Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “MEDLARS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources
PubMed1987

Evaluation of a program to teach health professionals to search MEDLINE.

This study analyzes the search behavior of end users who had taken a class in searching MEDLINE on the National Library of Medicine's MEDLARS system. Of the class alumni, 58% obtained passwords. Most of these were still conducting their own searches twelve to eighteen months later. Telephone interviews and search observations indicated that these end users were satisfied with their results and felt they had mastered the basic mechanics of searching. However, appropriate use of explodes and subheadings, as well as locating appropriate search terms, still presented difficulties for them. Further training in these areas may be required.

Education, Medical↗
PubMed1985

Research and writing in the history of health sciences, 1970-1982: a quantitative analysis of NLM's HISTLINE database.

HISTLINE, the MEDLARS file on the history of the health sciences, was analyzed to determine predominant areas of historical research and publication in the years 1970-1982, as reflected in this database produced within the History of Medicine Division at the National Library of Medicine. Subject content, chronologic and geographic breakdowns, and subjects of biographical studies are examined in view of their frequency in the file. Speculation for the predominance of particular descriptors and individuals is presented. An examination is made of the journals publishing the most medical history. Strengths and weaknesses of the database as reflected in this study also are discussed.

Biographies as Topic↗
PubMed1985

Prime time versus nonprime time on MEDLINE.

The number of users on the MEDLARS system varied more during nonprime time than on prime time; there were times of higher than average use and times of much lower use. This variation in the number of users influenced search time. The study found a variation of as much as 19% from the mean search time for times of high use versus times of low use. Added-time formulas showed the additional time allowed for a search on nonprime time before costs would equal those for the same search on prime time. (For example, a search with four citations that took five minutes on prime time could take up to eight minutes and thirty seconds on nonprime time before costs would be equal.) In all examples, nonprime time searching was the most cost-effective alternative.

Costs and Cost Analysis↗
PubMed1968

The Regional Medical Library Grant Program of the National Library of Medicine.

Recognizing the utility of a regional medical library system in improving the availability of existing and future medical library resources in the country, the Congress included provisions for the support of such a system in the Medical Library Assistance Act. Grants will be made to major medical libraries which have the potential to provide supportive services to other libraries within a geographic area encompassing a major fraction of the nation's health professional manpower. Approximately ten of these regional libraries will receive these grants. Support for the system and consequently the extension of the services of the system will of necessity by implemented in a stepwise fashion. The central function of a regional medical library is to provide back-stopping interlibrary loan service and also to provide access to MEDLARS services for the region. Additional services for the region will include traditional reference service, training, surveillance of regional needs, announcement services, support for programs of continuing education for the health professions, and certain central technical processing for the region.

Financing, Government↗
PubMed1982

A problem-oriented approach to journal selection for hospital libraries.

This paper describes a problem-oriented approach to journal selection (PAJS), including general methodology, theoretical terms, and a brief description of results when the system was applied in three different hospitals. The PAJS system relates the objective information which the MEDLARS data base offers about the universe of biomedical literature to objective, problem-oriented information supplied by the hospital's medical records. The results were manipulated quantitatively to determine (1) the relevance of various journals to each of the hospital's defined significant information problems and (2) the overall utility of each journal to the institution as a whole. The utility information was plotted on a graph to identify the collection of journal titles which would be most useful to the given hospital. Attempts made to verify certain aspects of the whole process are also described. The results suggest that the methodology is generally able to provide an effective library response. The system optimizes resources vis-a-vis information and can be used for both budget allocation and justification. It offers an algorithm to which operations researchers can apply any one of a variety of mathematical programming methods. Although originally intended for librarians in the community hospital environment, the PAJS system is generalizable and has application potential in a variety of special library settings.

Libraries, Hospital↗
PubMed1981

[Biomedical information networks: the experience of the United States National Library of Medicine].

A rapid and intensive flow of biomedical information is perceived increasingly as a requirement for the advancement of research, professional training, and the delivery of health services to an ever-growing human population. This article examines the concept of a network of information and cooperative services among medical libraries and national, regional and international data banks to maximize the sharing and use of the available resources. The background and record of the National Library of Medicine of the United States, which established the MEDLARS System, are described as a model for guidance. Since the end of the 19th century, when J. S. Billings, the foresighted first director of the Library, devised the first system for the indexing of medical literature, new techniques have been introduced step by step to facilitate the dissemination of biomedical information: mechanization and automatization of the placement of requests and data retrieval, telecommunications and satellite links to the fifteen data banks currently accessible to the user by direct communication through MEDLINE. For such a network to operate successfully, there must be a shift from the idea of regional or national benefit to the plane of global cooperation, through which a higher degree of self-sufficiency can be achieved. Also, relations between the various levels of the system must be based on a collaboration in which each entity pursues its own function subject to the character and multifarious scope of the common purposes. The success of BIREME in Latin America is cited as an incentive to developing countries to participate in the use and distribution of vital information through activities based on individual priorities without forgetting that what is important is not ideals and abstractions, but the human being with his needs, problems and real situation.

History, 19th Century↗
PubMed1982

Cervicofacial high-pressure hydraulic injection injury. Report of a case.

High-pressure petroleum injection injuries and best known in the distal part of the upper extremity. A recent Medlars search revealed several articles dealing with this type of injury in the hands and wrists, but, as yet, there have been no publications of this type of trauma to the head and neck region. A 35-year-old farmer sustained a high-pressure petroleum injection injury to the lower part of the left cheek and neck. This case might serve as a guide for management of similar cases in the future.

Abscess↗
PubMed1992

Secondary dyslipidemia. Inadvertent effects of drugs in clinical practice.

OBJECTIVE: To examine the available literature on commonly prescribed drugs and their effects on blood lipid and lipoprotein levels. DATA SOURCES: The review was based on searches of English-language articles from 1975 to 1990 by Medlars II and MEDLINE programs, the Index Medicus for 1980 to 1990, and references from identified articles. Relevant journals published within the last 6 months were also examined. STUDY SELECTION: More than 500 articles were identified for inclusion. Articles were selected on the basis of appropriateness of design to demonstrate significant results, determined by consensus when necessary. DATA EXTRACTION: Studies were classified according to type (observational or interventional), length of follow-up, and type of controls. Quanitative analysis of lipid, lipoprotein, and apoprotein changes induced by drugs was computed as the percentage of change observed during the course of the study (interventional) or compared with the controls at a given time (observational). DATA SYNTHESIS: Steroid hormones that have strong progestogenic and androgenic properties, retinoids, cyclosporine A, and phenothiazines are potentially atherogenic. Steroid hormones with dominant estrogenic properties, several anticonvulsants, biguanides, high-dose ketoconazole, and aminosalicylic acid are potentially antiatherogenic. Corticosteroids appear to elevate all the lipoprotein cholesterol levels. Oral estrogens, retinoids, and corticosteroids also can elevate triglyceride levels. Other drugs with questionable effects on lipoprotein metabolism are reviewed. CONCLUSION: Although the long-term implications of drug-induced lipoprotein changes are still undefined, physicians need to consider these effects in clinical practice.

Adrenal Cortex Hormones↗
PubMed1998

Pathophysiology and treatment of diabetic neuropathy.

The scope of the present review is to describe epidemiology, classification, symptomatology and treatment of diabetic peripheral somatic neuropathy and autonomic neuropathy. Special attention is paid to the use of local anaesthetic agents in painful diabetic neuropathy. Denervation hypersensitivity is a characteristic of autonomic neuropathy in diabetic patients. The pathophysiology behind this phenomenon is elucidated in this review and most recent studies related to diabetic encephalopathy are reviewed. References for this review were acquired via a MedLine and MedLars literature search.

Autonomic Nervous System Diseases↗
PubMed1995

Hepatocellular carcinoma during pregnancy and its comparison with other pregnancy-associated malignancies.

BACKGROUND: Cancer in pregnancy is rare and hepatocellular carcinoma (HCC) in pregnancy even rarer. The impact of pregnancy on the prognosis of patients with different types of cancer remains controversial. Reported cases of HCC in pregnancy are largely isolated and highly scattered. Thus, the effect of pregnancy on the prognosis of patients with HCC and the risk factors of developing HCC in pregnancy are not well documented. METHODS: A series of five patients with HCC in pregnancy seen at two different centers is reported. A Medlar search for articles between 1957 and 1993 with the key words "Hepatocellular Carcinoma" and "Pregnancy" was conducted. All reported cases were combined and analyzed in terms of race, age, parity, hepatitis B surface antigen status, cirrhosis, serum alpha-fetoprotein (AFP) levels at presentation, history of taking oral contraceptive pills and fetal and maternal outcome. The impact of pregnancy on 12 other malignancies as reported in the medical literature also was reviewed. RESULTS: To the authors' knowledge, The five cases reported here constitute the largest series of HCC in pregnancy. A literature search revealed 23 additional cases. Analysis of the 28 cases suggests that the rarity of HCC in pregnancy results from a combination of three factors: the male predominance of HCC, the late age at which the tumor usually presents in women, and decreased fertility in women with advanced cirrhosis (hepatitis is a predisposing factor for HCC development). Long term use of oral contraceptives and high parity enhance the risk. Elevated AFP level is useful for diagnosis. The median survival is shorter than for patients who are not pregnant. There is no significant difference in survival between pregnant and not pregnant women matched by tumor stage, age, and other clinical parameters in most malignancies except in some tumors like lymphoma, thyroid cancer, and nasopharyngeal carcinoma. CONCLUSION: Pregnancy has an adverse effect on the prognosis of patients with HCC, lymphoma, thyroid cancer, and nasopharyngeal carcinoma but not of most other malignancies. Measurement of AFP level is recommended for screening HCC in pregnant women at high risk.

Adult↗
PubMed1998

4-Hydroxyanisole: the most suitable monophenolic substrate for determining spectrophotometrically the monophenolase activity of polyphenol oxidase from fruits and vegetables.

A continuous spectrophotometric method for determining the monophenolase activity of polyphenol oxidase from several plant sources is described. This assay method is based on the coupling reaction between 3-methyl-2-benzothiazolinone hydrazone and the quinone product of the oxidation of 4-hydroxyanisole in the presence of polyphenol oxidase. 4-Hydroxyanisole proved to be the best monophenol assayed to measure the monophenolase activity of polyphenol oxidase from apple, artichoke, avocado, medlar, pear, and strawberry. Kinetic constants of 4-hydroxyanisole were compared to those of p-hydroxyphenyl propionic acid, a very sensitive monophenol previously reported to assay the monophenolase activity of polyphenol oxidase from apple, pear, and mushroom. The high values of the maximum steady state rate obtained for 4-hydroxyanisole suggest the existence of high catalytic constant toward this monophenol. These kinetic values were supported by nuclear magnetic resonance assays which predicted the highest reactivity of 4-hydroxyanisole. Therefore nuclear magnetic resonance assays proved to be a valuable and useful tool to predict the best monophenolic substrate for plant polyphenol oxidases. The 3-methyl-2-benzothiazlolinone-adduct for 4-hydroxyanisole was stable, with high molar absorptivity at the optimum pHs of the polyphenol oxidases assayed. All this together makes the use of 4-hydroxyanisol as monophenolic substrate and 3-methyl-2-benzothiazolinone as coupling reagent the most sensitive and precise assay method up to date reported in the literature to determine the monophenolas activity of polyphenol oxidase from fruits and vegetables.

Anisoles↗
PubMedDate not supplied

Technetium bone scanning in the diagnosis of osteomyelitis: a meta-analysis of test performance. Diagnostic Technology Assessment Consortium.

PURPOSE: To determine the diagnostic performance of technetium bone scanning in the setting of possible osteomyelitis in the foot of a patient who has diabetes or other vasculopathy. DESIGN: Meta-analysis. Data identification and study selection: To be eligible for inclusion, a report must have used intravenous technetium-99m methylene diphosphonate or a similar agent in humans over the age of 16 years, must have addressed possible osteomyelitis of the lower extremity with ulcer or soft-tissue inflammation in the setting of diabetes, neuropathy, or vasculopathy, and must have allowed the generation of a two-by-two table. A structured search of the MEDLARS database found 296 possibly eligible reports; ten met all the inclusion criteria. DATA EXTRACTION AND SYNTHESIS: The reported sensitivity and specificity of each report were converted to their logistic transforms and a straight line was fitted by weighted least-squares regression. The line was then back-transformed to yield a summary receiver operating characteristic curve. The false-positive rate of the bone scan is at best in the range of 10 to 20%. This occurs at sensitivities between 70 and 80%. The studies with increased sensitivity also reported sizable increases in the false-positive rate ranging from 20 to over 90%. Even small increases in sensitivity have necessitated large sacrifices in specificity. Seven of the ten studies reported specificities under 70%. CONCLUSIONS: Published data defining the effectiveness of technetium bone scanning for the diagnosis of osteomyelitis in the impaired foot indicate relatively poor performance. In many clinical situations, the specificity of the bone scan will not be high enough to confirm the diagnosis of osteomyelitis.

False Positive Reactions↗
PubMed2003

Determination of antioxidant properties of aromatic herbs, olives and fresh fruit using an enzymatic sensor.

The aim was to experimentally evaluate the antioxidant capacity of different fresh aromatic herbs (field balm, marjoram, parsley, rosemary, sage, sweet basil), several varieties of olives from Central Italy ('Carboncello', 'Rosciolo', 'Olivastro', 'Coratello', 'Leccino', 'Frantoio') and several types of fresh fruit (apple, apricot, banana, cherry, fig, grape, medlar, melon, peach, pear, pineapple, plum, water melon, yellow plum) using a superoxide dismutase (SOD) biosensor developed by the present authors. Measurements were carried out by comparing the biosensor response to the concentration of superoxide radical produced in solution using a xanthine/xanthine oxidase system in the presence and absence of the antioxidant sample considered. Tests carried out on different samples of fruit and aromatic herbs showed that the homogenised samples had better antioxidant properties than the centrifuged ones (obtained by centrifuging the homogenate), which sometimes gave extremely low antioxidant capacity values. The reliability of the proposed method was checked by comparing the trend of some experimental results found using the SOD biosensor with those reported in the literature obtained using the classic (ORAC) method. The precision of this method of analysis was found to be good for samples of aromatic herbs (RSD% <or=8%), acceptable for homogenised fruit samples (RSD% <or=13%) and less good for homogenised and centrifuged samples (RSD% <or=20%).

Antioxidants↗
PubMed1989

Is school-based reporting of injuries at school reliable? A literature review and an empirical study.

One quarter of all injuries in children of school age occur at school. The prevention of these injuries presupposes some kind of reporting system. In this study the reliability of routine reporting of injuries at school was analyzed. Only those injuries requiring treatment by a physician were included. All studies of injuries at school indexed in MEDLARS since 1970 were reviewed. In school-based systems carried out on a routine base, an average of 17 injuries per 1,000 student-years were recorded. Yet, both in hospital/health center-based systems and in school-based studies carried out during a limited time, conspicuously higher frequencies were recorded: 38 and 71 injuries per 1,000 student-years, respectively. In the empirical study all injuries were recorded in the compulsory schools of Linköping (about 13,000 students) during two periods. During a first period of three years, injuries were routinely reported by the school nurses. During a second period of one year, all staff at school were repeatedly encouraged to report injuries. In the first period 9.8 injuries per 1,000 student-years and in the second period 17.7 injuries were recorded. These findings indicate that routine reporting of injuries at school results in substantial underreporting.

Accidents↗
PubMed1992

Hepatobiliary complications in patients with human immunodeficiency virus infection.

Human immunodeficiency virus (HIV) infection has been associated with a number of hepatic and biliary tract disorders. Case reports, series of liver biopsies, and postmortem studies that examined the hepatobiliary system were retrieved with a MEDLARS search and form the basis of this review. The liver and biliary tract are frequently involved with opportunistic infections (most commonly mycobacteria and cytomegalovirus) and neoplasms (mainly Kaposi's sarcoma) in patients with HIV infection. The patients are often asymptomatic but may have elevated levels of serum liver enzymes. These abnormalities are nonspecific. Sulfa drugs, pentamidine, and ketoconazole are the medications used in HIV-related infections that are most likely to result in abnormalities on liver tests. Acalculous cholecystitis and sclerosing cholangitis also occur in HIV infection. Cytomegalovirus and Cryptosporidium are the organisms most commonly associated with these conditions. Imaging studies of the liver may detect parenchymal abnormalities and guide liver biopsy. The role of this procedure in the diagnosis of opportunistic infections and neoplasms is controversial because these lesions are generally disseminated at the time liver abnormalities are evident. A liver biopsy is best used when other less invasive procedures have failed to provide a diagnosis. Endoscopic retrograde cholangiopancreatography is a useful diagnostic procedure with therapeutic potential in patients with abdominal pain, fever, or an elevated serum alkaline phosphatase level.

Biliary Tract Diseases↗
PubMed1994

Global information infrastructure.

The High Performance Computing and Communications Program (HPCC) is a multiagency federal initiative under the leadership of the White House Office of Science and Technology Policy, established by the High Performance Computing Act of 1991. It has been assigned a critical role in supporting the international collaboration essential to science and to health care. Goals of the HPCC are to extend USA leadership in high performance computing and networking technologies; to improve technology transfer for economic competitiveness, education, and national security; and to provide a key part of the foundation for the National Information Infrastructure. The first component of the National Institutes of Health to participate in the HPCC, the National Library of Medicine (NLM), recently issued a solicitation for proposals to address a range of issues, from privacy to 'testbed' networks, 'virtual reality,' and more. These efforts will build upon the NLM's extensive outreach program and other initiatives, including the Unified Medical Language System (UMLS), MEDLARS, and Grateful Med. New Internet search tools are emerging, such as Gopher and 'Knowbots'. Medicine will succeed in developing future intelligent agents to assist in utilizing computer networks. Our ability to serve patients is so often restricted by lack of information and knowledge at the time and place of medical decision-making. The new technologies, properly employed, will also greatly enhance our ability to serve the patient.

Computer Communication Networks↗
PubMed1996

Implementation of a reference management system, MacRefer, under HyperCard.

We have developed a reference management system, MacRefer, using HyperTalk on Macintosh personal computers. Using this program, one can automatically acquire data from databases created by EndNote Plus and from OVID- or Medlar-formatted records downloaded via an online use of Medline. The MacRefer's capability of formatting bibliographic database in user-defined formats is comparable with the exemplified bibliography maker, EndNote Plus. Moreover, MacRefer has several competitive features, which are insufficiently equipped with EndNote Plus. For example, MacRefer is capable of (1) maintaining subsets within a database, (2) executing complex, structured searches combining up to nine keywords for any data field with the results and search conditions preserved, and (3) easily browsing (a portion of) reference database. Although MacRefer cannot be recognized as an absolute alternative of EndNote Plus because of several limitations inherent to HyperCard, the compensatory use of these two programs will expand the personal utilization of bibliographic databases.

Computers↗
PubMed1992

Was the Dalkon Shield a safe and effective intrauterine device? The conflict between case-control and clinical trial study findings.

OBJECTIVE: To compare the findings of the case-control and cohort studies used to indict the Dalkon Shield (A.H. Robins Company, Inc., Richmond, VA) with the findings of the Dalkon Shield clinical trials. DATA IDENTIFICATION: All published reports on the Dalkon Shield were identified through MEDLARS system (United States National Library of Medicine) searches and by cross checking all references in these reports. The same approach was used to identify all case-control and cohort studies of the purported relationship between intrauterine devices (IUDs) and pelvic inflammatory disease (PID). STUDY SELECTION: Only studies of interval patients that included 50 or more women and 6 or more months of follow up that computed standard IUD event rates (rates of pregnancy and expulsion and removal for pain and bleeding) were selected for this study. All case-control and cohort studies identified were included except two case-control studies that included women with sterile chronic salpingitis. RESULTS: The 16 case-control and 2 cohort studies found or suggested that the Dalkon Shield increased the risk of PID. The 71 clinical trials of the Dalkon Shield show that when this device is inserted by an experienced clinician it is a safe and effective contraceptive method, comparable with other IUDs used at the time. There was no evidence of an increased risk of PID found in these clinical trials. CONCLUSIONS: This study offers convincing evidence that the indictment of the Dalkon Shield was a mistake. Additionally, this study shows that physician skill and experience is far more important to successful IUD insertion than previously recognized, a finding with considerable implications for IUD study designs and for marketing strategies.

Case-Control Studies↗