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Primary obsessional slowness: long-term findings.

Cases of slowness among patients who spent large amounts of time to perform daily activities were first reported in 1974, and described as primary obsessional slowness (POS). It was observed that it was neither obsessive thoughts nor compulsions that directly hindered their daily activities. However, in more than 20 years following the original report, the diagnostic independence of POS remains controversial, some insisting that obsessional slowness can be explained as secondary. The authors experienced four cases in Japan which share the same characteristics as the original cases. Long-term observation and treatment has led us to support the diagnostic independence of POS. Slowness remained after other accompanying symptoms of obsessive-compulsive disorder had been successfully treated, showing that the slowness of our patients was not secondary.

Activities of Daily Living↗

Phenomenological and pharmacological study of provoked obsessive/anxiety symptoms in obsessive-compulsive disorder: a preliminary study.

BACKGROUND: Inclusion of obsessive-compulsive disorder (OCD) as an anxiety disorder in DSM-i.v. assumes that anxiety is the primary symptom of OCD; however, persuasive empirical evidence in support of this view has not been presented yet. In the present study we hypothesized that provoked anxiety symptoms respond better to intravenous diazepam than would provoked obsessions. We, therefore, reasoned that anxiety symptoms are secondary symptoms of OCD. METHODS: To test the hypothesis we designed a double-blind, randomized, placebo-controlled crossover study. Patients underwent four experimental conditions in which the sequence of symptom provocation and i.v. injection of (placebo or diazepam) were alternated. Baseline and i.v. injection-induced symptom changes were assessed using visual analogs. RESULTS: Obsessions and anxiety correlated strongly for all four experimental conditions in which the sequence of the symptom provocation and diazepam i.v. injections was alternated. i.v. diazepam injection before and after symptom provocation failed to preferentially modulate anxiety symptoms over obsessions. Unexpectedly, in the group in which i.v. diazepam injection preceded the symptom provocation, reduction of mean obsessions was even more pronounced. CONCLUSIONS: Strong correlations between anxiety and obsessions at baseline, during symptom provocation, and after i.v. diazepam infusion suggest that anxiety and obsessions are tightly coupled phenomena in OCD.

Adult↗

Effect of acute intravenous clomipramine and antiobsessional response to proserotonergic drugs: is gender a predictive variable?

BACKGROUND: Previous studies on serotonergic responsivity in obsessive-compulsive disorder (OCD) showed about 50% of patients experiencing an acute worsening of OC symptoms when administered meta-chlorophenylpiperazine or i.v. clomipramine. The aim of this study was to determine what variables influence the response to acute i.v. clomipramine. Could this response be predictive of the response to chronic treatment with two serotonergic drugs with differing selectivity profiles: clomipramine and fluvoxamine? METHODS: Fifty OC patients were consecutively recruited. All underwent a challenge with 25 mg i.v. clomipramine and placebo and were administered 10-week oral clomipramine or fluvoxamine according to a double-blind design. The efficacy of the antiobsessional treatment was evaluated by Yale-Brown Obsessive-Compulsive Scale and Clinical Global Impression scale scores. RESULTS: Obsessions worsened in 42% patients as rated by change values in 100-mm visual analogue scale scores for the clomipramine vs. placebo infusion. There was a significant difference in gender distribution between "worsened" and "unchanged" patients, since female subjects were more frequently "unchanged." Thirty-one patients completed the 10-week treatment. According to both qualitative and quantitative evaluations, female subjects showed a better antiobsessional response, and this difference was enhanced in the clomipramine-treated group. CONCLUSIONS: Results suggest a role for reproductive hormones in the pathophysiology or treatment of OC patients.

Administration, Oral↗

Beliefs about worry and intrusions: the Meta-Cognitions Questionnaire and its correlates.

This report describes the development of the Meta-Cognitions Questionnaire to measure beliefs about worry and intrusive thoughts. Factor analyses of the scale demonstrated five empirically distinct and relatively stable dimensions of meta-cognition. Four of the factors representing beliefs were: Positive Beliefs About Worry: Negative Beliefs About the Controllability of Thoughts and Corresponding Danger; Cognitive Confidence; and Negative Beliefs about Thoughts in General, including Themes of Superstition, Punishment and Responsibility. The fifth factor represented Meta-Cognitive processes-Cognitive Self-Consciousness-a tendency to be aware of and monitor thinking. The measure showed good psychometric properties on a range of indices of reliability and validity. Scores on the questionnaire subscales predicted measures of worry proneness, proneness to obsessional symptoms, and anxiety. Regression analyses showed that the independent predictors of worry were: Positive Beliefs about Worry; Negative Beliefs About the Controllability of Thoughts and Corresponding Danger: and Cognitive Confidence. Significant differences in particular MCQ subscales were demonstrated between patients with intrusive thoughts, clinical controls and normals. The implications of these findings for models of worry and intrusive thoughts are discussed.

Adolescent↗

Religiosity and obsessionality: the relationship between Freud's "religious practices".

Freud (1907/1961) outlined parallels between obsessive actions and religious practices, describing how both neurotic and religious practice serve as defensive, self-protective measures involved in the repression of instinctual impulse. Freud also described some differences between the two concepts. To examine these observations, measures of religiosity (the Francis Scale of Attitudes Towards Christianity; Francis & Stubbs, 1987) and obsessional traits and symptoms (the Sandler-Hazari Obsessionality Inventory; Sandler & Hazari, 1960) were administered (N = 139). In both male and female samples, significant correlations were found between the measure of religiosity and obsessional traits but not between religiosity and obsessional symptoms. The results support previous findings linking religiosity and obsessional traits but suggest that differences between religious practices and obsessive actions are greater than their similarities. These findings further illuminate the general relationship between the Francis Scale of Attitudes Towards Christianity and personality.

Adult↗

The family interview.

Families of study children were interviewed, with a focus on parents' observations of the personality and behavior of their offspring. The family interview was also the primary source of information about the home environment and possible psychopathology in nonschizophrenic parents. By parental report, index children were more likely than controls to have developed psychopathological symptoms related to mood, social withdrawal, antisocial behavior, eating, and obsessive-compulsive behavior. Traits of self-esteem, adaptability, reliability, and degree of task orientation were more poorly developed in index than control subjects. Index subjects also tended to have poorer relationships with both peers and family members. While boys and girls showed similar patterns of psychopathology, boys tended to have somewhat higher levels of impairment. No differences or interactions due to type of rearing were found.

Adaptation, Psychological↗

Chronic thought suppression.

We conducted several tests of the idea that an inclination toward thought suppression is associated with obsessive thinking and emotional reactivity. Initially, we developed a self-report measure of thought suppression through successive factor-analytic procedures and found that it exhibited acceptable internal consistency and temporal stability. This measure, the White Bear Suppression Inventory (WBSI), was found to correlate with measures of obsessional thinking and depressive and anxious affect, to predict signs of clinical obsession among individuals prone toward obsessional thinking, to predict depression among individuals motivated to dislike negative thoughts, and to predict failure of electrodermal responses to habituate among people having emotional thoughts. The WBSI was inversely correlated with repression as assessed by the Repression-Sensitization Scale, and so taps a trait that is quite unlike repression as traditionally conceived.

Affect↗

Shared obsessive-compulsive disorder.

BACKGROUND: Shared psychotic disorder (folie à deux) is an uncommon entity reported mainly in the context of delusions. Obsessions and compulsions occur very rarely as shared psychopathology. MATERIAL AND METHODS: We present two sisters who manifested shared obsessive-compulsive disorder. RESULTS: Both sisters were managed in keeping with their shared obsessive-compulsive disorder leading onto a similar pattern of response. CONCLUSIONS: Shared obsessions could represent the continuum concept of obsessions and delusions, and their relationship needs to be evaluated in greater detail.

Adult↗

Obsession in the strict sense: A helpful psychopathological phenomenon in the differential diagnosis between obsessive-compulsive disorder and schizophrenia.

The paper presented follows the hypothesis that differentiation between obsessive-compulsive disorder and schizophrenia is possible only by focusing on the single phenomenon of obsession. The statement of a nosological specificity of obsession, called obsession in the strict sense, is set against the current views of ICD-10 and DSM-IV of obsession as a ubiquitous, non-specific phenomenon appearing in comorbidities. In the succession of the paper, the historical development of these two very different views and their clinically mixing is reconstructed. The phenomenological clarification of the structure of the obsessive phenomena leads to the term of obsession in the strict sense. The distinction between obsessive-compulsive disorder and schizophrenia can take place at the psychopathological interface between obsession in the strict sense and delusional idea. The examination of the literature on the connection between obsessive-compulsive disorder and schizophrenia shows that there is no definitive connection between obsession in the strict sense and schizophrenia. Finally, some case reports are presented to sharpen clinical suspicion for other possibly wrong diagnoses.

Adult↗