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At least 181 records · Page 10Linked to original sources
PubMed2004

Intrauterine devices and reproductive health: American women in feast and famine.

Intrauterine contraception has been available in the United States since the early 1960s. During the past 4 decades, American women have mainly used nine different devices and accumulated approximately 47 million person-years of use. Interest in IUDs, as expressed by both use patterns and market forces that created and retired products, varied tremendously over this period. In the peak years, women had unfettered access to, and choice of, IUDs, over time availability has declined. The American experience with IUDs involved a unique combination of factors: invention, expansion of publicly funded services, mass media, medical missteps, conflicting research, medical opinion and tort law. The IUD generated a controversial balance sheet of risks, benefits and reputation that still impacts reproductive health today.

Humans↗
PubMed2004

Obesity and post-prandial lipid metabolism. Feast or famine?

Both in Western countries and in third world countries there is an increasing incidence of obesity. Obesity per se or insulin resistance associated with obesity may increase cardiovascular risk factors including dyslipidemia, hypertension and Type 2 diabetes. Over the past decade the understanding has increased of specific mediators in the hypothalamus that are involved in regulating food intake and body weight. In obese humans fasting plasma lipids can be normal but postprandial lipid metabolism is abnormal with an accumulation of triglyceride-rich remnant lipoproteins. In viscerally obese men chylomicron remnant catabolism was markedly decreased when compared with lean individuals. The decreased clearance of chylomicron remnants in viscerally obese subjects may be explained by competition between chylomicron remnants and the increased hepatic production of VLDL for clearance by low density lipoprotein receptors. Increased food intake in rodent models of obesity was shown to be associated with a delay in the catabolism of remnant lipoprotein particles. Prevention of hyperphagia was found to correct the impairment in the metabolism of remnant lipoproteins. Under fasting and food restricted conditions the improvement of remnant metabolism was associated with an increased oxidation of remnant lipids as determined by a novel stable isotope breath test. Anti-obesity and lipid lowering drugs have been used for the treatment of obesity. Inhibitors of cholesterol synthesis inhibitors (statins) have been shown to be effective in treating dyslipidemia. Inhibition of cholesterol synthesis with Atorvastatin was shown to improve chylomicron metabolism by increasing chylomicron remnant catabolism in obese subjects as assessed by the newly developed stable isotope breath test.

Adipose Tissue↗
PubMed2005

Metagenomic marine nitrogen fixation--feast or famine?

Natural populations of bacteria in different environments can be astonishingly diverse, as was revealed graphically by large-scale sequencing of samples of their so-called metagenomes. Among the sequence datasets from four different samples of marine bacterial metagenomes, we noted that nitrogen fixation (nif) genes were conspicuous by their absence from three of them. However, in one sample, more than one-third of the bacteria appeared to have a complement of these genes. Here, some reasons behind this site-to-site variability and their implications for how molecular methods, involving large-scale sequencing and/or functional metagenomics, can best be used to describe bacterial diversity in natural environments are discussed.

Bacteria↗