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PubMed2002

Cell motility: insights from the backstage.

In the true spirit of Michael Abercrombie's pioneering studies on cell locomotion, the Fifth Abercrombie's Symposium on Cell Behaviour--held in St Catherine's College at Oxford University (September 15-18, 2002)--celebrated the intricate beauty of cell motility with an explosion of new technologies that Abercrombie could only have dreamed of. Building on the complementary approaches of quantitative cell biology, biochemistry and genetics, the meeting provided new insights into the ever-growing complexity of the signal transduction pathways involved in cell movement.

Cell Movement↗
PubMed1985

The female analyst and the erotized transference.

The concept of erotized transference is discussed from Freud's original writings on the subject to those of recent contributors. It is noted that there exists an almost complete absence of reports in the literature of male patients developing an erotized transference to their female analysts. The question of how significant the gender of the analyst is in the unfolding of the transference and its vicissitudes is raised. It is maintained that the four possible analyst/analysand dyads differ qualitatively in that resistance and identification in the transference may be enhanced or inhibited by the gender of the analyst and/or the homosexual or heterosexual nature of the dyad. The erotized transference to the female analyst is focused upon as a vehicle to the study of such qualitative differences. It is hypothesized that the expression of strong erotic urges to the female analyst by the male patient is somewhat inhibited by the fantasy of the overwhelming pre-oedipal mother. In contrast, such erotic feelings are freely expressed by the female patient. Two cases, a male and a female, are described to support the above hypothesis.

Adult↗
PubMed1996

The characterological basis of multiple personality.

This review has focused on the characterological features of dissociative identity disorder (DID), extending the "state versus trait" debate to the realm of the dissociative disorders. A number of different theories are presented describing DID as a variant of, on a continuum with, or being comorbid with the narcissistic and the borderline personality disorders. It is then hypothesized that DID is best considered a distinct characterological entity. Two theories are put forth, which describe a personality disorder whose predominant defense is dissociation. The more developed model which possibly has more explanatory value is the "dissociative character." In this schema, DID would be considered a lower-level dissociative character, utilizing primitive forms of dissociation in which splitting is enhanced by an autohypnotic defensive altered state of consciousness. These altered states originate in response to the overstimulation of external trauma, but get reactivated in the service of here-and-now intrapsychic conflicts. Recognition of this dual quality of dissociation seems helpful in psychodynamic treatment, which allows for analysis of the defense and analysis of the content of these states. The nature of the content of what is "in dissociation" appears to have a dreamlike quality to it that may correspond to previous trauma but also be subject to some secondary revision. There is clinical evidence to suggest that "dream work" of the ego is operative in both the representation of a separate self in dreams and in alter personalities. Another organizing influence which contributes to seemingly separate identities is that of perverse sexuality. It appears that a number of dissociated sexual pathways may be followed in the same individual, which encapsulate aggression, childhood trauma, anxiety, and a sense of self. When this exceedingly complex psychic structure is successful, it may then free up some ego to proceed with aspects of healthy development.

Borderline Personality Disorder↗
PubMed2003

Essential hypertension: genes and dreams.

Herein we review all of the data from linkage by genome scanning and from association studies in essential hypertension. Genome scans have yielded loci linked to hypertension on almost every chromosome. We tabulate all of these loci to highlight the striking inconsistency. Similarly, association studies have implicated > 66 genes to date, which we also list, but virtually all have failed to show consistent replication in other settings. Nevertheless, we believe that molecular genetics should eventually find all of the major gene variants for essential hypertension. This will be a great scientific achievement and lead to new treatments. The dream, however, of using this information in clinical genetic testing could turn out to be a nightmare. Thus at present the hype surrounding genes for complex polygenic diseases like hypertension far exceeds the reality.

Genetic Carrier Screening↗
PubMed2004

[Bioartificial liver support system: state of the art].

The temporary function replacement and intensive support play a pivotal role in the treatment of patients with acute or chronic end-stage organ failure. The hemodialysis and peritoneal dialysis have become routine techniques in the management of acute or chronic renal failure. But for the complexity of hepatic function, e.g. metabolism, biosynthesis and biotransformation for endogenous or exogenous substrates, the simulation or partial replacement of hepatic function is a great dream of bionic technologists. With the development of cell biology and biomedical material, the combination of biomaterial and the hepatocyte cultured ex vivo could provide a range of human liver-specific functions. The combination of biomaterial and viable cell was called hybrid or bioartificial liver support system (BALSS). It is a chimera of biomaterials and hepatocytes. The bionic technologists study the cell and its culture in vitro, which is the main component of BASLL. Many types of BALSS were translated into the early clinical stage. In this overview, we review the hepatocyte culture and the design of different bioreactors. It includes the immune obstacles in xeno-hemoperfusion and how to assess pre-clinical and clinical effectiveness.

Bioreactors↗
PubMed2000

Parapraxes in the plays of William Shakespeare.

Parapraxes in the psychopathology of everyday life are "mistakes" that reveal the workings of the unconscious. (Obviously they existed before Freud's time, but it was Freud who gave them a name and dissected their complex psychological meanings.) When they occur in a great work of art (as in Shakespeare's plays) they are obviously not "mistakes" at all but carefully planted details of the artist's over-all aesthetic conception. Just as fictional dreams, as in Jensen's Gradiva, seem to follow the rules of nocturnal dream process and can be subjected to psychoanalytic scrutiny, fictional parapraxes are doubly interesting because they not only express the inwardness of a protagonist but reveal something of the writer's aesthetic method as well. This paper attempts to address these double points of entry into the mystery of Shakespeare's plays, posing the question, "Can the seemingly trivial or irrelevant (a handful of parapraxes in 38 plays) shed any light on the most complex characters in Western literature and the extraordinary mind of their creator?"

Amnesia↗
PubMed1984

Psychic trauma and masochism.

Three analyses are presented in which acute trauma (overwhelming internal or external stimulation so great as to preclude the patient's utilizing his usual defenses adequately) in childhood contributed to the development of masochism. The patients later attempted mastery through repetition, reversal, and erotization , and employed regression as a defense against feared oedipal wishes.

Child↗
PubMed1994

Pulsatile blood flow from impeller pump: a dream has come true.

For decades many investigations have been made on producing a pulsatile blood flow with an impeller pump. It has been foiled because of excessive hemolysis. Other investigators foretold that a pulsatile centrifugal pump is impossible in the near future, without increasing the complexity of the system remarkably. The author has presevered in this study and made progress steadily. An axial pulsatile impeller pump with constant-rotating speed was developed, in which the impeller reciprocates along its axis while rotates. Meanwhile, a pulsatile implantable impeller centrifugal pump is now in animal surviving experimental stage. The pulsatility of the blood flow is achieved by changing the rotating speed of the impeller periodically, via introducing a square wave form voltage into the motor coil. The hemodynamic and physiological superiorities to both nonpulsatile impeller pump and diaphragm pump were demonstrated. The hematological and biochemical data indicated low hemolysis and thrombogenesis, low renal and heptic dysfunction. Furthermore, a pulsatile implantable impeller total heart has completed its acute biventricular assist animal experiments. This is an almost unique total heart at the present, it is driven by a single motor, the left and right pumps eject the blood simultaneously, and the volume equilibrium of both pumps is achieved naturally. The dream of producing a pulsatile blood flow with an impeller pump has come true. Doubtlessly, an impeller heart with simplicity, pulsatility, implantability, compatibility and reliability, will be a viable alternative to diaphragm heart, really.

Animals↗
PubMed1997

Fairy-tales in psychotherapy.

Fairy-tales, like mythologies, can be found all over the world containing the same motif and chains of motifs. In this paper I have presented some theories on the occurrence of this archetypal phenomenon ranging from the old migration theory to Sheldrake's theory of morphogenetic fields. I have then tried to show how fairy-tale-motifs can appear in various ways in analytical therapy, often in hidden forms. We find them in patients' dreams as well as in their fantasies and associations. If the therapist is open to them they will also appear in his or her amplifications. He or she might then take note of the fairy-tale or point it out to the patient; in the latter case it might provide better access to the patient's problems and complexes as fairy-tales have an emotional completeness because of their pictorial character. Finally I have described the favourite fairy-tale of one of my patients and related it to his symptoms, his central complex and his personal ways of experiencing and behaving. This survey of how fairy-tales can be used in therapy with children and with adults far from exhaustive.

Adult↗
PubMed1996

Studies on hysteria one hundred years on: a century of psychoanalysis.

In this paper the author shows how 'Studies on Hysteria' ushered in a new century of psychiatry. While hysteria as a clinical entity remains as difficult as ever to define, the entire theoretical edifice of psychoanalysis rests upon it, as it allowed the discovery of the laws of conscious and unconscious thought and fantasy and thereby made it possible to explain symptoms and dreams. The author points out that many of the basic concepts of psychoanalysis are already to be found in the Studies and that, although some important ideas were thereafter forgotten, these have now come to be regarded as essential again. The notions of splitting and dissociation featured prominently in that seminal work and have now been reintegrated into mainstream theory. Present-day psychoanalysis is considered to have returned to its roots as embodied in the Studies, much less emphasis now being laid on the later concepts of drives, phases and libido theory. Female development and the woman's Oedipus complex are, in the author's view, as problematic as in Freud's day, perhaps because of his countertransference problems and neglect of the role of the mother, as exemplified in the Dora analysis. As the author shows, only the French analysts have remained consistently faithful to the concept of hysteria, whereas in other countries it no longer exists as a diagnosis. Yet the concept is stated to be important both historically and for clinical practice today.

Dreams↗
PubMed1982

Toward a psychophysiology of waking fantasy: EEG studies.

EEG investigations into the psychophysiology of waking fantasy have yielded interesting but inconclusive results. The most promising lines of research are reviewed with particular reference to the methodological complexities involved. Studies of alpha blocking, alpha states, theta states, and cerebral asymmetries are described. Comparisons are drawn between these lines of investigation and the methods of experimental dream research.

Alpha Rhythm↗
PubMed1996

High-power graphic computers for visual simulation: a real-time--rendering revolution.

Advances in high-end graphics computers in the past decade have made it possible to render visual scenes of incredible complexity and realism in real time. These new capabilities make it possible to manipulate and investigate the interactions of observers with their visual world in ways once only dreamed of. This paper reviews how these developments have affected two preexisting domains of behavioral research (flight simulation and motion perception) and have created a new domain (virtual environment research) which provides tools and challenges for the perceptual psychologist. Finally, the current limitations of these technologies are considered, with an eye toward how perceptual psychologist might shape future developments.

Aircraft↗