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PubMed2005

Regret and quality of life across the adult life span: the influence of disengagement and available future goals.

Two studies examined the associations between life regrets and indicators of quality of life across the adult life span. Given that opportunities to undo regrets decline with age, regret intensity was expected to be inversely associated with subjective well-being and health among older adults. In addition, the research explored protective factors that have the potential to reduce older adults' regret intensity. It was suggested that being disengaged from undoing the consequences of regrets and having many future goals available may reduce older adults' intensity of regret and thereby contribute to a better quality of life. Across both studies, the findings demonstrate that older adults perceived reduced opportunities to undo the consequences of their regrets and that regret intensity predicted a reduced quality of life only among older adults. Furthermore, the findings support the adaptive value of disengagement and available future goals for managing life regrets in older adults.

Adult↗
PubMed2003

Quality of life philosophy V. Seizing the meaning of life and becoming well again.

This paper presents a positive philosophy of life developed to support and inspire patients to take more responsibility for their own lives and to draw more efficiently on their known or hidden resources. The idea is that everybody can become wiser, use themselves better, and thus improve quality of life, subjective health, and the ability to function. To be responsible means to see yourself as the cause of your own existence and state of being. To be the one who forms your own life to your liking, so that others do not shape it in the way they prefer to see you. Seen this way, taking responsibility in practice is one of the most difficult things to do. One of the greatest and most difficult things to do in this context is to be able to love. To be the one who loves, instead of being the one who demands love, care, awareness, respect, and acceptance from somebody else. Since almost all of us have had parents who maybe loved us too little and mostly conditionally, we all harbor a deep yearning to be loved as we are, unconditionally. A lot of our energy is spent trying to find recognition and acceptance, more or less as we did as children from our parents, who created the framework and defined the rules of the game. But today, reality is different. We have grown up and now life is about shaping our own existence. So we must be the ones who love. This is what responsibility is all about. Taking responsibility is, quite literally, moving the barriers in our lives inside ourselves. Taking responsibility for life means that you are willing to see that the real barriers are not all these external ones, but something that can be found within yourself. Of course there is an outside world that cannot be easily shaped according to your dreams. But a responsible point of view is that although it is difficult, the problem is not impossible; it is your real challenge and task. If there is something you really want, you can achieve it, but whether it happens depends on your wholehearted, goal-oriented, and continuous attempts. This paper describes the philosophy about seizing the meaning of life and becoming well again, even when there is little time left.

Animals↗
PubMed2006

Negative life events and quality of life in adults with asthma.

BACKGROUND: The relationship between stress and quality of life in adults with asthma has not been well studied. Stress, quantified by negative life events, may be linked to quality of life in asthma through multiple pathways, including increase in disease severity and adverse effects on socioeconomic status (SES). METHODS: The responses to a self-completed questionnaire assessing negative life events (NLEs) in the previous 12 months (from a 24-item checklist) among 189 adults with asthma from a well-characterised cohort were analysed. The relationship between the number of NLEs reported and asthma-specific quality of life (AQOL) was measured with the Marks instrument. General linear modelling was used to test the conjoint effects of NLEs, SES and disease severity based on the Severity of Asthma Score, a validated acute and chronic disease measure. RESULTS: Those with annual family incomes < 60,000 dollars reported significantly more NLEs than those with higher incomes (p = 0.03). The number of NLEs did not differ significantly between those with forced expiratory volume in 1 s <80% predicted and those with >80% predicted, nor among those with lower compared with higher Severity of Asthma Score. The frequency of NLEs was associated with poorer (higher numerical score) AQOL (p = 0.002). When studied together in the same model, combinations of income level and asthma severity (greater or lesser Severity of Asthma Score; p < 0.001) and number of NLEs (p = 0.03) were both significantly associated with AQOL. CONCLUSION: NLEs are associated with quality of life among adults with asthma, especially among those of lower SES. Clinicians should be aware of this relationship, especially in vulnerable patient subsets.

Adult↗
PubMedDate not supplied

Study on effects of life review activities on the quality of life of the elderly: a randomized controlled trial.

BACKGROUND: The objective of this study was to evaluate the mid-term efficacy of life review activities on the quality of life (QOL) of the elderly by conducting a randomized controlled trial, and to identify the factors that should be taken into consideration when conducting life review activities. METHODS: Written consent was obtained from 80 of the 97 eligible elderly persons. After randomly assigning them to two groups, an intervention group and a control group, group life review activities were conducted in the intervention group and discussion activities about health were conducted in the control group. In both the intervention group and the control group, life satisfaction, self-esteem, depression, and hopelessness were evaluated using self-rating scales at three points: at baseline, immediately after completion of the 8 weeks of sessions, and 3 months after completion of the intervention. RESULTS: Repeated measures analysis of covariance showed significant differences between the two groups in the changes in scores for depression (p = 0.04) and hopelessness (p = 0.04). Regarding the factors that were associated with depression and hopelessness, 3 months after completion of the intervention, depression and hopelessness of a more severe nature at baseline and having greater unresolved conflicts in the past were extracted by multiple regression analysis. CONCLUSIONS: The results suggested that group life review activities have a role in assisting the developmental stage of old age and supporting mental health, and have mid- to long-term effectiveness in maintaining and improving the QOL of the elderly.

Aged↗
PubMedDate not supplied

Metabolic control, quality of life, and negative life events: a longitudinal study of well-controlled and poorly regulated patients with type 1 diabetes after changeover to insulin pen treatment.

In a previous study of a group of 74 patients with Type I diabetes, quality of life was found to be consistently enhanced a year after transition to multiple injection therapy with the insulin pen, whereas metabolic control (HbA1C) only improved moderately. The aim of the present investigation was to examine quality of life, recent life events, and metabolic control longitudinally in this original study group over a 5-year period beginning 1 year after transition to the insulin pen. Multiple analysis of variance with a repeated-measures design was used to analyze the data longitudinally and compare metabolic control in subgroups of well-controlled and poorly regulated patients during the study period. For the group as a whole, quality of life was found to change only moderately, whereas metabolic control deteriorated significantly across time following transition to the insulin pen. The two subgroups exhibited distinct differences, however, in quality of life, recent life events, and metabolic control patterns. These findings are discussed in terms of the clinical suitability of a multiple injection regimen.

Aged↗
PubMed1990

Life-stress events, depression and purpose-in-life in first-admission alcoholics and members of Alcoholics Anonymous.

The relationship between alcoholism, depression, life-stress events and purpose-in-life is a very complex one. Thirty-five first admission alcoholics and an equal number of members of Alcoholics Anonymous were assessed, using objective measures of alcoholism, depression, stress and purpose-in-life. The results indicate that there were significant differences between the two groups on drinking behaviour, depression and purpose-in-life. No differences were found between the groups on the stress questionnaire. Positive correlations were found between drinking behaviour and depression, life events and purpose-in-life.

Adult↗
PubMed1980

Adaptation problems of Vietnamese refugees. II. Life changes and perception of life events.

The Vietnamese refugees have encountered a multitude of acute psychological, social, cultural, economic, and political upheavals. This study documents the Vietnamese perceptions of the life events that have swirled about them as well as the occurrences of these life events. Questionnaires were administered in 1975 and 1976 as part of an ongoing study. The expected high amount of life change in the year of the evacuation and resettlement (1975) continued into the following year (1976). Financial, life-style, work, spouse, and schooling problems continued to plague them and were increased in the second year. There was a positive correlation between life change and health status. The Vietnamese rank ordered the impact of life events in a fashion similar to the Americans, but there were differences in mean magnitude estimations. Substantial reductions in magnitude estimations at second administration of the Social Readjustment Rating Questionnaire indicated a change in the situational perception set with time.

Acculturation↗
PubMed2006

Validation of the adult attention-deficit/hyperactivity disorder quality-of-life Scale (AAQoL): a disease-specific quality-of-life measure.

INTRODUCTION: A growing body of evidence suggests that symptoms of attention-deficit/hyperactivity disorder (ADHD) persist into adulthood and are associated with ongoing impairment and co-morbidity. The absence of a conceptually sound and well-validated ADHD-specific quality-of-life measure has been an obstacle to understanding this impact. To address this gap, the Adult ADHD Quality-of-Life Scale (AAQoL) was developed based on well accepted methods for designing patient reported outcomes. The purpose of this study was to validate the AAQoL. METHODS: Nine Hundred and Eighty Nine adults in a retrospective cohort study were administered the AAQoL and psychometric validation was conducted according to an a priori statistical analysis plan. RESULTS: A 29-item AAQoL was found to have robust scale structure with four domains: Life Productivity, Psychological Health, Relationships and Life outlook. Internal consistency was adequate (0.93 for overall, 0.75-0.93 for subscales), and construct and known-groups validity were supported. conclusion: The AAQoL appears to be a valid measure of quality of life for adults with ADHD and can be considered for incorporation into future studies. The ability to quantify the quality-of-life consequences of adult ADHD should facilitate future research, assist clinicians in identifying appropriate treatment targets and contribute to the ultimate goal of improving the well-being and functioning of adults with ADHD.

Activities of Daily Living↗
PubMed1985

Growth rate and life spain in Drosophila. IV. Role of cell size and cell number in the biphasic relationship between life span and growth rate.

The patterns of variation of wing cell size and number were studied under developmental conditions leading to a biphasic relationship between life span and growth rate while duration of development remained constant (development on an agar-only medium with a varying added yeast amount, constant temperature (25 degrees C) and constant larval density). Across the yeast range, a 125% increase of body weight was accompanied by a roughly 30% increase in the wing linear dimensions, wing cell size and wing cell number while estimated duration of cell division and its reciprocal mitotic division rate remained constant. Furthermore, cell size (but not cell number) varied with growth rate in a similar biphasic pattern to that observed for life span. Finally, from a simultaneous examination of the covariation patterns of life span, growth rate, cell size and cell number with decreasing yeast amount, it became apparent that there was a "critical" yeast amount, approximately 125 mg/120 eggs, below which: (a) cell number abruptly started to decrease linearly from a roughly constant value; (b) the rate of the slow decrease of cell size now tripled and that of growth rate increased even more; and (c) life span which, in the upper yeast range, increased slowly with decreasing yeast, apparently reached a maximum at the critical yeast level and decreased three times faster below that level. These data taken together suggest that: (i) the decrease of all parameters (including life span) below the critical yeast level results from a presumably suboptimal or disturbed development because of and in proportion to the lack of nutrients and (ii) the increase of life span with decreasing yeast amount above the critical yeast level has not been definitely explained but some possibilities are suggested such as changes in subcellular organelle numbers, size and/or functional properties, or other changes due to a phenomenon equivalent to food restriction in rats, probably without changes in overall metabolic rate of the flies.

Aging↗
PubMed2004

Life extension versus improving quality of life.

There are two principal directions in ageing research: (i) the quest for understanding the mechanisms that determine the length of life and the use of such knowledge in order to find a potentially life extending treatment and (ii) the attempt to improve the quality of life in the elderly by reversing or preventing functional decline of different tissues without primarily extending life span. This chapter addresses the importance of assessing the potential impact of interventions on quality of life rather than extending life.

Aging↗
PubMed2004

Smoking decreases the duration of life lived with and without cardiovascular disease: a life course analysis of the Framingham Heart Study.

AIMS: To compare the burden of cardiovascular disease in terms of lifetime risk and life years lived with disease between smokers and non-smokers. METHODS AND RESULTS: We constructed multi-state life tables describing transitions through various cardiovascular diseases for 4723 smokers and non-smokers observed during 20 biannual observations in the Original Framingham Heart Study. Non-smokers live 8.66 (95% CI 7.61-9.63) (men) and 7.59 (95% CI 6.33-8.92) (women) years longer than smokers and more years free of cardiovascular disease: 6.22 (95% CI 5.09-7.30) years for males and 4.93 (95% CI 3.54-6.29) for females. But non-smokers spend more years with cardiovascular disease over the life course: 2.43 (95% CI 1.72-3.16) years for males and 2.66 (95% CI 1.87-3.38) years for females. The risk of cardiovascular disease before age 70 is higher among smokers, but over the entire lifecourse male non-smokers have higher risks of coronary heart disease, myocardial infarction, stroke and congestive heart failure, and female non-smokers have higher risks of coronary heart disease and congestive heart failure. CONCLUSION: Smoking, by shortening life, decreases both the probability and duration of cardiovascular disease throughout the life course. Non-smokers live many years longer and longer free of cardiovascular disease than smokers, but at the end of their life non-smokers will have lived longer with cardiovascular disease.

Adult↗
PubMed2001

Life as a set of matter transformation cycles: ecological attributes of life.

An approach to searching for extraterrestrial life on the base of "autotroph" concept of the origin of life is presented in the paper. According to this concept the origin of life took place in three stages. The first stage was developed inside the global geochemical cycle in which the turnover of different chemical transformations was implemented by solar radiation and/or heat energy of bowels of the Earth. At the second stage, after the autocatalytic systems have emerged these systems evolved as a result of "natural selection" by autocatalysis parameters up to emergence of special inheritance systems that drastically improved the autocatalysis parameters. The best in terms of autocatalysis parameters were the autocatalysis systems based on phase-separated particles where complex structures can form not only on the basis of covalent interactions. Such autocatalysis systems can emerge only in liquid in a certain range of temperatures and pressures. At this stage the geochemical cycle complicated involving new substances. At the third stage the evolution involved improvement of inheritance systems resulting in formation of the modern type of genetic apparatus. This concept formed the basis to consider approaches to experimental modeling of major aspects of the origin of life and to outlining some general features of life that can extend the sensitive horizon of searching for extraterrestrial life.

Biological Evolution↗
PubMed2005

Evaluation of life and death studies course on attitudes toward life and death among nursing students.

The aim of this study was to evaluate attitudes toward life and death among nursing students after attending the life and death studies (LDS) program. Both qualitative and quantitative methods were used to collect data. The pretest-posttest control group design randomly assigned students to an experimental (n = 47) or control group (n = 49). The 13-week course included lectures, video appraisal, games, simulations, films, books, assignments and group sharing. Statistical and content analysis were used to analyze qualitative and quantitative data. The findings showed a significant improvement in perception of the meaningfulness of life in four categories of improvement: expanded viewpoint, sadness about death, treating life sincerely, and instilling hope in life. The qualitative data indicated that a positive change in meaning of life was associated with interaction with others and self-reflection.

Adolescent↗
PubMed2003

[ICD-10 diagnosis and quality of life. A pilot study of quality of life of children and adolescents with psychiatric disorders].

OBJECTIVE: The present study examined whether the quality of life in children and adolescents with psychological disorders, as judged by the patients themselves and their mothers, differed according to the various ICD-10 diagnoses or the number of axes involved. METHODS: 151 children/adolescents and 125 mothers, referred consecutively to the clinic, completed the Inventory for Evaluation of Quality of Life in Children and Adolescents (Inventar zur Erfassung der Lebensqualität bei Kindern und Jugendlichen; ILK) by Mattejat et al. ICD-10 diagnoses were grouped for evaluation. RESULTS: No significant interaction between the five diagnostic axes and the several domains of quality of life was found. However, mothers of children and adolescents with attention deficit/hyperactivity disorders and/or conduct disorder more often tended to judge their children's quality of life as unsatisfactory in all domains, while the patients themselves did not. Thus, rather than the children themselves it seems to be the children's environment which considers "external disorders" to be distressing. CONCLUSIONS: The authors conclude that the quality of life as measured by the ILK cannot be captured by ICD-10 criteria. Apparently it is not so much the diagnosis itself but its subjective meaning that has the most essential impact on an individual's assessment of quality of life.

Activities of Daily Living↗
PubMed1996

Still participating after all these years: a study of life task participation in later life.

The authors examined in 618 older Americans the extent to which individual levels of life satisfaction were connected to participation in the shared tasks of late adulthood (e.g., community service and social life participation). Participation in these shared tasks was an important predictor of life satisfaction, controlling for health, self-reported vitality, social support, individual differences in congeniality, organizational affiliation, and prior levels of satisfaction. Social life participation was particularly important for retirees in predicting life satisfaction, more so than for study participants who were still able to derive enjoyment from work activity. This difference between retired and nonretired subjects was especially pronounced for men and illustrates how the important domains of activity shift with sociocultural expectations and opportunities of a given life phase.

Aged↗
PubMed2006

Life stress and the long-term treatment course of recurrent depression: III. Nonsevere life events predict recurrence for medicated patients over 3 years.

Research has consistently documented the significance of severe life events for onset of major depression. Theory, however, suggests other forms of stress are relevant for depression's recurrence. Nonsevere life events were tested in relation to depression for 126 patients with recurrent depression in a 3-year randomized maintenance protocol. Life stress was assessed every 12 weeks and rated along dimensions of severity, focus, and independence. A significant interaction between specific types of nonsevere life events and medication was found. For medicated patients, subject-focused independent nonsevere life events predicted recurrence; for unmedicated patients, these events predicted fewer recurrences. Other nonsevere life events did not predict recurrence. The findings underscore the potential importance of specific stressors for triggering recurrences of depression.

Adult↗
PubMed2005

Coping strategies, social support, life orientation and health-related quality of life following traumatic brain injury.

OBJECTIVE: To study coping strategies, social support and life orientation in patients following moderate and severe traumatic brain injury (TBI) in relation to health-related quality of life. SUBJECTS: Eighty-five patients with moderate or severe TBI and 68 control persons. METHODS: Estonian versions of the COPE-D test, the Brief Social Support Questionnaire, the Life Orientation Test and the RAND-36 questionnaire. RESULTS: Persons with TBI reported using task-oriented and social/emotional support strategies less often and avoidance-oriented strategies more often than control persons (p < 0.05). The social support network, satisfaction with it and optimism as life orientation were lower in the patient group (p < 0.05). Task-oriented coping styles, satisfaction with social support and optimistic life orientation were associated with the majority of the domains of health-related quality of life and resuming work after TBI. CONCLUSIONS: To achieve effective rehabilitation and to enhance patients' well-being, it is important to improve the quality and amount of social support network, as well as to support patients' adequate coping efforts for promoting an active lifestyle.

Adaptation, Psychological↗
PubMed1990

Fall-off in reporting life events: effects of life change, desirability, and anticipation.

The influence of event characteristics on recall was examined by directly comparing fall-off in reporting life events as a function of life change, desirability, and anticipation. We collected information from a sample of 1,669 blue-collar workers on stressful life events that occurred in a 1-year interval before the questionnaire was administered. The results indicated no fall-off in reporting events associated with marked life changes (ie, salient events). In contrast, significant fall-off was observed for events characterized by varying degrees of desirability and anticipation. Although ratings of desirability and saliency were not independent, saliency of life events emerged as the dimension most closely associated with accuracy of event reporting. Research on the reliability of measures of life events and the association between event characteristics and illness should consider the kinds of systematic reporting differences observed here.

Aged↗