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PubMed1997

[Inguinal hernia in a young girl; sporadic manifestation of testicular feminization].

Examination of a woman aged 17 years with primary amenorrhoea revealed normal breasts and external genital organs, hardly any axillary or pubic hair growth, a blind vaginal pouch and no palpable uterus or adnexa. At additional examination, uterus and adnexa proved to be absent, the serum testosterone concentration was substantially increased and the karyotype was 46,XY. The diagnosis was 'testicular feminization' (androgen insensitivity syndrome). The patient in childhood had undergone a bilateral inguinal hernia operation, at which 'ovaries' were found in the hernial sacs. It might have been interpreted as the first sign of the syndrome; such a finding necessitates further examination. Most patients with testicular feminization seek medical advice because of primary amenorrhoea. Early diagnosis is important because the risk of malignant degeneration of the intra-abdominal testes increases with advancing age (sometimes also in relatives). Also it makes it possible gradually to prepare the child for her future.

Adolescent↗
PubMed1990

Evidence for modulation of hepatic mass by estrogens and hepatic "feminization".

Animals with end-to-side portacaval shunts and sham-operated animals, wherein the body weight and liver weight of the animals varied spontaneously over a considerable range, were studied. The relationships between hepatic androgen- and estrogen-receptor content, serum testosterone and estradiol levels and hepatic mass were characterized. Animals with portacaval shunts were smaller than those without shunts. Moreover, they had reduced serum levels of testosterone and estradiol. The reduction in serum testosterone was greater than that of estradiol. As a result, the calculated estrogen/testosterone ratio of the two groups of animals was greater for the portacaval shunt animals than for the controls. The dissociation constant values for the androgen receptor and estrogen receptor in the liver did not differ between groups. The activity of the androgen receptor (p less than 0.01) and estrogen receptor (p less than 0.05) was reduced markedly in the animals with portacaval shunts compared with controls. Moreover, the hepatic cytosolic estrogen receptor activity--but not that of the androgen receptor--correlated with the measured hepatic mass in both groups of animals. These data suggest that hepatic feminization is either associated with or is a hepatic regenerative signal in the rat.

Animals↗
PubMed1984

Malignant feminizing Leydig cell tumor.

A patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradiol, and total estrogens. Eleven years after the onset of his disease he remains clinically well.

Aged↗
PubMed1984

Fine structure of submandibular glands of mice with testicular feminization (Tfm/Y).

The fine structure of the submandibular gland of the mouse with testicular feminization (Tfm/Y) was studied by light and electron microscopy. The architecture of the Tfm/Y gland proved to be rather similar to that of the normal female mouse in both tubular ratio and structure. Granular convoluted tubular cells in Tfm/Y mice characteristically had fewer secretory granules and increased cytoplasmic vacuoles than normal littermates, suggesting an altered synthesis of secretory granules in this cell type of the Tfm/Y mouse. Moreover, there were differences in the ultrastructure of submandibular glands between Tfm/Y and normal female mice. In the gland of the Tfm/Y mouse, basal striations of the striated secretory tubular cells were not so developed and granular intercalated duct cells were less than those of normal females. These findings support the evidence that the secretory tubule of the mouse submandibular gland responds to androgens, resulting in accentuated development in the male, while also suggesting the possibility that the mouse submandibular gland is regulated by other factors which lead to the prominent sexual dimorphism observed in this gland.

Animals↗
PubMed1995

Action of testosterone on the estradiol-induced feminization of the male chick embryo.

The early treatment of male chick embryos with estradiol induces the feminization of their sex tract, i.e. both their gonads and müllerian tract exhibit female features. The additional treatment of estrogenized male embryos with testosterone propionate antagonizes the effects of estradiol on both gonads and müllerian ducts. Our data give further support to the view that testosterone and estrogens act respectively as agonist and antagonist modulators of the secretion of the anti-müllerian hormone.

Androgen-Insensitivity Syndrome↗
PubMed1994

Feminization as a result of both peripheral conversion of androgens and direct estrogen production from an adrenocortical carcinoma.

A 45-year-old man presented with gynecomastia, hypertension and a large left adrenal mass. Further evaluation revealed elevated serum concentrations of estrogen, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, deoxycorticosterone, and aldosterone and increased 24-hour urinary 17-ketosteroid and free cortisol excretion. Removal of a 10 kg adrenocortical carcinoma led to normalization of the hormone concentrations and partial resolution of the gynecomastia. There was no clinical evidence of metastases. Incubation of tumor slices demonstrated that the tumor had an active aromatase and sulfotransferase. We estimated that about half the serum estrone arose from peripheral conversion of androstenedione. Feminizing adrenocortical carcinomas are rare and this case is unusual given the lack of clinical metastases and the probable dual source of estrogen from tumor as well as from the peripheral conversion of tumor-derived androgens.

Adrenal Cortex Neoplasms↗
PubMed2002

Feminization of genetic males by a symbiotic bacterium in a butterfly, Eurema hecabe (Lepidoptera: Pieridae).

Wolbachia are symbiotic bacteria found in many arthropods and filarian nematodes. They often manipulate the reproduction of host arthropods. In the present study, female-biased sex-ratio distortion in the butterfly Eurema hecabe was investigated. Breeding experiments showed that this distorted sex ratio is maternally inherited. When treated with tetracycline, adult females of the thelygenic line produced male progeny only. After PCR using Wolbachia-specific primers for the ftsZ gene a positive result was seen in the thelygenic females, but not in male progeny from tetracycline-treated females, or individuals from a Tokyo population with normal sex ratio and reproduction. Cytological observations showed that thelygenic females lack the sex chromatin body (W chromosome). The results strongly suggest that the sex-ratio distortion in E. hecabe is due to feminization of genetic males by Wolbachia.

Animals↗
PubMed1986

Estrogenic feminization of the LH response to orchidectomy: association with prolonged nuclear estradiol receptor retention and induction of cytoplasmic progestin receptors in brain and pituitary.

A sex difference in the LH rise after gonadectomy is clearly observable in the rat. While male rats respond with an early (10-12 h) increase in LH after orchidectomy, a delayed response (2-3 days) is recorded after ovariectomy. In this study we tested the hypothesis that the delayed response to gonadectomy in the E2-treated males is due to a more prolonged retention of E2 (when compared with the corresponding male feedback signal, testosterone) within specific central nuclear receptor sites. Orchidectomized (ORDX) animals implanted with either empty or E2-filled Silastic capsules were sacrificed at 0, 24, 48 and 72 h after ORDX or E2-capsule removal. LH levels in ORDX rats rose several-fold by 24 h, whereas E2-treated, ORDX rats, showed no changes in peripheral LH levels until 72 h after E2-capsule removal. At the time of E2-capsule removal (0 h) large increases in nuclear estradiol receptor (NER) levels were seen in anterior pituitary, preoptic area, and hypothalamus (HYP). Twenty-four hours after E2-capsule removal, NER levels were still high in the 3 areas, and by 48 h NER values had returned to control (ORDX) levels, with the exception of HYP where they were slightly but significantly elevated. The increase in NER, as well as the subsequent decline after E2-capsule removal was paralleled by similar changes in cytosolic progestin receptor (CPR) levels in all three regions. Cytosolic testosterone levels were not changed by the E2-treatment. The results indicate that the feminized response to orchidectomy observed in E2-implanted males is related to a prolonged retention of the E2-receptor in nuclear sites. Further, they indicate that E2-treatment in males, as is the case in females, can induce a marked increase in progestin receptor levels within specific brain regions as well as in the pituitary. The reduction in NER and CPR levels to castrate values precedes the first detectable increase in peripheral LH levels. In conclusion, the pattern of LH rise after gonadectomy in the rat is dependent upon the steroidal milieu at the time of removal of the gonads.

Animals↗
PubMed1995

Feminized responses in fish to environmental estrogens.

Effluent from sewage-treatment works entering British rivers contains an estrogenic chemical, or mixture of chemicals, that stimulates vitellogenin synthesis in male fish. If the effluent constitutes a significant proportion of the flow of the river, lengthy stretches of entire rivers can be estrogenic to fish. The chemical, or chemicals, responsible for this feminizing effect have not yet been identified. However, many man-made chemicals known to be estrogenic to fish (and other vertebrates) are present in effluent, although which of these, if any, is responsible for the effects noted when caged fish are placed in rivers is unclear presently. In laboratory studies, exposure to estrogenic alkylphenolic chemicals caused a reduction in the rate of testicular development in trout undergoing sexual maturation.

Animals↗
PubMed1995

Functional dissection of the Drosophila mushroom bodies by selective feminization of genetically defined subcompartments.

Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved insect brain centers implicated in associative learning and various other aspects of behavior. Expression of transformer in lines that mark certain subsets of mushroom body intrinsic neurons, and in a line that marks a component of the antennal lobe, causes males to exhibit nondiscriminatory sexual behavior: they court mature males in addition to females. Expression of transformer in other mushroom body domains, and in control lines, has no such effect. Our data support the view that genetically defined subsets of mushroom body intrinsic neurons perform different functional roles.

Animals↗
PubMed2000

Searching for feminism: an analysis of community psychology literature relevant to women's concerns.

Articles published in both the American Journal of Community Psychology and Journal of Community Psychology, from their inception in 1973 through 1997, were content analyzed for women relevance, diversity, feminism, and historical change. Overall, 9.8% of the articles reviewed (N = 2,178) were considered women relevant, 4% recognized diversity among women, and 3% were considered feminist. There was an average yearly increase in women-relevant and feminist articles from 7.3 pre-1990 to 11.2 post-1990, and 1.6 pre-1990 to 4.6 post-1990, respectively. Overall, mental health and motherhood were the most addressed content areas. Among feminist articles, gender roles and violence against women were most salient. Race and SES were the most noted issues of diversity in both women-relevant and feminist articles. While an increase in feminist publications by both journals is promising, stereotypes of women and other oppressed groups continue to be perpetuated.

Bibliometrics↗
PubMed2002

Different for girls? Feminism, health information and librarianship.

This paper focuses on the provision and organization of health information materials in women's health centres in UK and Ireland in the late 20th century Such centres sprung from the work of feminist activists and health workers from the late 1960s onwards, promoting health information and other interventions to counteract women's devalued status within society, and the stereotypes perpetuated by health care and other systems. Centres that developed were (and still are) typically within the voluntary sector, have a strong feminist perspective and are run by lay workers. This paper will draw on research into information provision in these centres, its scope, organization and who provides it. It will argue that this work is of interest to mainstream librarianship, but there are minimal linkages as feminist thinking within librarianship has been unable overall to make common cause with the work of these, and other such agencies, which has inhibited potential developments of mutual benefit. This paper draws on ongoing research into feminism and librarianship, and findings that have been presented in a number of settings.

Female↗
PubMed1984

Treatment of primary hyperparathyroidism with cyclofenil--a synthetic stilbestrol derivative with minimal feminizing effects.

In eight patients with primary hyperparathyroidism (HPT) the laboratory effects of cyclofenil, which is a synthetic stilbestrol derivative with weak feminizing effects, were studied over a period of 5-13 weeks. In all the patients there were during treatment clear reductions of the serum calcium levels as well as the urinary excretions of calcium and hydroxyproline. These findings are in accordance with earlier reports that oestrogens reduce bone resorption mediated by parathyroid hormone. It has previously been demonstrated that cyclofenil can be given, on other indications, for several years to both male and female patients without oestrogenic side-effects. This pilot study, therefore, indicates that treatment with cyclofenil might be of value in some cases of primary HPT where surgery is not considered.

Aged↗
PubMed2005

Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring.

Prochloraz is a commonly used fungicide that has shown multiple mechanisms of action in vitro. It antagonizes the androgen and the estrogen receptors, agonizes the Ah receptor, and inhibits aromatase activity. In vivo prochloraz acts antiandrogenically in the Hershberger assay by reducing weights of reproductive organs, affecting androgen-regulated gene expressions, and increasing luteinizing hormone (LH) levels. The purpose of this study was to investigate reproductive toxic effects after exposure during gestation and lactation to prochloraz alone and a mixture of five pesticides (deltamethrin, methiocarb, prochloraz, simazine, and tribenuron-methyl). Prochloraz (30 mg/kg/day) or the mixture (20 mg/kg/day) was dosed to pregnant Wistar dams from gestational day (GD) 7 until postnatal day (PND) 16. Some dams were taken for cesarean section at GD 21, and others were allowed to give birth. Results showed that prochloraz and the mixture significantly reduced plasma and testicular testosterone levels in GD 21 male fetuses, whereas testicular progesterone was increased. Gestational length was increased by prochloraz. Chemical analysis of the rat breast milk showed that prochloraz was transferred to the milk. In males a significant increase of nipple retention was found, and the bulbourethral gland weight was decreased, whereas other reproductive organs were unaffected. In addition cytochrome P450 (CYP)1A activities in livers were induced by prochloraz, possibly as a result of Ah receptor activation. Behavioral studies showed that the activity level and sweet preference of adult males were significantly increased. Overall these results strongly indicate that prochloraz feminizes the male offspring after perinatal exposure, and that these effects are due, at least in part, to diminished fetal steroidogenesis.

Animals↗
PubMed1998

Evidence for widespread Wolbachia infection in isopod crustaceans: molecular identification and host feminization.

Wolbachia are maternally inherited, intracellular, alpha proteobacteria that infect a wide range of arthropods. They cause three kinds of reproductive alterations in their hosts: cytoplasmic incompatibility, parthenogenesis and feminization. There have been many studies of the distribution of Wolbachia in arthropods, but very few crustacean species are known to be infected. We investigated the prevalence of Wolbachia in 85 species from five crustacean orders. Twenty-two isopod species were found to carry these bacteria. The bacteria were found mainly in terrestrial species, suggesting that Wolbachia came from a continental environment. The evolutionary relationships between these Wolbachia strains were determined by sequencing bacterial genes and by interspecific transfers. All the bacteria associated with isopods belonged to the Wolbachia B group, based on 16S rDNA sequence data. All the terrestrial isopod symbionts in this group except one formed an independent clade. The results of interspecific transfers show evidence of specialization of Wolbachia symbionts to their isopod hosts. They also suggest that host species plays a more important role than bacterial phylogeny in determining the phenotype induced by Wolbachia infection.

Animals↗
PubMed1988

An unbalanced autosomal translocation (7;9) associated with feminization.

A newborn girl presented with generalized mild dysmorphic features. She later developed heart failure and hydrocephalus, and died aged 5 months. Chromosome analysis revealed an unbalanced reciprocal translocation (with partial trisomy for half of the long arm of 7 and partial monosomy for the short arm of chromosome 9) and normal but inappropriate sex chromosomes (XY). The karyotype (46,XY,-9, +der(9),t(7;9)(q31.1;p23)pat) was inferred from her father who was a balanced carrier: 46, XY,(7;9)(q31.1;p23). The evidence of the present case, when considered with that of previous reports, suggests that deletion of genes on the 9p may have caused the feminization and therefore that the 9p region may contain genes which are important in the normal process of testis formation.

Chromosomes, Human, Pair 7↗