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PubMed2003

Mind and matter as asymptotically disjoint, inequivalent representations with broken time-reversal symmetry.

Many philosophical and scientific discussions of topics of mind-matter research make implicit assumptions, in various guises, about the distinction between mind and matter. Currently predominant positions are based on either reduction or emergence, providing either monistic or dualistic scenarios. A more-involved framework of thinking, which can be traced back to Spinoza and Leibniz, combines the two scenarios, dualistic (with mind and matter separated) and monistic (with mind and matter unseparated), in one single picture. Based on such a picture, the transition from a domain with mind and matter unseparated to separate mental and material domains can be viewed as a result of a general kind of symmetry breaking, which can be described formally in terms of inequivalent representations. The possibility of whether this symmetry breaking might be connected to the emergence of temporal directions from temporally non-directed or even non-temporal levels of reality will be discussed. Correlations between mental and material aspects of reality could then be imagined as remnants of such primordial levels. Different conceivable types of inequivalent representations would lead to correlations with different characteristics.

Humans↗
PubMed2003

The self and action in theory of mind research.

Research on children's developing theories of mind has contributed to our understanding of the developmental relation of self and action (1) by exploring the relation of the development of self knowledge to the development of knowledge of others' minds and (2) by investigating the relation between theory of mind development and the development of action control. We argue that evidence on theory of mind reasoning in children with deficient action control (ADHD-diagnosed children) is especially relevant to the second issue and we present some first evidence supporting the bi-directional hypothesis, that is, the view that theory of mind leads to improved action control which in turn supports the ability to represent mental states on-line.

Adult↗
PubMed1999

Development of theory of mind and executive control.

Several recent studies have demonstrated a developmental link, in the age range of 3-5 years, between the acquisition of a 'theory of mind' and self control. In this review, we consider the existence of such a link in assessing five competing theoretical hypotheses that might help us to understand the nature of this developmental advance: (1) executive control depends on theory of mind; (2) theory of mind development depends on executive control; (3) the relevant theory of mind tasks require executive control; (4) both kinds of task require the same kind of embedded conditional reasoning; (5) theory of mind and executive control involve the same brain region. We briefly describe these theoretical accounts and evaluate them in the light of existing empirical evidence. At present, only account (3) can be ruled out with some confidence.

Journal Article↗
PubMed2002

Theory of mind deficit in people with schizophrenia during remission.

BACKGROUND: The authors' goal was to investigate the presence or absence of theory of mind impairments among people with schizophrenia during remission. Recent research results interpret theory of mind deficits as state rather than trait characteristics, connecting these impairments mainly to the acute episode of psychosis. METHODS: Twenty patients with schizophrenia in remission and 20 matched control subjects were evaluated. Participants were presented with one first-order theory of mind task, one second-order theory of mind task, two metaphor and two irony tasks adapted from previous studies. RESULTS: The schizophrenic patients performed a statistically significant impairment in the irony task, as there were no significant differences in the cases of the other evaluated tasks. CONCLUSIONS: These preliminary results suggest that theory of mind impairments can be detected not only in the acute phase as found in previous research studies, but also in remission.

Case-Control Studies↗
PubMed1997

Intersubjectivity in Wittgenstein and Freud: other minds and the foundations of psychiatry.

Intersubjectivity, the cooperation of two or more minds, is basic to human behavior, yet eludes the grasp of psychiatry. This paper traces the dilemma to the "problem of other minds" assumed with the epistemologies of modern science. It presents the solution of Wittgenstein's later philosophy, known for his treatment of other minds in terms of "human agreement in language." Unlike recent studies of "Wittgenstein's psychology," this one reviews the Philosophical Investigations' "private language argument," the crux of his mature views on mind. It reads that argument as recording his shift from the modern egocentric paradigm of mind to an intersubjective one. The paper contrasts the merits of Wittgenstein's reduction of subject and object to grammar with the problems of Freud's metapsychological reduction. It shows how Wittgenstein's intersubjective method avoids the excesses of behaviorism and phenomenology, offering a specifically human way to adapt mechanistic and interpretive means to the communicative ends of psychiatry.

Communication↗
PubMed1999

The TOM test: a new instrument for assessing theory of mind in normal children and children with pervasive developmental disorders.

This article describes a first attempt to investigate the reliability and validity of the TOM test, a new instrument for assessing theory of mind ability in normal children and children with pervasive developmental disorders (PDDs). In Study 1, TOM test scores of normal children (n = 70) correlated positively with their performance on other theory of mind tasks. Furthermore, young children only succeeded on TOM items that tap the basic domains of theory of mind (e.g., emotion recognition), whereas older children also passed items that measure the more mature areas of theory of mind (e.g., understanding of humor, understanding of second-order beliefs). Taken together, the findings of Study 1 suggest that the TOM test is a valid measure. Study 2 showed for a separate sample of normal children (n = 12) that the TOM test possesses sufficient test-retest stability. Study 3 demonstrated for a sample of children with PDDs (n = 10) that the interrater reliability of the TOM test is good. Study 4 found that children with PDDs (n = 20) had significantly lower TOM test scores than children with other psychiatric disorders (e.g., children with Attention-deficit Hyperactivity Disorder; n = 32), a finding that underlines the discriminant validity of the TOM test. Furthermore, Study 4 showed that intelligence as indexed by the Wechsler Intelligence Scale for Children was positively associated with TOM test scores. Finally, in all studies, the TOM test was found to be reliable in terms of internal consistency. Altogether, results indicate that the TOM test is a reliable and valid instrument that can be employed to measure various aspects of theory of mind.

Adolescent↗
PubMed1997

Mother-child participation in conversation about the past: relationships to preschoolers' theory of mind.

Forty 3.5 to 4.5-year-olds discussed 3 past events with their mothers and completed a set of theory of mind tasks indexing their ability to reason about conflicting mental representations and their understanding of knowledge. Semipartial correlations and analyses of covariance showed that children's theory of mind scores were related to their participation in memory conversations, independent of age and linguistic skill. The frequency with which mothers provided new information was related to children's theory of mind scores, although mothers' direct replies to children were generally unrelated to children's understanding of mind. This research takes an important step toward examining the relevance of theory of mind skills to real-world, social interaction. The results have implications for explaining the emergence of autobiographical memory.

Attention↗
PubMed1998

The getting of wisdom: theory of mind in old age.

Theory of mind, the ability to attribute mental states, has been little explored beyond the early school years. Yet, later development, including possible patterns of breakdown, has important implications for current debate concerning the modularity/domain-specificity of the cognitive and neurological systems underlying theory of mind. This article reports a first study of theory of mind in normal aging. The results suggest that although performance on tasks with nonmental content may decrease with age, performance on theory of mind tasks remains intact and may even improve over the later adult years. The implications of these findings for the cognitive processes underlying theory of mind are discussed.

Adolescent↗
PubMed2004

Concordance in attachment states of mind and styles with respect to fathers and mothers.

It is believed that by adulthood, independent attachments to the mother and the father coalesce into a single state of mind with respect to attachment. If true, states of mind with respect to mothers and fathers should be concordant. Fifty-six young adults were administered two versions of the Adult Attachment Interview, each of which asked about their relationship with one parent. State of mind with respect to the father was significantly related to state of mind with respect to the mother, as were attachment styles regarding the two parents. Perceptions of attachment styles were not very related to corresponding states of mind but were related to inferred loving from a parent.

Adolescent↗
PubMed2003

A conserved sequence at the C-terminus of MinD is required for binding to the membrane and targeting MinC to the septum.

MinD is a key component of an oscillatory system that spatially regulates cell division in Escherichia coli. It is a peripheral membrane ATPase that recruits MinC and oscillates between the two halves of the cell in a MinE dependent manner. In vitro MinD binds to phospholipid vesicles in an ATP-dependent manner and is released through MinE-stimulated ATP hydrolysis. In this study we examined the function of the conserved C-terminus of MinD. Short truncations of three and ten amino acids dramatically decreased the ability of MinD to localize to the membrane and spatially regulate division. These truncations bound MinC but were deficient in targeting MinC to the septum. In vitro they dimerized, but were deficient in binding to phospholipid vesicles and undergoing MinE stimulation. We suggest a model in which the ATP-dependent dimerization of MinD affects the conformation of the C-terminal region, a potential amphipathic helix, triggering membrane binding.

Adenosine Triphosphatases↗
PubMed2006

Mindfulness, acceptance, and hypnosis: Cognitive and clinical perspectives.

The authors propose that hypnosis and mindfulness-based approaches can be used in tandem to create adaptive response sets and to deautomatize maladaptive response sets. They summarize recent research on the effectiveness of mindfulness-based approaches in clinical and nonclinical contexts and propose that the cognitive underpinnings of mindfulness approaches can be conceptualized in terms of the metacognitive basis of mindful attention, Toneatto's elucidation of the Buddhist perspective on cognition, and Kirsch and Lynn's response-set theory. They also suggest that mindfulness can serve as a template for generating an array of suggestions that provides cognitive strategies to contend with problems in living and to ameliorate stress and negative affect more generally. Many of the ideas the authors advance are speculative and are intended to spur additional research and clinical work.

Adaptation, Psychological↗
PubMedDate not supplied

Aging and mind wandering: reduced inhibition in older adults?

Hasher and Zacks (1988) theorize that aging disrupts the efficient operation of an inhibitory mechanism that, when functioning normally, is thought to suppress information irrelevant to one's cognitive goals. Problems with this inhibitory mechanism should produce increased mind wandering, and the present experiment examined this possibility using a performance-based measure of mind wandering. Younger and older participants were presented with a long list of words and were occasionally stopped (at unpredictable intervals) and asked to recall the most recently presented items. Mind wandering was inferred by conditionalizing recall on these unpredictable trials with recall on short, predictable trials (in which, presumably, participants were able to maintain full attention to the recall task). Whereas mind wandering was shown to be higher on longer trials than shorter ones, there was no evidence of age differences in mind wandering.

Adolescent↗
PubMed2004

The use of mindfulness-based approaches for suicidal patients.

Mindfulness-based approaches are becoming more widely used for individuals at risk of suicidal behavior: in the treatment of borderline personality disorder (in Dialectical Behavior Therapy), and as a way to reduce relapse in recurrent major depression (in Mindfulness-based Cognitive Therapy). This article describes and examines the commonalities and differences in the use of mindfulness in these two treatments. The reasons for considering the use of mindfulness-based approaches with suicidal individuals more widely are considered and potential risks outlined. The article closes with case examples to illustrate the use of mindfulness in the treatment of suicidal thoughts and behaviors.

Journal Article↗
PubMed2001

"Theory of mind" impairments and their relationship to executive functioning following frontal lobe excisions.

It has been suggested that mental states play an important role in determining behaviour and that mental state attributions ("theory of mind") underlie the ability to understand and predict other peoples' behaviour. Theory of mind was investigated in 31 patients with unilateral frontal lobe lesions (15 right-sided and 16 left-sided) by comparing their performance with that of 31 matched control subjects. The ability to infer first- and second-order beliefs was tested by requiring subjects to listen to stories in which a protagonist acted upon a false belief. Both patient groups exhibited significantly impaired performance on the two theory of mind measures. Both frontal lobe groups also exhibited a range of deficits in tests of executive functions, but analyses revealed that these seemed to be independent of theory of mind impairments. These findings are discussed in terms of the hypothesis of a specialized, adaptive brain system underlying theory of mind reasoning ability, and are related to observed difficulties in social functioning among patients with frontal lobe damage.

Adult↗
PubMed2001

Severe impairment in grammar does not preclude theory of mind.

Debates about the role of language in human thinking are increasingly prominent in the cognitive sciences. There are claims that certain forms of reasoning can only be performed through access to the resources of the language faculty. In particular, a component of social cognition involving the representation of the mental states of others ('theory of mind' reasoning) has been claimed necessarily to involve propositions of natural language. A recent case study reported a man (SA) with severe agrammatic aphasia who was unable to understand or produce language propositions in any modality of language use, but who was able to complete theory of mind tasks. We report a replication of this finding using a modified picture theory of mind task with a second patient (MR). Despite severe aphasia and impaired performance on a test of executive function, MR demonstrated retained theory of mind reasoning. These results reveal the functional autonomy of theory of mind from the capacity for propositional/grammatical language, and support its independence from executive function.

Aphasia, Broca↗
PubMed1996

Theory of mind in deaf adults and the organization of verbs of knowing.

Naive theories of mind provide an organizing scheme for concept formation and categorization. Additionally, they highlight what is important within a domain. This study investigated how deaf adults with hearing parents orgaize 17 cognitive verbs of knowing as a way of describing their naive theory of mind. Deaf adults rated on 1 to 7 scale the similarity of pairs of cognitive verbs in terms of whether 'the words are alike or different based on how you would use your mind when you do that mental activity'. We directly compared the similarity of cognitive verbs in these deaf adults with data collected in earlier research describing the organisation of cognitive verbs in hearing adults. We conducted multidimensional scaling, additive similarity tree, and Pathfinder analyses to assess global, categorical, and local relations in the domain. Deaf adults' theory of mind revealed distinction among mental verbs in terms of information-processing components and constructive certainty components. In all analyses, the deaf group showed a very similar organization to that of hearing adults examined in previous research. We conclude that, although deaf adults might be expected to view congnitive processes differently than hearing adults, they nonetheless exhibit a theory of mind that is highly similar to that of hearing adults.

Journal Article↗
PubMed1995

Modeling other minds.

Nine normal volunteers performed a 'theory of mind' task while their regional brain blood flow pattern was recorded using the PET [15O]H2O technique. Control conditions induced subjects to attend to the visual and semantic attributes of known objects. In a third condition, subjects had to infer the function of an unfamiliar object from its form. In the 'theory of mind' condition, subjects had to infer function based on the form of both familiar and unfamiliar objects and in addition, model the knowledge and rationality of another mind about the function of these objects. Performance during the 'theory of mind' condition evoked the activation of a distributed set of neural networks with prominent activation of the left medial frontal lobe (Brodmann area 9) and left temporal lobe (Brodmann areas 21, 39/19, 38). This result suggests that when inferential reasoning depends on constructing a mental model about the beliefs and intentions of others, the participation of the prefrontal cortex is required. When access to such knowledge is affected by central nervous system dysfunction, such as that found in autism, modeling other minds may prove difficult.

Adolescent↗
PubMed2000

Neural correlates of theory-of-mind reasoning: an event-related potential study.

Everyday understanding of human behavior rests on having a theory of mind--the ability to relate people's actions to underlying mental states such as beliefs and desires. It has been suggested that an impaired theory of mind may lie at the heart of psychological disorders that are characterized by deficits in social understanding, such as autism. In this study, we employed the event-related potential methodology to index the activity of neural systems that are engaged during theory-of-mind reasoning in adults. Specifically, neural activity elicited by tasks that required thinking about mental as compared with nonmental representations (i.e., beliefs vs. photographs) was characterized by a focally enhanced positivity over left frontal areas, which was diminished over left parietal areas. These findings provide an important perspective on both children's theory-of-mind development and the neurobiology of disorders in which theory of mind seems to be impaired.

Adolescent↗