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[A new milk formula: iron bioavailability and effect on prevention of iron deficiency in infants].

Iron bioavailability from a modified cow milk, formula (LPM) (which included additional iron as 5 mg/l ferrous sulfate and ascorbic acid, 50 mg/l) was examined in 11 adult women using the extrinsic radioactive tag method. The geometric mean absorption from LPM was 13% (reference dose absorption = 26%). The effect of this formula on iron nutrition of infants was studied in 43 healthy term infants weaned spontaneously before 3 months of age which were given LPM until 9 months of age. Another 45 infants (controls) were fed full fat, non fortified powdered cow's milk (LP) as delivered through the National Complementary Food Program (PNAC-Chile) and additional 45 infants were given fortified a cow's milk formula (LF) with ferrous sulfate (iron: 15 mg/l and ascorbic acid: 100 mg/l). Solid foods (vegetables and meat) were introduced to all these babies from age 4 months. At 9 months of age 4% infants fed LPM had evidence of anemia vs. 2% and 20% of infants given LF and LP formulae respectively. This results suggests that LPM is effective in preventing iron deficiency anemia in infants.

Adult↗

Use of a liquid diet as the sole source of nutrition in six dysphagic horses and as a dietary supplement in seven hypophagic horses.

Six horses with dysphagia (attributable to botulism, glossitis, or guttural pouch mycosis) were given a commercially available liquid diet as the sole source of nutrition. Seven horses with hypophagia caused by severe bacterial pleuropneumonia or peritonitis were given the liquid diet to supplement food consumed voluntarily. The liquid diet was administered through a nasogastric tube 2 or 3 times daily. Body weight did not change significantly, and pertinent laboratory values remained at satisfactory concentrations throughout the feeding period. Serious complications were not encountered. Three horses developed loose, low-volume feces, but did not require treatment.

Animals↗

[Role of nutrition in acute and long-term therapy of chronic inflammatory bowel diseases].

The clinical picture and course of inflammatory bowel disease are influenced by nutritional abnormalities and malnutrition. Interest at present concentrates on high-fibre low-refined sugar diets, elimination diets with identification of specific food intolerance and low-residue diets. All three failed to show significant positive effects on the course of the disease, need for hospitalisation, surgical procedures required or post-operative recurrence. Only a low lactose diet seems to be justified, since we found lactose intolerance in 25-35% of patients with inflammatory bowel disease, as compared with 5-10% in the normal population. In 25 patients with Crohn's disease (CD) a reduction in inflammatory activity and improvement of nutritional status was obtained with parenteral nutrition (PN). Nevertheless, longer follow up periods revealed no additional benefit in comparison with conventional therapies. Furthermore, the combination of PN and total bowel rest resulted in the same improvement as with PN alone. 25 patients with CD manifesting an acute phase of the condition were treated with tube feeding (TF) as primary therapy. TF reduced CD activity and improved nutritional status in 15 patients with small bowel disease, whereas the patients with colonic disease and extraintestinal manifestations did not react. A comparison of the effect of PN and TF in 10 patients with CD showed no significant difference with regard to clinical course and objective parameters. In view of the high costs and risks of complications of PN, TF is recommended as primary therapy for the acute phase of CD. The importance of substitution therapy, especially of vitamin D, is documented.

Colitis, Ulcerative↗

Modular enteral diets: cost and nutritional value comparisons.

For selected patients, especially those with hepatic or renal failure, it may be necessary to restrict fluid, protein, electrolytes, and/or other micronutrients. The provision of enteral formulas with fixed percentages of nutrients that need to be restricted often results in the patient's receiving inadequate amounts of many that do not need to be restricted. One means of avoiding this problem is to use a micronutrient-free commercial solution, thus allowing the controlled addition of specific micronutrient "modules" needed to meet nutritional goals. There are only two formulas of this type available; however, they are more costly than any other product in our formulary and contain specific amino acid patterns developed for a specific disorder. We have designed, from macronutrient and micronutrient modules, modular tube feeding diets that can vary according to patient needs. We report on five patients treated. The protein quality (chemical score) provided by the modular diet is better than that provided by the nonmodular diet. The average daily cost to the hospital for a modular diet, including labor, is approximately one-third the cost of the nonmodular commercial diet, including labor ($7.72 vs $28.93). One anticipated difficulty is the high level of nutrition knowledge required by the prescribing individual.

Adult↗

[Endoscopic placement of a jejunal tube and a method of conducting enteral feeding with special mixtures].

The endoscopic placement of a nasoenteral probe for jejunal nutrition can be brought about by four main technical modes: conducting the probe through the biopsy canal of the endoscope, placement along the string, parallel introduction with the endoscope and combination of the above methods. An emulsion product containing 1 kkal/ml, macro-, microelements, vitamins was used for the enteral nutrition. Three main methods of enteral probe nutrition were used depending on specificity of the main disease, character of functional disorders of the intestine and the presence of inflammation in digestive organs.

Digestive System Diseases↗

Dietary protein supplementation. Fundamentals and examples of practical application.

Involving the most expensive of all the nutrients required by the body, the biological utilization of dietary protein remains an important topic, particularly to Third World countries wherein protein supplies are frequently limited. Protein supplementation of cereals and other foodstuffs is often used as a means of increasing protein intake. Supplementation not only increases protein intake but often also changes the physiological usability of the protein component of the resultant mixture. Employing an updated biological method for assessment of protein nutritive value, the author investigated the nature of the change in protein assimilability as a result of graded changes in the proportions of certain proteins combined pairwise into single mixtures. Data are presented on the basis of which the digestibility and/or assimilability of the protein component of a given mixture can be estimated. Lastly, the author indicates the need to evaluate high-protein foods and protein supplements in terms of, not only protein content relative to cost, but also of inherent nutritive value and complementary effect.

Animals↗

[Experimental 3-month study of safety of textured soybeans Becsei].

The authors conducted a three-month safety test of a textured soy (TS) product manufactured by the Agricultural Plant, Boly. Young male and female rats received semisynthetic diets containing 8, 18 and 38% of TS protein or casein supplemented with methionine, as the only source of protein. The effect of the diet containing 18% of TS protein on the growth, on certain parameters of protein and fat metabolism and on the zinc and copper status corresponded to that produced by 18% of casein supplemented with methionine. When the content of TS protein was lower or higher than the optimal (18%), the development of rats fell behind the control ones receiving adequate amount of casein. High doses of TS protein produced a favourable effect on lipid metabolism in the liver, but its effect on zinc metabolism was unfavourable. No signs of toxic action of the TS product were recorded during the three-month safety test of TS.

Animals↗

Industrial corn flour enrichment with whole amaranth flour and milling fractions in corn-based products.

Whole flour and milling fractions of raw amaranth seeds were used in 90:10, 80:20 and 50:50 mixtures with industrialized corn flour (MINSA) to prepare tortillas and arepas, basic nutritional foods in several Latin American countries. The three corn-amaranth mixtures showed a good protein and fat content as well as amino acid profile, and presented adequate physical characteristics for making tortillas. Amaranth whole flour and commercial corn flour mixtures in the proportion of 80:20 and 50:50 were found suitable for the preparation of arepas. Protein and fat content were substantially improved, with no changes in organoleptic characteristics. The Mexican type of Amaranthus cruentus, selected due to its availability and bromatologic properties, yielded products of excellent nutritional quality, according to their amino acid content and protein efficiency ratio (PER). The protein-rich (1R) and starchy (2-R) fractions obtained by air classification, also yielded good results when substituting amaranth flour. The afore-mentioned flours and air-classified fractions of the 50:50 mixtures proved to be adequate in gruel preparations when used in 1:8 and 1:12 dilutions, as they improved their organoleptic characteristics. Flakes and extrudates were also used, yielding products with a 13.3-15% protein content, 1.7-3.7% fat, and 65.2-74.2% carbohydrates. In addition, extrudates were utilized to prepare snacks of better nutritional quality than existing similar commercial products. Improvement of the tortilla's mineral and fatty acid contents was achieved in every case. Enrichment of this product with whole amaranth flour is, therefore, recommendable for use in programs aimed at improving the nutritional status of the population.

Amaranthus↗

[Nutritive value of lupine and its potential as human food].

The chemical composition and some indices of protein quality were measured in two species of sweet lupine Lupinus albus and Lupinus luteus grown at the Experimental Station in Gorbea, Chile: both samples showed a high protein content (39.5 and 44.6%). The protein efficiency ratio (PER) was measured in the rat and found to be 0.48 and 0.71, respectively, as compared to 2.57 for casein. Supplementation with 0.3% DL-methionine increased significantly those values, thus indicating that lupine protein is deficient in said amino acid. In another experiment the effect of cooking-extrusion on lupine flour (L. albus) was investigated and the chemical composition, protein efficiency ratio, methionine supplementation and digestibility of the protein were measured. The chemical composition was not changed but PER increased from 0.50 for raw lupine to 0.76 for processed lupine (P less than 0.05). Both values increased significantly with the addition of 0.3% DL-methionine. The protein digestibility of the supplemented lupine was not affected by the cooking extrusion process (76.5 and 77.8%, respectively). Supplementation of wheat flour with 5, 10, 15 and 20% lupine flour increased the PER of wheat flour from 0.92, to 1.39 for wheat flour supplemented with 10% lupine flour, and to 1.60 for the 15% level of the supplement. These studies seem to support the conclusion that sweet lupine is an interesting protein resource for human nutrition.

Animals↗