The central role of actinically degenerate elastic tissue.
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The echographic rhythmic palpation (echosismography) is a new method which completes classical sonography. It studies the elastic behaviour of the tissues after their mechanical excitation which are analysed in the T.M. mode. When displayed in classical sonographic technique the lesion is located with calipers. Calipers allow the recognizing of the tumor level at any moment in time motion mode. Vibrations are then applied on the skin as near as possible to the lesion. A regular frequency of 1,5 impulsion per second at a constant pressure of 500 gr on 4 cm2 is used. The response of resonating tissues to vibratory excitation is recorded and characterized by the amplitude of the oscillations (sinusoïdal shape). Benign tumors always gave sinusoïdal type oscillations. Most of this kind of tumors were semi-liquid or solid. Malignant tumors gave typical flat curves in 84% cases. Some malignant tumors (16%) gave benign type sinusoïdal oscillations. They had a small size, less then 2 cm diameter. Some of them where to superficial so they had easily induced oscillations over the excitation level. Echosismography enables to improve the diagnosis when compared with classical sonography in about 20% of cases.
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Supersonic shear imaging (SSI) is a new ultrasound-based technique for real-time visualization of soft tissue viscoelastic properties. Using ultrasonic focused beams, it is possible to remotely generate mechanical vibration sources radiating low-frequency, shear waves inside tissues. Relying on this concept, SSI proposes to create such a source and make it move at a supersonic speed. In analogy with the "sonic boom" created by a supersonic aircraft, the resulting shear waves will interfere constructively along a Mach cone, creating two intense plane shear waves. These waves propagate through the medium and are progressively distorted by tissue heterogeneities. An ultrafast scanner prototype is able to both generate this supersonic source and image (5000 frames/s) the propagation of the resulting shear waves. Using inversion algorithms, the shear elasticity of medium can be mapped quantitatively from this propagation movie. The SSI enables tissue elasticity mapping in less than 20 ms, even in strongly viscous medium like breast. Modalities such as shear compounding are implementable by tilting shear waves in different directions and improving the elasticity estimation. Results validating SSI in heterogeneous phantoms are presented. The first in vivo investigations made on healthy volunteers emphasize the potential clinical applicability of SSI for breast cancer detection.
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