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PubMed1991

[Adrenocortical function in children with connective tissue syndromes and funnel chest deformation].

Measurement of the content of C-21-corticosteroids in the diurnal urine by thin-layer chromatography has demonstrated that in children with isolated and syndromal forms of funnel-like chest deformation, grades II and III, adrenocortical function is decreased. In preschool children, such a decrease is accompanied by proneness to the tense biosynthesis of glucocorticoids. Children with congenital hereditary connective syndromes manifest adrenocortical dysfunction, most characteristic of Marfan's syndrome, and, to a less degree, of Ehlers-Danlos syndrome and unclassified complex of developmental defects with the Marfan-like phenotype. In view of this fact, the children with Marfan's, Ehlers-Danlos syndromes and with the unclassified complex of developmental defects with the Marfan-like phenotype and children with funnel-like chest deformation, grades II and III, should be given glucocorticoid hormones in stressful conditions (severe diseases, traumas, operations).

Adolescent↗
PubMedDate not supplied

[An index assessment of the degree of the respiratory failure in funnel chest].

An evaluation was done of respiratory failure in 149 children aged 3 to 15 presenting with funnel-shaped chest deformity (FCD). An original classification is suggested of degree of respiratory failure in FCD in children. Based on the index assessment of clinical and functional parameters an outline has been worked out for degree of respiratory failure. The criteria obtained are statistically significant; being able of giving quantitative assessment of degree of respiratory failure they can serve as control figures to be used in evaluations designed to study time course of changes in respiratory failure.

Adolescent↗