degrees, 45 degrees and 90 degrees) positions was made and compared with 66 retrograde venograms. The preoperative 'dynamic' antegrade phlebography has been performed in order to study the hemodynamic conditions of the varicocele, avoiding any pressure interference on the valvular function of the venous renospermatic area. This technique has allowed us to get useful anatomoradiological and physiopathological information about the spontaneous reflux into the internal spermatic vein by its positional filling and emptying. It has also permitted a good visualization of collateral channels, particularly in the pelvic, femorosaphenous and scrotal areas. We could, at the same time, simultaneously sample blood from the cubital and intrascrotal spermatic veins to determine the testosterone, cortisol and serotonin levels, in different positions; the evaluation of these biochemical data is being pursued. In our opinion, this diagnostic procedure is easy to perform and inexpensive. The procedure and the results are discussed in detail.

Adolescent↗

Double blind comparison between iohexol and metrizoate in phlebography of the lower limb.

A new, non-ionic low osmolar contrast medium, iohexol 240 mg I/ml, has been tested in a randomized double blind parallel investigation versus meglumine-Ca metrizoate 200 mg I/ml. The study was performed to evaluate the suitability of the contrast medium in phlebography. No post-phlebographic complications were seen in the 24 patients examined with iohexol 240 mg I/ml or in 8 patients examined with iohexol 300 mg I/ml. In the 19 patients examined with metrizoate 200 mg I/ml, 7 had a post-phlebographic thrombotic complication (37%). The radiographic image quality was not significantly different between the two contrast media, neither were the immediate side effects during contrast injections. It has thus been shown that iohexol is a suitable contrast medium in phlebography of the lower limb and that it is preferable to conventional contrast media.

Adult↗

[Phlebography of the upper extremity: assessment of various x-ray signs].

The article reports on the findings obtained in 56 serial phlebographies of the upper extremity. Using 17 phlebographies without pathological findings as basis, the physiological phenomena of venous contrasting in the region of the shoulder and arm are examined. The remaining phlebograms with pathological findings are assessed according to different criteria, such as localisation and extent of venous vascular occlusion, visualisation of vascular clot and formation of collaterals resulting in collateral circulation.

Arm↗

[Selective phlebography of the thymus gland with pneumomediastinum in patients with myasthenia gravis].

The authors describe the technique of selective phlebography of the thymus under conditions of pneumomediastinum. The investigation of the thymus in 40 patients with myasthenia enabled the authors to conclude that a preliminary administration of gas into the fatty tissue of the anterior mediastinum facilitated catheterization of the thymus veins and favoured a success of selective phlebography, elevated the reliability of differential diagnosis of tumorous and involutional changes of the thymus as well as tumors and portions of a dense fibro-fatty tissue of the anterior mediatinum. The method is characterized by a lower radiation load on the patient and is more economical.

Adolescent↗

Gravity large field phlebography of the limbs.

For the last two decades the most common method of radiographic study of the venous system of the lower limbs has been ascending phlebography, by injection of contrast material in a superficial vein on the dorsum of the foot. We report our own experience with another approach, using a large field technique on recumbent patients, with elevation of the limbs, thus taking advantage of gravity. The contrast injection is usually made in a more distal superficial vein of the foot after a tiny cut-down. Excellent results are consistently obtained in demonstrating all the deep veins, including the iliac vessels. The same principles may be applied to upper limb phlebography.

Arm↗

Intraosseous phlebography following allogenic bone transplantation in young buffalo. An experimental study.

Intraosseous phlebography is described in normal metatarsal bones of young buffalo and in metatarsal bone with surgical defects grafted with fresh or treated allogenic cortical bone. Venous flow across the bone graft was established earlier and more efficiently with fresh or frozen grafts than with autoclaved or merthiolated grafts. Intraosseous flow across a non-grafted defect was observed early but stasis and delayed drainage were observed later. Intraosseous phlebography can be used in the evaluation of bone graft acceptance.

Animals↗

[Phlebography in venous thrombosis of the lower limbs (author's transl)].

Phlebography is the best diagnostic technique for deep venous thromboses of the lower limbs. The authors use the "free flow" technique which they have modified by visualisation of the I. V. C. and I. V. A lacunar appearance or cupola-shaped interruption are indicative of a recent thrombosis, whilst the absence of a main venous trunk and a collateral circulation are more common in the presence of an old thrombosis. They emphasise the possible sources of error in interpretation and the difficulty in determining how long the thrombosis has been present. Despite its disadvantages, phlebography remains the essential examination in order to select treatment in patients in whom there is a suspicion of venous thrombosis or pulmonary embolism. Venous Doppler and rheoplethysmography, less sensitive and less specific, have a place in routine detection and the surveillance of treatment.

Diagnosis, Differential↗

[Orbital phlebography craniobasal meningiomas spreading into the orbit].

Analysis of the results of orbital phlebography performed in 39 patients with cranio-orbital meningiomas testifies to the important diagnostic value of this methods of examination in determining the spread of craniobasal meningiomas to the orbit. By means of orbital phlebography it is possible not only to precisely define the topography of the new growth in the orbital cavity, but to reveal disorders of venous drainage from the orbit and collateral tracts which provide the draining function of the superior ophthalmic vein.

Humans↗

[Complex phlebography of the lower extremities in venous diseases].

An original technique of complex vertical phlebography is described, which permits the examination of the total venous system of the leg under conditions of ortostatic load. The examination includes antegrade probing of the leg venous system through the popliteal vein after Seldinger and catheterization of the subcutaneous vein of the foot. The patient is subjected to the procedure in the vertical position. The technique was used in 54 patients with diseased veins of the legs. The results are described. Its advantages over well-known techniques of distal and proximal phlebography are shown.

Humans↗