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Results for “Dimethindene”

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PubMed1985

The influence of dimetindene maleate on the endogenous hydrocortisone synthesis suppressing potency of betamethasone.

Plasma hydrocortisone (cortisol) levels in 7 healthy volunteers were measured following administration of 0.25 mg betamethasone or 0.25 mg betamethasone and 1 mg dimetindene maleate. The H1-receptor antagonist dimetindene maleate did not influence the hydrocortisone suppressing activity of betamethasone, which was proved by comparison with the published plasma hydrocortisone levels of 162 young healthy untreated volunteers.

Adult↗

PubMed1986

[Efficacy and tolerance to mebhydroline in comparison with dimetindene maleate].

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Adolescent↗

PubMed1987

[Terfenadine and automobile driving. A placebo controlled double-blind study of the effect of different antihistamines on driving behavior].

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Adult↗

PubMed1978

[Local effect of Fenistil gel].

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Clinical Trials as Topic↗

PubMed1986

[The effect of the hydrogen ion concentration on membrane transport of dissociated drugs from saturated solutions].

Dissociating drugs diffuse from saturated solutions with suspended drug particles across lipophilic membranes according to zero order kinetics. The highest rate is maintained even if large fractions of the drug are dissociated due to the pH-conditions of the solution. The pH range of the highest and pH-independent membrane transport corresponds with drug solubility/pH-profiles, showing the solubility of the undissociated drug.

Carbutamide↗

PubMed1974

[Investigation of the local antihistamine effect of dermatological preparations].

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Administration, Topical↗

PubMed1966

A long-acting antihistamine.

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Dimethindene↗

PubMed1969

Local anaesthetic action of 3 different antihistaminics compared to procaine hydrochloride.

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Anesthesia, Local↗

PubMed1969

Comparative pharmacological action of different antihistaminics.

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Anesthetics, Local↗

PubMed1979

Inhibition of galactosamine induced edemas in the rat by drugs preventing macromolecular leakage from the hamster cheek pouch microvasculature.

We have shown that terbutaline and dimethpyrindene, 2 drugs which prevent macromolecular leakage in the in vivo--bio-assay of Hamster Cheek Pouch, either by direct action onendothelial cells or by blocking histamine receptors at the microvascular leakage sites, can also prevent macromolecular leakage in vivo in 2 different models of generalized edema.

Animals↗

PubMed1979