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At least 181 records · Page 10Linked to original sources
PubMed1988

Controversy in the management of optic pathway gliomas. 29 patients treated with radiation therapy at Baylor College of Medicine from 1967 through 1987.

The optic gliomas of 29 patients, including 14 with von Recklinghausen neurofibromatosis (NF-1), were subjected to X-ray therapy. The data indicate a projected 20-year survival rate of 92% for all 29 patients. Moreover, among the NF-1 patients, 86% were stabilized or improved, while among non-NF-1 patients, only 47% stabilized or were improved. Thus, these data suggest that there are differences in the biophysiological behavior of optic nerve gliomas in patients with NF-1, and, as well, that there is a salutary response to radiation treatment as measured by improvement or stabilization of vision, with and without radiologic evidence of concomitant tumor regression.

Adolescent↗
PubMed1988

Cerebrospinal fluid absorption in the rabbit. Optic pathways.

Fifteen rabbits were intrathecally perfused with horseradish peroxidase at normal cerebrospinal fluid pressures. Horseradish peroxidase was found in the subarachnoid space around the optic nerve; it permeated the pia and penetrated within the nerve, occupying extracellular spaces between myelinated axons and glial cells up to the area of the lamina cribrosa. Horseradish peroxidase also crossed the perineural sclera and the border tissue of Elschnig to spread into the choroid where it was mostly seen within choriocapillaris, venules, and veins crossing through interendothelial spaces. "Bulk" cerebrospinal fluid absorption in the eye appears to occur through venous drainage in the choroid and SAS.

Animals↗
PubMed1992

Emergence of optic pathway gliomas in children with neurofibromatosis type 1 after normal neuroimaging results.

We report the appearance of gliomas of the optic nerve or chiasm in four young children with neurofibromatosis type 1 whose previous neuroimaging studies showed no abnormalities; the age range of the children was 1 year 8 months to 5 years 9 months at the time the tumors were detected. Normal neuroimaging findings in an infant or young child with neurofibromatosis type 1 does not provide assurance that the optic nerves and chiasm will remain healthy.

Child, Preschool↗
PubMed1988

Occurrence of phospholipase A1-A2 and lysophosphatidylcholine acyltransferase activities in axolemma-enriched fractions of brain stem, optic pathway, and cranio-spinal nerves of the rabbit.

An axolemma-enriched fraction was isolated and characterized from homogenates of brain stem, pooled optic nerve and tract, and sciatic and hypoglossal nerves of adult rabbits. In these fractions, the phospholipase A1 and A2, as well as the activity of acyl-CoA:1-acyl-sn-glycero-3-phosphorylcholine and acyl-CoA:2-acyl-sn-glycero-3-phosphorylcholine acetyl transferase, using 1-acyl- and 2-acyl-GPC as acyl acceptors, were studied. The activity of the four enzymes was clearly detectable in the central nervous system (CNS) and peripheral nervous system (PNS) axolemmatic preparations, as well as in other subcellular fractions examined. The axolemma fractions, in which acetylcholinesterase displayed the highest activities, were particularly enriched in the acylation reaction enzymes. These latter showed specific activities about twofold higher compared with those of the homogenates and significant correlation with acetylcholinesterase. The noticeable presence of these enzyme activities in both CNS and PNS axolemma suggests that a deacylation-reacylation system for phospholipids may be operative in this membrane.

1-Acylglycerophosphocholine O-Acyltransferase↗