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Results for “Dextroamphetamine”

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PubMed1976

The combined effect of marihuana and dextroamphetamine.

The studies in mice indicated that locomotor activity could be stimulated THC and that this would enhance the effect produced by MAMP. We have previously shown that when 3, 6, or 9 mug/kg THC were administered to young adult males by MJ smoking, a dose-related impairment in standing steadiness (WB) and attentive motor performance (PM) resulted, although DAF and subjective evaluations were insensitive to these treatments. These same testing procedures after d-AMP 5, 10, and 15 mg/70 kg revealed no important performance effect. Systolic blood pressure was elevated with 15 mg/70 kg d-AMP, and subjective detection was positive and dose related. A combination of 25 mug/kg THC delivered by smoking an appropriate MJ cigarette and 10 mg/70 kd d-AMP taken orally produced subjective effects and psychomotor performance decrements not different from those with the MJ alone. The doses used were modest, yet most subjects believed their driving performance, a representative motor and metal skill, would be impaired. This judgment is supported by the laboratory measurements made. It is reasonable that realistically higher doses may not only have adverse psychological and cardiovascular effects but increase an accident potential.

Adult↗
PubMed1984

Dextroamphetamine and individual susceptibility to reinforcement in verbal operant conditioning.

The present investigation was designed to study the relationships between extraversion, d-amphetamine and modes of reinforcement in verbal operant conditioning. A factorial design involving two levels of extraversion (extraverts and introverts), two reinforcement conditions ('good' and 'electric shock') and three treatments (placebo and two doses, 7.5 and 12.5 mg, of d-amphetamine) with repeated measures on the last factor was used. Sixty postgraduate female students were individually subjected to Taffel's verbal conditioning procedure. The study supported the following conclusions: (1) under the placebo condition, the extraverted subjects condition better with the rewarding reinforcer while the introverted subjects condition better with the punishing reinforcer; (2) under the influence of d-amphetamine, the extraverted subjects condition better with the punishing reinforcer while the conditioning scores of introverted subjects decrease with the punishing reinforcer but are not influenced with the rewarding reinforcer.

Adult↗