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PubMed2005

Erythrocyte aggregation in Behçet's disease determined with the Sefam and Myrenne aggregometer. Lack of association with thrombosis and uveitis.

Behçet's disease (BD) is a chronic systemic vasculitis characterised by recurrent oral and genital ulcers and uveitis, in which 25-30% of patients develop thrombotic events of unknown etiology. In order to ascertain whether erythrocyte aggregation (EA) may be involved in thrombotic events and or uveitis in BD patients, we determined using two erythrocyte aggregometers i.e. Myrenne and Sefam (which provides the total disaggregation threshold, needed for erythrocytes to disaggregate), EA in 77 BD patients (42 male, 35 female, aged 44 +/- 12 years) and 77 controls (41 male, 36 female, aged 43 +/- 11 years). BD patients showed higher EA determined with both aggregometers: Myrenne (EA(0): P = 0.035; EA(1): P < 0.001) or the Sefam (Ta: P < 0.001, AI(10): P < 0.001, gammaD: P = 0.014) as well as higher fibrinogen and triglyceride levels (P < 0.001, P = 0.003, respectively) compared with the control group. However no differences were observed in any of the aggregation parameters determined either with the Myrenne (EA(0), EA(1)) or the Sefam (Ta, AI(10), gammaD) aggregometer when BD patients with thrombotic events (n = 23) or uveitis (n = 21) were compared with those who did not (P > 0.05). These results reinforce previous findings of our group, suggesting that EA does not seem to be involved in thrombotic events or in uveitis in BD patients.

Adult↗
PubMed1980

[Thyroid hormones, cholesterol, erythrocyte aggregation and fibrinogen degradation products in acute myocardial infarct].

One hundred and sixty-two patients with acute myocardial infarction, whose ages ranged from 36 to 65, were studied. The content of thyroid hormones was found to be reduced in the acute period of myocardial infarction. The triiodothyronine level was lower on the 2nd day of the disease, the thyroxine content decreased on the 10th day of the disease but became normal on the 20-25th day. An interrelation between the clinical course of the disease and the dynamics of changes in the cholesterol content, rate of erythrocyte aggregation, the content of fibrinogen degradation products, and the level of thyroid hormones was determined. Normalization of the values was determined. Normalization of the values studied occurred earlier in the group of patients with a more favourable course of the acute period of myocardial infarction than in those with severe myocardial infarction. The data obtained show a close interrelation between thyroid activity and values studied and the clinical course of the disease.

Adult↗
PubMed1985

[ Methodological evaluation and clinical significance of erythrocyte aggregation].

Red cell aggregation, which occurs in vivo when blood flow slows down, has been studied in 22 healthy subjects and 31 type I diabetics by means of Myrenne MA1 automatic aggregometer. First of all, the most reliable and precise technique has been studied: the best results have been obtained employing 25 microliters of K2-EDTA-anticoagulated blood stored between 0 and 20 degrees C for a maximum of 4 h. The present study has shown statistically significant differences (p = 0.01) between the two groups studied (controls: mean = 11.895 MEA +/- 0.863; diabetics: mean = 15.552 MEA +/- 0.985). Moreover, correlations between erythrocyte aggregability and hematochemical and rheological parameters like fibrinogen, ESR, serum proteins, plasma and blood viscosity, have been evaluated.

Blood Flow Velocity↗
PubMed1991

The influence of fractions of abnormal erythrocytes on aggregation.

Erythrocytes with abnormal shapes and deformability reduce cell aggregation and hence sedimentation. It is not known what influence small fractions of these abnormal cells have on the sedimentation behaviour of normal cells. We have used three different methods to alter erythrocyte properties (glutaraldehyde, heat treatment, and metabolic depletion). The admixture of such cells in increasing fractions to normal cells affected the sedimentation behaviour in three different ways. Heat-treated erythrocytes decreased the sedimentation proportionally. Small fractions of glutaraldehyde-treated cells increased the sedimentation, which was explained by a pro-aggregatory change of surface properties by glutaraldehyde. With 50% or more glutaraldehyde-treated cells sedimentation was inhibited, which was due to excessive formation of aggregates occupying the entire tube. The presence of small fractions of echinocytes produced by metabolic depletion decreased cell sedimentation disproportionally, which was explained by an inability of spiculated cells to form aggregates with normal erythrocytes. These results indicate that erythrocyte sedimentation is affected by fraction of abnormal cells in a complex way. Many diseases are characterized by fractions of abnormal erythrocytes. Our results may, therefore, contribute to a better understanding of these conditions.

Adenosine Triphosphate↗
PubMed1998

[Reversible erythrocyte aggregation in cancer patients].

Reversible aggregation of the peripheral blood erythrocytes was studied in patients with stages III-IV lung cancer and patients with stages II-III tumors of the head and neck (cancer of the tongue, larynx, and buccal mucosa). The parameters examined were as follows: U0 and Ud--minimal and maximal stability of aggregates, tau---red cell aggregation half-period, A--the amplitude of photometric signal (in mm) characterizing the count of erythrocytes, Ia--aggregation index, and K--integral coefficient. The findings indicate an appreciable intensification of reversible aggregation of red cells in cancer: a significant increase of U0, Ud, A, Ia, and K and decrease of tau.

Adult↗
PubMed1997

Erythrocyte aggregation tendency and cellular properties in horse, human, and rat: a comparative study.

Horse blood has a higher tendency to form red blood cell (RBC) aggregates compared with human blood, with this enhanced aggregation previously attributed to differences in plasma factors. Our results confirm this observation and further indicate that washed horse RBC also have a significantly higher aggregation tendency in dextran 70 solutions (i.e., horse RBC have a higher "aggregability"). In contrast, the aggregation tendency of rat RBC, both in autologous plasma and in dextran 70, is significantly less compared with human and horse RBC. Other rheological findings for horse and rat RBC include smaller changes in RBC deformation indexes over the same shear stress range and a lower RBC shape recovery time constant. Rat RBC also had higher two-phase aqueous polymer partition coefficients, suggesting a higher surface charge. Membrane protein analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed marked differences: 1) band 4.2 protein was lacking in horse RBC membranes, and 2) carbohydrate groups have different distributions in human, rat, and horse RBC, as indicated by different patterns in periodic acid-Schiff-stained protein bands. Our results clearly indicate significant differences in RBC aggregability among the three species and indicate that cellular factors contribute importantly to these differences. Furthermore, they suggest that systematic studies of blood and RBC from different species should provide insight into the mechanism(s) of RBC aggregation.

Animals↗