[Endocrine changes in obesity and emaciation].
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Immunomorphological manifestations of the wasting syndrome in a patient with myasthenia: thymus atrophy, reduction of the spleen lymphoid tissue, sclerosis of the lymph nodes, hyperplasia of the bone marrow, a decrease in the absolute number of T- and B-lymphocytes of the peripheral blood, intestinal necrosis, and cachexia, are first described. The condition developed along with exacerbation of the main pathological process and immunosuppressive therapy (roentgen irradiation of the thymus, cyclophosphan, hydrocortisone).
Data from a National Nutrition Survey conducted in 1988 in a probability sample of 13,236 households and 17,426 children under five, representative at the national level and for four regions (North, Center, South, and Mexico City), were analyzed. Risks for wasting and stunting and odds ratios were obtained by region, by district according to proportion of indigenous population and by level of urbanization, by level of education of both parents, by gender, and by various combinations of the former strata. A high risk of stunting and a low risk of wasting were found. The risk of stunting is greater in predominantly indigenous and rural districts, in the South and Center, and in families of mothers with low education and poor housing conditions. The results can be used for food and nutrition policy planning and for targeting nutrition intervention programs.
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An 18-month-old Quarter Horse gelding was examined because of weight loss and dysphagia of 1 month's duration. Clinical signs included lethargy, dehydration, ptyalism, and probable aspiration pneumonia. Severe dyspnea and cyanosis were evident after mild exercise. Endoscopy revealed laryngospasm and pharyngospasm. Because clinical signs and endoscopic findings were suggestive of hyperkalemic periodic paralysis (HPP), acetazolamide treatment was instituted. Marked improvement was observed within 48 hours. The horse was determined to be homozygous for HPP. It is likely that this horse's dysphagia, with resultant weight loss and aspiration pneumonia, were clinical manifestations and consequences of HPP. Regardless of age and serum potassium concentration, HPP should be considered as a differential diagnosis for pharyngeal and laryngeal abnormalities and dysphagia in horses with Quarter Horse breeding.
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Anorexia and elevated energy expenditure contributes to weight loss in cancer patients. Increased energy expenditure may explain 0.5-1.0 kg weight loss per month with regard to resting energy expenditure and even more with regard to total energy expenditure. The explanation behind elevated energy expenditure does not seem to be due to the tumour metabolism itself but rather to an increased host metabolic demand aimed at providing life-supporting protein synthesis and perhaps the immune system with energy. The trigger behind the activation of the synthesis of certain proteins is unknown. Only sparse information is available on the altered regulation of appetite in cancer disease. Changed metabolism and activity of neurotransmitters seem to be involved.
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A new refeeding program using only liquid formula was given to six anorexic inpatients (LF group) at the initial stage of hospitalization. These patients were compared with six other inpatients who received regular meals (RM group). The LF group did not develop a phobia of gaining weight, while the RM group showed a vicious cycle of gastrointestinal discomforts leading to fat phobia and stagnation in weight gain. By comparison, the LF group had fewer gastrointestinal symptoms, which resulted in the disruption of this cycle and seemed to help motivate these patients to obtain a steady gain in bodyweight.