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At least 181 records · Page 10Linked to original sources
PubMed1980

Laser coagulation in the upper GI tract: a preliminary light and scanning electron microscopic study.

Experimentally intact as well as artificially damaged mucosa of porcine stomach was endoscopically coagulated with Nd:YAG laser beams. Energy, intensity pattern, and time of application of the irradiation was varied and supracellular changes of the coagulated mucosa were subsequently investigated with the scanning electron microscope. The mucosa, damaged by laser beams, showed three typical zones: 1. a superficial, central carbonisation zone protected with a thin layer of coagulated mucus; 2. an elevated hyperemic ring with complete loss of superficial epithelium, but intact basement membrane and a blood clotting of the mucosal capillaries; 3. normal mucosa. After coagulating artificially induced bleeding of the mucosa the irradiated centre showed a deep depression with a carbonized surface. Two weeks later regeneration had occurred and there was complete reepithelialisation of the mucosa to about two-thirds of normal thickness.

Animals↗
PubMed2005

A Multicenter Study on the Efficacy and Safety of Interstitial Laser Coagulation Versus alpha-Blockade in Subjects With Symptomatic Benign Prostatic Hyperplasia: Preliminary Results.

Significant efforts have been made to develop minimally invasive surgical approaches to the treatment of benign prostatic hyperplasia, both to lessen the morbidity of the standard operative procedures and to avoid the need for continued drug therapy throughout the patient's life. Interstitial laser coagulation (ILC) is a minimally invasive procedure that can be performed with local, regional, or general anesthesia. With this operator-dependent procedure, the surgeon can selectively control placement of the laser fiber to achieve the optimum destruction of tissue. Preliminary (6-month) data from a randomized trial comparing alpha-blockade with ILC demonstrate that treatment with ILC is associated with a clinically significant decrease in American Urological Association symptom scores, a result superior to that achieved with an alpha-blocker.

Journal Article↗
PubMed1980

[Indications for laser coagulation in cases of branch vein occlusion (author's transl)].

Thirty-two patients suffering from branch vein occlusion were divided into three groups according to their fluorescein-angiographic lesions. In cases of venous stasis retinopathy with an intact perifoveal capillary arcade, spontaneous resolution may be expected. In eyes affected by hemorrhagic retinopathy the prognosis after laser coagulation was better than for untreated eyes.

Adult↗
PubMed1988

Functional and histological restitution in the urinary tract after Nd:YAG laser coagulation.

Current development in endourologic equipment has made possible the endoscopic application of the Nd:YAG laser in the treatment of urothelial tumors of the whole urinary tract. The clinical results are rather promising. We controlled with various methods the healing processes of 14 rabbit ureters after Nd:YAG laser treatment as to morphological repair and physiological function. The ureters were irradiated transrenally with an energy of 60 J coagulating all wall layers. Healing of the laser lesions nearly to normal in all animals was observed 4 to 6 weeks after treatment. The prevailing histological and physiological changes in the ureter are extremely slight and do not disturb the normal ureteral function. The results show the complete healing process of the ureter after laser coagulation and make the application of Nd:YAG laser in the upper urinary tract much more predictable.

Animals↗
PubMed1989

[Treatment of distal urethral cancer by laser coagulation].

Primary carcinoma of the urethra is a rare lesion, and there are no standard therapeutical modalities suggested in the literature. We report the case of a 65-year-old woman with transitional cell carcinoma of the distal urethra and metastasis to the inguinal lymph nodes (T2 N1 MO G2). Locally, the lesion was treated by Nd:YAG laser coagulation in four sessions. Ileoinguinal and pelvic lymph-node dissection was performed as a diagnostic and therapeutic procedure. Twenty-eight months after the initial treatment, no evidence of tumor recurrence has been found, although extensive biopsy specimens have been taken. Clinical staging showed no evidence of metastases.

Biopsy↗
PubMed2005

Local anesthesia during interstitial laser coagulation of the prostate.

With the emergence of minimally invasive therapies for the management of symptoms of benign prostatic hyperplasia (BPH), as well as the reality of a changing medical economic environment, there is a need for a reliable local anesthesia protocol. The protocol described here for prostate anesthetic block is a safe, economical, and effective way to perform interstitial laser coagulation and other minor endoscopic urologic procedures in the office setting. Most patients experience little discomfort and recover quickly, with prompt return to normal activities. Urologists should be aware of and comfortable with these techniques.

Journal Article↗
PubMed1993

[Results of laser coagulation of central retinal vein occlusion].

BACKGROUND: In the literature laser treatment in ischemic central retinal vein occlusion (CRVO) is established to prevent iris neovascularization. We investigated the relationship of morphological and fluorescein angiographic findings with the results of laser treatment. PATIENTS AND METHODS: In 70 (56%) of 125 examined patients with central retinal vein occlusion laser treatment was performed. Indications were either ischemic type of occlusion or macular edema with visual acuity < or = 0.5. RESULTS: The results compare visual acuity before and after laser treatment (three months and 11.5 months on average) examined by Wilcoxon-test. There was no significant improvement in visual acuity (p = 0.62). After laser treatment 3 (9%) patients with ischemic CRVO developed iris neovascularization and 2 (6%) neovascular glaucoma. There was no correlation between visual outcome and ischemia type (non ischemic type p = 0.61, ischemic type p = 0.67), maculopathy (cystoid macula edema p = 0.87, ischemic maculopathy p = 0.5) and internal diseases (hypertension p = 0.43, diabetes mellitus p = 0.74). CONCLUSIONS: The results of this study indicate that there is no significant visual improvement in patients with CRVO after laser treatment. There are no morphological and angiographic findings indicating a subgroup with good visual prognosis.

Fluorescein Angiography↗
PubMed1999

[Trans-scleral diode laser coagulation for therapy of acute retinopathia praematurorum].

BACKGROUND: Lens opacities were noted in single cases after transpupillar laser photocoagulation in retinopathy of prematurity (ROP) using the laser indirect ophthalmoscope. The diode laser with its wavelength in the near infrared (810 nm) makes lens sparing transscleral retinal coagulation possible. PATIENTS AND METHODS: In a controlled clinical study 60 eyes of 30 very low birth weight infants (gestational age 23-31 weeks, mean 26.6 +/- 1.8 weeks; birth weight 510-1200 g, 856 +/- 170 g) with threshold ROP were treated with diode laser photocoagulation. One eye of each infant was coagulated transsclerally while the fellow eye had transpapillary coagulation using the laser indirect ophthalmoscope. Follow-up ranged from 2 to 38 months (19 +/- 11 months). RESULTS: In 29 (97%) out of 30 eyes treated transsclerally and in 30 (100%) out of 30 eyes treated transpapillary the outcome was a flat, attached retina. Three eyes had a second laser treatment and 2 eyes had additional retinal detachment surgery. One eye (3%) with zone I disease failed after transscleral laser treatment and additional retinal detachment surgery with partially detached retina (stage 4 B) No adverse side effects as a result of laser treatment were noted except for a small amount of retinal/preretinal bleeding in the ridge and a vitreous bleeding. There were no adverse side effects (e.g., bleeding, cataract formation) in the anterior segments of the eyes. CONCLUSION: Transscleral diode laser coagulation for treatment of threshold ROP proved to be as effective as transpapillary diode laser photocoagulation. Only minor side effects were noticed. Transscleral diode laser photocoagulation is an advantageous treatment method in eyes with preexisting risk of cataract formation in transpapillary laser treatment.

Child, Preschool↗
PubMed2006

[Laser coagulation in the endoscopic management of fourth branchial pouch sinus].

OBJECTIVES: To describe a new method of treatment of the fourth branchial pouch sinuses by laser endoscopic coagulation of the fistula. MATERIAL AND METHODS: Retrospective study of two children aged 3 and 12 years with fourth branchial pouch sinuses. Both children presented recurrent cervical abscesses. The diagnosis was established on results of ultrasound, barium study, CT scan and pharyngoscopy. After recovering from infection, the definitive treatment was a laser diode cauterization of the fistulous route and its pharyngeal opening. RESULTS: Outcome was rapidly favorable in both children without complications or recurrence. DISCUSSION: These two cases and other reports in the literature confirm the role of endoscopic management for the treatment of the fourth branchial pouch sinus. Laser treatment is especially useful because of its convenience, its harmlessness and its reliability. CONCLUSION: Fourth branchial pouch sinuses are rare. Surgery, which can be difficult and not without risks, is the generally accepted treatment. This new laser method combines ease of treatment and efficacy.

Branchial Region↗
PubMed2005

[The clinical application and research on vas deferens laser coagulation sterilization].

OBJECTIVE: To study the effect of Ar(+) laser on human vas deferens and to compare the effects of using different radiation levels with varying thickness of tissue and varying levels of injury. METHODS: After initial tests on animals, four human scrotums were opened and treated directly with Ar(+) laser radiation. Then 58 human individual scrotums were treated with radiation by the method of trans-skin puncture. The rate of sperm reduction and elimination was tested. RESULTS: In 60 cases, the sperms were found to be eliminated completely after six months of radiation treatment. In 2 cases the sperms were found not to be eliminated completely due to the insufficient radiation. CONCLUSION: Ar(+) laser is one of the best forms of radiation for coagulation of vas deferens. It can be used to coagulate vas deferens without any complications or sequelae.

Adult↗
PubMed1976

[Occurrence of diffusions shown by fluorescence angiography of the laser coagulation in animals (author's transl)].

Laser treated rat fundi were observed angiographically and with the fluorescence microscope for 3 months. Angiographically diffusions have been observable up to about one week post laser, fluorescence microscopically, however, for the whole observation time of 3 months. From the 2nd week, these diffusions were produced mainly by neovascularizations which angiographically were not visible. They started from the choroid and penetrated into the outer part of the retina.

Animals↗
PubMed1992

Adriamycin absorption after Nd:YAG laser coagulation compared to electrosurgical resection of the bladder wall.

The toxicity of intravesical drugs used for the treatment of bladder cancer is increased by systemic absorption. Therefore, treatment is often delayed several weeks after transurethral resection until sufficient healing occurs. Since a neodymium:YAG laser causes tissue injury by thermal coagulation, we investigated differences in bladder permeability after laser treatment compared to TUR. Comparable 2.5 cm in diameter areas of tissue injury were created in the bladder of mongrel dogs either by Nd:YAG laser coagulation or transurethral electrocautery resection (TUR). Subsequently, 30 mg. of adriamycin were instilled intravesically. A control group consisted of animals receiving adriamycin alone. Blood was taken at 10, 30, 60, and 120 minutes after instillation and the serum concentration of adriamycin measured quantitatively by high performance liquid chromatography (HPLC) with fluorescence detection. The maximum serum ADM concentration during 120 minutes for the control group was 28.0 +/- 12.9 ng/ml compared to 38.9 +/- 4.8 for the laser group and 102.9 +/- 29.9 for TUR. The area under the curve was 35.1 +/- 10.2 ng x hours/ml for control, 43.5 +/- 3.9 for laser and 127.7 +/- 49.9 for TUR. Using a two-tailed Student's t test, the difference between the TUR and the laser group was significant (p less than 0.01). There was no difference between laser and control. These results suggest that laser treatment has minimal effect on the absorption of drugs from the bladder. The clinical practice of delaying intravesical therapy after TUR is verified but a similar policy may not be necessary after laser treatment.

Administration, Intravesical↗