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Cerebro-cerebellar learning loops in apes and humans.

In the cerebro-cerebellar system of anthropoid apes and humans, the cerebellum seems able to contribute not only to motor skills but also to mental and language skills. Anatomical evidence suggests that in these species the cerebellum can function at two different hierarchical levels. At a lower level, the cerebellum can supply signals to the frontal motor areas for effecting the manipulation of muscles. At a higher level, the cerebellum can supply signals to some prefrontal areas for effecting the manipulation of symbols. At both levels, the cerebellum can function in essentially the same way: when incoming information is processed repeatedly in the neural loops in which the cerebellum is embedded, the cerebellum can learn to generate new sequences of signals, which constitute new programs for carrying out learned procedures. If cerebellar programs are used in the frontal motor areas (area 4 and are 6), motor manipulations can be effected rapidly and skillfully. Similarly, if cerebellar programs are used in some prefrontal areas (e.g., area 8 and the inferior frontal convolution), mental and language manipulations could be effected rapidly and skillfully. The cerebellum, in its contributions to these mental and language functions, as in its contributions to motor function, could serve as an adaptive mechanism whose signals enable the frontal cortex to execute learned procedures optimally. In the absence of such cerebellar signals, the frontal cortex would have to perform these procedures less rapidly and fluently. Modern testing techniques can reveal such a subtle difference in performance. These techniques are therefore now being used to test human subjects, in an attempt to validate or refute this broadened concept of cerebellar function. If the new concept is validated, it can provide powerful explanations for some unresolved mysteries about the human brain.

Animals↗

Training clinical researchers in neurology: we must do better.

The pace of scientific discoveries, the increasing complexity of managing patients, and the runaway cost of neurological services have created an urgent need for a wide range of clinical research in neurology. Despite increasing recognition of this need and recent increases in funding for training clinical investigators, neurologists conducting cellular and molecular investigations are more likely to join faculties, maintain research careers, and attain academic advancement. Because academic departments of neurology are successful in producing and nurturing basic science researchers, why aren't they just as triumphant in spawning clinical investigators? This crisis in the preparation of clinical investigators has been brought about by many factors: competing time demands for clinical service, lack of methodologically rigorous training in the disciplines necessary to conduct clinical research, and lack of mentorship. Neurology residents contemplating a clinical research career may observe junior faculty who lack career guidance, are ill-prepared as independent investigators, and must juggle patient demands while trying to write a research grant or conduct a study. Already burdened by medical school debts, is it any wonder that our neurology graduates don't leap to a career with a future that seems so insecure? Academic departments of neurology must develop full-scale clinical research training programs if they are to meet the pressing need for clinical research. As a starting point, they must free themselves from their dependence on providing clinical services to generate income. Following the model which has produced successful basic researchers, much greater effort must be given to establishing rigorous methodological training in collaboration with other departments, creating senior role models, and protecting time for clinical investigators to conduct research. Unless we create incentives to careers in clinical research, we will never answer the growing number of clinical research questions we face today.

Humans↗

Reporting charity care. Hospitals must prepare to comply with new AICPA accounting rules.

To comply with new accounting rules issued by the American Institute of Certified Public Accountants (AICPA), hospitals will have to change the way they report charity care in the financial statements they prepare for fiscal years ending mid-July 1991 and later. In the past, those hospitals which did report charity care information usually lumped it with bad debts under a caption such as "uncompensated services" or disclosed a specific amount of charity care to comply with Hill-Burton or other governmental programs. From now on, however, providers' financial statements must distinguish bad debt from charity care, not report gross patient revenues in the income statement, not imply that charity services generate revenue or receivables, make specific disclosures about the level of charity care provided, and report bad debts as an expense, rather than as a deduction from revenue. Distinguishing bad debts from charity care will be difficult. The AICPA defines bad debts as actual or expected uncollectibles resulting from an extension of credit, and charity care as services for which the provider does not expect payment. The AICPA believes that facilities which establish a definitive management policy on charity care should be able to distinguish between the two. To collect the data necessary to meet the AICPA requirements, hospitals need to establish a method to catalog the charity services they provide. Facilities should also ensure that patients and staff are familiar with their charity care policies.

Accounting↗

The distributional effects of changing the averaging period and minimum benefit provisions.

This study evaluates the effects of changing the averaging period used to calculate Social Security benefits from 35 years to 38 or 40 years and the introduction of a minimum benefit provision for future retirees born during the early part of the baby boom generation. Proposals to change the averaging period have been recommended by a majority of the 1994-96 Advisory Council on Social Security. Based on the Survey of Income and Program Participation (SIPP) matched to Social Security Administration earnings records, the study projects retirement benefits for different subgroups of the population under existing and proposed benefit rules. The magnitudes of the retirees' benefit changes vary by demographic group. The minimum benefit provision substantially mitigates the effects of the change to a 40-year averaging period for some groups of women.

Education↗

Streets, drugs, and the economy of sex in the age of AIDS.

Drug addicted women whose economic and social base is urban streets face limited options for income generation and multiple dangers of predation, assault, arrest, and illness. Exchanging sex for money or drugs offers one important source of income in this context. Yet the legal, social, and safety risks associated with these exchanges reduce the likelihood of regular safer sex practices during these encounters, thereby increasing the risk of HIV infection. Such conditions lead women engaged in sexual exchanges for money to varied and complex responses influenced by multiple and often contradictory pressures, both personal and contextual. Street-recruited women drug users in an AIDS prevention program in Hart-ford, Connecticut reported a range of condom use when engaging in sex for money exchanges. This paper explores their differences by ethnicity, economic resources, and drug use, and analyzes these and other factors that impact on street risks through sexual income generation. Surveys and in-depth interviews with drug-addicted women sex workers describe their various approaches to addressing multiple risks on the streets and suggest significant effort by women in these contexts to avoid the many risks, including HIV infection.

Adult↗

The evolution of the State Children's Health Insurance Program (SCHIP) in New York: changing program features and enrollee characteristics.

BACKGROUND: The State Children's Health Insurance Program (SCHIP) has been operating for >5 years. Policy makers are interested in the characteristics of children who have enrolled and changes in the health care needs of enrolled children as programs mature. New York State's SCHIP evolved from a similar statewide health insurance program that was developed in 1991 (Child Health Plus [CHPlus]). Understanding how current SCHIP enrollees differ from early CHPlus enrollees together with how program features changed during the period may shed light on how best to serve the evolving SCHIP population. OBJECTIVE: To 1) describe changes in the characteristics of children enrolled in 1994 CHPlus and 2001 SCHIP; 2) determine if changes in the near-poor, age-eligible population during the time period could account for the evolution of enrollment; and 3) describe changes in the program during the period that could be responsible for the enrollment changes. SETTING: New York State, stratified into 4 regions: New York City, New York City environs, upstate urban counties, and upstate rural counties. DESIGN: Retrospective telephone interviews of parents of 2 cohorts of CHPlus enrollees: 1) children who enrolled in CHPlus in 1993 to 1994 and 2) children who enrolled in New York's SCHIP in 2000 to 2001. The Current Population Survey (CPS) 1992 to 1994 and 1999 to 2001 were used to identify secular trends that could explain differences in the CHPlus and SCHIP enrollees. PROGRAM CHARACTERISTICS: 1994 CHPlus and 2001 SCHIP were similar in design, both limiting eligibility by age, family income, and insurance status. SCHIP 2001 included 1) expansion of eligibility to adolescents 13 to 19 years old; 2) expansion of benefits to include hospitalizations, mental health, and dental benefits; 3) changes in premium contributions; 4) more participating insurance plans, limited to managed care; 5) expansions in marketing and outreach; and 6) a combined enrollment application for SCHIP and several low-income programs including Medicaid. SAMPLE: Cohort 1 included 2126 new CHPlus enrollees 0 to 13 years old who were enrolled for at least 9 months, stratified by geographic region. Cohort 2 included 1100 new SCHIP enrollees 0 to 13 years old who were enrolled for at least 9 months, stratified by geographic region, age, race, and ethnicity. Results were weighted to be representative of statewide CHPlus or SCHIP new enrollees who met the sampling criteria. Samples of age- and income-eligible children from New York State were drawn from the CPS and pooled and reweighted (1992-1994 and 1999-2001) to generate a comparison group of children targeted by CHPlus and SCHIP. MEASURES: Sociodemographic characteristics, race and ethnicity (white non-Hispanic, black non-Hispanic, and Hispanic), prior health insurance, health care access, and first source of information about the program. ANALYSES: Weighted bivariate analyses (comparisons of means and rates) adjusted for the complex sampling design to compare measures between the 2 program cohorts and between the 2 CPS samples. We tested for equivalence by using chi2 statistics. RESULTS: As the program evolved from CHPlus to SCHIP, relatively more black and Hispanic children enrolled (9% to 30% black from 1994 to 2001, and 16% to 48% Hispanic), more New York City residents (46% to 69% from 1994 to 2001), more children with parents who had less than a high school education (10% to 25%), more children from lower income families (59% to 75% below 150% of the federal poverty level), and more children from families with parents not working (7% to 20%) enrolled. These socioeconomic and demographic changes were not reflected in the underlying age- and income-eligible population. A greater proportion of 2001 enrollees were uninsured for some time immediately before enrollment (57% to 76% had an uninsured gap), were insured by Medicaid during the year before enrollment (23% to 48%), and lacked a USC (5% to 14%). Although "word of mouth" was the most common means by which families heard about both programs, a greater proportion of 2001 enrollees learned about SCHIP from marketing or outreach sources. CONCLUSION: As New York programs for the uninsured evolved, more children from minority groups, with lower family incomes and education, and having less baseline access to health care were enrolled. Although changes in the underlying population were relatively small, progressively increased marketing and outreach, particularly in New York City, the introduction of a single application form for SCHIP and Medicaid, and expansions in the benefit package may have accounted, in part, for the large change in the characteristics of enrollees.

Adolescent↗

Overview of the diets of lower- and higher-income elderly and their food assistance options.

With the elderly becoming an ever-larger proportion of the American population, their dietary well-being is of increasing concern. In particular, lower-income elderly may face special challenges in maintaining a healthful diet. This group makes up a sizeable proportion of the elderly population; we estimate that almost 1 in 5 (19%) of the elderly have household incomes at or below 130% of the federal poverty level, the income level that generally qualifies a household to participate in the federal Food Stamp Program. Here we examine the dietary intakes and related behaviors, as well as the food security status, of lower- and higher-income elderly and review major US government food and nutrition assistance programs that can be of benefit to the elderly, particularly those of low income. Our subjects are individuals 60 years of age and over, living in community (noninstitutionalized) settings. Data on dietary intakes and behaviors were obtained from the US Department of Agriculture's Continuing Survey of Food Intakes by Individuals (CSFII), 1994-96. Food security data were obtained from the 1999 Current Population Survey (CPS), conducted by the US Census Bureau. For both the CSFII and the CPS, sampling weights were used to generate nationally representative estimates. We found that lower-income elderly consume significantly fewer calories than higher-income elderly, fewer servings of major Food Guide Pyramid food groups, and most nutrients. Approximately 6% of elderly households report some degree of food insecurity. Although food and nutrition assistance programs can benefit elderly individuals, many do not participate. Many lower-income elderly also face physiological and social obstacles to obtaining a healthful diet. How best to meet these varied needs is a challenge for nutrition educators, researchers, and policy makers.

Aged↗

Medication use patterns and health outcomes among patients using a subsidized prescription drug program.

OBJECTIVE: To evaluate medication adherence, medication safety, health care utilization, and health outcomes among patients enrolled in a subsidized prescription program. DESIGN: Cross-sectional study. SETTING: Conducted as part of the Prescription Access program, a subsidized prescription program serving indigent patients residing in Franklin County, Ohio. PATIENTS: Patients qualifying for enrollment in the program were uninsured and had a household income of 200% or less of federal poverty level. Approximately 5% of the 2,500 patients (mean age, 70.6 years) enrolled in the program were systematically selected from a computer-generated patient enrollment report. INTERVENTION: Telephone interviews conducted by a pharmacist or advanced student pharmacist between January and September 2002. MAIN OUTCOME MEASURES: Patterns of medication use and safety, level of health care utilization, and health outcomes. RESULTS: A total of 104 patients reported taking a mean (+/- SD) of 6.7 +/- 3.8 medications. A total of 72 (69%) patients reported taking their medications correctly, and 90 (87%) reported finishing their medication course as prescribed. Medication refills were obtained by 75 (72%) patients, but of these patients, only 55 (73%) indicated that they obtained their refills on time. Adverse effects occurred in 25 (24%) patients, and 2 patients reported an allergic reaction. A total of 51 (49%) patients made unscheduled visits to their primary care physician, another health care facility, an emergency department, and/or were admitted to a hospital. Unscheduled visits occurred more often among nonadherent patients (59%) than adherent patients (44%), but not significantly so. In addition, 82 (79%) patients reported an improvement in health-related quality of life (QOL); 90 (87%) had a means of transportation to obtain medications; and 93 (89%) indicated that they would have to skip medications or give up necessities, if they were not enrolled in a subsidized prescription program. CONCLUSION: An improvement in self-reported QOL and a high rate of medication adherence demonstrate support for the benefits of this and similar subsidized prescription drug programs. A high rate of additional health care utilization, especially among nonadherent patients, indicates an area for further analysis, program revisions, and/or patient education.

Aged↗

Machos and sluts: gender, sexuality, and violence among a cohort of Puerto Rican adolescents.

During the past decade, interpersonal violence increasingly has become a public health concern. As a result, prevention programs now aim to decrease violence among diverse populations. This article describes the beliefs and rationale for gender-based violence among a cohort of low-income, predominantly second-generation, mainland Puerto Rican adolescents. Based on a three-year (1989-91) ethnographic study, the findings describe how these young people, through the use of gender-based social constructs such as "machos" and "sluts," justify violence by linking it to beliefs about gender roles, sexuality, and biology, and thus perpetuate gender-role conformity, particularly heterosexual male dominance. The findings suggest that if the public health community is going to reduce gender-based violence among Puerto Rican youth, it needs to acknowledge that gender and sexuality are important ingredients that support violence and avoid a simplified and stereotypical model of culture that ignores other social factors and changes in traditional Latino gender roles.

Adolescent↗

The development of an instrument measuring unintentional injuries in young children in low-income settings to serve as an evaluation tool for a childhood home injury prevention program.

PROBLEM: Responding to the lack of standardized instrumentation, especially as applied in low-income contexts, the researchers decided that an instrument should be developed to serve as an evaluation tool for a childhood (unintentional) injury prevention program as well as a tool from which injury risks (poisonings, burns and falls) could be identified within households. METHODS: Cross-sectional samples of 521 households in four low-income sites in Cape Town and Johannesburg, South Africa, participated in the three phases of the study. The generation of an item pool based on a table of specifications, subsequent scientific item reduction procedures, reviews from experts and pilot tests were used to develop the scales for measuring the injury risks. RESULTS: The developed instrument complies with all the requirements for a valid and reliable measurement instrument. CONCLUSION: The instrument allows valid comparison of risks between communities, as well as before and after comparisons for an intervention program. IMPACT: The provision of this instrument may bring enormous benefits to research studies. It can also provide proactive, rather than reactive, information about injury risks before they develop into injuries and thus allows focusing of safety efforts for improvement of problematic areas in the households.

Accident Prevention↗

Evaluating sire selection practices using lifetime net income functions.

Dairy farmers do not take full advantage of opportunities available for genetic improvement through use of artificial insemination, perhaps because economic advantages of good sire selection may not be fully recognized or understood. This study was undertaken to document differences between use of AI and non-AI bulls and to develop prediction equations to compare lifetime economic merit of future progeny from alternative sire selection policies. We describe the use of two methods of measuring lifetime economic merit, with and without adjustment for opportunity cost of a postponed replacement. Comparison of lifetime relative net income adjusted for opportunity cost on groups of cows sired by different kinds of bulls showed that daughters of proven AI bulls generated $148 and $120 more lifetime net income under fluid and manufactured milk market conditions than daughters of non-AI bulls. Daughters of proven AI bulls produced $60 more than daughters of AI young sires in progeny testing programs at the time of daughter conception. We developed prediction equations from combinations of genetic evaluations for production, productive life, SCS, and linear type traits on sires to predict lifetime relative net income of progeny produced from alternative sire selection strategies. Prediction equations explained 14 to 18% of variation in relative net income (not adjusted for opportunity cost), but herd and year of first freshening accounted for considerably more variation than did genetic evaluations on the sire of the cow. Finally, two independent data sets were used to develop and test predictions of lifetime relative net income adjusted for opportunity cost using genetic evaluations based on the eight traits included in the Merit indexes for the sire of each cow. Prediction equations from odd numbered herds were used to predict lifetime economic merit in even numbered herds and vice versa. Coefficients of determination ranged from 0.088 to 0.103 and averaged 0.004 higher than prediction equations with Net or Fluid Merit. Accuracy of predictions showed that Net and Fluid Merit were robust and useful indexes that accurately identified bulls whose daughters generated highest lifetime economic merit.

Animals↗

Patient supply charges: still a revenue source?

Patient supply charges, billed to patients for the consumption of medical/surgical supplies, have been in use since the first medical insurance programs were established. But, as healthcare costs have escalated, so have supply charges. In turn, initiatives to limit supply charges have been promulgated, and healthcare financial managers should be sensitive to the fact that the cost of a patient supply charge program can exceed the real contribution generated by such a program.

Cost-Benefit Analysis↗

Economic models of fertility dynamics: a study of Swedish fertility.

"This paper estimates semiparametric reduced-form neoclassical models of life-cycle fertility in Sweden. Rising female wages delay times to all conceptions and reduce total conceptions. These results are robust across a variety of empirical specifications. We find a particular neoclassical model that predicts fertility attained at different ages as well as the aggregate time series of birth rates. A model that excludes wages and incomes predicts fertility attained at different ages but fails to predict the aggregate time series, and is dominated by the neoclassical model in terms of non-nested test criteria. Cohort drift found in estimated parameters is consistent with the expansion of pronatal social programs. The estimated neoclassical model produces strong short-run responses of birth rates to wages and incomes of the sort that have been found in the time series literature on fertility while generating the relatively weak long-run responses to economic variables found in the cross-sectional literature on completed fertility."

Age Factors↗

Hospital outpatient pharmacies and durable medical equipment.

Factors to consider when planning and implementing a durable medical equipment (DME) business are discussed. Although hospital pharmacists have begun to provide home health-care and other outpatient-care services, few hospital pharmacies have implemented DME businesses in conjunction with those services. By providing DME to patients, hospital pharmacies can realize substantial net income while improving continuity of patient care. Before establishing a DME business, pharmacists should consider where the showroom will be located, who will deliver and set up the equipment and train patients to use the equipment, and how the business will be promoted within the hospital; they must also become familiar with methods of reimbursement for DME. It is also important for pharmacists to decide whether the hospital should enter into a joint-venture relationship with an established community-based DME dealer or act as sole owner of the DME business. As hospitals search for ways to generate income from sources other than inpatient care and to encourage patients to use hospital services, hospital pharmacists should not overlook the possibility of establishing a DME business in conjunction with other outpatient-care programs.

Ambulatory Care↗

A "three-legged stool" for financing long-term care. Is it an acceptable approach?

To overcome the difficulty of seeking new funds for long-term care when public and private resources are severely constrained, a program entitled "Social Security/Long-Term Care" is proposed under which 5% of Social Security cash benefits can be traded (with exemption for low-income people) for a basic level of long-term care protection using social insurance. This program could be supplemented by private long-term care insurance, with Medicaid as a safety net. Financing thus generated may be used for home care, community-based care, and nursing home care. In 1994, 1% of Social Security cash benefits is equal to about $3.2 billion. Funds from Social Security/Long-Term Care could be used to help pay for a benefit package that could include case management.

Health Care Reform↗

Medicare fraud and abuse: implications for physicians.

Since the inception of the Prospective Payment System, the physician fee freeze, and other cost-cutting measures, physicians have been approached with many income-generating opportunities relating to their practices. Unfortunately, many of these opportunities also present potential criminal and civil liability under federal Medicare anti-fraud and abuse provisions. The recent passage of the Medicare and Medicaid Program Patient Protection Act of 1987 has updated federal anti-fraud and abuse laws and expanded the sanctions which may be imposed on physicians. This article describes the types of activities prohibited by federal laws and discusses the operation of these laws in light of common joint venture, incentive, and contract arrangements frequently seen in medical practice.

Crime↗