Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “INCISOR”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10Linked to original sources
PubMed1995

Axial movements of rat mandibular incisors measured under artificial respiration with halothane anaesthesia.

The axial movements of rat incisors were recorded continuously for over 20 h. The rats were anaesthetized with halothane delivered by intratracheal intubation using an artificial respirator. A haemostatic clamp was used to immobilize the jaw and the displacement detector exhibited high resolution, good linearity and low drift. The previously impeded and unimpeded eruption rates (the average extrusive movements) were 406 and 548 microns/24 h, respectively. The previously unimpeded rate was lower than the normal unimpeded rates obtained by other investigators. It appears that the eruptive movement of the previously unimpeded incisor was inhibited by halothane anaesthesia. Circadian rhythm was not observed in the eruption rates of previously impeded or unimpeded incisors. Following the i.p. injection of a lethal dose of pentobarbital sodium, the incisors retracted. The average intrusive movement was significantly greater in the previously impeded group (29 microns) than in the previously unimpeded group (12 microns) at 30 min after the lethal injection. It is assumed that the elimination of the pushing force at death may cause the stretched periodontal fibres to recoil, thereby pulling the tooth in an intrusive direction. It is also likely that the mechanical strength of the ligament is reduced in the previously unimpeded group by repeated shortening of the incisors; therefore the force needed to retract previously unimpeded incisors may be less than that needed to retract previously impeded incisors.

Animals↗
PubMed1990

The incisor absent rat: an animal model for the study of otosclerosis.

The incisor absent (ia) rat is introduced as an animal model for the study of otosclerosis. Previous animal models have failed to accurately reflect the dynamic nature of this disease. Auditory brainstem response testing suggested a conductive hearing loss in the incisor absent rat as compared to age-matched normal controls. The hearing loss, which was manifested during puberty, was progressive in nature up to 18 weeks of age. Microscopic dissection of the middle ear revealed bony abnormalities of the ossicles and oval window in the incisor absent rat. Scanning electron microscopy of the ossicles demonstrated bony lesions at the incudostapedial joint and stapes footplate. Histologic examination demonstrated thickened spongiotic bone involving the otic capsule and ossicles. The incisor absent rat model possesses an inheritable defect of the otic capsule and ossicles that results in a progressive conductive hearing loss. The genetically transmitted lesion appears histologically similar to otospongiosis. The bony pathology in the incisor absent rat is caused by defective osteoclasts and transplantation of bone marrow cells from normal rats to the incisor absent rats corrects the cellular abnormality. The incisor absent rat may represent the best animal model to date for the study of otosclerosis, its cause, and clinical treatment.

Animals↗
PubMed1995

Accelerated eruption of rat lower incisor. Relationship between impeded and unimpeded eruption rates, rate of attrition, tooth length, and production of dentin and enamel.

The present investigation studies the effects of persistently cutting one lower rat incisor out of occlusion. Within four days, the rate of eruption of the cut (unimpeded) incisor increased to 216% and that of the uncut (impeded) contralateral to 136% of the baseline rate. While the former remained high, the latter decreased gradually to about 90% within three weeks. The rate of attrition of the impeded incisor increased to 233% of the baseline rate within two days, then fell abruptly, and remained at a slightly lower level than the rate of eruption. Accordingly, the length of the erupted part of the impeded incisor decreased initially, but increased gradually after about four days. Measurements made on SEM micrographs of the series of transverse tooth segments obtained when cutting the incisor out of occlusion, showed that growth-related increase in mesiodistal tooth width was arrested from the 10th segment, dentin thickness decreased gradually to about 50% in the 12th segment, and enamel thickness, after an initial increase, decreased to about 80% in the 11th segment. The present study provides experimental evidence that accelerated eruption affects morphogenesis and histogenesis of the rat lower incisor. An impeded incisor, especially the contralateral, may not serve as an ideal control.

Animals↗
PubMed1994

Incisor microwear of Sumatran anthropoid primates.

Several studies have suggested that incisor microwear reflects diet and feeding adaptations of anthropoids. However, such studies have been largely qualitative, and interpretations have relied on anecdotal references to diet and tooth use reported in the socioecology literature. The current study relates incisor microwear in four anthropoid primates to specific ingestive behaviors and food types. Central incisor casts of wild-shot museum specimens of Hylobates lar, Macaca fascicularis, Pongo pygmaeus, and Presbytis thomasi were examined by scanning electron microscopy, and analyzed using a semiautomated image analysis procedure. Microwear patterns were used to generate predictions regarding diet and anterior tooth use. These predictions were evaluated using data collected during a 1 year study of feeding behavior of these same taxa in the wild (Ungar, 1992, 1994a,b). Results suggest that (1) enamel prism relief is associated with the effectiveness of etching reagents in foods, (2) dental calculus buildup results from a lack of incisor use and perhaps the ingestion of sugar-rich foods, (3) striation density varies with degree of anterior tooth use in the ingestion of abrasive food items, (4) striation breadth is proposed to relate to the ratio of exogenous grit to phytoliths consumed; and (5) preferred striation orientation indicates the direction that food items are pulled across the incisors during ingestion. It is concluded that incisor microwear studies can contribute to the understanding of diets and feeding behaviors of extinct primates.

Analysis of Variance↗
PubMed1975

Cellular renewal in the enamel organ and the odontoblast layer of the rat incisor as followed by radioautography using 3H-thymidine.

Renewal of the cell populations of the incisor was studied in 100 gm male rats injected with a single dose of 3H-thymidine and sacrificed at various times from one hour to 32 days after injection. Radioautographs showed that a cohort of labeled cells within the enamel organ, odontoblast layer, and pulp was carried passively with the erupting incisor from the apical end towards the gingival margin where the life cycle of these cells was terminated. Labeled cells in the upper and lower incisor, although traversing different absolute lengths, were found in approximately the same functional stage of their life cycle at similar times after the injection. Thus, by one and on-half days labeled ameloblasts began inner enamel secretion and, by eight days (upper) or nine days (lower), complement outer enamel secretion. By 32 days labeled ameloblasts had traversed the entire enamel maturation zone and were located at the gingival margin. Labeled odontoblasts followed closely the movement of labeled ameloblasts. The mean rate of ameloblast migration was 567 mum/day on the upper incisor and 651 mim/day on the lower. For the odontoblasts this rate was 55 mum/day (upper) and 631 mum/day (lower). Finally, it was found that as the rat age, the duration of the life cycle for epithelial and pulp cell populations of the incisor increased because of growth within the lonitudinal axis of the tooth. It was concluded that the apical end of the incisor literally "grows backward" in the bony socket, and hence, the duration of the life cycle becomes greater simply because it takes cells longer to physically reach the gingival margin.

Ameloblasts↗
PubMed1989

A method for sampling the stages of amelogenesis on mandibular rat incisors using the molars as a reference for dissection.

A method for locating specific stages of amelogenesis on continuously erupting incisors was devised for rats weighing 101 +/- 5 g (n = 32). The technique is based on reflecting reference lines from the mandibular molars as perpendiculars to the labial surface of mandibular incisors. From these reference lines additional measurements are then made along the midline of the labial surface of the incisor in an apical or incisal direction to find the site desired for sampling. Histological studies on 24 decalcified incisors split into segments by using such reference lines and reconstructed by morphometry indicated that a reference line reflected from the contact point between the 2nd and 3rd molars crossed the enamel organ and adjacent enamel at 3,181 +/- 329 microns incisal to the start of the secretory zone of amelogenesis. A reference line from the 2nd and 1st molars crossed the enamel organ and enamel at 1,238 +/- 424 microns incisal to the start of the maturation zone of amelogenesis, while a reference line from the mesial side of the 1st molar crossed the enamel organ and enamel almost exactly where the enamel becomes completely soluble following prolonged decalcification in EDTA. Although reference lines were reproducible within a group of male rats having similar body weights, the linear distance between the apical end of the incisor and the point at which they crossed the tooth increased at a rate of 1 mm per 159 g for rats between 50 and 300 g body weight. This suggests that molars do not maintain a fixed relationship to incisors over time, and extreme care must be taken to standardize an experiment to a specific body weight when using this method.

Amelogenesis↗
PubMed2006

Cortical, callosal, and thalamic connections from primary somatosensory cortex in the naked mole-rat (Heterocephalus glaber), with special emphasis on the connectivity of the incisor representation.

We investigated the distribution of cortical, callosal, and thalamic connections from the primary somatosensory area (S1) in naked mole-rats, concentrating on lower incisor and forelimb representations. A neuronal tracer (WGA-HRP) was injected into the center of each respective representation under guidance from microelectrode recordings of neuronal activity. The locations of cells and terminals were determined by aligning plots of labeled cells with flattened cortical sections reacted for cytochrome oxidase. The S1 lower incisor area was found to have locally confined intrahemispheric connections and longer connections to a small cluster of cells in the presumptive secondary somatosensory (S2) and parietal ventral (PV) incisor fields. The S1 incisor area also had sparse connections with anterior cortex, in presumptive primary motor cortex. Homotopic callosal projections were identified between the S1 lower incisor areas in each hemisphere. Thalamocortical connections related to the incisor were confined to ventromedial portions of the ventral posterior medial subnucleus (VPM) and posterior medial nucleus (Po). Injections into the S1 forelimb area revealed reciprocal intrahemispheric connections to S2 and PV, to two areas in frontal cortex, and to two areas posterior to S1 that appear homologous to posterior lateral area and posterior medial area in rats. The S1 forelimb representation also had callosal projections to the contralateral S1 limb area and to contralateral S2 and PV. Thalamic distribution of label from forelimb injections included ventral portions of the ventral posterior lateral subnucleus (VPL), dorsolateral Po, the ventral lateral nucleus, and the ventral medial nucleus and neighboring intralaminar nuclei.

Animals↗
PubMed1994

Comparisons of nipple attachment and incisor growth among four species of voles (Microtus).

Patterns of nipple attachment and incisor growth were compared between four species of voles (Microtus). Offspring of two highly social species, prairie voles (M. ochrogaster) and pine voles (M. pinetorum), were shown to cling tightly to the nipples of their dams on Days 2, 6, and 10. This pattern contrasted to weak nipple attachment displayed by two less-social species, meadow voles (M. pennsylvanicus) and montane voles (M. montanus). Lengths of the upper (maxillary) and lower (mandibular) incisors of the four species were recorded throughout the first 10 days of age and in adults. Incisors of the pine and prairie voles typically erupted earlier and grew longer than those of the meadow or montane voles during the first few days of development. Incisors grew at a substantial rate in the latter two species, such that they equalled or surpassed the incisor lengths of the former two species as Day 10 and weaning approached. Patterns of incisor growth, in part, reflected those for nipple attachment, but do not appear to account substantially for differences in nipple attachment.

Animals↗
PubMed1996

Three-dimensional interpretation of labiolingual bone width of the lower incisors. Part II.

For quantitative evaluation of the different imaging quality of cephalograms and computed tomography in the region of the lower incisors, the macroscopic and histological findings of specimens were compared with the corresponding radiological findings. After removal of the soft tissue from 11 mandibular dentate segments, 15 artificial bone defects of different dimensions were produced in the region of the lower incisors. In comparison with the microscopic jaw measurements, the mean labiolingual diameter of the frontal alveolar process of the single incisors was overestimated in the cephalograms by 0.3 to 1.2 mm. Most of the anatomical-radiological correlations of the cephalometric measurements was insignificant. Individual metric assessment of the labiolingual bone width or of the facial/lingual cortical bone plates or the identification of the artificial defects of lower incisors in the cephalograms were generally not possible. In the CT-images the mean labiolingual diameter of the frontal alveolar process of the single incisors was overestimated by 0.1 to 0.5 mm, but the correlations were highly significant. The facial/lingual cortical bone plates of the lower incisors were evaluated and measured in the CT-scans. Thirteen of 15 artificial bone defects (80%) were identified in the CT-scans. CT-scanning is the only imaging technique offering three-dimensional quantitative evaluation of the labiolingual alveolar bone width and the facial/lingual cortical bone plates.

Alveolar Process↗
PubMed1995

[Incisor roots in the mandibular symphysis in the computed tomogram and in the lateral teleradiogram].

On the basis of lateral cephalograms and computer tomograms (CT) the position of the incisor roots and the bone structure surrounding them were studied. Nine patients each had an axial CT of the mandibular symphysis area and, in addition, 6 of these patients had lateral cephalograms. In order to compare both images, we defined a classification scheme as follows: Class 1 = the incisor roots are projected into the midst of the oral corticalis of the symphysis; class 2 = the roots are in contact with the oral corticalis; class 3 = the incisor roots are at a distance to the oral corticalis. The results from the 2 types of visualization were then compared. When looking at the bone structures surrounding the incisor roots, the lateral cephalograms failed to yield an exact differentiation. Such details can be best examined in the axial CT layers, because in the lateral cephalogram the 4 incisor roots are over projected to 1 root. The space for movement of the incisors is narrow. The root of each and every patient showed a different position in oro-buccal direction. This fact must be taken into consideration in clinical practice, especially when employing fixed appliances with 3-dimensional root control.

Evaluation Studies as Topic↗
PubMed2006

Dual odontogenic origins develop at the early stage of rat maxillary incisor development.

Developmental process of rat maxillary incisor has been studied through histological analysis and investigation of tooth-related gene expression patterns at initial tooth development. The tooth-related genes studied here are fibroblast growth factor-8 (Fgf-8), pituitary homeobox gene-2 (Pitx-2), sonic hedgehog (Shh), muscle segment homeobox-1 (Msx-1), paired box-9 (Pax-9) and bone morphogenetic protein-4 (Bmp-4). The genes are expressed in oral epithelium and/or ectomesenchyme at the stage of epithelial thickening to the early bud stage of tooth development. Both the histological observation and tooth-related gene expression patterns during early stage of maxillary incisor development demonstrate that dual odontogenic origins aligned medio-laterally in the medial nasal process develop, subsequently only single functional maxillary incisor dental placode forms. The cascade of tooth-related gene expression patterns in rat maxillary incisor studied here is quite similar to those of the previous studies in mouse mandibular molar, even though the origins of oral epithelium and ectomesenchyme involved in development of maxillary incisor and mandibular molar are different. Thus, we conclude that maxillary incisor and mandibular molar share a similar signaling control of Fgf-8, Pitx-2, Shh, Msx-1, Pax-9 and Bmp-4 genes at the stage of oral epithelial thickening to the early bud stage of tooth development.

Animals↗
PubMed2002

Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis.

dHAND/Hand2 is a basic helix-loop-helix transcription factor required for the development of the heart, pharyngeal arches, and vasculature and is expressed during embryogenesis. However, there are no reports on the involvement of the dHAND gene in tooth development. In the present study, the expression of dHAND was examined in developing tooth germs of mice. The dHAND gene was expressed in the mesenchyme of the presumptive incisor region of the lower jaw at an early stage and in the mesenchyme of the lower incisor tooth germ at a later stage. However, the dHAND gene was not expressed in the upper incisor region or the upper and lower molar regions during jaw development. Treatment of tooth germ explants of lower incisors with antisense oligodeoxinucleotide (ODN) against dHAND prevented the differentiation of tooth germ cells, including ameloblasts and odontoblasts, the formation of dentin and enamel, and the proliferation of tooth germ cells and increased the apoptosis of tooth germ cells, suggesting that dHAND is essential for these cells during development. On the other hand, the treatment of tooth germ explants of upper incisor and upper or lower molars did not induce severe effects on their development. Treatment of the explants with basic fibroblast growth factor in association with antisense ODN partially rescued them from the effects of antisense ODN. The present results suggest that the dHAND gene plays important roles in type-specific development of lower incisors, and that basic fibroblast growth factor is involved downstream of the dHAND pathway in tooth germ cells.

Ameloblasts↗
PubMed1983

Incisor position in Scandinavian children with ideal occlusion. A comparison with the Ricketts and Steiner standards.

A cephalometric study, with particular emphasis on incisor pattern, was carried out on thirty Norwegian children with clinically excellent occlusion in the young permanent dentition. The material was selected from a sample of all 12-year-old children within a particular geographic area (Nittedal) of Oslo. The frequency of ideal occlusion was 5.3 percent. A computer-based method of cephalometric analysis was used. The findings indicated that persons with untreated ideal occlusion tended to have a particular facial morphology and dental pattern. More precisely, they were likely to be brachyfacial (horizontal), with somewhat procumbent incisors and a small interincisal angle. Only one patient had dolichofacial (high-angle) characteristics. On average, the lower incisors were 2.5 mm. in front of the APo plane (S.D. 1.7). Remarkably, the lower incisors were not behind the APo plane in any single case with ideal occlusion. Clearly, the lower incisors were clinically significantly more protruded and proclined than those described in previous studies on Scandinavian children and were, in fact, even slightly more procumbent than the Ricketts and Steiner standards. The similarity, with regard to both incisor position and skeletal pattern, of the present findings to some recent studies on American Caucasian children with normal occlusion is stressed. The significance of the observations is discussed in relationship to considerations in orthodontic treatment planning.

Cephalometry↗
PubMed1990

The effect of cyclophosphamide on the eruption of impeded and resected incisors in rats.

It is known that a single dose of cyclophosphamide (40 mg.kg-1 intraperitoneal) slows the eruption of unimpeded incisors but has no effect on impeded incisors. In this study incisors that were impeded when cyclophosphamide was given were subsequently made unimpeded. When they were unimpeded they erupted more slowly than the controls. Therefore the changes cyclophosphamide produces which slow eruption are formed in impeded incisors but have an effect only in unimpeded incisors. It has been reported that cyclophosphamide slows the eruption of resected incisors when it is given before the resection. In a second experiment cyclophosphamide was given after the resection and had no effect on eruption rates. It is suggested from these and earlier findings that cyclophosphamide slows eruption by imposing a maximum on the rate at which it can occur and that it does so through the changes it produces in the periodontal ligament. The periodontal changes make it harder for the tooth to move rather than altering the forces moving the tooth. This explanation of how cyclophosphamide slow eruption produces an alternative interpretation of some, but not all, of the findings that have been cited as evidence that there are two mechanisms of tooth eruption.

Animals↗
PubMed1990

Immunolocalization of transforming growth factor beta 1 and epidermal growth factor receptor epitopes in mouse incisors and molars with a demonstration of in vitro production of transforming activity.

Day-14 lower incisors and day-18 first lower molars of mouse embryos produced in vitro transforming activities for non-confluent NRK cells co-cultured in agar, and mitogenic activities for exponentially growing NRK and BHK cells. The patterns of distribution of TGF beta 1 and EGF receptor, both known to regulate cell proliferation, differentiation and transformation in vitro and suspected to play important roles in developmental processes, were studied during mouse odontogenesis by means of indirect immunofluorescence on fixed or frozen fixed sections. TGF beta 1 epitopes were detected in the stellate reticulum of day-13 to day-16 incisors and of molars from day-17 onwards. Dental mesenchyme of day-14 incisors and postnatal molars, and peridental mesenchyme of bud and cap stage molars and incisors were also stained by TGF beta 1 antibodies. EGF receptor was localized in the enamel organs of incisors and molars; the inner dental epithelium and later the outer dental epithelium rapidly became negative while the stellate reticulum remained stained. Incisor apical mesenchyme showed an intense reaction with EGF receptor antibodies after birth.

Animals↗
PubMed1989

Dens invaginatus of a maxillary lateral incisor: endodontic treatment.

A right maxillary central incisor and an adjacent lateral incisor with a dens invaginatus were identified as requiring endodontic treatment. Both teeth were treated by nonsurgical means. Thirteen months postoperatively the central incisor showed evidence of periapical resolution, whereas the lateral incisor did not. The lateral incisor was then treated with apical curettage, an apicoectomy, and retrograde amalgam filling. One year after the surgical procedure the periapical tissues of both the lateral and central incisors exhibited satisfactory resolution. This case demonstrates that certain cases of dens invaginatus can be successfully treated only with a surgical approach.

Adult↗
PubMed1988

Resorption of maxillary lateral incisors caused by ectopic eruption of the canines. A clinical and radiographic analysis of predisposing factors.

Factors predisposing to resorption of adjacent permanent lateral incisors caused by ectopic eruption of maxillary canines were evaluated. The subjects consisted of two groups: one with 40 lateral incisors with resorption caused by ectopic eruption and a control group of 118 ectopic eruption cases with no lateral incisor resorption. The mean age of the children in the two groups differed by only 0.7 of a year and ranged from 10.0 to 15.0 years, covering the normal eruption period of the maxillary canine. Resorption of lateral incisors was three times as common in girls as in boys. The resorption cases showed a more advanced dental development, a more medial canine position in the dental arch, and a slightly more mesial horizontal path of eruption (an average of 10 degrees) than that of the control cases. Factors such as the width of the dental follicle and proclination or distal tilting of the lateral incisor showed no correlation to the resorption. Potential resorption cases are always those in which the canine cusp in periapical and panoramic films is positioned medially to the midline of the lateral incisor. Such situations should be carefully investigated with polytomography if necessary. The risk of resorption also will increase with a more mesial horizontal path of eruption. From 10 years of age or younger, annual clinical examination by palpation of the canine eruption path is recommended. This clinical examination should be supplemented with a stepwise extended radiographic procedure in cases in which ectopic eruption of the maxillary canines is suspected.

Adolescent↗
PubMed2005

The effects of computer-aided anteroposterior maxillary incisor movement on ratings of facial attractiveness.

BACKGROUND: Before planning orthodontic treatment, it is necessary to understand societal preferences for facial esthetics. The anteroposterior (AP) position of the maxillary incisors affects the appearance of the soft tissue profile and can be manipulated by orthodontic techniques. To improve the ability to predict the most suitable maxillary incisor position, numerous cephalometric and profilometric measurements have been suggested. Among them are the Six Elements to Orofacial Harmony proposed by L. F. Andrews, whereby forehead angulation is used to dictate maxillary incisor sagittal position. Our aim was to evaluate differences in preference for the AP position of the maxillary incisor between orthodontic and lay panels. METHODS: A smiling profile photograph was taken of a female subject who best fit the chosen soft tissue normative values and whose maxillary incisors were in an Element II position. The photograph was manipulated to simulate maxillary protrusion and retrusion at 1-mm increments to a maximum of +/-4 mm. Panels of orthodontists and nonorthodontists scored the attractiveness of the photographic variations according to a 100-mm visual analogue scale. RESULTS: The 4-mm retrusive photograph was significantly less desirable than all others, which suggests that, from an esthetic standpoint, it is preferable to either leave a normally protrusive maxillary dentition where it is or advance rather than retract the maxillary anterior teeth. Orthodontic training did not significantly affect the magnitude of the ratings or pattern of preference in our sample. CONCLUSIONS: Andrews' Element II provides an additional useful method to evaluate attractiveness relative to the maxillary incisor position.

Adult↗