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At least 181 records · Page 10Linked to original sources
PubMed1987

PUVA-induced pigmented macules: a case involving palmoplantar skin.

A patient with palmoplantar psoriasis received a local treatment regimen of psoralens with long-wave ultraviolet A radiation (PUVA). After approximately 12 months of treatment, she developed hyperpigmented macules on her palms and soles. A biopsy showed changes consistent with PUVA-induced pigmented macules, as well as pronounced pigmentary incontinence. No cytologic atypia was noted. PUVA-induced pigmented macules should now be included in the differential diagnosis of palmoplantar hyperpigmented macules.

Female↗
PubMed1988

Therapeutic evaluation for intralesional injection of bleomycin sulfate in 143 resistant warts.

A 1 U/ml solution of bleomycin sulfate in physiologic saline solution was injected intralesionally in 38 patients, and was compared with physiologic saline solution injection into paired warts in the same patient. No patient received more than 2 ml of bleomycin. Ninety-seven of 143 warts (67.8%) showed complete resolution after one or two bleomycin injections, while 25 warts (17.5%) showed incomplete resolution. Bleomycin local injection failed to elicit any therapeutic response in 21 warts (14.7%). The cure rate was 77% for warts on the extremities, 71.4% for periungual warts, and 47.6% for the plantar warts. The responsive warts showed hemorrhagic eschars that healed without scarring. It is concluded that this form of treatment for resistant warts, up to the dose used, is safe, reliable, and accepted by the patient.

Adolescent↗
PubMed1988

Resistant discoid lupus erythematosus of palms and soles: successful treatment with azathioprine.

We present the case of two patients with an unusual form of discoid lupus erythematosus that was confined almost exclusively to the palms and soles. In both patients this form of discoid lupus erythematosus did not respond to conventional therapies, which included topical steroids, intralesional steroids, prednisone, quinacrine hydrochloride, hydroxychloroquine sulfate, colchicine, and dapsone. Both patients were then treated with azathioprine. One patient dramatically improved with azathioprine, worsened each time the azathioprine was stopped or reduced, and responded again to the reinstitution of therapy. The other patient began taking azathioprine 8 months ago and has also experienced relief of her symptoms. These cases suggest that discoid lupus erythematosus principally involving the palms and soles is difficult to treat with conventional medication and that azathioprine, which appears to be useful, should be tried after the failure of other therapies.

Adult↗
PubMed1988

Thyroid function in patients with pustulosis palmoplantaris.

Fifty consecutive patients (45 women and 5 men) with pustulosis palmoplantaris were evaluated for thyroid disease. Five women had previously had thyroid disorders for which they were receiving thyroxine substitution therapy. Of the other 40 women three had a raised serum concentration of thyroid-stimulating hormone and nine had high concentrations of antibodies against thyroid "microsomal antigen." During a 4-year follow-up hypothyroidism developed in two women with initially raised thyroid-stimulating hormone, and laboratory test results for one woman indicated subclinical hyperthyroidism. Four of nine patients with thyroid abnormality also had evidence of gastric autoimmunity. Of the patients 94% smoked at the onset of pustulosis palmoplantaris compared with 33% in age- and sex-matched healthy controls. The prevalence of thyroid disease in women with pustulosis palmoplantaris was significantly higher than in a comparable population sample of women from the same geographic region. We conclude that patients with pustulosis palmoplantaris should be screened for thyroid disease.

Adult↗
PubMed1988

Diphencyprone.

Explore the source record for details and available documents.

Adolescent↗
PubMed1989

Acral localized acquired cutis laxa.

We report the first case of acral localized acquired cutis laxa. The skin laxity was preceded by swelling of the fingers and toes and by the appearance of papular urticaria. Dapsone therapy was effective in controlling the swelling. Examination of skin biopsy specimens showed fragmentation and almost total loss of elastic fibers in the areas of cutis laxa. Electron microscopy showed no abnormalities in elastic structure and function in unaffected skin. In addition, electron microscopic examination of an urticarial lesion showed a neutrophilic dermatosis with polymorphonuclear leukocytes attached to the surface of either normal elastic fibers or fibers showing early degenerative changes. These findings suggest that there is no primary defect in the elastic fibers and that the polymorphonuclear leukocytes play a significant role in the destruction of the elastic fibers and the subsequent development of cutis laxa in this case.

Adult↗
PubMed1994

Acral Darier's disease: report of a case complicated by Kaposi's varicelliform eruption.

We report a case of acral Darier's disease in a 16-year-old Korean boy that was complicated by Kaposi's varicelliform eruption. It is uncommon in Darier's disease for dyskeratotic papules to be limited to acral areas. In our patient, Kaposi's varicelliform eruption occurred on the face where there were no preexisting lesions of Darier's disease.

Adolescent↗
PubMed1996

Treatment of dermatophyte nail infections: an open randomized study comparing intermittent terbinafine therapy with continuous terbinafine treatment and intermittent itraconazole therapy.

BACKGROUND: terbinafine persists in the nail at effective concentrations for several weeks after discontinuation of treatment. OBJECTIVE: Our purpose was to verify whether intermittent terbinafine therapy is effective in dermatophytic onychomycosis and to compare the results of intermittent terbinafine with those of intermittent itraconazole and continuous terbinafine treatment. METHODS: An open, randomized study of 63 patients was performed with three treatment regimens: terbinafine, 250 mg daily (21 patients); terbinafine, 500 mg daily for 1 week every month (21 patients); or itraconazole, 400 mg daily for 1 week every month (21 patients). Treatment was continued for 4 months in toenail infections (60 patients) and 2 months in fingernail infections (3 patients). RESULTS: At the end of the follow-up period (6 months after discontinuation of treatment) 16 of the 17 patients (94.1%) with toenail onychomycosis were mycologically cured in the terbinafine 250 mg group, 16 of 20 (80%) in the terbinafine 500 mg group, and 15 of 20 (75%) in the itraconazole group. CONCLUSION: The percentage of patients who were mycologically cured was higher in the continuous terbinafine group than in the intermittent terbinafine and itraconazole groups, but statistical analysis did not reveal any significant difference between these cure rates.

Administration, Oral↗
PubMed1996

Intermittent fluconazole dosing in patients with onychomycosis: results of a pilot study.

BACKGROUND: Therapeutic limitations of griseofulvin in treating onychomycosis have led to a search for alternative antimycotic agents. An optimal dosing regimen for fluconazole has yet to be defined. OBJECTIVE: Our purpose was to evaluate the intermittent use of fluconazole (either once-weekly or alternate-day dosing) without concurrent nail avulsion in patients with moderate to severe onychomycosis. METHODS: Eleven patients with mycologically confirmed onychomycosis of the toenails or fingernails (43 infected nails) were treated with intermittent fluconazole until clinical cure was obtained. Eight patients received fluconazole 300 mg once weekly, one patient received 200 mg once weekly, and two patients received 100 or 200 mg of fluconazole every other day. Eight patients also used an adjunctive topical antimycotic preparation. RESULTS: All six patients with toenails involved (32 infected nails) were clinically cured after a mean treatment duration of 6 months, and all five patients with fingernails involved (11 infected nails) were cured after 3.7 months. There were no significant clinical or laboratory adverse events. CONCLUSION: Intermittent fluconazole, taken once weekly or on alternate days, is a well-tolerated and efficacious method to treat onychomycosis.

Administration, Cutaneous↗
PubMed1996

Onychomycosis caused by Scytalidium dimidiatum.

We report a case of onychomycosis caused by Scytalidium dimidiatum (syn., Hendersonula toruloidea) in a patient who did not live in an endemic area. This nondermatophyte mold may produce disease indistinguishable from dermatophyte fungi, but it does not respond to current systemic antimycotic therapy. Distal subungual onychomycosis, lateral onycholysis followed by lateral nail plate invasion, and chronic paronychia are common nail presentations.

Aged↗