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PubMed2001

Intergenerational transmission: individuation and intimacy across three generations.

This study examined the transmission of intergenerational family processes across three generations, employing Williamson's construct of Personal Authority in the Family System (PAFS) as a theoretical back-drop. From a PAFS perspective, psychological health is viewed as directly related to the degree of individuation and intimacy (PAFS) experienced within the family of origin. Overall, the results provided a degree of support for the intergenerational transmission hypothesis. The strongest predictor of the transmission process was from the participant/parent relationship to the participant/spouse relationship (spousal fusion/individuation). Separate male and female analyses of the Spousal Fusion/Individuation model found a moderate effect for females and a large effect for males. A small effect was found in predicting nuclear family triangulation from parent and spouse variables, although there was no gender effect. The findings suggest that degree of individuation and its related constructs are more critical in the transmission process than is intimacy.

Adult↗
PubMed2000

Intergenerational and environmental factors influencing pregnancy outcomes.

PURPOSE: Factors that relate to the mother's own course of growth and development might influence later reproductive performances. This study examines the effect of maternal birth weight and maternal height and maternal weight gain, on term-small for gestational age (SGA) and preterm delivery.METHODS: Data used for this study were from the South Carolina Pregnancy Risk Assessment Monitoring System (PRAMS) and birth certificate files for 1993-1995. Since PRAMS data were weighted to adjust for sampling probabilities, non-response and survey design, Survey Data Analysis (SUDAAN) software was used in all analyses.RESULTS: Maternal birth weight was strongly associated with term SGA (OR = 3.65; 95% CI = 1.83-7.29), but not preterm delivery among black mothers; it was associated with preterm delivery (OR = 1.86; 95% CI = 1.09-3.17), but not term-SGA for white mothers. Maternal birth weight was associated with term SGA among nonsmokers only (OR = 2.34; 95% CI = 1.33-4.11). Maternal weight gain modified the effect of height on birth outcomes. Among women with inadequate weight gain, there was a 3-fold increase in risk for term-SGA (OR = 3.06; 95% CI = 2.41-3.89) for short maternal height, but not for preterm delivery. Among women with adequate plus weight gain, the association between short maternal height and term-SGA was 2.7 (95% CI = 0.55-9.43) compared to 3.67 (95% CI = 0.1.41-9.56) between short maternal height and preterm delivery. Maternal weight gain also modified the effect of maternal height on both outcomes for black mothers and for nonsmokers only.CONCLUSIONS: Findings indicate the need for interventions directed to those women who can benefit most from appropriate targeted weight gain recommendations. Therefore, prevention methods should be implemented to encourage short stature women to gain adequate weight during pregnancy.

Journal Article↗
PubMed1998

Earned security, daily stress, and parenting: a comparison of five alternative models.

Research suggests that adults who have developed a coherent perspective on their negative, early attachment relationships (i.e., earned secures) do not reenact poor parenting practices with their own children. However, no studies have addressed whether earned secures maintain positive parenting under the pressures of aversive environmental conditions. This study tested five alternative models that predict how earned secures parent under low and high stress in comparison to adults who had a positive upbringing (i.e., continuous secures) and adults who have an incoherent perspective on a troubled childhood (i.e., insecures). Only if earned secures exhibit effective caregiving under high stress, in comparison to the other security groups, can it be assumed that they have broken the intergenerational cycle of poor parenting. The Adult Attachment Interview was used to classify 97 mothers as earned secure, continuous secure, and insecure. Home observations of parenting and maternal self-reports of daily hassles (our stress measure) were obtained when children were 27 months old. Planned comparisons revealed that the diathesis-stress/incoherent present state of mind model most accurately predicted parenting. Thus, under high stress, the earned secures parented equivalently to the continuous secures and more positively than the insecures; under low stress no group differences were obtained. These findings indicate that in a normative sample earned secures break the intergenerational cycle and exhibit resilient parenting even under high stress conditions.

Adult↗
PubMed1995

A proposed intergenerational model of substance abuse, family functioning, and abuse/neglect.

Although the link between substance abuse and child maltreatment has been relatively well established, there is a general recognition that this is not a simple cause-effect relationship. The current study explored the relationships among substance abuse, family functioning, and abuse/neglect in a sample of incarcerated substance abusers. Data were gathered on the earlier life experiences of 81 men and women serving sentences in two maximum security prisons, including assessments of their parents' substance abuse problems; levels of family competence within their families-of-origin; their exposure, as children and adults, to physical, emotional, and sexual abuse and physical/emotional neglect; and their own levels of substance abuse. Results showed generally high percentages of parental substance abuse and abuse/neglect, and relatively low levels of family competence. Correlational analyses revealed significant direct and indirect relationships among parental substance abuse, family dynamics, and exposure to both child and adult maltreatment. These four variables were also significantly associated with respondents' own substance abuse in later life, suggesting the potential for continuation of these patterns into successive generations. An intergenerational model of these family and personal functioning variables is presented and implications for service delivery with correctional clients is discussed.

Adolescent↗
PubMed1987

An improved method for protoplast formation and its application in the fusion of Rhodotorula rubra with Saccharomyces cerevisiae.

Protoplasts from various strains of red-pigmented yeasts were generated at high frequency using improved procedures. The use of sulphur-containing amino acids and 2-deoxyglucose in growth media led to impaired cell wall synthesis and rendered cells very susceptible to treatment with mercapto-ethanol and various lytic enzymes. Use of individual lytic enzymes separately resulted in relatively low frequencies of protoplasts from most of the red yeasts examined, whilst use of beta-glucuronidase, Novozyme and Zymolyase in series markedly increased stable protoplast formation. The latter effects were shown to be strain specific. The ability to generate large numbers of red yeast protoplasts prompted the attempt to examine intergeneric fusion between auxotrophs of a strain of Saccharomyces cerevisiae and Rhodotorula rubra. Putative hybrids were selected as variously-pigmented prototrophic colonies growing on minimal medium and stabilised by subculturing on the latter medium. Unusual cream, orange and yellow hybrid colonies were generated, composed of cells of varying morphologies (chains, multibudded). The majority of stable hybrids contained one nucleus, although several heterokaryons were also observed. Some hybrids possessed the phenotypes of both parents: fusant wcat41 grew as rapidly as the S. cerevisiae parent but also contained an inducible phenylalanine ammonia-lyase (PAL) which appeared to be more active than that of the Rhodotorula parent.

Culture Media↗
PubMed1997

[Effect of maternal paternal transmissions on clinical manifestations of CTG repeat on myotonic dystrophy].

The increasing size of the CTG repeat in successive generations is considered to the molecular basis for anticipation in DM. Maternal offspring show severe clinical manifestation than paternal transmitted offspring. The intergenerational amplification of this repeat is influenced by the sex of the parent transmitting mutant allele, in that a greater average intergenerational amplification is seen on maternal transmission. Also in the severest form of CDM almost exclusively transmitted maternal allele, the number of repeats is generally higher than that seen in non-CDM. But whether the unknown another maternal factor influence defined children having large mutant allele from mother is important question. The parental bias based on the different methylation patterns, mitochondria genome or different expressions of mRNA species are unlikely. The maternal effect might be explained the differences of the expressions of mRNA according to alternating splicing. And intrauterine effect, chromosomal imprinting or other unknown maternal factors have been expected to be involved in the pathophysiology.

Alleles↗
PubMed1994

Increased fertility of Corynebacterium glutamicum recipients in intergeneric matings with Escherichia coli after stress exposure.

Corynebacterial recipient cells exposed to heat, organic solvents, pH shifts, or detergents show an increased fertility in subsequent interspecific matings with Escherichia coli. This effect is independent of de novo protein biosynthesis and seems to be due to a direct inactivation of a restriction system active against foreign DNA that enters the cell by IncP-mediated conjugation.

Conjugation, Genetic↗
PubMed1997

The intergenerational costs of parental social stressors: academic and social difficulties in early adolescence for children of young mothers.

Social stressors embedded in parents' occupational and family roles have been shown to have effects on family interaction and the cognitive and emotional development of young children. Here we consider whether these patterns also hold for children in early adolescence. We study 1,158 10 to 14-year-old children born to the early childbearers among the female respondents of the National Longitudinal Survey of Youth cohort. We find that both poor quality of parental employment and low quality of mothers' relationships with their partners have adverse effects on the cognitive stimulation and maternal warmth children receive; living in informal unions is also associated with poorer parent-child interaction. These family interaction patterns in turn both buffer the effects of stressful family conditions and shape academic and behavior outcomes directly. Some work and family conditions interact in their effects: In particular, single mothering has less adverse effects on cognitive stimulation and behavior problems when mothers are employed in occupations providing higher complexity. The effects of current conditions are diminished but seldom eliminated when we control for possible selection effects by using data from earlier waves to control for earlier levels of child problems. These findings suggest that current parental social stressors continue to have consequences for both academic and behavioral outcomes during early adolescence.

Achievement↗
PubMedDate not supplied

Intergenerational activities involving persons with dementia: an observational assessment.

Although benefits of intergenerational programs (IGP) have been identified for older adults, adults with dementia are rarely targeted for such programs. Characteristics of dementia challenge caregivers to find appropriate activities that successfully engage the adults. With consideration of participants' abilities and interests, beneficial IGP can be facilitated. A co-located program for children and seniors was assessed for effects of IGP on adults with dementia. Results indicate that affect was higher during IGP for treatment group members than during non-IGP activities for treatment and comparison group members. Behaviors supporting personhood were common during IGP and non-IGP activities for treatment and comparison group members. Cognitive ability was unassociated with participation in IGP and affect during IGP. Findings suggest IGPs are appropriate and effective for persons with dementia.

Affect↗
PubMed1996

Attitudes toward physical discipline as a function of disciplinary history and self-labeling as physically abused.

To examine the relation between childhood experience with punitive discipline, perceptions of a punitive childhood history, and adult attitudes regarding appropriate discipline, a total of 1359 university undergraduates completed a screening questionnaire to assess their childhood disciplinary histories and their perceptions of that history. A sample of 207 of the screened participants who reported a diverse range of childhood disciplinary histories participated in a second test session to assess attitudes regarding appropriate discipline. Among persons with severely punitive histories, those who did not label themselves as abused were less likely to classify events as physically abusive than those who labeled themselves abused. Persons with less severe punishment histories were comparable to those with severely punitive histories who also labeled themselves abused. Additionally, persons who had experienced a specific form of physical discipline as a child were less likely to label that form of discipline abusive. However, this effect of experience did not obtain among subjects who described a history of discipline-produced injury. Implications of these patterns for the intergenerational transmission of abuse are discussed.

Adult↗
PubMed2003

Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs.

Previous studies from our laboratory have demonstrated that administration of a myogenic plasmid that encodes a protease-resistant growth hormone-releasing hormone (HV-GHRH) to pregnant rat dams augmented long-term growth in first-generation progeny. In the present study, gilts were injected intra-muscularly at day 85 of gestation with 0, 0.1, 0.5, 1, or 5 mg of the HV-GHRH-expressing plasmid and were then electroporated. Piglets were weighed and bled periodically from birth to 100 kg. Piglets from gilts treated with 1 and 5 mg of HV-GHRH plasmid were larger at birth and weaning compared with controls. These two groups reached 100 kg 9 days earlier than the other groups. GHRH levels were increased at birth in piglets from treated gilts. IGF-I levels were significantly increased in the 5-mg group beginning at 21 days of age compared with controls. Pituitaries from the 5-mg group contained a significantly increased number of somatotrophs and lactotrophs from birth to 100 kg. This study confirms that enhanced maternal GHRH production results in intergenerational growth augmentation and that the magnitude of the response is dose dependent. The similarity of the response across species suggests that the effect is likely exerted as a fundamental component of gestational and developmental physiology.

Animals↗
PubMed1996

Directive counseling on long-acting contraception.

National rates of unintended births are a major public health concern. The availability of highly effective long-acting contraceptives has prompted some public officials to promote the coercive use of these methods to reduce such problems as intergenerational poverty and child abuse. Broad-brush public policies that require long-term contraceptive use are unethical. However, persuasion to use these methods can be appropriate. One place for exerting ethically justified influence is in family planning counseling. The dominant nondirective counseling model, which excludes the possibility of vigorous persuasion, is overly rigid. Family planning professionals should develop practice protocols that permit and guide the exercise of directive counseling to use long-acting contraception.

Child↗
PubMed1996

Associations among attachment classifications of mothers, fathers, and their infants.

Associations are reported among classifications of Adult Attachment Interviews (AAIs) obtained from expectant parents and subsequent classifications of their infants in the Strange Situation Procedure (SSP). Mothers' AAIs predicted infant-mother SSPs (chi 2 = 41.87, N = 96, df = 9, p < or = .0001), and fathers' AAIs predicted infant-father SSPs (chi 2 = 18.94, N = 90, df = 6, p < or = .005). Associations between parents' AAIs and infant-parent SSPs were lessened by the failure to predict the insecure-resistant pattern with mother and the absence of this pattern with father. Counter to expectation, infant-father SSPs were associated with infant-mother SSPs (chi 2 = 3.78, N = 90, df = 1, p < or = .05), which could not be accounted for in terms of an overlap between parental AAIs. A secondary analysis of the data suggested that this dependency effect of SSPs may be explained by the influence of maternal AAIs upon child-father SSPs. Results are discussed in terms of intergenerational and relationship-specific influences upon attachment during infancy, the possible influence of infant temperament, and the relative influence of mother and father upon the child's evolving representations of attachments within the family.

Adult↗
PubMed1989

Time preference for health in cost-effectiveness analysis.

In program evaluation, should a predicted health status gain of 1 quality-adjusted life year (QALY) occurring 10 years from now be valued the same as a 1-QALY increase realizable 5 years from now? Or 1 year from now? If not, how should these future gains (or losses) be evaluated from a present-time perspective? Such questions arise frequently in cost-effectiveness analyses of disease prevention-health promotion programs. This report argues there are actually two distinct interpretations of time preference jointly relevant in many multiperiod program evaluations. 1) In ongoing programs where both present and future population cohorts are, in effect, vying for resources, decision makers must establish a relative social weighting of cohorts by specifying (now) the dollar worth of any unit QALY gain achievable in each. This is a problem of intergenerational equity in the resource allocation process. 2) Individuals, in any cohort, may possess a time preference for the sequence of events comprising their own multiperiod health outcomes. Current models, typically discounting future health gains to present value at some constant rate (r), can well accommodate the first interpretation but not (simultaneously) the second. In response, this report introduces a two-step evaluation procedure featuring the "scenario strategy," a holistic multiattribute preference approach to evaluating multiperiod health outcomes. It allows one to isolate statistically time preference effects at the individual or group level and to incorporate them naturally into the overall evaluation of multiperiod outcomes. A survey-based example and an appendix illustrate the main points.

Attitude to Health↗
PubMed1988

Intergeneric rosettes: sequestered surface recognition among human periodontal bacteria.

The human oral bacteria, Streptococcus sanguis and Bacteroides loescheii, when mixed in equal numbers in vitro, formed large settling coaggregates. As the relative number of each cell type was changed, coaggregates became smaller until at cell-type ratios of 10 to 1, rosettes formed. Rosettes consisting of a streptococcal cell in the center surrounded by bacteroides cells exhibited surface recognition properties of only the bacteroides, which coaggregated with many other cell types such as Actinomyces naeslundii, and formed large settling multigeneric aggregates. The ecological significance of these results derives from the following: (i) the direct demonstration that intergeneric coaggregates can protect the central cell from or prevent its access to other cells in the environment, and (ii) the potential for these effects to occur during bacterial succession of various cell types observed in progressively more severe stages of human periodontal disease.

Bacterial Adhesion↗
PubMedDate not supplied

Improving intergenerational health care communication.

The relationship between health care providers and their older adult patients may suffer from miscommunication problems stemming from agist stereotyping. Stereotypes of older adults by younger adults may be revealed through patronizing speech--or elder-speak, which is the overaccommodation of speech interaction. Over- and underaccommodation strategies based on these stereotypes are often used by young health care providers when communicating with older adults. As the population ages and the demand for health care services increases, health care providers must improve their communicative effectiveness with their older patients. Attention to the individual needs of health care consumers, cognizance of age or role stereotyping, and proper training of health care providers would increase communicative effectiveness and enhance the patient-provider relationship.

Adult↗
PubMed1997

The status of ORT (oral rehydration therapy) in Bangladesh: how widely is it used?

During 1980-1990 BRAC, a Bangladeshi non-governmental organization, taught over 12 million mothers how to prepare oral rehydration therapy (ORT) at home with lobon (common salt) and gur (unrefined brown sugar). This was followed by a strong promotion and distribution of prepackaged ORS by various agencies including the government. In 1993 we assessed knowledge of ORT preparation, its local availability and its use for the management of diarrhoea. Over 9000 households in 90 villages were revisited; 306 government outreach health workers, 296 drug sellers, and 237 village doctors were interviewed; 152 government facilities and 495 pharmacies/shops were visited. ORT prepared by mothers in a sub-sample of the households was analyzed for chloride content and interviewers collected information on use of ORT for diarrhoeal episodes occurring in the preceding two weeks. The data quality was assessed through a resurvey of sample respondents within two weeks of the first interview. Over 70% of the mothers could prepare a chemically 'safe and effective' ORS. A significant proportion of these mothers were very young at the time of the mass campaigns using house to house teaching, implying an intergenerational transfer of the knowledge on ORT. ORT was found to be used in 60% of all diarrhoeal episodes, but the rate varied with the type of diarrhoea, being highest for daeria (severe watery diarrhoea) and lowest for amasha (dysentery). Drug sellers and village doctors now recommend ORT much more frequently than before. Members of the medical profession (qualified and unqualified) still lag behind in prescribing the use of ORT. The availability of pre-packaged ORS in rural pharmacies has improved enormously. There is convincing evidence that the widescale promotion in the past of ORS for dehydration in diarrhoea has led to this marked improvement today. Nevertheless the use of rice-based ORS, culturally appropriate messages and the promotion of ORS with food offer opportunities to further improve the utilization of ORT.

Adolescent↗
PubMed1987

Grandparents as interactive and social support agents for families with young infants.

The role of grandparents in infancy was examined in a comparative analysis of grandparent-infant grandchild and parent-infant interaction patterns. A second focus of the study was an exploration of the extent to which grandparents function as social support agents for their adult children and infant grandchildren. Grandparents (30 grandmothers and 21 grandfathers) and parents (30 mothers and 30 fathers) of seven-month-old infants were observed in individual five-minute dyadic play sessions with the infant in the parents' homes, yielding twenty minutes of agent-infant interaction. The observations were scored using both time-sampling and global coding schemes. Information on grandparental support to the young parents and infants, relative to other social support sources, were also obtained from grandparents and parents. Results indicated that both grandmothers and grandfathers are active interactive and support agents, with a pattern of similarities and differences in interactive style across generation and gender. Although there was a high degree of overlap in parent and grandparent interaction styles, parents were rated as more competent. Gender consistencies were found between female agents (mothers and grandmothers) and male agents (fathers and grandfathers). High levels of intergenerational contact were reported, with both parents and grandparents highly satisfied with the contact. The results of this study support an expanded view of the effects of various agents in young children's social environment.

Adult↗