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At least 181 records · Page 10Linked to original sources
PubMed1985

Benoxaprofen reduces osteophyte formation and fibrillation after articular cartilage injury.

We examined the in vivo effect of benoxaprofen on the degeneration of articular cartilage after injection of sodium iodoacetate into the guinea pig knee. As shown previously, 3 weeks after the injection, samples from the ipsilateral knee of animals that did not receive benoxaprofen invariably exhibited marked loss of chondrocytes, absence of staining with safranin-O, fibrillation, and prominent osteophytes. In contrast, in samples from animals which received daily benoxaprofen (25 mg/kg) orally after the intraarticular injection of iodoacetate, pericellular safranin-O staining persisted, cell loss was less marked, osteophyte formation was markedly diminished and fibrillation occurred in only one of 5 samples. Knee cartilage from 2 animals that received benoxaprofen but were not injected with iodoacetate exhibited focal fibrillation, which may have been unrelated to the drug. Thus, benoxaprofen exhibited a marked protective effect in this chemically induced model of cartilage injury.

Animals↗
PubMed1984

Exercise increases osteophyte formation and diminishes fibrillation following chemically induced articular cartilage injury.

The present study shows that a treadmill exercise regimen imposed on guinea-pigs whose articular cartilage has been damaged by intra-articular injection of IA reduces chondrocyte depletion, results in an increase in pericellular Safranin-O staining around surviving chondrocytes, and prevents fibrillation of the articular surface. The data suggest that exercise protected, or facilitated recovery of, chondrocytes subjected to chemical injury, and that the surviving cells then synthesised a matrix which was sufficiently normal to withstand impulsive joint loading. On the other hand, the exercise regimen accelerated osteophyte formation, and led to formation of osteophytes in sites at which they did not develop in animals which received intra-articular IA but which were not exercised.

Animals↗
PubMed1995

Evaluation of dual-energy X-ray absorptiometry bone mineral measurement--comparison of a single-beam and fan-beam design: the effect of osteophytic calcification on spine bone mineral density.

Dual energy X-ray absorptiometry (DXA) using a single-beam (SB) design is a well-established procedure for measuring bone mineral area density (BMD). Recently, fan beam (FB) techniques have become available to measure BMD. We evaluated the QDR1000 and QDR2000 densitometers with regard to precision and cross-compared values using single beam (SB) and FB techniques. To study the effect of osteoarthritic changes on bone measurement (BMC in g) and bone mineral area density (BMD in g/cm2), both parameters were measured in patients with and without osteophytic calcifications (OC) of the lumbar spine. Precision errors for BMD in vitro over 1 and 6 months using the QDR2000 were 0.4% and 0.6% for SB and 0.5% and 0.7% for the three FB modes. For QDR1000 only SB is available. Using this scan mode, the BMD difference (delta = 0.1%) in vitro between QDR1000 and QDR2000 was not significant. The short-term (same day) reproducibility of BMD in vivo was 0.85% for SB mode and 1.1% for FB scan mode (n = 33). The midterm (1 month) precision errors were 0.9% for SB and 1.5% for FB (n = 11). The spine BMD of 751 patients from our outpatient clinic and department of rheumatology was 1.7% lower with FB than with SB (0.878 +/- 0.137 versus 0.888 +/- 0.146 g/cm2). Lower (1.8%) BMD values were also found in the hip with FB compared to SB (0.805 +/- 0.111 versus 0.821 +/- 0.111 g/cm2). There was a highly significant (P < 0.00001) correlation between SB and FB on the spine (r = 0.99) and hip (r = 0.98) using the QDR2000. Correlations found QDR1000 and QDR2000 were lower on the spine (r = 0.97) and hip (r = 0.93).(ABSTRACT TRUNCATED AT 250 WORDS)

Absorptiometry, Photon↗
PubMed1995

Lateral spine dual-energy X-ray absorptiometry bone mineral measurement with fan-beam design: effect of osteophytic calcifications on lateral and anteroposterior spine BMD.

Recently, fan beam (FB) designs have been made available by several manufacturers (Aloka, Hologic Lunar and Sophar) to measure lumbar spine bone mineral area density (BMD) in both an anteroposterior (AP) and a lateral projection. The present study was performed to evaluate some characteristics of a new dual energy X-ray absorptiometry (DXA) system for supine lateral scans in normals and to study possible advantages for patients with osteophytic calcifications (OC). The precision errors of in vitro and in vivo measurements were estimated by an anthropomorphic phantom and in healthy volunteers. To study the effect of osteoarthritic changes on AP and lateral DXA measurements, BMC (bone mineral content) and BMD were measured in age-matched women (n = 150) with and without OC. Precision errors for lateral BMD in vitro over 1 and 6 months were 0.58/0.67% (slow/fast scan modes) and 0.67/0.77% (slow/fast scan modes), respectively. The short- and mid-term reproducibility of BMD values were 2% and 3.5%, respectively, using the compare function (3.5% and 7.5%, respectively, without the compare facility). The analysis of women with and without OC (n = 150) demonstrated higher mean values for AP BMD (0.892 +/- 0.145 g/cm2) in patients with OC (n = 75) than in normals (0.836 +/- 0.135 g/cm2, n = 75, difference 6.3%). For lateral scans, BMD differed to a minor degree (3.1%) in patients with OC (0.629 +/- 0.133 g/cm2) compared with normals (0.610 +/- 0.117 g/cm2). Corresponding results were obtained in fast FB mode. Furthermore, we found significant (P < 0.0001) correlations between BMD in lateral and AP scans in patients without OC (r = 0.63) and in patients with OC (r = 0.57). Although the FB design facilitated fast AP and lateral scans, the higher precision errors of lateral scans could limit its application in longitudinal studies. The use of compare function should be recommended. However, BMD of lateral scans was less influenced by OC.

Absorptiometry, Photon↗
PubMed1995

Dysphagia caused by an anterior cervical osteophyte: case report.

Cervical spondylosis and ankylosing hyperostosis of the cervical vertebrae are commonly asymptomatic. Dysphagia caused by cervical osteophyte formation is rare. We report a case of spondylotic dysphagia with striking radiographic findings. A massive anterior cervical hyperostosis was resected via the anterior cervical approach with excellent relief of dysphagia.

Cervical Vertebrae↗
PubMed2005

Residual posterior femoral condyle osteophyte affects the flexion range after total knee replacement.

We followed up 92 patients with total knee replacement and a pre-operative knee flexion of at least 90 degrees . The patients were followed up regularly at 3 months, 6 months and 1 year. The outcome measured was the amount of maximum passive knee flexion at the end of 1 year after replacement. The potential factors affecting the final flexion range were investigated. After regression analysis, apart from pre-operative knee flexion (p<0.001), the most significant independent surgical factors that predict the amount of post-operative flexion were presence of residual posterior femoral condyle osteophyte (p=0.046) and overstuffing the patella by more than 2 mm during resurfacing of the patella (p<0.001).

Aged↗
PubMed2005

Traumatic pseudoaneurysm of the descending thoracic aorta inflicted by a spinal osteophyte.

This report describes a case involving a traumatic pseudoaneurysm of the descending thoracic aorta resulting from direct contusion inflicted by the tip of a spinal osteophyte at the level of T11-T12. Endovascular repair with placement of a custom-made endograft by the femoral route was performed after routine arteriography to locate the origin of the Adamkiewicz artery.

Aneurysm, False↗
PubMed1990

Osteophytic reaction to a polytetrafluoroethylene temporomandibular joint implant. Report of a case.

Alloplastic disk substitutes of polytetrafluoroethylene (PTFE) used in the management of late stage temporomandibular joint disease have often been accompanied by morbid tissue reactions and resultant destructive changes. Numerous clinicians have reported cases of severe radiographic and clinical bony destruction and degeneration accompanied by marked foreign body giant cell reactions in the adjacent soft tissues. The case reported here demonstrates just the opposite event. Osteophytic enlargement of the lateral portion of the zygomatic arch and glenoid fossa, with adaptation to the contours of the implant, along with severe condylar osteophytosis, was diagnosed through tomographic and CT imaging and was confirmed at surgery.

Adult↗
PubMedDate not supplied

[Obstructive sleep apnea syndrome associated with cervical osteophyt due to diffuse idiopathic skeletal hyperostosis--clinical case].

Obstructive sleep apnea syndrome and diffuse idiopathic skeletal hyperostosis are frequent diseases in the elderly, however its association has rarely been described. The authors describe a case of obstructive sleep apnea syndrome in a patient with diffuse idiopathic skeletal hyperostosis, with a giant osteophyt of the cervical column, which leads to obstruction of the pharynx and they discuss the association between both entities.

Cervical Vertebrae↗
PubMedDate not supplied

Dysphagia due to cervical osteophytes.

A case of a 64-year-old man is presented with painless dysphagia and loud noise on swallowing due to large anterior cervical osteophytes demonstrated on plain radiographs and magnetic resonance imaging accompanied by a brief review of the literature.

Cervical Vertebrae↗
PubMed2003

Differentiation between lumbosacral transitional vertebrae, pseudolumbarisation, and lumbosacral osteophyte formation in ventrodorsal radiographs of the canine pelvis.

Ventrodorsal radiographs of the pelvis (n=150) of Rottweilers, Golden Retrievers, and German Shepherd dogs and macerated spines (n=800) from a variety of breeds were assessed for morphological evidence of lumbosacral transitional vertebrae as well as for factors that might lead to radiographic misinterpretation of this condition. Those alterations closely resembling the radiographic appearance of transitional vertebrae were identified to be: (1) calcification of the dorsal and ventral sacroiliac ligaments (=pseudolumbarisation), which might be interpreted as a costal process at S1 (or the corresponding vertebra in cases of numerical vertebral variations); and (2) osteophyte formation at the lumbosacral junction simulating separation of the cranial articular processes from the assembly of the sacral wing as seen in transitional vertebrae.

Animals↗
PubMed1997

Distribution of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic bone.

Connective tissues synthesise and secrete a family of matrix metalloproteinases (MMPs) which are capable of degrading most components of the extracellular matrix. Animal studies suggest that the MMPs play a role in bone turnover. Using specific polyclonal antisera, immunohistochemistry was used to determine the patterns of synthesis and distribution of collagenase (MMP-1), stromelysin (MMP-3), gelatinase A (MMP-2) and gelatinase B (MMP-9) and of the tissue inhibitor of metalloproteinases-1 (TIMP-1) within developing human osteophytic bone. The different MMPs and TIMP showed distinct patterns of localisation. Collagenase expression was seen at sites of vascular invasion, in osteoblasts synthesising new matrix and in some osteoclasts at sites of resorption. Chondrocytes demonstrated variable levels of collagenase and stromelysin expression throughout the proliferative and hypertrophic regions, stromelysin showing both cell-associated and strong matrix staining. Intense gelatinase B expression was observed at sites of bone resorption in osteoclasts and mononuclear cells. Gelatinase A was only weakly expressed in the fibrocartilage adjacent to areas of endochondral ossification. There was widespread but variable expression of TIMP-1 throughout the fibrous tissue, cartilage and bone. These results indicate that MMPs play a role in the development of human bone from cartilage and fibrous tissue and are likely to have multiple functions.

Bone and Bones↗
PubMed2004

Flexion-extension gap changes during total knee arthroplasty: effect of posterior cruciate ligament and posterior osteophytes removal.

Flexion and extension gap heights were measured in 50 consecutive primary posterior-stabilized total knee arthroplasties (TKAs) to determine whether posterior cruciate ligament (PCL) release or re-establishment of the posterior condylar recess increased gap width. After PCL release, a slight symmetrical increase was noted in both gaps. In extension, gap width increased on average 1.3 mm and 1 mm in the medial and lateral compartments, respectively. The same pattern was observed in flexion, averaging 1.3 mm medially and 1.3 mm laterally. Another increase in the two gaps was observed after the posterior condylar osteophytes were removed and the posterior recess was re-established. The gaps in extension increased, with respect to the base-line value, on average 1.8 mm medially and 1.8 mm laterally, whereas flexion increased an average 2 mm medially and 2.2 mm laterally. No statistical differences were noted between flexion and extension gaps. No independent differences between the flexion and extension gaps were found in any surgical phase. Posterior cruciate ligament removal and re-establishment of posterior condylar recess does not require additional consideration in gap balancing during posterior-stabilized TKA.

Aged↗
PubMed1976

Inhibition of secondary osteophyte formation in rheumatoid arthritis.

Using radiographically demonstrated joint narrowing as an index of joint damage, a reduced incidence of osteophyte size and number as a measure of osteoarthritic change in the PIP and knee joints of patients with RA as compared to DJD has been demonstrated. The possible pathogenetic factors discussed include reduced joint use in RA, increased resilience of juxta-articular bone associated with osteoporosis in RA and the possibility that products of inflammation in the RA joint act locally or via juxta-articular vascular mechanisms to inhibit the secondary changes of DJD. Further study of the possible pathogenic mechanisms including the roles of joint stress, juxta-articular osteoporosis, and possible effects of the inflammatory reaction of the rheumatoid joint on intra-articular structures and juxta-articular vascular phenomena are needed.

Adult↗